Incidental Mutation 'R9032:Tmem132a'
ID 687166
Institutional Source Beutler Lab
Gene Symbol Tmem132a
Ensembl Gene ENSMUSG00000024736
Gene Name transmembrane protein 132A
Synonyms 6720481D13Rik, Hspa5bp1
MMRRC Submission 068861-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R9032 (G1)
Quality Score 225.009
Status Validated
Chromosome 19
Chromosomal Location 10835186-10847304 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 10843835 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Lysine at position 174 (Q174K)
Ref Sequence ENSEMBL: ENSMUSP00000025645 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025645] [ENSMUST00000038128] [ENSMUST00000120524]
AlphaFold Q922P8
Predicted Effect probably damaging
Transcript: ENSMUST00000025645
AA Change: Q174K

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000025645
Gene: ENSMUSG00000024736
AA Change: Q174K

DomainStartEndE-ValueType
signal peptide 1 32 N/A INTRINSIC
Pfam:TMEM132D_N 44 167 1.6e-35 PFAM
low complexity region 206 223 N/A INTRINSIC
Pfam:TMEM132 403 745 4.1e-108 PFAM
low complexity region 759 776 N/A INTRINSIC
Pfam:TMEM132D_C 809 897 1.5e-31 PFAM
low complexity region 906 923 N/A INTRINSIC
low complexity region 932 944 N/A INTRINSIC
low complexity region 960 976 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000038128
SMART Domains Protein: ENSMUSP00000039529
Gene: ENSMUSG00000034659

DomainStartEndE-ValueType
signal peptide 1 33 N/A INTRINSIC
Pfam:BRI3BP 57 231 9.9e-57 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000120524
AA Change: Q174K

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000113696
Gene: ENSMUSG00000024736
AA Change: Q174K

