Incidental Mutation 'R9032:Zfp51'
ID 687162
Institutional Source Beutler Lab
Gene Symbol Zfp51
Ensembl Gene ENSMUSG00000023892
Gene Name zinc finger protein 51
Synonyms zfec12, Zfp-51
MMRRC Submission 068861-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.390) question?
Stock # R9032 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 21670636-21685849 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 21684660 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Histidine at position 425 (L425H)
Ref Sequence ENSEMBL: ENSMUSP00000045684 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039577]
AlphaFold Q3U4L8
Predicted Effect probably damaging
Transcript: ENSMUST00000039577
AA Change: L425H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000045684
Gene: ENSMUSG00000023892
AA Change: L425H

DomainStartEndE-ValueType
KRAB 43 103 1.71e-22 SMART
ZnF_C2H2 214 236 2.36e-2 SMART
ZnF_C2H2 242 264 8.94e-3 SMART
ZnF_C2H2 270 292 7.9e-4 SMART
ZnF_C2H2 298 320 3.44e-4 SMART
ZnF_C2H2 326 348 7.15e-2 SMART
ZnF_C2H2 354 376 4.54e-4 SMART
ZnF_C2H2 382 404 3.44e-4 SMART
ZnF_C2H2 410 432 9.88e-5 SMART
ZnF_C2H2 438 460 3.16e-3 SMART
ZnF_C2H2 466 488 1.58e-3 SMART
ZnF_C2H2 494 517 2.57e-3 SMART
ZnF_C2H2 523 545 3.63e-3 SMART
ZnF_C2H2 551 573 1.4e-4 SMART
ZnF_C2H2 579 601 4.17e-3 SMART
ZnF_C2H2 607 629 2.79e-4 SMART
ZnF_C2H2 635 657 4.24e-4 SMART
ZnF_C2H2 663 685 9.08e-4 SMART
ZnF_C2H2 691 713 8.47e-4 SMART
ZnF_C2H2 719 741 1.36e-2 SMART
ZnF_C2H2 747 769 6.82e1 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency 100% (56/56)
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5031439G07Rik C T 15: 84,844,782 (GRCm39) M78I probably benign Het
Abca8b C T 11: 109,848,073 (GRCm39) V803M probably benign Het
Acap1 T C 11: 69,772,491 (GRCm39) E728G probably damaging Het
Afg1l G A 10: 42,194,637 (GRCm39) T385M probably damaging Het
Ankib1 T C 5: 3,819,641 (GRCm39) I93V probably benign Het
Aopep C T 13: 63,444,681 (GRCm39) R752* probably null Het
Apoa4 T A 9: 46,154,275 (GRCm39) L292Q probably damaging Het
Arhgap29 T A 3: 121,808,249 (GRCm39) D1142E probably benign Het
Asb5 A T 8: 55,038,929 (GRCm39) D265V probably benign Het
Ash1l C T 3: 88,889,294 (GRCm39) A391V probably benign Het
Ash1l T C 3: 88,891,529 (GRCm39) V1136A probably benign Het
Cacna1c G T 6: 118,615,466 (GRCm39) Y1308* probably null Het
Ctif CGGGGCACACTTTGCTCTTACCTCCCGGAGGCACGTGTAGATGGGGCACACTTTGCTCTTACCTCCCGGAGGCACGTGTAGATGGGGCACAC CGGGGCACACTTTGCTCTTACCTCCCGGAGGCACGTGTAGATGGGGCACAC 18: 75,604,874 (GRCm39) probably benign Het
Dmtn A G 14: 70,853,534 (GRCm39) S92P probably damaging Het
Edc4 T C 8: 106,613,639 (GRCm39) F353S probably damaging Het
Emc1 T C 4: 139,094,474 (GRCm39) Y676H possibly damaging Het
Epb41l4b A T 4: 57,041,064 (GRCm39) probably null Het
