Mutagenetix > Incidental Mutation

Incidental Mutation 'R9030:Vmn2r108'

687021

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r108

Ensembl Gene

ENSMUSG00000091805

Gene Name

vomeronasal 2, receptor 108

Synonyms

EG627805

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.077) question?

Stock #

R9030 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

20462373-20481236 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 20470050 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 507 (S507P)

Ref Sequence

ENSEMBL: ENSMUSP00000130373 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000167314]

AlphaFold

E9PYS0

Predicted Effect

probably benign
Transcript: ENSMUST00000167314
AA Change: S507P

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)

SMART Domains

Protein: ENSMUSP00000130373
Gene: ENSMUSG00000091805
AA Change: S507P

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	83	467	6e-33	PFAM
Pfam:NCD3G	510	563	9.2e-22	PFAM
Pfam:7tm_3	593	831	2.2e-51	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.1%

Validation Efficiency

100% (57/57)

Allele List at MGI

Other mutations in this stock

Total: 59 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110008L16Rik	T	C	12: 55,379,407	F514S	probably damaging	Het
Actr5	A	C	2: 158,632,401	I375L	probably benign	Het
Adgrl2	G	T	3: 148,839,125	T778K	possibly damaging	Het
Cdc73	A	T	1: 143,609,496	L478H	probably damaging	Het
Cdh7	C	A	1: 110,100,113	H529Q	probably benign	Het
Cep55	T	C	19: 38,071,144		probably null	Het
Chd9	G	A	8: 90,956,570	R546Q	unknown	Het
Ddit4	A	T	10: 59,950,693	L178Q	probably damaging	Het
Dgke	A	T	11: 89,050,411	N315K	possibly damaging	Het
Dsg1a	A	G	18: 20,340,492	D874G	probably damaging	Het
Dsp	T	A	13: 38,168,697	Y184N	probably damaging	Het
Dynlt1c	A	G	17: 6,603,517	I20V	probably benign	Het
Ephx4	A	G	5: 107,429,683	H291R	possibly damaging	Het
Epx	A	T	11: 87,872,644	M250K	probably benign	Het
Fan1	T	C	7: 64,373,013	Y164C	probably benign	Het
Fer1l6	A	T	15: 58,630,745	Y1365F	probably damaging	Het
Fndc8	A	G	11: 82,898,696	T227A	probably benign	Het
Gbp7	T	C	3: 142,538,037	I115T	probably damaging	Het
Gm5145	A	G	17: 20,571,008	E216G	probably benign	Het
Gm94	A	T	18: 43,781,261	F77L	possibly damaging	Het
Grik3	C	A	4: 125,632,392	H139Q	probably benign	Het
Gucy2e	T	C	11: 69,225,001	T852A	probably damaging	Het
Hif1a	T	C	12: 73,936,236	S274P	probably damaging	Het
Hmcn1	T	A	1: 150,817,119	I268L	probably benign	Het
Klk15	C	T	7: 43,938,366	H73Y	possibly damaging	Het
Lin52	T	A	12: 84,545,907	S87T		Het
Lrrc74b	A	G	16: 17,549,776		probably null	Het
Mapk10	T	C	5: 102,996,633	K136R	probably damaging	Het
Nlrp2	A	T	7: 5,322,458	N738K	probably null	Het
Nlrp5	A	T	7: 23,430,148	Q880L	possibly damaging	Het
Nov	A	T	15: 54,752,291	Y284F	probably damaging	Het
Olfr1167	A	T	2: 88,149,374	I215N	possibly damaging	Het
Olfr1381	T	A	11: 49,551,981	V78E	probably damaging	Het
Olfr811	G	T	10: 129,802,057	P156Q	probably damaging	Het
P4htm	G	A	9: 108,597,428	P46L	probably benign	Het
Pcsk4	A	T	10: 80,329,024	H69Q	probably damaging	Het
Pdzd2	A	G	15: 12,374,299	S1917P	probably benign	Het
Pnpla5	A	G	15: 84,113,886	V385A	possibly damaging	Het
Rims2	C	T	15: 39,476,477	R856C	probably damaging	Het
Rprd2	A	G	3: 95,784,310	Y218H	probably benign	Het
Sat2	T	A	11: 69,622,243		probably benign	Het
Sf1	C	T	19: 6,376,306	R186C		Het
Snrnp200	A	G	2: 127,211,546		probably benign	Het
Sqor	A	T	2: 122,787,594	D124V	probably benign	Het
Ssh2	A	G	11: 77,421,236	H191R	possibly damaging	Het
Stac	C	A	9: 111,690,252		probably benign	Het
Svs4	T	C	2: 164,277,138	M93V	unknown	Het
Tbc1d32	A	T	10: 56,161,145	S668T	possibly damaging	Het
Tex10	A	G	4: 48,452,056	F690S	probably damaging	Het
Tex30	A	G	1: 44,091,196	M88T		Het
Tgfbrap1	T	C	1: 43,056,677	T534A	probably benign	Het
Tmco1	C	T	1: 167,308,563		probably benign	Het
Tnrc18	T	C	5: 142,726,063	E2647G	probably damaging	Het
Trim43a	GATTTATTTATTTATTTATTTATTTATTTATTTATTTATT	GATTTATTTATTTATTTATTTATTTATTTATTTATTTATTTATT	9: 88,582,989		probably benign	Het
Tubb3	A	T	8: 123,418,957	R62W	probably damaging	Het
Vmn2r116	A	G	17: 23,384,890	K30E	possibly damaging	Het
Vmn2r14	G	A	5: 109,220,188	H313Y	probably damaging	Het
Wdr37	C	T	13: 8,835,388	V340M	probably damaging	Het
Zfp799	A	G	17: 32,820,591	F234L	possibly damaging	Het

