Incidental Mutation 'R9033:Vmn2r74'
ID 687185
Institutional Source Beutler Lab
Gene Symbol Vmn2r74
Ensembl Gene ENSMUSG00000090774
Gene Name vomeronasal 2, receptor 74
Synonyms EG546980
MMRRC Submission 068862-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.105) question?
Stock # R9033 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 85601075-85610690 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 85606414 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Asparagine at position 311 (Y311N)
Ref Sequence ENSEMBL: ENSMUSP00000126917 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000166355]
AlphaFold E9PW21
Predicted Effect probably benign
Transcript: ENSMUST00000166355
AA Change: Y311N

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000126917
Gene: ENSMUSG00000090774
AA Change: Y311N

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 77 467 7.3e-28 PFAM
Pfam:NCD3G 510 562 4.7e-20 PFAM
Pfam:7tm_3 592 830 1.3e-52 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 94% (30/32)
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A730049H05Rik G A 6: 92,808,934 (GRCm39) G87D unknown Het
Actg1 T C 11: 120,237,826 (GRCm39) K238R probably benign Het
Arhgef10l G A 4: 140,321,463 (GRCm39) R115C probably damaging Het
Aspm T C 1: 139,405,865 (GRCm39) F1584S probably damaging Het
Atp2b4 C T 1: 133,634,725 (GRCm39) R1168H probably benign Het
Catsper1 G A 19: 5,387,864 (GRCm39) probably null Het
Chgb A C 2: 132,634,914 (GRCm39) K285N probably damaging Het
Csnk1g1 A G 9: 65,915,070 (GRCm39) Y243C probably damaging Het
Dpysl5 G T 5: 30,948,941 (GRCm39) D399Y probably damaging Het
Enam A G 5: 88,646,475 (GRCm39) R259G probably benign Het
Foxf2 C T 13: 31,810,085 (GRCm39) P8L unknown Het
Fpr1 C T 17: 18,097,691 (GRCm39) W99* probably null Het
Itprid2 A G 2: 79,465,938 (GRCm39) S19G probably damaging Het
Kansl1 A G 11: 104,248,356 (GRCm39) S533P probably benign Het
Klhl25 T A 7: 75,516,681 (GRCm39) M529K probably damaging Het
Mtss2 G A 8: 111,465,651 (GRCm39) R697H probably damaging Het
Nup210l G A 3: 90,105,396 (GRCm39) V1515I probably benign Het
Pcdh15 T C 10: 74,302,138 (GRCm39) F926L probably damaging Het
Pfkfb2 T A 1: 130,626,475 (GRCm39) K433* probably null Het
Pirb G C 7: 3,720,584 (GRCm39) Q305E probably benign Het
Pld5 T C 1: 175,967,585 (GRCm39) D90G probably damaging Het
Rergl T C 6: 139,471,900 (GRCm39) Y83C probably damaging Het
Rorb G A 19: 18,965,422 (GRCm39) probably benign Het
Rsf1 ATGGCG ATGGCGACGGTGGCG 7: 97,229,111 (GRCm39) probably benign Het
Shank2 A G 7: 143,965,236 (GRCm39) Q948R probably damaging Het
Slc4a5 C T 6: 83,237,457 (GRCm39) R147* probably null Het
Tdpoz6 T C 3: 93,600,168 (GRCm39) Y67C probably damaging Het
Tdrd7 G T 4: 46,007,468 (GRCm39) D507Y probably damaging Het
Tspan31 C A 10: 126,904,349 (GRCm39) probably benign Het
