Incidental Mutation 'R9030:Or2y11'
ID 687003
Institutional Source Beutler Lab
Gene Symbol Or2y11
Ensembl Gene ENSMUSG00000095187
Gene Name olfactory receptor family 2 subfamily Y member 11
Synonyms MOR256-26, Olfr1381, GA_x6K02T2QP88-5884501-5883566
MMRRC Submission 068859-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.070) question?
Stock # R9030 (G1)
Quality Score 225.009
Status Validated
Chromosome 11
Chromosomal Location 49442576-49443511 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 49442808 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glutamic Acid at position 78 (V78E)
Ref Sequence ENSEMBL: ENSMUSP00000149881 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000167248] [ENSMUST00000213256] [ENSMUST00000215360]
AlphaFold Q7TQT4
Predicted Effect probably damaging
Transcript: ENSMUST00000167248
AA Change: V78E

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000126003
Gene: ENSMUSG00000095187
AA Change: V78E

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 5.9e-48 PFAM
Pfam:7TM_GPCR_Srsx 35 219 2.4e-5 PFAM
Pfam:7tm_1 41 289 1.2e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213256
AA Change: V78E

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Predicted Effect probably benign
Transcript: ENSMUST00000215360
Meta Mutation Damage Score 0.7423 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (57/57)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actr5 A C 2: 158,474,321 (GRCm39) I375L probably benign Het
Adgrl2 G T 3: 148,544,761 (GRCm39) T778K possibly damaging Het
Ccn3 A T 15: 54,615,687 (GRCm39) Y284F probably damaging Het
Cdc73 A T 1: 143,485,234 (GRCm39) L478H probably damaging Het
Cdh20 C A 1: 110,027,843 (GRCm39) H529Q probably benign Het
Cep55 T C 19: 38,059,592 (GRCm39) probably null Het
Chd9 G A 8: 91,683,198 (GRCm39) R546Q unknown Het
Ddit4 A T 10: 59,786,515 (GRCm39) L178Q probably damaging Het
Dgke A T 11: 88,941,237 (GRCm39) N315K possibly damaging Het
Dsg1a A G 18: 20,473,549 (GRCm39) D874G probably damaging Het
Dsp T A 13: 38,352,673 (GRCm39) Y184N probably damaging Het
Dynlt1c A G 17: 6,870,916 (GRCm39) I20V probably benign Het
Ephx4 A G 5: 107,577,549 (GRCm39) H291R possibly damaging Het
Epx A T 11: 87,763,470 (GRCm39) M250K probably benign Het
Fan1 T C 7: 64,022,761 (GRCm39) Y164C probably benign Het
Fer1l6 A T 15: 58,502,594 (GRCm39) Y1365F probably damaging Het
Fndc8 A G 11: 82,789,522 (GRCm39) T227A probably benign Het
Gbp7 T C 3: 142,243,798 (GRCm39) I115T probably damaging Het
Gm5145 A G 17: 20,791,270 (GRCm39) E216G probably benign Het
Gm94 A T 18: 43,914,326 (GRCm39) F77L possibly damaging Het
Grik3 C A 4: 125,526,185 (GRCm39) H139Q probably benign Het
Gucy2e T C 11: 69,115,827 (GRCm39) T852A probably damaging Het
Hif1a T C 12: 73,983,010 (GRCm39) S274P probably damaging Het
Hmcn1 T A 1: 150,692,870 (GRCm39) I268L probably benign Het
Klk15 C T 7: 43,587,790 (GRCm39) H73Y possibly damaging Het
Lin52 T A 12: 84,592,681 (GRCm39) S87T Het
Lrrc74b A G 16: 17,367,640 (GRCm39) probably null Het
Mapk10 T C 5: 103,144,499 (GRCm39) K136R probably damaging Het
Nlrp2 A T 7: 5,325,457 (GRCm39) N738K probably null Het
