Incidental Mutation 'R9027:Ints5'
ID 686838
Institutional Source Beutler Lab
Gene Symbol Ints5
Ensembl Gene ENSMUSG00000116347
Gene Name integrator complex subunit 5
Synonyms 1110055N21Rik
MMRRC Submission 068856-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.511) question?
Stock # R9027 (G1)
Quality Score 225.009
Status Validated
Chromosome 19
Chromosomal Location 8870369-8875252 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 8873322 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Glutamine at position 427 (P427Q)
Ref Sequence ENSEMBL: ENSMUSP00000093968 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000096246] [ENSMUST00000096249] [ENSMUST00000187504] [ENSMUST00000191089]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000096246
SMART Domains Protein: ENSMUSP00000093965
Gene: ENSMUSG00000071650

DomainStartEndE-ValueType
signal peptide 1 32 N/A INTRINSIC
low complexity region 157 169 N/A INTRINSIC
Pfam:Gal_mutarotas_2 275 346 3.9e-24 PFAM
Pfam:Glyco_hydro_31 387 832 8.7e-136 PFAM
low complexity region 888 898 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000096249
AA Change: P427Q

PolyPhen 2 Score 0.769 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000093968
Gene: ENSMUSG00000071652
AA Change: P427Q

DomainStartEndE-ValueType
low complexity region 7 25 N/A INTRINSIC
Pfam:INTS5_N 29 252 1e-82 PFAM
low complexity region 254 267 N/A INTRINSIC
Pfam:INTS5_C 289 998 2.2e-249 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000187504
SMART Domains Protein: ENSMUSP00000139692
Gene: ENSMUSG00000096740

DomainStartEndE-ValueType
Pfam:Lbh 1 101 2.5e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000191089
SMART Domains Protein: ENSMUSP00000140564
Gene: ENSMUSG00000116347