Usp40 T C 1: 87,923,499 (GRCm39) probably benign Het
Zbtb11 T A 16: 55,818,492 (GRCm39) S639T probably benign Het
Zfp52 T C 17: 21,780,655 (GRCm39) F168L possibly damaging Het
Other mutations in Vmn2r74
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00899:Vmn2r74 APN 7 85,606,338 (GRCm39) missense probably benign 0.03
IGL00904:Vmn2r74 APN 7 85,606,788 (GRCm39) missense probably benign 0.05
IGL01285:Vmn2r74 APN 7 85,606,692 (GRCm39) missense possibly damaging 0.54
IGL01300:Vmn2r74 APN 7 85,606,414 (GRCm39) missense probably benign 0.00
IGL01410:Vmn2r74 APN 7 85,610,500 (GRCm39) missense possibly damaging 0.83
IGL01827:Vmn2r74 APN 7 85,606,800 (GRCm39) missense probably benign 0.00
IGL02094:Vmn2r74 APN 7 85,610,669 (GRCm39) missense probably benign 0.01
IGL02252:Vmn2r74 APN 7 85,606,531 (GRCm39) missense probably benign 0.41
IGL02349:Vmn2r74 APN 7 85,601,724 (GRCm39) missense probably damaging 0.99
IGL02438:Vmn2r74 APN 7 85,601,824 (GRCm39) missense probably damaging 0.98
IGL02554:Vmn2r74 APN 7 85,606,581 (GRCm39) missense probably benign 0.00
IGL03036:Vmn2r74 APN 7 85,601,900 (GRCm39) nonsense probably null
IGL03370:Vmn2r74 APN 7 85,607,265 (GRCm39) missense probably benign
R0115:Vmn2r74 UTSW 7 85,606,564 (GRCm39) missense probably benign 0.00
R0333:Vmn2r74 UTSW 7 85,601,491 (GRCm39) missense probably benign 0.06
R0415:Vmn2r74 UTSW 7 85,610,618 (GRCm39) missense probably damaging 1.00
R0571:Vmn2r74 UTSW 7 85,601,629 (GRCm39) missense probably damaging 1.00
R0626:Vmn2r74 UTSW 7 85,610,517 (GRCm39) nonsense probably null
R0659:Vmn2r74 UTSW 7 85,605,122 (GRCm39) splice site probably benign
R1202:Vmn2r74 UTSW 7 85,610,545 (GRCm39) missense possibly damaging 0.83
R1473:Vmn2r74 UTSW 7 85,610,618 (GRCm39) missense probably damaging 1.00
R1908:Vmn2r74 UTSW 7 85,601,650 (GRCm39) missense probably benign
R2079:Vmn2r74 UTSW 7 85,606,383 (GRCm39) missense probably benign 0.00
R2368:Vmn2r74 UTSW 7 85,610,522 (GRCm39) missense probably benign 0.39
R3782:Vmn2r74 UTSW 7 85,605,322 (GRCm39) missense probably benign 0.01
R3824:Vmn2r74 UTSW 7 85,607,466 (GRCm39) missense probably damaging 1.00
R3977:Vmn2r74 UTSW 7 85,607,345 (GRCm39) missense probably benign 0.01
R4182:Vmn2r74 UTSW 7 85,606,395 (GRCm39) missense possibly damaging 0.87
R4289:Vmn2r74 UTSW 7 85,606,562 (GRCm39) missense probably benign
R4294:Vmn2r74 UTSW 7 85,606,624 (GRCm39) missense probably benign 0.14
R4645:Vmn2r74 UTSW 7 85,606,317 (GRCm39) missense probably benign
R4646:Vmn2r74 UTSW 7 85,606,782 (GRCm39) missense probably benign 0.42
R4655:Vmn2r74 UTSW 7 85,610,555 (GRCm39) missense probably benign
R4901:Vmn2r74 UTSW 7 85,605,199 (GRCm39) nonsense probably null
R5532:Vmn2r74 UTSW 7 85,601,197 (GRCm39) missense probably benign 0.32
R5642:Vmn2r74 UTSW 7 85,606,588 (GRCm39) missense probably benign 0.00
R5913:Vmn2r74 UTSW 7 85,601,098 (GRCm39) missense probably damaging 0.98
