Incidental Mutation 'R9026:Nsd3'
| ID |
686741 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Nsd3
|
| Ensembl Gene |
ENSMUSG00000054823 |
| Gene Name |
nuclear receptor binding SET domain protein 3 |
| Synonyms |
Whsc1l1, WHISTLE |
| MMRRC Submission |
068855-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.361)
|
| Stock # |
R9026 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
8 |
| Chromosomal Location |
26091617-26209694 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 26172576 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Arginine
at position 778
(S778R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000081040
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000084026]
[ENSMUST00000139966]
[ENSMUST00000142395]
[ENSMUST00000146919]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000084026
AA Change: S778R
PolyPhen 2
Score 0.100 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000081040
Gene: ENSMUSG00000054823
AA Change: S778R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
128 |
151 |
N/A |
INTRINSIC |
|
low complexity region
|
193 |
225 |
N/A |
INTRINSIC |
|
PWWP
|
278 |
341 |
1.6e-12 |
SMART |
|
low complexity region
|
680 |
701 |
N/A |
INTRINSIC |
|
PHD
|
713 |
756 |
4.49e-7 |
SMART |
|
PHD
|
761 |
808 |
5.82e-1 |
SMART |
|
PHD
|
809 |
861 |
3.06e0 |
SMART |
|
PHD
|
874 |
963 |
1e-4 |
SMART |
|
PWWP
|
968 |
1030 |
8.62e-18 |
SMART |
|
AWS
|
1103 |
1154 |
2.61e-17 |
SMART |
|
SET
|
1155 |
1278 |
2.17e-41 |
SMART |
|
PostSET
|
1279 |
1295 |
2.63e-3 |
SMART |
|
low complexity region
|
1309 |
1326 |
N/A |
INTRINSIC |
|
PHD
|
1332 |
1375 |
4.32e-9 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000139966
AA Change: S778R
PolyPhen 2
Score 0.100 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000122096
Gene: ENSMUSG00000054823
AA Change: S778R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
128 |
151 |
N/A |
INTRINSIC |
|
low complexity region
|
193 |
225 |
N/A |
INTRINSIC |
|
PWWP
|
278 |
341 |
1.6e-12 |
SMART |
|
low complexity region
|
680 |
701 |
N/A |
INTRINSIC |
|
PHD
|
713 |
756 |
4.49e-7 |
SMART |
|
PHD
|
761 |
808 |
5.82e-1 |
SMART |
|
PHD
|
809 |
861 |
3.06e0 |
SMART |
|
PHD
|
874 |
914 |
5.24e-8 |
SMART |
|
PWWP
|
919 |
981 |
8.62e-18 |
SMART |
|
AWS
|
1054 |
1105 |
2.61e-17 |
SMART |
|
SET
|
1106 |
1229 |
2.17e-41 |
SMART |
|
PostSET
|
1230 |
1246 |
2.63e-3 |
SMART |
|
low complexity region
|
1260 |
1277 |
N/A |
INTRINSIC |
|
PHD
|
1283 |
1326 |
4.32e-9 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000142395
AA Change: S778R
PolyPhen 2
Score 0.100 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000117778
Gene: ENSMUSG00000054823
AA Change: S778R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
128 |
151 |
N/A |
INTRINSIC |
|
low complexity region
|
193 |
225 |
N/A |
INTRINSIC |
|
PWWP
|
278 |
341 |
1.6e-12 |
SMART |
|
low complexity region
|
680 |
701 |
N/A |
INTRINSIC |
|
PHD
|
713 |
756 |
4.49e-7 |
SMART |
|
PHD
|
761 |
808 |
5.82e-1 |
SMART |
|
PHD
|
809 |
861 |
3.06e0 |
SMART |
|
PHD
|
874 |
963 |
1e-4 |
SMART |
|
PWWP
|
968 |
1030 |
8.62e-18 |
SMART |
|
AWS
|
1103 |
1154 |
2.61e-17 |
SMART |
|
SET
|
1155 |
1278 |
2.17e-41 |
SMART |
|
PostSET
|
1279 |
1295 |
2.63e-3 |
SMART |
|
low complexity region
|
1309 |
1326 |
N/A |
INTRINSIC |
|
PHD
|
1332 |
1375 |
4.32e-9 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000146919
|
| SMART Domains |
Protein: ENSMUSP00000115470
Gene: ENSMUSG00000054823
