Incidental Mutation 'R9030:Fer1l6'
ID 687017
Institutional Source Beutler Lab
Gene Symbol Fer1l6
Ensembl Gene ENSMUSG00000037106
Gene Name fer-1 like family member 6
Synonyms EG631797
MMRRC Submission 068859-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.068) question?
Stock # R9030 (G1)
Quality Score 225.009
Status Validated
Chromosome 15
Chromosomal Location 58381897-58536936 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 58502594 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 1365 (Y1365F)
Ref Sequence ENSEMBL: ENSMUSP00000125718 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000161028]
AlphaFold E0CZ42
Predicted Effect probably damaging
Transcript: ENSMUST00000161028
AA Change: Y1365F

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000125718
Gene: ENSMUSG00000037106
AA Change: Y1365F

DomainStartEndE-ValueType
low complexity region 4 20 N/A INTRINSIC
C2 83 179 4.09e-12 SMART
FerI 165 235 2.06e-36 SMART
C2 243 354 5.19e-14 SMART
low complexity region 412 449 N/A INTRINSIC
FerB 714 787 2.53e-45 SMART
C2 829 936 8.84e-8 SMART
C2 1000 1099 3.05e0 SMART
low complexity region 1189 1203 N/A INTRINSIC
low complexity region 1256 1270 N/A INTRINSIC
C2 1361 1460 5.78e-12 SMART
low complexity region 1518 1529 N/A INTRINSIC
C2 1601 1731 1.01e-2 SMART
Pfam:Ferlin_C 1765 1857 2.3e-40 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (57/57)
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actr5 A C 2: 158,474,321 (GRCm39) I375L probably benign Het
Adgrl2 G T 3: 148,544,761 (GRCm39) T778K possibly damaging Het
Ccn3 A T 15: 54,615,687 (GRCm39) Y284F probably damaging Het
Cdc73 A T 1: 143,485,234 (GRCm39) L478H probably damaging Het
Cdh20 C A 1: 110,027,843 (GRCm39) H529Q probably benign Het
Cep55 T C 19: 38,059,592 (GRCm39) probably null Het
Chd9 G A 8: 91,683,198 (GRCm39) R546Q unknown Het
Ddit4 A T 10: 59,786,515 (GRCm39) L178Q probably damaging Het
Dgke A T 11: 88,941,237 (GRCm39) N315K possibly damaging Het
Dsg1a A G 18: 20,473,549 (GRCm39) D874G probably damaging Het
Dsp T A 13: 38,352,673 (GRCm39) Y184N probably damaging Het
Dynlt1c A G 17: 6,870,916 (GRCm39) I20V probably benign Het
Ephx4 A G 5: 107,577,549 (GRCm39) H291R possibly damaging Het
Epx A T 11: 87,763,470 (GRCm39) M250K probably benign Het
Fan1 T C 7: 64,022,761 (GRCm39) Y164C probably benign Het
Fndc8 A G 11: 82,789,522 (GRCm39) T227A probably benign Het
Gbp7 T C 3: 142,243,798 (GRCm39) I115T probably damaging Het
Gm5145 A G 17: 20,791,270 (GRCm39) E216G probably benign Het
Gm94 A T 18: 43,914,326 (GRCm39) F77L possibly damaging Het
Grik3 C A 4: 125,526,185 (GRCm39) H139Q probably benign Het
Gucy2e T C 11: 69,115,827 (GRCm39) T852A probably damaging Het
Hif1a T C 12: 73,983,010 (GRCm39) S274P probably damaging Het
Hmcn1 T A 1: 150,692,870 (GRCm39) I268L probably benign Het