DomainStartEndE-ValueType
low complexity region 15 37 N/A INTRINSIC
Meta Mutation Damage Score 0.0901 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 98% (59/60)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The Integrator complex is a complex that associates with the C-terminal domain of RNA polymerase II large subunit. This complex is brought to U1 and U2 small nuclear RNA genes, where it is involved in the transcription and processing of their transcripts. The protein encoded by this gene represents a subunit of the Integrator complex. [provided by RefSeq, Aug 2016]
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam1b C A 5: 121,640,788 (GRCm39) E86* probably null Het
Ahnak T G 19: 8,984,617 (GRCm39) I1967S possibly damaging Het
Alox12e A G 11: 70,212,600 (GRCm39) V83A possibly damaging Het
Arhgap20 A T 9: 51,754,977 (GRCm39) R439S probably damaging Het
Arl1 A G 10: 88,569,458 (GRCm39) I20V probably damaging Het
Atad2 T C 15: 57,995,628 (GRCm39) D93G probably benign Het
Btbd7 T G 12: 102,804,838 (GRCm39) K67N probably damaging Het
C130050O18Rik A G 5: 139,400,301 (GRCm39) N118S probably benign Het
Ccz1 A C 5: 143,946,120 (GRCm39) probably benign Het
Cdk19 A G 10: 40,355,728 (GRCm39) S479G unknown Het
Chrd A G 16: 20,555,737 (GRCm39) T503A probably damaging Het
Clca4b G A 3: 144,617,827 (GRCm39) R759* probably null Het
Cpa5 G T 6: 30,612,604 (GRCm39) M1I probably null Het
Cr2 A T 1: 194,834,029 (GRCm39) I920N probably benign Het
Crmp1 C A 5: 37,437,947 (GRCm39) Y430* probably null Het
Dars1 A T 1: 128,296,163 (GRCm39) V390D possibly damaging Het
Dmtn A G 14: 70,853,555 (GRCm39) S85P probably damaging Het
Ermardl1 A G 17: 15,242,364 (GRCm39) E416G unknown Het
Fancm C A 12: 65,122,605 (GRCm39) D42E probably damaging Het
Gabrg3 T A 7: 56,423,122 (GRCm39) Y192F possibly damaging Het
Gpr3 A T 4: 132,938,209 (GRCm39) Y154* probably null Het
Huwe1 G A X: 150,716,084 (GRCm39) R4331Q unknown Het
Jhy A T 9: 40,828,823 (GRCm39) V361D probably benign Het
Klhl33 G A 14: 51,130,322 (GRCm39) Q131* probably null Het
Lama2 A T 10: 27,080,881 (GRCm39) C981S probably damaging Het
Mks1 C A 11: 87,748,041 (GRCm39) L225I probably damaging Het
Ms4a20 A T 19: 11,083,055 (GRCm39) Y122N probably damaging Het
Nfasc T A 1: 132,539,343 (GRCm39) S402C probably damaging Het
Or2a57 T C 6: 43,213,358 (GRCm39) I272T possibly damaging Het
Or4k50-ps1 A T 2: 111,522,517 (GRCm39) Y218F unknown Het
Or51g2 T C 7: 102,622,560 (GRCm39) D213G probably damaging Het
Pbx4 T A 8: 70,316,999 (GRCm39) D85E possibly damaging Het
Plcd1 T C 9: 118,913,709 (GRCm39) T50A probably damaging Het
Plk5 C G 10: 80,193,830 (GRCm39) R40G probably damaging Het
Psen2 C A 1: 180,056,972 (GRCm39) E351* probably null Het
Rragd G A 4: 32,996,083 (GRCm39) V143I probably damaging Het
Rsph14 A T 10: 74,795,423 (GRCm39) M254K probably damaging Het
Selenoi C T 5: 30,437,607 (GRCm39) probably benign Het
Six6 T C 12: 72,986,935 (GRCm39) S36P Het
Slc12a8 T C 16: 33,445,215 (GRCm39) S370P probably benign Het
Slc25a46 A G 18: 31,716,432 (GRCm39) Y357H probably benign Het
Socs2 A T 10: 95,248,948 (GRCm39) V55D probably damaging Het
Socs6 T C 18: 88,888,852 (GRCm39) E21G probably benign Het
Spata31e4 C T 13: 50,857,007 (GRCm39) Q882* probably null Het
Speg A T 1: 75,365,076 (GRCm39) T486S possibly damaging Het
Spryd3 A G 15: 102,027,843 (GRCm39) Y235H probably damaging Het
Sry GCTGCTGGTGGTGGTCATGGAACTGCTGCTTCTGCTGGTGGTGGTCATGGAACTGCTGCTTCTGCTGGTGGTGGTCATGGAACTGCTGCTTCTGCTG GCTGCTGGTGGTGGTCATGGAACTGCTGCTTCTGCTGGTGGTGGTCATGGAACTGCTGCTTCTGCTG Y: 2,662,638 (GRCm39) probably benign Het
Stxbp5l T C 16: 37,165,473 (GRCm39) K82E probably damaging Het
Sugt1 A G 14: 79,825,155 (GRCm39) probably benign Het
Synm T C 7: 67,384,440 (GRCm39) Y1074C probably damaging Het
Sytl2 A G 7: 90,028,748 (GRCm39) T476A probably benign Het
Tbc1d1 T C 5: 64,414,349 (GRCm39) S237P probably benign Het
Tbc1d5 C A 17: 51,063,692 (GRCm39) M629I probably damaging Het
Tlr11 G A 14: 50,598,749 (GRCm39) G245D probably damaging Het
Tspan4 T C 7: 141,069,577 (GRCm39) V59A probably benign Het
Tulp4 T A 17: 6,283,472 (GRCm39) V1167E possibly damaging Het
Usp42 G A 5: 143,708,906 (GRCm39) T204M probably damaging Het
Vapb A G 2: 173,617,948 (GRCm39) K147R possibly damaging Het
Vmn1r228 T C 17: 20,997,422 (GRCm39) D32G probably benign Het
Vmn2r33 A G 7: 7,554,168 (GRCm39) F795S probably damaging Het
Vmn2r34 A T 7: 7,675,527 (GRCm39) N620K probably damaging Het
Vwf G T 6: 125,643,626 (GRCm39) C2389F Het
Wdr81 T C 11: 75,332,908 (GRCm39) E652G Het
Wdr81 A T 11: 75,343,207 (GRCm39) S687T probably benign Het
Zcrb1 A G 15: 93,285,456 (GRCm39) probably null Het
Other mutations in Ints5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01448:Ints5 APN 19 8,872,851 (GRCm39) missense possibly damaging 0.93
IGL01915:Ints5 APN 19 8,874,357 (GRCm39) missense probably benign
IGL01993:Ints5 APN 19 8,872,829 (GRCm39) missense probably benign
IGL02264:Ints5 APN 19 8,873,076 (GRCm39) missense probably benign 0.02
IGL02367:Ints5 APN 19 8,872,959 (GRCm39) missense probably benign 0.06
IGL02955:Ints5 APN 19 8,875,014 (GRCm39) missense probably damaging 1.00
FR4449:Ints5 UTSW 19 8,874,594 (GRCm39) missense probably benign 0.10
R0348:Ints5 UTSW 19 8,873,114 (GRCm39) missense probably damaging 0.97
R0379:Ints5 UTSW 19 8,874,497 (GRCm39) missense possibly damaging 0.90
R0617:Ints5 UTSW 19 8,873,383 (GRCm39) missense probably damaging 1.00
R1954:Ints5 UTSW 19 8,872,260 (GRCm39) missense probably damaging 1.00
R2172:Ints5 UTSW 19 8,873,646 (GRCm39) missense possibly damaging 0.73
R2370:Ints5 UTSW 19 8,874,143 (GRCm39) missense probably benign
R3116:Ints5 UTSW 19 8,872,136 (GRCm39) missense possibly damaging 0.84
R4395:Ints5 UTSW 19 8,873,808 (GRCm39) missense probably damaging 0.96
R5390:Ints5 UTSW 19 8,873,931 (GRCm39) missense possibly damaging 0.73
R6868:Ints5 UTSW 19 8,874,750 (GRCm39) missense probably damaging 1.00
R7133:Ints5 UTSW 19 8,872,923 (GRCm39) missense probably damaging 1.00
R7685:Ints5 UTSW 19 8,874,168 (GRCm39) missense probably benign 0.10
R7999:Ints5 UTSW 19 8,874,407 (GRCm39) missense probably benign
R8024:Ints5 UTSW 19 8,873,504 (GRCm39) missense probably damaging 1.00
R8296:Ints5 UTSW 19 8,872,484 (GRCm39) missense probably damaging 1.00
R8672:Ints5 UTSW 19 8,873,370 (GRCm39) missense probably damaging 1.00
R9493:Ints5 UTSW 19 8,872,686 (GRCm39) missense probably damaging 1.00
X0066:Ints5 UTSW 19 8,873,595 (GRCm39) missense probably damaging 1.00
Z1177:Ints5 UTSW 19 8,872,337 (GRCm39) missense probably damaging 0.99
Z1177:Ints5 UTSW 19 8,872,299 (GRCm39) missense probably benign 0.31
Predicted Primers PCR Primer
(F):5'- TCGGCACAGTATCTGGAGAAC -3'
(R):5'- ACACAGTTCTCCAACATGGTTTC -3'

Sequencing Primer
(F):5'- GAGAACTTGTGGACTGCCTC -3'
(R):5'- CCAACATGGTTTCGTAATGCATC -3'
Posted On 2021-11-19