DomainStartEndE-ValueType
signal peptide 1 32 N/A INTRINSIC
low complexity region 206 223 N/A INTRINSIC
Meta Mutation Damage Score 0.3014 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency 100% (56/56)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that is highly similar to the rat Grp78-binding protein (GBP). Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5031439G07Rik C T 15: 84,844,782 (GRCm39) M78I probably benign Het
Abca8b C T 11: 109,848,073 (GRCm39) V803M probably benign Het
Acap1 T C 11: 69,772,491 (GRCm39) E728G probably damaging Het
Afg1l G A 10: 42,194,637 (GRCm39) T385M probably damaging Het
Ankib1 T C 5: 3,819,641 (GRCm39) I93V probably benign Het
Aopep C T 13: 63,444,681 (GRCm39) R752* probably null Het
Apoa4 T A 9: 46,154,275 (GRCm39) L292Q probably damaging Het
Arhgap29 T A 3: 121,808,249 (GRCm39) D1142E probably benign Het
Asb5 A T 8: 55,038,929 (GRCm39) D265V probably benign Het
Ash1l C T 3: 88,889,294 (GRCm39) A391V probably benign Het
Ash1l T C 3: 88,891,529 (GRCm39) V1136A probably benign Het
Cacna1c G T 6: 118,615,466 (GRCm39) Y1308* probably null Het
Ctif CGGGGCACACTTTGCTCTTACCTCCCGGAGGCACGTGTAGATGGGGCACACTTTGCTCTTACCTCCCGGAGGCACGTGTAGATGGGGCACAC CGGGGCACACTTTGCTCTTACCTCCCGGAGGCACGTGTAGATGGGGCACAC 18: 75,604,874 (GRCm39) probably benign Het
Dmtn A G 14: 70,853,534 (GRCm39) S92P probably damaging Het
Edc4 T C 8: 106,613,639 (GRCm39) F353S probably damaging Het
Emc1 T C 4: 139,094,474 (GRCm39) Y676H possibly damaging Het
Epb41l4b A T 4: 57,041,064 (GRCm39) probably null Het
Fat1 A T 8: 45,492,894 (GRCm39) N3872I probably benign Het
Fer T A 17: 64,228,767 (GRCm39) M214K probably damaging Het
Fgf17 A G 14: 70,874,436 (GRCm39) F129L probably damaging Het
Fnbp1 T C 2: 30,973,017 (GRCm39) D161G probably damaging Het
Frmd4b A C 6: 97,269,334 (GRCm39) S993A probably benign Het
Hsh2d T C 8: 72,954,385 (GRCm39) S256P probably benign Het
Il31ra T C 13: 112,660,628 (GRCm39) S654G Het
Lmnb2 T C 10: 80,740,091 (GRCm39) D442G probably benign Het
Med19 A G 2: 84,515,660 (GRCm39) M115V probably damaging Het
Mroh5 T C 15: 73,655,302 (GRCm39) Y641C probably benign Het
Mrpl18 A T 17: 13,134,582 (GRCm39) V61E probably damaging Het
Mrtfb A C 16: 13,230,092 (GRCm39) T926P probably damaging Het
Mtap AC A 4: 89,090,515 (GRCm39) probably null Het
Muc2 T A 7: 141,287,058 (GRCm39) C154S probably damaging Het
Mypn T G 10: 62,983,894 (GRCm39) probably null Het
Naip5 T A 13: 100,356,338 (GRCm39) E1092D probably benign Het
Nes T G 3: 87,887,069 (GRCm39) V1776G possibly damaging Het
Nxn A G 11: 76,169,383 (GRCm39) I132T probably damaging Het
Oxr1 G A 15: 41,718,317 (GRCm39) V798I probably benign Het
Papss1 C A 3: 131,324,817 (GRCm39) H425N probably damaging Het
Pde4dip T C 3: 97,601,385 (GRCm39) N2344S probably benign Het
Pfas C T 11: 68,879,421 (GRCm39) G263S Het
Pknox1 C T 17: 31,822,229 (GRCm39) T332M possibly damaging Het
Plch2 T C 4: 155,084,976 (GRCm39) D321G probably damaging Het
Pnma1 T C 12: 84,193,806 (GRCm39) N299S probably benign Het
Psg23 T G 7: 18,348,660 (GRCm39) N49T possibly damaging Het
Qrfpr A G 3: 36,276,099 (GRCm39) F97S probably damaging Het
Rbl1 A G 2: 157,035,073 (GRCm39) F336L probably benign Het
Rpap1 G A 2: 119,608,776 (GRCm39) P143S probably benign Het
Rsph6a A T 7: 18,799,250 (GRCm39) N294Y probably damaging Het
Serpinb9h T C 13: 33,581,781 (GRCm39) Y113H probably damaging Het
Sesn1 C T 10: 41,686,835 (GRCm39) probably benign Het
Sh3d19 T C 3: 86,033,992 (GRCm39) Y782H probably damaging Het
Siglecg T C 7: 43,061,049 (GRCm39) V374A probably benign Het
Slc35d2 A G 13: 64,256,227 (GRCm39) F156S probably damaging Het
Slc6a11 A T 6: 114,202,808 (GRCm39) I301F probably damaging Het
Slx4ip A G 2: 136,910,240 (GRCm39) K412E possibly damaging Het
Tas2r115 A T 6: 132,714,327 (GRCm39) V208E probably benign Het