Klk15 C T 7: 43,587,790 (GRCm39) H73Y possibly damaging Het
Lin52 T A 12: 84,592,681 (GRCm39) S87T Het
Lrrc74b A G 16: 17,367,640 (GRCm39) probably null Het
Mapk10 T C 5: 103,144,499 (GRCm39) K136R probably damaging Het
Nlrp2 A T 7: 5,325,457 (GRCm39) N738K probably null Het
Nlrp5 A T 7: 23,129,573 (GRCm39) Q880L possibly damaging Het
Or2y11 T A 11: 49,442,808 (GRCm39) V78E probably damaging Het
Or5d39 A T 2: 87,979,718 (GRCm39) I215N possibly damaging Het
Or6c215 G T 10: 129,637,926 (GRCm39) P156Q probably damaging Het
P4htm G A 9: 108,474,627 (GRCm39) P46L probably benign Het
Pcsk4 A T 10: 80,164,858 (GRCm39) H69Q probably damaging Het
Pdzd2 A G 15: 12,374,385 (GRCm39) S1917P probably benign Het
Pnpla5 A G 15: 83,998,087 (GRCm39) V385A possibly damaging Het
Prorp T C 12: 55,426,192 (GRCm39) F514S probably damaging Het
Rims2 C T 15: 39,339,873 (GRCm39) R856C probably damaging Het
Rprd2 A G 3: 95,691,622 (GRCm39) Y218H probably benign Het
Sat2 T A 11: 69,513,069 (GRCm39) probably benign Het
Sf1 C T 19: 6,426,336 (GRCm39) R186C Het
Snrnp200 A G 2: 127,053,466 (GRCm39) probably benign Het
Sqor A T 2: 122,629,514 (GRCm39) D124V probably benign Het
Ssh2 A G 11: 77,312,062 (GRCm39) H191R possibly damaging Het
Stac C A 9: 111,519,320 (GRCm39) probably benign Het
Svs4 T C 2: 164,119,058 (GRCm39) M93V unknown Het
Tbc1d32 A T 10: 56,037,241 (GRCm39) S668T possibly damaging Het
Tex10 A G 4: 48,452,056 (GRCm39) F690S probably damaging Het
Tex30 A G 1: 44,130,356 (GRCm39) M88T Het
Tgfbrap1 T C 1: 43,095,837 (GRCm39) T534A probably benign Het
Tmco1 C T 1: 167,136,132 (GRCm39) probably benign Het
Tnrc18 T C 5: 142,711,818 (GRCm39) E2647G probably damaging Het
Trim43a GATTTATTTATTTATTTATTTATTTATTTATTTATTTATT GATTTATTTATTTATTTATTTATTTATTTATTTATTTATTTATT 9: 88,465,042 (GRCm39) probably benign Het
Tubb3 A T 8: 124,145,696 (GRCm39) R62W probably damaging Het
Vmn2r108 A G 17: 20,690,312 (GRCm39) S507P probably benign Het
Vmn2r116 A G 17: 23,603,864 (GRCm39) K30E possibly damaging Het
Vmn2r14 G A 5: 109,368,054 (GRCm39) H313Y probably damaging Het
Wdr37 C T 13: 8,885,424 (GRCm39) V340M probably damaging Het
Zfp799 A G 17: 33,039,565 (GRCm39) F234L possibly damaging Het
Other mutations in Fer1l6
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0009:Fer1l6 UTSW 15 58,534,636 (GRCm39) missense probably damaging 1.00
R0141:Fer1l6 UTSW 15 58,430,251 (GRCm39) missense probably damaging 1.00
R0178:Fer1l6 UTSW 15 58,509,763 (GRCm39) splice site probably null
R0304:Fer1l6 UTSW 15 58,462,411 (GRCm39) missense probably benign 0.08
R0379:Fer1l6 UTSW 15 58,420,187 (GRCm39) missense probably benign 0.05
R0457:Fer1l6 UTSW 15 58,509,943 (GRCm39) critical splice donor site probably null
R0546:Fer1l6 UTSW 15 58,430,257 (GRCm39) splice site probably null
R0602:Fer1l6 UTSW 15 58,449,794 (GRCm39) missense probably damaging 0.98