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
128 |
151 |
N/A |
INTRINSIC |
|
low complexity region
|
193 |
225 |
N/A |
INTRINSIC |
|
Pfam:PWWP
|
278 |
388 |
1.6e-25 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.2%
|
| Validation Efficiency |
100% (81/81) |
| MGI Phenotype |
FUNCTION: This gene encodes a member of the SET domain family of histone lysine N-methyltransferase proteins. This protein methylates histone H3 at lysine residues 4 and 27, which represses gene transcription. It acts in opposition to the histone demethylase Jmjd1c. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2015]
|
| Allele List at MGI |
All alleles(5) : Gene trapped(5)
|
| Other mutations in this stock |
Total: 81 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1110002E22Rik |
C |
A |
3: 137,770,909 (GRCm39) |
Q33K |
possibly damaging |
Het |
| Acap2 |
A |
G |
16: 30,925,906 (GRCm39) |
L550P |
probably damaging |
Het |
| Acsm3 |
A |
T |
7: 119,373,845 (GRCm39) |
S244C |
probably benign |
Het |
| Adam28 |
T |
A |
14: 68,846,593 (GRCm39) |
D740V |
probably benign |
Het |
| Adcy4 |
C |
A |
14: 56,016,426 (GRCm39) |
V342L |
probably damaging |
Het |
| Adcyap1r1 |
A |
G |
6: 55,458,107 (GRCm39) |
T303A |
probably benign |
Het |
| Agr2 |
T |
C |
12: 36,046,091 (GRCm39) |
V74A |
probably benign |
Het |
| Akp3 |
A |
T |
1: 87,054,786 (GRCm39) |
T374S |
possibly damaging |
Het |
| Ankrd36 |
A |
T |
11: 5,610,696 (GRCm39) |
I1181L |
probably benign |
Het |
| Arhgap11a |
A |
T |
2: 113,664,411 (GRCm39) |
V624E |
probably benign |
Het |
| Arhgap30 |
A |
T |
1: 171,228,258 (GRCm39) |
D112V |
probably damaging |
Het |
| Atp8b4 |
A |
G |
2: 126,184,883 (GRCm39) |
F927L |
probably benign |
Het |
| Bend4 |
C |
A |
5: 67,584,475 (GRCm39) |
G150C |
unknown |
Het |
| Cd300lg |
T |
A |
11: 101,944,998 (GRCm39) |
S403T |
probably damaging |
Het |
| Cep57l1 |
T |
A |
10: 41,607,086 (GRCm39) |
Q159L |
probably damaging |
Het |
| Cipc |
C |
T |
12: 86,999,634 (GRCm39) |
T57M |
probably damaging |
Het |
| Def8 |
T |
C |
8: 124,186,391 (GRCm39) |
C377R |
probably damaging |
Het |
| Dock1 |
A |
G |
7: 134,720,746 (GRCm39) |
D1285G |
probably damaging |
Het |
| Efcab10 |
A |
G |
12: 33,448,398 (GRCm39) |
D77G |
probably damaging |
Het |
| Eml4 |
C |
T |
17: 83,764,479 (GRCm39) |
T663M |
probably damaging |
Het |
| Ercc8 |
A |
G |
13: 108,320,389 (GRCm39) |
E325G |
possibly damaging |
Het |
| Ermap |
C |
A |
4: 119,035,240 (GRCm39) |
A583S |
probably damaging |
Het |
| F13a1 |
C |
T |
13: 37,102,506 (GRCm39) |
G406S |
probably null |
Het |
| Faap20 |
T |
A |
4: 155,335,426 (GRCm39) |
C141S |
probably benign |
Het |
| Fam193a |
A |
G |
5: 34,616,536 (GRCm39) |
T904A |
possibly damaging |
Het |
| Garin2 |
T |
C |
12: 78,757,097 (GRCm39) |
F18S |
probably benign |
Het |
| Gas8 |
A |
G |
8: 124,260,134 (GRCm39) |
D455G |
probably benign |
Het |
| Gm21863 |
T |
C |
12: 20,004,521 (GRCm39) |
S6P |
probably damaging |
Het |
| Gm4841 |
A |
T |
18: 60,403,988 (GRCm39) |
I35N |
probably damaging |
Het |
| Grk4 |
T |
A |
5: 34,877,084 (GRCm39) |
C260S |
probably damaging |
Het |
| Huwe1 |
G |
A |
X: 150,716,084 (GRCm39) |
R4331Q |
unknown |
Het |
| Ighv5-6 |
A |
G |
12: 113,589,247 (GRCm39) |
Y78H |
probably benign |
Het |
| Itpr3 |
G |
A |
17: 27,337,651 (GRCm39) |
|
probably benign |
Het |
| Kl |
T |
A |
5: 150,876,491 (GRCm39) |
S104T |
probably benign |
Het |
| Lyve1 |
C |
A |
7: 110,453,182 (GRCm39) |
C138F |
probably damaging |
Het |
| Med27 |
G |
A |