Fat1 A T 8: 45,492,894 (GRCm39) N3872I probably benign Het
Fer T A 17: 64,228,767 (GRCm39) M214K probably damaging Het
Fgf17 A G 14: 70,874,436 (GRCm39) F129L probably damaging Het
Fnbp1 T C 2: 30,973,017 (GRCm39) D161G probably damaging Het
Frmd4b A C 6: 97,269,334 (GRCm39) S993A probably benign Het
Hsh2d T C 8: 72,954,385 (GRCm39) S256P probably benign Het
Il31ra T C 13: 112,660,628 (GRCm39) S654G Het
Lmnb2 T C 10: 80,740,091 (GRCm39) D442G probably benign Het
Med19 A G 2: 84,515,660 (GRCm39) M115V probably damaging Het
Mroh5 T C 15: 73,655,302 (GRCm39) Y641C probably benign Het
Mrpl18 A T 17: 13,134,582 (GRCm39) V61E probably damaging Het
Mrtfb A C 16: 13,230,092 (GRCm39) T926P probably damaging Het
Mtap AC A 4: 89,090,515 (GRCm39) probably null Het
Muc2 T A 7: 141,287,058 (GRCm39) C154S probably damaging Het
Mypn T G 10: 62,983,894 (GRCm39) probably null Het
Naip5 T A 13: 100,356,338 (GRCm39) E1092D probably benign Het
Nes T G 3: 87,887,069 (GRCm39) V1776G possibly damaging Het
Nxn A G 11: 76,169,383 (GRCm39) I132T probably damaging Het
Oxr1 G A 15: 41,718,317 (GRCm39) V798I probably benign Het
Papss1 C A 3: 131,324,817 (GRCm39) H425N probably damaging Het
Pde4dip T C 3: 97,601,385 (GRCm39) N2344S probably benign Het
Pfas C T 11: 68,879,421 (GRCm39) G263S Het
Pknox1 C T 17: 31,822,229 (GRCm39) T332M possibly damaging Het
Plch2 T C 4: 155,084,976 (GRCm39) D321G probably damaging Het
Pnma1 T C 12: 84,193,806 (GRCm39) N299S probably benign Het
Psg23 T G 7: 18,348,660 (GRCm39) N49T possibly damaging Het
Qrfpr A G 3: 36,276,099 (GRCm39) F97S probably damaging Het
Rbl1 A G 2: 157,035,073 (GRCm39) F336L probably benign Het
Rpap1 G A 2: 119,608,776 (GRCm39) P143S probably benign Het
Rsph6a A T 7: 18,799,250 (GRCm39) N294Y probably damaging Het
Serpinb9h T C 13: 33,581,781 (GRCm39) Y113H probably damaging Het
Sesn1 C T 10: 41,686,835 (GRCm39) probably benign Het
Sh3d19 T C 3: 86,033,992 (GRCm39) Y782H probably damaging Het
Siglecg T C 7: 43,061,049 (GRCm39) V374A probably benign Het
Slc35d2 A G 13: 64,256,227 (GRCm39) F156S probably damaging Het
Slc6a11 A T 6: 114,202,808 (GRCm39) I301F probably damaging Het
Slx4ip A G 2: 136,910,240 (GRCm39) K412E possibly damaging Het
Tas2r115 A T 6: 132,714,327 (GRCm39) V208E probably benign Het
Tlcd5 C T 9: 43,022,664 (GRCm39) R230Q probably benign Het
Tmem132a G T 19: 10,843,835 (GRCm39) Q174K probably damaging Het
Tmtc1 A T 6: 148,237,749 (GRCm39) Y338* probably null Het
Vav3 C T 3: 109,413,722 (GRCm39) A220V probably benign Het
Wt1 C A 2: 104,957,160 (GRCm39) Q7K probably benign Het
Zbtb4 T A 11: 69,672,650 (GRCm39) F204L probably benign Het
Other mutations in Zfp51
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00420:Zfp51 APN 17 21,683,714 (GRCm39) missense probably benign 0.11