Nlrp5 A T 7: 23,129,573 (GRCm39) Q880L possibly damaging Het
Or5d39 A T 2: 87,979,718 (GRCm39) I215N possibly damaging Het
Or6c215 G T 10: 129,637,926 (GRCm39) P156Q probably damaging Het
P4htm G A 9: 108,474,627 (GRCm39) P46L probably benign Het
Pcsk4 A T 10: 80,164,858 (GRCm39) H69Q probably damaging Het
Pdzd2 A G 15: 12,374,385 (GRCm39) S1917P probably benign Het
Pnpla5 A G 15: 83,998,087 (GRCm39) V385A possibly damaging Het
Prorp T C 12: 55,426,192 (GRCm39) F514S probably damaging Het
Rims2 C T 15: 39,339,873 (GRCm39) R856C probably damaging Het
Rprd2 A G 3: 95,691,622 (GRCm39) Y218H probably benign Het
Sat2 T A 11: 69,513,069 (GRCm39) probably benign Het
Sf1 C T 19: 6,426,336 (GRCm39) R186C Het
Snrnp200 A G 2: 127,053,466 (GRCm39) probably benign Het
Sqor A T 2: 122,629,514 (GRCm39) D124V probably benign Het
Ssh2 A G 11: 77,312,062 (GRCm39) H191R possibly damaging Het
Stac C A 9: 111,519,320 (GRCm39) probably benign Het
Svs4 T C 2: 164,119,058 (GRCm39) M93V unknown Het
Tbc1d32 A T 10: 56,037,241 (GRCm39) S668T possibly damaging Het
Tex10 A G 4: 48,452,056 (GRCm39) F690S probably damaging Het
Tex30 A G 1: 44,130,356 (GRCm39) M88T Het
Tgfbrap1 T C 1: 43,095,837 (GRCm39) T534A probably benign Het
Tmco1 C T 1: 167,136,132 (GRCm39) probably benign Het
Tnrc18 T C 5: 142,711,818 (GRCm39) E2647G probably damaging Het
Trim43a GATTTATTTATTTATTTATTTATTTATTTATTTATTTATT GATTTATTTATTTATTTATTTATTTATTTATTTATTTATTTATT 9: 88,465,042 (GRCm39) probably benign Het
Tubb3 A T 8: 124,145,696 (GRCm39) R62W probably damaging Het
Vmn2r108 A G 17: 20,690,312 (GRCm39) S507P probably benign Het
Vmn2r116 A G 17: 23,603,864 (GRCm39) K30E possibly damaging Het
Vmn2r14 G A 5: 109,368,054 (GRCm39) H313Y probably damaging Het
Wdr37 C T 13: 8,885,424 (GRCm39) V340M probably damaging Het
Zfp799 A G 17: 33,039,565 (GRCm39) F234L possibly damaging Het
Other mutations in Or2y11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01621:Or2y11 APN 11 49,442,964 (GRCm39) missense probably damaging 1.00
IGL02166:Or2y11 APN 11 49,442,757 (GRCm39) missense probably damaging 1.00
IGL02723:Or2y11 APN 11 49,443,506 (GRCm39) missense probably benign 0.28
R0518:Or2y11 UTSW 11 49,443,291 (GRCm39) missense probably damaging 1.00
R0521:Or2y11 UTSW 11 49,443,291 (GRCm39) missense probably damaging 1.00
R2109:Or2y11 UTSW 11 49,443,260 (GRCm39) missense probably damaging 1.00
R4198:Or2y11 UTSW 11 49,443,461 (GRCm39) missense possibly damaging 0.61
R6155:Or2y11 UTSW 11 49,443,411 (GRCm39) missense possibly damaging 0.93
R6181:Or2y11 UTSW 11 49,443,120 (GRCm39) missense probably damaging 0.97
R6250:Or2y11 UTSW 11 49,442,711 (GRCm39) missense probably damaging 1.00
R6372:Or2y11 UTSW 11 49,442,757 (GRCm39) missense probably damaging 1.00
R6616:Or2y11 UTSW 11 49,442,868 (GRCm39) missense probably damaging 0.97
R7391:Or2y11 UTSW 11 49,443,371 (GRCm39) missense probably damaging 1.00
R9566:Or2y11 UTSW 11 49,443,162 (GRCm39) missense probably benign
Z1177:Or2y11 UTSW 11 49,443,111 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CATTTTAGTGGGCTTCTCAGACTG -3'
(R):5'- ACAACCAATGCTCTGCAGAG -3'

Sequencing Primer
(F):5'- TCAGACTGGCCTCACCTAG -3'
(R):5'- CCAATGCTCTGCAGAGAACAGG -3'
Posted On 2021-11-19