R0619:Fer1l6 UTSW 15 58,534,784 (GRCm39) splice site probably null
R0669:Fer1l6 UTSW 15 58,425,573 (GRCm39) splice site probably null
R0854:Fer1l6 UTSW 15 58,431,037 (GRCm39) missense probably benign 0.00
R0948:Fer1l6 UTSW 15 58,435,924 (GRCm39) missense probably benign 0.00
R1180:Fer1l6 UTSW 15 58,474,160 (GRCm39) splice site probably benign
R1483:Fer1l6 UTSW 15 58,509,819 (GRCm39) missense possibly damaging 0.84
R1627:Fer1l6 UTSW 15 58,513,728 (GRCm39) missense probably benign 0.41
R1635:Fer1l6 UTSW 15 58,518,930 (GRCm39) missense probably damaging 1.00
R1834:Fer1l6 UTSW 15 58,429,718 (GRCm39) missense possibly damaging 0.58
R1921:Fer1l6 UTSW 15 58,497,080 (GRCm39) missense probably damaging 1.00
R2000:Fer1l6 UTSW 15 58,474,160 (GRCm39) splice site probably benign
R2041:Fer1l6 UTSW 15 58,430,155 (GRCm39) missense probably damaging 1.00
R2144:Fer1l6 UTSW 15 58,499,383 (GRCm39) missense probably benign
R2145:Fer1l6 UTSW 15 58,499,383 (GRCm39) missense probably benign
R2981:Fer1l6 UTSW 15 58,435,926 (GRCm39) missense probably damaging 0.99
R4164:Fer1l6 UTSW 15 58,431,087 (GRCm39) missense possibly damaging 0.83
R4192:Fer1l6 UTSW 15 58,518,998 (GRCm39) missense probably damaging 1.00
R4273:Fer1l6 UTSW 15 58,499,371 (GRCm39) missense probably benign 0.41
R4573:Fer1l6 UTSW 15 58,498,129 (GRCm39) critical splice donor site probably null
R4581:Fer1l6 UTSW 15 58,512,075 (GRCm39) missense probably damaging 1.00
R4624:Fer1l6 UTSW 15 58,425,554 (GRCm39) missense probably damaging 1.00
R4755:Fer1l6 UTSW 15 58,512,060 (GRCm39) missense probably benign 0.09
R4774:Fer1l6 UTSW 15 58,449,798 (GRCm39) missense probably damaging 0.99
R4894:Fer1l6 UTSW 15 58,490,751 (GRCm39) missense probably damaging 1.00
R4896:Fer1l6 UTSW 15 58,509,869 (GRCm39) missense probably damaging 1.00
R4921:Fer1l6 UTSW 15 58,472,160 (GRCm39) critical splice acceptor site probably null
R4962:Fer1l6 UTSW 15 58,443,250 (GRCm39) missense probably benign 0.03
R5029:Fer1l6 UTSW 15 58,515,769 (GRCm39) missense probably benign 0.00
R5134:Fer1l6 UTSW 15 58,512,003 (GRCm39) missense probably damaging 1.00
R5175:Fer1l6 UTSW 15 58,422,126 (GRCm39) missense probably damaging 1.00
R5227:Fer1l6 UTSW 15 58,453,752 (GRCm39) nonsense probably null
R5561:Fer1l6 UTSW 15 58,532,674 (GRCm39) missense probably damaging 0.97
R5621:Fer1l6 UTSW 15 58,430,175 (GRCm39) missense probably damaging 1.00
R5670:Fer1l6 UTSW 15 58,494,331 (GRCm39) missense probably benign 0.00
R5745:Fer1l6 UTSW 15 58,443,238 (GRCm39) missense probably benign 0.01
R5807:Fer1l6 UTSW 15 58,462,399 (GRCm39) nonsense probably null
R5823:Fer1l6 UTSW 15 58,462,352 (GRCm39) nonsense probably null
R5892:Fer1l6 UTSW 15 58,435,917 (GRCm39) missense probably benign
R6006:Fer1l6 UTSW 15 58,518,893 (GRCm39) missense probably damaging 1.00
R6137:Fer1l6 UTSW 15 58,431,055 (GRCm39) missense probably damaging 0.97