2: 29,399,446 (GRCm39) |
W92* |
probably null |
Het |
| Mical3 |
A |
T |
6: 120,986,848 (GRCm39) |
|
probably benign |
Het |
| Mrgpra4 |
C |
A |
7: 47,631,208 (GRCm39) |
R131L |
possibly damaging |
Het |
| Myf5 |
T |
C |
10: 107,321,308 (GRCm39) |
N162S |
probably benign |
Het |
| Myh15 |
G |
A |
16: 49,007,433 (GRCm39) |
E1835K |
probably damaging |
Het |
| Myo9a |
T |
A |
9: 59,716,757 (GRCm39) |
Y486N |
probably damaging |
Het |
| Ncapg |
T |
A |
5: 45,853,115 (GRCm39) |
N860K |
probably benign |
Het |
| Nr4a3 |
T |
C |
4: 48,052,194 (GRCm39) |
F316S |
possibly damaging |
Het |
| Or2r2 |
A |
G |
6: 42,463,795 (GRCm39) |
F111L |
probably damaging |
Het |
| Or4c119 |
A |
T |
2: 88,986,988 (GRCm39) |
V177E |
probably benign |
Het |
| Or4c31 |
A |
G |
2: 88,292,196 (GRCm39) |
I190V |
probably damaging |
Het |
| Or5p6 |
A |
G |
7: 107,631,286 (GRCm39) |
F88S |
probably damaging |
Het |
| Or7e173 |
T |
C |
9: 19,938,344 (GRCm39) |
N297D |
|
Het |
| Or8b37 |
T |
A |
9: 37,958,885 (GRCm39) |
Y122* |
probably null |
Het |
| Or8w1 |
A |
T |
2: 87,465,369 (GRCm39) |
C241S |
probably damaging |
Het |
| Or9m2 |
A |
G |
2: 87,820,568 (GRCm39) |
T38A |
probably damaging |
Het |
| Pdlim4 |
C |
T |
11: 53,946,280 (GRCm39) |
G231S |
probably benign |
Het |
| Pknox2 |
C |
T |
9: 36,821,044 (GRCm39) |
V273I |
possibly damaging |
Het |
| Pm20d1 |
A |
G |
1: 131,739,822 (GRCm39) |
H390R |
probably benign |
Het |
| Prkg2 |
A |
T |
5: 99,114,386 (GRCm39) |
D587E |
probably benign |
Het |
| Prps1l1 |
T |
A |
12: 35,035,546 (GRCm39) |
D220E |
possibly damaging |
Het |
| Prss3l |
A |
G |
6: 41,422,990 (GRCm39) |
F4L |
probably benign |
Het |
| Ptchd3 |
T |
C |
11: 121,721,682 (GRCm39) |
V185A |
possibly damaging |
Het |
| Rag2 |
A |
T |
2: 101,460,494 (GRCm39) |
N268I |
possibly damaging |
Het |
| Rarres2 |
A |
G |
6: 48,549,020 (GRCm39) |
|
probably null |
Het |
| Rrp12 |
T |
C |
19: 41,860,223 (GRCm39) |
H1000R |
probably benign |
Het |
| S100a2 |
A |
T |
3: 90,498,811 (GRCm39) |
Y104F |
unknown |
Het |
| Sell |
A |
G |
1: 163,893,042 (GRCm39) |
Y86C |
probably damaging |
Het |
| Serpinb6d |
A |
T |
13: 33,851,656 (GRCm39) |
T138S |
possibly damaging |
Het |
| Slamf7 |
T |
A |
1: 171,466,312 (GRCm39) |
I228F |
probably benign |
Het |
| Slc11a1 |
G |
A |
1: 74,416,325 (GRCm39) |
V92M |
probably damaging |
Het |
| Spi1 |
A |
G |
2: 90,912,862 (GRCm39) |
N5S |
unknown |
Het |
| Stard9 |
G |
T |
2: 120,536,283 (GRCm39) |
D4151Y |
probably damaging |
Het |
| Stmnd1 |
A |
G |
13: 46,452,983 (GRCm39) |
T220A |
probably benign |
Het |
| Tacc2 |
G |
T |
7: 130,225,266 (GRCm39) |
W650C |
probably damaging |
Het |
| Tmc5 |
A |
G |
7: 118,241,594 (GRCm39) |
N429S |
possibly damaging |
Het |
| Tmem201 |
A |
C |
4: 149,812,627 (GRCm39) |
L230V |
probably benign |
Het |
| Tmem222 |
T |
C |
4: 132,997,119 (GRCm39) |
E94G |
possibly damaging |
Het |
| Trappc4 |
A |
G |
9: 44,315,655 (GRCm39) |
F186S |
probably damaging |
Het |
| Trim17 |
A |
G |
11: 58,862,273 (GRCm39) |
N435S |
probably benign |
Het |
| Trim68 |
A |
T |
7: 102,329,447 (GRCm39) |
L227Q |
probably damaging |
Het |
| Tuba3b |
T |
G |
6: 145,563,996 (GRCm39) |
V14G |
possibly damaging |
Het |
| Ubr2 |
G |
T |
17: 47,245,041 (GRCm39) |
H1662N |
probably damaging |
Het |
| Vps13c |
T |
A |
9: 67,861,863 (GRCm39) |
V2915E |
probably damaging |
Het |
| Vsig10 |
C |
T |
5: 117,476,323 (GRCm39) |
T259I |
probably benign |
Het |
| Zfp267 |
A |
G |
3: 36,219,066 (GRCm39) |
Y363C |
possibly damaging |
