Incidental Mutation 'R9029:Mcrip2'
ID 686963
Institutional Source Beutler Lab
Gene Symbol Mcrip2
Ensembl Gene ENSMUSG00000025732
Gene Name MAPK regulated corepressor interacting protein 2
Synonyms Fam195a, 9530058B02Rik
MMRRC Submission 068858-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.227) question?
Stock # R9029 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 26082672-26087738 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 26082989 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 146 (E146G)
Ref Sequence ENSEMBL: ENSMUSP00000026828 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026828] [ENSMUST00000079461] [ENSMUST00000176923]
AlphaFold Q9CQB2
Predicted Effect probably damaging
Transcript: ENSMUST00000026828
AA Change: E146G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000026828
Gene: ENSMUSG00000025732
AA Change: E146G

DomainStartEndE-ValueType
Pfam:FAM195 59 158 8.3e-33 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000079461
SMART Domains Protein: ENSMUSP00000078426
Gene: ENSMUSG00000073434

DomainStartEndE-ValueType
low complexity region 32 53 N/A INTRINSIC
Pfam:DUF667 60 183 5e-26 PFAM
Pfam:DUF667 210 271 3.7e-9 PFAM
low complexity region 381 396 N/A INTRINSIC
WD40 478 519 5.94e0 SMART
WD40 522 565 3.2e0 SMART
WD40 572 612 3.3e1 SMART
WD40 687 725 1.15e1 SMART
WD40 728 766 5.75e-1 SMART
WD40 768 808 9.24e-4 SMART
WD40 811 850 4.13e0 SMART
WD40 853 892 4.62e-1 SMART
WD40 950 993 1.07e1 SMART
WD40 996 1035 5.75e-1 SMART
WD40 1040 1077 1.58e-2 SMART
WD40 1290 1334 5.23e-3 SMART
WD40 1337 1378 1.27e-1 SMART
WD40 1384 1419 1.83e2 SMART
WD40 1422 1469 3.08e0 SMART
WD40 1472 1509 9.9e0 SMART
WD40 1568 1607 9.02e-7 SMART
WD40 1610 1655 5.75e-1 SMART
WD40 1659 1697 2.98e-1 SMART
WD40 1700 1749 6.14e1 SMART
WD40 1850 1888 1.92e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000176678
Predicted Effect probably benign
Transcript: ENSMUST00000176923
SMART Domains Protein: ENSMUSP00000135420
Gene: ENSMUSG00000073434