Other mutations in Vmn2r108

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00903:Vmn2r108	APN	17	20462512	missense	probably damaging	0.98
IGL01143:Vmn2r108	APN	17	20462465	missense	possibly damaging	0.82
IGL01311:Vmn2r108	APN	17	20462677	nonsense	probably null
IGL01411:Vmn2r108	APN	17	20471020	missense	probably benign	0.01
IGL01414:Vmn2r108	APN	17	20471680	missense	probably benign	0.00
IGL01536:Vmn2r108	APN	17	20463281	missense	probably damaging	1.00
IGL01748:Vmn2r108	APN	17	20463214	missense	probably benign	0.03
IGL01769:Vmn2r108	APN	17	20471018	missense	probably benign	0.02
IGL02022:Vmn2r108	APN	17	20471725	missense	possibly damaging	0.77
IGL02041:Vmn2r108	APN	17	20463136	missense	probably damaging	1.00
IGL02049:Vmn2r108	APN	17	20471346	missense	probably benign	0.00
IGL02344:Vmn2r108	APN	17	20469143	missense	probably damaging	1.00
IGL02939:Vmn2r108	APN	17	20471283	missense	probably benign	0.05
IGL03202:Vmn2r108	APN	17	20471057	nonsense	probably null
PIT4498001:Vmn2r108	UTSW	17	20463017	missense	probably damaging	1.00
R0112:Vmn2r108	UTSW	17	20471635	missense	probably benign	0.07
R0505:Vmn2r108	UTSW	17	20462834	missense	possibly damaging	0.77
R0833:Vmn2r108	UTSW	17	20471459	missense	probably benign
R0836:Vmn2r108	UTSW	17	20471459	missense	probably benign
R0943:Vmn2r108	UTSW	17	20471135	nonsense	probably null
R1411:Vmn2r108	UTSW	17	20462845	missense	probably damaging	0.98
R1442:Vmn2r108	UTSW	17	20472361	nonsense	probably null
R1587:Vmn2r108	UTSW	17	20472121	missense	probably damaging	1.00
R1751:Vmn2r108	UTSW	17	20462524	missense	probably damaging	1.00
R1773:Vmn2r108	UTSW	17	20469073	missense	probably damaging	1.00
R2021:Vmn2r108	UTSW	17	20470990	missense	probably benign	0.00
R2159:Vmn2r108	UTSW	17	20469101	missense	probably benign	0.41
R2224:Vmn2r108	UTSW	17	20481033	nonsense	probably null
R2226:Vmn2r108	UTSW	17	20481033	nonsense	probably null
R2517:Vmn2r108	UTSW	17	20472315	missense	probably damaging	1.00
R3710:Vmn2r108	UTSW	17	20462670	missense	probably benign
R4470:Vmn2r108	UTSW	17	20462728	missense	probably damaging	1.00
R4686:Vmn2r108	UTSW	17	20471374	missense	probably damaging	0.99
R4729:Vmn2r108	UTSW	17	20472370	missense	probably damaging	0.99
R4799:Vmn2r108	UTSW	17	20462629	missense	probably damaging	1.00
R4993:Vmn2r108	UTSW	17	20481187	missense	probably benign	0.04
R5088:Vmn2r108	UTSW	17	20470192	missense	possibly damaging	0.46
R5213:Vmn2r108	UTSW	17	20471493	missense	probably benign	0.00
R5289:Vmn2r108	UTSW	17	20471604	missense	probably damaging	1.00