Het |
|
| Other mutations in Nsd3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00435:Nsd3
|
APN |
8 |
26,166,728 (GRCm39) |
missense |
probably benign |
0.40 |
|
IGL00718:Nsd3
|
APN |
8 |
26,196,562 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL00727:Nsd3
|
APN |
8 |
26,131,174 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01324:Nsd3
|
APN |
8 |
26,152,836 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01614:Nsd3
|
APN |
8 |
26,156,095 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
IGL01834:Nsd3
|
APN |
8 |
26,130,668 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02066:Nsd3
|
APN |
8 |
26,203,515 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02229:Nsd3
|
APN |
8 |
26,200,775 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02481:Nsd3
|
APN |
8 |
26,181,143 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02686:Nsd3
|
APN |
8 |
26,156,086 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL03394:Nsd3
|
APN |
8 |
26,165,765 (GRCm39) |
splice site |
probably benign |
|
|
Pine
|
UTSW |
8 |
26,169,952 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
D3080:Nsd3
|
UTSW |
8 |
26,203,572 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
IGL02802:Nsd3
|
UTSW |
8 |
26,130,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0136:Nsd3
|
UTSW |
8 |
26,149,870 (GRCm39) |
nonsense |
probably null |
|
|
R0195:Nsd3
|
UTSW |
8 |
26,170,709 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0207:Nsd3
|
UTSW |
8 |
26,173,273 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0471:Nsd3
|
UTSW |
8 |
26,138,450 (GRCm39) |
splice site |
probably benign |
|
|
R0511:Nsd3
|
UTSW |
8 |
26,168,732 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R0524:Nsd3
|
UTSW |
8 |
26,190,605 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0581:Nsd3
|
UTSW |
8 |
26,200,718 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0589:Nsd3
|
UTSW |
8 |
26,131,303 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0645:Nsd3
|
UTSW |
8 |
26,199,096 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0664:Nsd3
|
UTSW |
8 |
26,204,267 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0738:Nsd3
|
UTSW |
8 |
26,168,725 (GRCm39) |
splice site |
probably null |
|
|
R1148:Nsd3
|
UTSW |
8 |
26,203,407 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1148:Nsd3
|
UTSW |
8 |
26,203,407 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1265:Nsd3
|
UTSW |
8 |
26,172,578 (GRCm39) |
missense |
probably benign |
|
|
R1298:Nsd3
|
UTSW |
8 |
26,169,952 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R1424:Nsd3
|
UTSW |
8 |
26,190,594 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1493:Nsd3
|
UTSW |
8 |
26,203,407 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1528:Nsd3
|
UTSW |
8 |
26,188,795 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2051:Nsd3
|
UTSW |
8 |
26,181,116 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2199:Nsd3
|
UTSW |
8 |
26,156,073 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3414:Nsd3
|
UTSW |
8 |
26,190,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3522:Nsd3
|
UTSW |
8 |
26,196,642 (GRCm39) |
missense |
probably benign |
|
|
R3623:Nsd3
|
UTSW |
8 |
26,152,835 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3624:Nsd3
|
UTSW |
8 |
26,152,835 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3798:Nsd3
|
UTSW |
8 |
26,188,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4345:Nsd3
|
UTSW |
8 |