DomainStartEndE-ValueType
low complexity region 32 53 N/A INTRINSIC
Pfam:DUF667 60 252 5.1e-14 PFAM
low complexity region 363 378 N/A INTRINSIC
WD40 460 501 5.94e0 SMART
WD40 504 547 3.2e0 SMART
WD40 554 594 3.3e1 SMART
WD40 669 707 1.15e1 SMART
WD40 710 748 5.75e-1 SMART
WD40 750 790 9.24e-4 SMART
WD40 793 832 4.13e0 SMART
WD40 835 874 4.62e-1 SMART
WD40 932 975 1.07e1 SMART
WD40 978 1017 5.75e-1 SMART
WD40 1022 1059 1.58e-2 SMART
WD40 1272 1316 5.23e-3 SMART
WD40 1319 1360 1.27e-1 SMART
WD40 1366 1401 1.83e2 SMART
WD40 1404 1451 3.08e0 SMART
WD40 1454 1491 9.9e0 SMART
WD40 1550 1589 9.02e-7 SMART
WD40 1592 1637 5.75e-1 SMART
WD40 1641 1679 2.98e-1 SMART
WD40 1682 1731 6.14e1 SMART
WD40 1832 1870 1.92e-1 SMART
Meta Mutation Damage Score 0.2297 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (56/56)
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankrd35 A T 3: 96,591,460 (GRCm39) K582M probably benign Het
Catsper3 T G 13: 55,954,147 (GRCm39) V305G probably damaging Het
Chd9 G A 8: 91,683,198 (GRCm39) R546Q unknown Het
Cnot6l G A 5: 96,246,136 (GRCm39) T171I probably benign Het
Cpne3 A G 4: 19,535,292 (GRCm39) Y247H possibly damaging Het
Cramp1 C G 17: 25,232,884 (GRCm39) A39P probably damaging Het
Cyp26b1 A T 6: 84,554,035 (GRCm39) V194E probably benign Het
Dchs1 A G 7: 105,402,919 (GRCm39) S3208P probably benign Het
Dhrs3 A G 4: 144,653,755 (GRCm39) Y292C probably damaging Het
Eif3l T C 15: 78,968,412 (GRCm39) V227A probably damaging Het
Eif4enif1 T C 11: 3,174,716 (GRCm39) V290A probably damaging Het
Epb41l4a A C 18: 34,012,042 (GRCm39) Y159* probably null Het
Gm5460 T A 14: 33,739,326 (GRCm39) S103T Het
Gsto1 A T 19: 47,852,837 (GRCm39) Y224F probably benign Het
Hpd G A 5: 123,313,973 (GRCm39) T271M probably damaging Het
Ift74 T C 4: 94,506,271 (GRCm39) I18T probably benign Het
Kif12 A G 4: 63,087,704 (GRCm39) C260R probably damaging Het
Klk15 C T 7: 43,587,790 (GRCm39) H73Y possibly damaging Het
Luc7l3 A G 11: 94,188,676 (GRCm39) V201A unknown Het
Mctp1 T A 13: 76,836,741 (GRCm39) Y323N probably benign Het
Micu2 T A 14: 58,156,363 (GRCm39) I370F probably damaging Het
Mug2 T A 6: 122,061,328 (GRCm39) V1416E probably damaging Het
Mup3 T C 4: 62,003,540 (GRCm39) N110D probably damaging Het
Nav3 C T 10: 109,699,613 (GRCm39) D294N possibly damaging Het
Nphs2 G A 1: 156,140,592 (GRCm39) A110T probably benign Het
Or1a1 T C 11: 74,086,563 (GRCm39) I78T possibly damaging Het
Or5t7 A G 2: 86,506,831 (GRCm39) M282T probably damaging Het
Or6c215 G T 10: 129,637,926 (GRCm39) P156Q probably damaging Het
Otof C T 5: 30,527,419 (GRCm39) probably null Het
Pgrmc2 G T 3: 41,037,105 (GRCm39) R109S probably benign Het
Plb1 G A 5: 32,439,079 (GRCm39) V214I probably damaging Het
Ppp2r5d C T 17: 46,998,906 (GRCm39) S52N probably benign Het
Rrp12 C A 19: 41,859,718 (GRCm39) E1082* probably null Het
Skint3 A G 4: 112,111,151 (GRCm39) E92G probably damaging Het
Slc12a1 C G 2: 124,996,004 (GRCm39) N52K probably benign Het
Smu1 A G 4: 40,738,361 (GRCm39) Y458H probably damaging Het
Spsb3 C T 17: 25,110,506 (GRCm39) P317S unknown Het
Ssc5d A T 7: 4,930,919 (GRCm39) Q167L probably damaging Het
Ssh2 T C 11: 77,328,454 (GRCm39) V340A probably damaging Het
Stag3 G A 5: 138,296,296 (GRCm39) R453H probably damaging Het
Svil T A 18: 5,056,239 (GRCm39) F371I probably benign Het
Tas2r140 A C 6: 133,032,181 (GRCm39) S192R possibly damaging Het
Tdrp T C 8: 14,003,840 (GRCm39) I166V possibly damaging Het
Tgm3 C A 2: 129,871,680 (GRCm39) Q269K probably benign Het
Thsd7b G A 1: 130,087,426 (GRCm39) C1181Y probably damaging Het
Tinag A T 9: 76,934,296 (GRCm39) probably benign Het
Tnrc6b T C 15: 80,763,179 (GRCm39) V227A possibly damaging Het
Tox3 A C 8: 90,996,864 (GRCm39) L133R possibly damaging Het
Tshz1 A T 18: 84,031,639 (GRCm39) I923N probably damaging Het
Vps13c T A 9: 67,855,429 (GRCm39) V2498D probably damaging Het
Vps41 T A 13: 18,994,723 (GRCm39) probably null Het
Xylt2 T C 11: 94,555,462 (GRCm39) D850G probably damaging Het
Zfp229 T A 17: 21,964,321 (GRCm39) S184T possibly damaging Het
Zfp518a G A 19: 40,901,225 (GRCm39) V385I probably benign Het
Zfp595 C A 13: 67,468,989 (GRCm39) M12I probably benign Het
Zfp750 T C 11: 121,403,149 (GRCm39) Q533R probably benign Het
Other mutations in Mcrip2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02957:Mcrip2 APN 17 26,087,499 (GRCm39) missense probably damaging 0.96
R4860:Mcrip2 UTSW 17 26,083,621 (GRCm39) missense possibly damaging 0.50
R4860:Mcrip2 UTSW 17 26,083,621 (GRCm39) missense possibly damaging 0.50
R8030:Mcrip2 UTSW 17 26,083,306 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- ACAGGTGCAAAAGTCCAAATGTTG -3'
(R):5'- AGTGAGCCTTCTCCTATGCC -3'

Sequencing Primer
(F):5'- CCAAATGTTGGCACTTCAGG -3'
(R):5'- TCTATACCAGGTAGCCTCAGGTAG -3'
Posted On 2021-11-19