R5290:Vmn2r108	UTSW	17	20471403	missense	probably benign	0.00
R5713:Vmn2r108	UTSW	17	20471028	missense	probably damaging	1.00
R5753:Vmn2r108	UTSW	17	20462917	missense	probably damaging	0.99
R5792:Vmn2r108	UTSW	17	20463136	missense	probably damaging	0.99
R5798:Vmn2r108	UTSW	17	20472283	missense	probably benign	0.39
R5897:Vmn2r108	UTSW	17	20471318	missense	probably benign	0.01
R6018:Vmn2r108	UTSW	17	20463006	missense	possibly damaging	0.83
R6093:Vmn2r108	UTSW	17	20481140	missense	probably benign	0.00
R6156:Vmn2r108	UTSW	17	20472185	missense	probably benign	0.03
R6199:Vmn2r108	UTSW	17	20462382	missense	probably benign	0.01
R6259:Vmn2r108	UTSW	17	20463109	missense	possibly damaging	0.95
R6309:Vmn2r108	UTSW	17	20471398	missense	probably damaging	0.98
R6324:Vmn2r108	UTSW	17	20471715	nonsense	probably null
R6364:Vmn2r108	UTSW	17	20470998	missense	probably benign	0.00
R6446:Vmn2r108	UTSW	17	20472347	nonsense	probably null
R6541:Vmn2r108	UTSW	17	20481218	missense	probably benign	0.02
R7025:Vmn2r108	UTSW	17	20471083	missense	possibly damaging	0.67
R7063:Vmn2r108	UTSW	17	20481148	missense	probably damaging	1.00
R7092:Vmn2r108	UTSW	17	20481076	missense	probably benign	0.10
R7096:Vmn2r108	UTSW	17	20462500	missense	probably damaging	1.00
R7203:Vmn2r108	UTSW	17	20462776	missense	probably benign	0.12
R7458:Vmn2r108	UTSW	17	20472270	missense	probably benign	0.17
R7619:Vmn2r108	UTSW	17	20472195	missense	probably benign	0.02
R7841:Vmn2r108	UTSW	17	20470043	critical splice donor site	probably null
R7944:Vmn2r108	UTSW	17	20471628	missense	probably damaging	0.99
R8048:Vmn2r108	UTSW	17	20471500	missense	probably benign	0.29
R8213:Vmn2r108	UTSW	17	20470088	missense	probably benign	0.03
R8218:Vmn2r108	UTSW	17	20463203	missense	probably damaging	1.00
R8507:Vmn2r108	UTSW	17	20462933	nonsense	probably null
R8708:Vmn2r108	UTSW	17	20462425	missense	probably damaging	0.98
R8845:Vmn2r108	UTSW	17	20471099	missense	probably benign	0.03
R9226:Vmn2r108	UTSW	17	20471068	missense	probably benign
R9278:Vmn2r108	UTSW	17	20472299	missense	probably benign	0.11
X0022:Vmn2r108	UTSW	17	20471109	missense	probably damaging	1.00
Z1088:Vmn2r108	UTSW	17	20471113	missense	probably benign	0.01
Z1177:Vmn2r108	UTSW	17	20470957	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- GGTGCTGAAAATTTCCTCTTCC -3'
(R):5'- ACAATATGAGTTTCGGTGGGAGAC -3'

Sequencing Primer
(F):5'- GCTGAAAATTTCCTCTTCCATTGTG -3'
(R):5'- TTTCGGTGGGAGACAGAAATTAAATG -3'

Posted On

2021-11-19