Tlcd5 C T 9: 43,022,664 (GRCm39) R230Q probably benign Het
Tmtc1 A T 6: 148,237,749 (GRCm39) Y338* probably null Het
Vav3 C T 3: 109,413,722 (GRCm39) A220V probably benign Het
Wt1 C A 2: 104,957,160 (GRCm39) Q7K probably benign Het
Zbtb4 T A 11: 69,672,650 (GRCm39) F204L probably benign Het
Zfp51 T A 17: 21,684,660 (GRCm39) L425H probably damaging Het
Other mutations in Tmem132a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01401:Tmem132a APN 19 10,838,888 (GRCm39) splice site probably benign
IGL02508:Tmem132a APN 19 10,835,882 (GRCm39) missense probably damaging 1.00
R0514:Tmem132a UTSW 19 10,836,355 (GRCm39) missense probably damaging 0.99
R0918:Tmem132a UTSW 19 10,835,477 (GRCm39) missense probably damaging 1.00
R1160:Tmem132a UTSW 19 10,835,938 (GRCm39) missense probably damaging 0.98
R1205:Tmem132a UTSW 19 10,836,448 (GRCm39) missense probably benign 0.03
R1619:Tmem132a UTSW 19 10,839,062 (GRCm39) missense probably damaging 1.00
R1777:Tmem132a UTSW 19 10,835,870 (GRCm39) missense probably damaging 1.00
R1815:Tmem132a UTSW 19 10,838,931 (GRCm39) nonsense probably null
R1869:Tmem132a UTSW 19 10,836,052 (GRCm39) missense possibly damaging 0.48
R1888:Tmem132a UTSW 19 10,840,863 (GRCm39) missense probably damaging 1.00
R1888:Tmem132a UTSW 19 10,840,863 (GRCm39) missense probably damaging 1.00
R2133:Tmem132a UTSW 19 10,841,430 (GRCm39) missense probably benign 0.26
R2441:Tmem132a UTSW 19 10,837,501 (GRCm39) missense probably damaging 0.96
R2570:Tmem132a UTSW 19 10,837,106 (GRCm39) missense probably null 1.00
R3157:Tmem132a UTSW 19 10,836,901 (GRCm39) nonsense probably null
R3159:Tmem132a UTSW 19 10,836,901 (GRCm39) nonsense probably null
R4152:Tmem132a UTSW 19 10,836,427 (GRCm39) missense probably benign 0.04
R4281:Tmem132a UTSW 19 10,839,090 (GRCm39) missense possibly damaging 0.81
R4547:Tmem132a UTSW 19 10,837,564 (GRCm39) missense possibly damaging 0.83
R4793:Tmem132a UTSW 19 10,842,857 (GRCm39) missense probably damaging 1.00
R4947:Tmem132a UTSW 19 10,844,298 (GRCm39) missense possibly damaging 0.90
R4998:Tmem132a UTSW 19 10,836,305 (GRCm39) missense probably benign 0.02
R5226:Tmem132a UTSW 19 10,844,508 (GRCm39) missense possibly damaging 0.50
R5323:Tmem132a UTSW 19 10,841,371 (GRCm39) missense possibly damaging 0.81
R6659:Tmem132a UTSW 19 10,837,685 (GRCm39) missense probably damaging 0.99
R6814:Tmem132a UTSW 19 10,840,669 (GRCm39) missense probably damaging 1.00
R6872:Tmem132a UTSW 19 10,840,669 (GRCm39) missense probably damaging 1.00
R7205:Tmem132a UTSW 19 10,844,295 (GRCm39) missense probably damaging 1.00
R7383:Tmem132a UTSW 19 10,844,358 (GRCm39) missense probably benign 0.01
R7505:Tmem132a UTSW 19 10,836,037 (GRCm39) missense probably damaging 1.00
R7513:Tmem132a UTSW 19 10,837,492 (GRCm39) missense probably damaging 0.98
R7595:Tmem132a UTSW 19 10,835,569 (GRCm39) missense probably damaging 1.00
R8327:Tmem132a UTSW 19 10,836,311 (GRCm39) missense probably benign 0.45
R8442:Tmem132a UTSW 19 10,835,833 (GRCm39) missense probably damaging 1.00
R8550:Tmem132a UTSW 19 10,837,745 (GRCm39) missense probably benign
R8905:Tmem132a UTSW 19 10,842,647 (GRCm39) missense probably damaging 1.00
R9025:Tmem132a UTSW 19 10,837,525 (GRCm39) missense probably damaging 0.97
R9085:Tmem132a UTSW 19 10,843,835 (GRCm39) missense probably damaging 0.99
R9095:Tmem132a UTSW 19 10,844,412 (GRCm39) missense probably benign 0.32
R9563:Tmem132a UTSW 19 10,838,960 (GRCm39) missense probably benign 0.04
R9744:Tmem132a UTSW 19 10,840,678 (GRCm39) missense probably damaging 1.00
R9774:Tmem132a UTSW 19 10,842,904 (GRCm39) nonsense probably null
Z1088:Tmem132a UTSW 19 10,836,299 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTGCCCTAAAACCATGCATC -3'
(R):5'- CGACCCTACAGATGAGCATG -3'

Sequencing Primer
(F):5'- TGCATCATGGACTGAAATCCTC -3'
(R):5'- TTCCAGGTGGTCCCTCCTAGG -3'
Posted On 2021-11-19