R6195:Fer1l6 UTSW 15 58,509,806 (GRCm39) missense probably damaging 1.00
R6234:Fer1l6 UTSW 15 58,432,488 (GRCm39) missense probably damaging 1.00
R6237:Fer1l6 UTSW 15 58,509,855 (GRCm39) missense probably damaging 1.00
R6237:Fer1l6 UTSW 15 58,497,026 (GRCm39) nonsense probably null
R6271:Fer1l6 UTSW 15 58,513,767 (GRCm39) missense probably benign 0.01
R6336:Fer1l6 UTSW 15 58,431,081 (GRCm39) nonsense probably null
R6784:Fer1l6 UTSW 15 58,443,275 (GRCm39) missense possibly damaging 0.63
R6852:Fer1l6 UTSW 15 58,466,727 (GRCm39) missense probably damaging 1.00
R7030:Fer1l6 UTSW 15 58,501,227 (GRCm39) missense probably damaging 1.00
R7088:Fer1l6 UTSW 15 58,435,899 (GRCm39) missense possibly damaging 0.69
R7181:Fer1l6 UTSW 15 58,447,146 (GRCm39) missense probably benign 0.00
R7226:Fer1l6 UTSW 15 58,462,384 (GRCm39) missense probably benign 0.00
R7266:Fer1l6 UTSW 15 58,499,446 (GRCm39) missense probably benign
R7463:Fer1l6 UTSW 15 58,445,450 (GRCm39) nonsense probably null
R7464:Fer1l6 UTSW 15 58,445,096 (GRCm39) splice site probably null
R7469:Fer1l6 UTSW 15 58,462,419 (GRCm39) splice site probably null
R7483:Fer1l6 UTSW 15 58,513,794 (GRCm39) missense possibly damaging 0.83
R7491:Fer1l6 UTSW 15 58,472,281 (GRCm39) missense probably damaging 1.00
R7534:Fer1l6 UTSW 15 58,509,875 (GRCm39) missense probably damaging 1.00
R7562:Fer1l6 UTSW 15 58,432,331 (GRCm39) missense probably benign 0.00
R7580:Fer1l6 UTSW 15 58,430,245 (GRCm39) missense probably benign 0.41
R7599:Fer1l6 UTSW 15 58,499,438 (GRCm39) missense probably benign
R7607:Fer1l6 UTSW 15 58,534,581 (GRCm39) nonsense probably null
R7677:Fer1l6 UTSW 15 58,474,139 (GRCm39) missense probably benign 0.00
R8202:Fer1l6 UTSW 15 58,502,486 (GRCm39) missense probably damaging 1.00
R8261:Fer1l6 UTSW 15 58,432,345 (GRCm39) missense possibly damaging 0.84
R8847:Fer1l6 UTSW 15 58,414,012 (GRCm39) missense possibly damaging 0.72
R9022:Fer1l6 UTSW 15 58,455,329 (GRCm39) missense probably damaging 0.99
R9160:Fer1l6 UTSW 15 58,515,715 (GRCm39) missense possibly damaging 0.94
R9180:Fer1l6 UTSW 15 58,494,230 (GRCm39) missense probably benign 0.19
R9289:Fer1l6 UTSW 15 58,490,766 (GRCm39) missense probably damaging 1.00
R9559:Fer1l6 UTSW 15 58,429,759 (GRCm39) missense possibly damaging 0.88
R9562:Fer1l6 UTSW 15 58,490,370 (GRCm39) missense possibly damaging 0.70
R9682:Fer1l6 UTSW 15 58,422,113 (GRCm39) missense probably benign 0.03
R9775:Fer1l6 UTSW 15 58,497,098 (GRCm39) missense probably benign
X0021:Fer1l6 UTSW 15 58,441,051 (GRCm39) nonsense probably null
X0027:Fer1l6 UTSW 15 58,501,189 (GRCm39) missense probably damaging 1.00
X0063:Fer1l6 UTSW 15 58,490,423 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATTTCCACCACAGGGCTCAC -3'
(R):5'- GAAACTTAATGGGATTGGACCTATGG -3'

Sequencing Primer
(F):5'- ACAGGGCTCACTATGGTTTC -3'
(R):5'- TACAAGCCAGCAGAATAGGTTC -3'
Posted On 2021-11-19