IGL00971:Zfp51 APN 17 21,683,844 (GRCm39) missense probably benign 0.03
IGL02002:Zfp51 APN 17 21,684,221 (GRCm39) missense probably damaging 0.98
IGL02268:Zfp51 APN 17 21,683,681 (GRCm39) nonsense probably null
IGL03249:Zfp51 APN 17 21,683,701 (GRCm39) missense probably damaging 1.00
R1569:Zfp51 UTSW 17 21,676,642 (GRCm39) missense probably benign 0.01
R1853:Zfp51 UTSW 17 21,684,585 (GRCm39) missense probably damaging 1.00
R1989:Zfp51 UTSW 17 21,676,582 (GRCm39) missense possibly damaging 0.90
R2285:Zfp51 UTSW 17 21,684,137 (GRCm39) missense probably damaging 1.00
R2407:Zfp51 UTSW 17 21,684,093 (GRCm39) missense probably damaging 0.98
R2890:Zfp51 UTSW 17 21,684,118 (GRCm39) missense probably damaging 1.00
R3918:Zfp51 UTSW 17 21,683,702 (GRCm39) missense probably benign
R4529:Zfp51 UTSW 17 21,684,998 (GRCm39) missense probably damaging 1.00
R4587:Zfp51 UTSW 17 21,685,178 (GRCm39) nonsense probably null
R4866:Zfp51 UTSW 17 21,682,012 (GRCm39) missense possibly damaging 0.61
R4872:Zfp51 UTSW 17 21,684,933 (GRCm39) missense probably benign 0.26
R4961:Zfp51 UTSW 17 21,676,615 (GRCm39) missense probably benign 0.01
R5392:Zfp51 UTSW 17 21,685,584 (GRCm39) missense possibly damaging 0.60
R5611:Zfp51 UTSW 17 21,684,354 (GRCm39) missense probably damaging 1.00
R7109:Zfp51 UTSW 17 21,683,831 (GRCm39) missense possibly damaging 0.80
R7129:Zfp51 UTSW 17 21,681,971 (GRCm39) missense probably damaging 1.00
R7269:Zfp51 UTSW 17 21,683,960 (GRCm39) missense probably benign 0.09
R7303:Zfp51 UTSW 17 21,684,058 (GRCm39) missense probably benign 0.24
R7514:Zfp51 UTSW 17 21,683,762 (GRCm39) missense probably benign 0.37
R7665:Zfp51 UTSW 17 21,683,843 (GRCm39) missense probably benign 0.00
R8073:Zfp51 UTSW 17 21,684,294 (GRCm39) missense probably damaging 1.00
R8177:Zfp51 UTSW 17 21,684,129 (GRCm39) missense probably benign 0.05
R8560:Zfp51 UTSW 17 21,685,635 (GRCm39) missense probably benign 0.00
R8877:Zfp51 UTSW 17 21,682,017 (GRCm39) missense probably damaging 1.00
R9085:Zfp51 UTSW 17 21,684,660 (GRCm39) missense probably damaging 1.00
R9307:Zfp51 UTSW 17 21,684,733 (GRCm39) missense probably benign 0.30
R9489:Zfp51 UTSW 17 21,684,291 (GRCm39) missense probably damaging 1.00
R9605:Zfp51 UTSW 17 21,684,291 (GRCm39) missense probably damaging 1.00
R9686:Zfp51 UTSW 17 21,683,871 (GRCm39) missense probably damaging 1.00
R9735:Zfp51 UTSW 17 21,685,413 (GRCm39) nonsense probably null
R9795:Zfp51 UTSW 17 21,682,051 (GRCm39) critical splice donor site probably null
X0062:Zfp51 UTSW 17 21,685,257 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- CCCAATTTCAGGACACATCAGAA -3'
(R):5'- TCTAAGATATGCACGCTGGGTAAA -3'

Sequencing Primer
(F):5'- GGCAGGGAATTTCACCAGCTTTC -3'
(R):5'- CACGCTGGGTAAAGGATTTGTCAC -3'
Posted On 2021-11-19