26,131,333 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4370:Nsd3
|
UTSW |
8 |
26,138,524 (GRCm39) |
missense |
probably benign |
0.13 |
|
R4421:Nsd3
|
UTSW |
8 |
26,131,288 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4583:Nsd3
|
UTSW |
8 |
26,200,703 (GRCm39) |
missense |
probably benign |
0.20 |
|
R4664:Nsd3
|
UTSW |
8 |
26,188,894 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4741:Nsd3
|
UTSW |
8 |
26,163,382 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4876:Nsd3
|
UTSW |
8 |
26,181,161 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4888:Nsd3
|
UTSW |
8 |
26,188,939 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5000:Nsd3
|
UTSW |
8 |
26,172,593 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5132:Nsd3
|
UTSW |
8 |
26,168,855 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R5632:Nsd3
|
UTSW |
8 |
26,169,985 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5760:Nsd3
|
UTSW |
8 |
26,149,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5778:Nsd3
|
UTSW |
8 |
26,149,834 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5779:Nsd3
|
UTSW |
8 |
26,172,685 (GRCm39) |
nonsense |
probably null |
|
|
R5860:Nsd3
|
UTSW |
8 |
26,156,107 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5911:Nsd3
|
UTSW |
8 |
26,156,092 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6168:Nsd3
|
UTSW |
8 |
26,181,188 (GRCm39) |
missense |
probably null |
1.00 |
|
R6467:Nsd3
|
UTSW |
8 |
26,130,646 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6490:Nsd3
|
UTSW |
8 |
26,204,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6519:Nsd3
|
UTSW |
8 |
26,152,955 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6554:Nsd3
|
UTSW |
8 |
26,152,891 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7038:Nsd3
|
UTSW |
8 |
26,131,279 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7088:Nsd3
|
UTSW |
8 |
26,156,050 (GRCm39) |
missense |
probably benign |
0.40 |
|
R7244:Nsd3
|
UTSW |
8 |
26,156,055 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7308:Nsd3
|
UTSW |
8 |
26,130,740 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7678:Nsd3
|
UTSW |
8 |
26,149,833 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7717:Nsd3
|
UTSW |
8 |
26,172,578 (GRCm39) |
missense |
probably benign |
|
|
R8064:Nsd3
|
UTSW |
8 |
26,190,698 (GRCm39) |
nonsense |
probably null |
|
|
R8242:Nsd3
|
UTSW |
8 |
26,196,567 (GRCm39) |
nonsense |
probably null |
|
|
R8312:Nsd3
|
UTSW |
8 |
26,153,268 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8547:Nsd3
|
UTSW |
8 |
26,184,811 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8954:Nsd3
|
UTSW |
8 |
26,163,394 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8995:Nsd3
|
UTSW |
8 |
26,131,169 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9281:Nsd3
|
UTSW |
8 |
26,152,961 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9320:Nsd3
|
UTSW |
8 |
26,199,088 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R9563:Nsd3
|
UTSW |
8 |
26,204,230 (GRCm39) |
missense |
|
|
|
R9703:Nsd3
|
UTSW |
8 |
26,131,228 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0026:Nsd3
|
UTSW |
8 |
26,190,621 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Nsd3
|
UTSW |
8 |
26,131,018 (GRCm39) |
small deletion |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AGCTCAGAGTCCTCACCTAG -3'
(R):5'- ATAAACAGAAGGCCTGCCGC -3'
Sequencing Primer
(F):5'- CCCAACACTTTGAATGGTTC -3'
(R):5'- CCTGCCGCCATTGCTGG -3'
|
| Posted On |
2021-11-19 |
Incidental Mutation