R6035:Vmn2r74 UTSW 7 85,601,098 (GRCm39) missense probably damaging 0.98
R6035:Vmn2r74 UTSW 7 85,601,098 (GRCm39) missense probably damaging 0.98
R6039:Vmn2r74 UTSW 7 85,607,526 (GRCm39) critical splice acceptor site probably null
R6039:Vmn2r74 UTSW 7 85,607,526 (GRCm39) critical splice acceptor site probably null
R6170:Vmn2r74 UTSW 7 85,606,348 (GRCm39) missense probably benign 0.03
R6232:Vmn2r74 UTSW 7 85,607,498 (GRCm39) missense possibly damaging 0.82
R6238:Vmn2r74 UTSW 7 85,601,280 (GRCm39) missense probably damaging 1.00
R6255:Vmn2r74 UTSW 7 85,601,659 (GRCm39) missense possibly damaging 0.90
R6468:Vmn2r74 UTSW 7 85,610,599 (GRCm39) missense probably benign 0.34
R6732:Vmn2r74 UTSW 7 85,606,758 (GRCm39) missense probably damaging 1.00
R6816:Vmn2r74 UTSW 7 85,610,621 (GRCm39) nonsense probably null
R6836:Vmn2r74 UTSW 7 85,606,630 (GRCm39) missense probably benign 0.00
R6995:Vmn2r74 UTSW 7 85,606,860 (GRCm39) critical splice acceptor site probably null
R6995:Vmn2r74 UTSW 7 85,601,943 (GRCm39) missense probably benign 0.01
R7186:Vmn2r74 UTSW 7 85,601,150 (GRCm39) nonsense probably null
R7246:Vmn2r74 UTSW 7 85,605,173 (GRCm39) missense probably benign
R7374:Vmn2r74 UTSW 7 85,606,630 (GRCm39) missense probably benign 0.02
R7505:Vmn2r74 UTSW 7 85,606,279 (GRCm39) nonsense probably null
R7525:Vmn2r74 UTSW 7 85,610,510 (GRCm39) missense probably benign
R7569:Vmn2r74 UTSW 7 85,601,544 (GRCm39) missense probably damaging 0.99
R7644:Vmn2r74 UTSW 7 85,606,746 (GRCm39) missense probably benign 0.11
R7956:Vmn2r74 UTSW 7 85,605,166 (GRCm39) missense probably benign 0.09
R8119:Vmn2r74 UTSW 7 85,610,690 (GRCm39) start codon destroyed probably null 0.08
R8131:Vmn2r74 UTSW 7 85,601,943 (GRCm39) missense probably benign 0.01
R8147:Vmn2r74 UTSW 7 85,605,227 (GRCm39) nonsense probably null
R8181:Vmn2r74 UTSW 7 85,605,324 (GRCm39) missense probably damaging 1.00
R8184:Vmn2r74 UTSW 7 85,601,454 (GRCm39) missense probably benign 0.00
R8375:Vmn2r74 UTSW 7 85,601,914 (GRCm39) missense possibly damaging 0.64
R8948:Vmn2r74 UTSW 7 85,606,569 (GRCm39) missense probably damaging 1.00
R8950:Vmn2r74 UTSW 7 85,606,569 (GRCm39) missense probably damaging 1.00
R9342:Vmn2r74 UTSW 7 85,606,624 (GRCm39) missense probably benign 0.14
R9578:Vmn2r74 UTSW 7 85,606,101 (GRCm39) missense probably benign 0.01
R9607:Vmn2r74 UTSW 7 85,610,619 (GRCm39) missense probably benign 0.02
R9776:Vmn2r74 UTSW 7 85,605,212 (GRCm39) missense possibly damaging 0.70
Z1176:Vmn2r74 UTSW 7 85,604,835 (GRCm39) missense probably damaging 1.00
Z31818:Vmn2r74 UTSW 7 85,604,729 (GRCm39) splice site probably null
Predicted Primers PCR Primer
(F):5'- CTAATCCAAGTGGTGTCATGAATAACC -3'
(R):5'- TCCTGGCTGTTACAGAGTTAC -3'

Sequencing Primer
(F):5'- GGTGGAACAATTCTTGAGCTTCTTAC -3'
(R):5'- CCTGGCTGTTACAGAGTTACATATG -3'
Posted On 2021-11-19