Mutagenetix > Incidental Mutation

Incidental Mutation 'R9036:Dync1h1'

687419

Institutional Source

Beutler Lab

Gene Symbol

Dync1h1

Ensembl Gene

ENSMUSG00000018707

Gene Name

dynein cytoplasmic 1 heavy chain 1

Synonyms

MAP1C, Loa, Dnec1, Dnchc1, dynein heavy chain, retrograde transport, 9930018I23Rik, Swl

MMRRC Submission

068865-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R9036 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

110567886-110633379 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 110606186 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 2419 (T2419A)

Ref Sequence

ENSEMBL: ENSMUSP00000018851 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000018851]

AlphaFold

no structure available at present

PDB Structure

Microtubule binding domain from mouse cytoplasmic dynein as a fusion with seryl-tRNA synthetase [X-RAY DIFFRACTION]
High affinity dynein microtubule binding domain - tubulin complex [ELECTRON MICROSCOPY]
Low affinity dynein microtubule binding domain - tubulin complex [ELECTRON MICROSCOPY]
Structure of the entire stalk region of the dynein motor domain [X-RAY DIFFRACTION]

Predicted Effect

probably benign
Transcript: ENSMUST00000018851
AA Change: T2419A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000018851
Gene: ENSMUSG00000018707
AA Change: T2419A

Domain	Start	End	E-Value	Type
low complexity region	46	61	N/A	INTRINSIC
low complexity region	83	95	N/A	INTRINSIC
Pfam:DHC_N1	237	830	1.9e-145	PFAM
coiled coil region	1171	1198	N/A	INTRINSIC
Pfam:DHC_N2	1317	1721	3.3e-116	PFAM
AAA	1899	2043	5.39e-2	SMART
low complexity region	2102	2116	N/A	INTRINSIC
AAA	2214	2365	2.13e0	SMART
low complexity region	2394	2405	N/A	INTRINSIC
AAA	2585	2735	8.6e-7	SMART
Blast:AAA	2777	2811	2e-13	BLAST
AAA	2927	3093	4.79e-5	SMART
Pfam:MT	3197	3534	1.1e-44	PFAM
Pfam:AAA_9	3554	3778	8.5e-75	PFAM
Pfam:Dynein_heavy	3919	4642	4.3e-163	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.6%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains.This gene encodes a member of the cytoplasmic dynein heavy chain family. [provided by RefSeq, Oct 2008]
PHENOTYPE: Mice homozygous for either the Cra1 or Loa ENU mutation exhibit neonatal lethality with reduced anterior horn cell number, abnormal motor neuron innervation, neuronal inclusions, and abnormal axonal transport. Heterozygotes display motor neuron degeneration and muscle spasms. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 93 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acsl6	G	T	11: 54,227,840 (GRCm39)		probably null	Het
Anapc5	A	G	5: 122,957,716 (GRCm39)	L69P	possibly damaging	Het
Aoc1l3	CCTAAATTTCCTATCCCGATCAGCAAGGGTGGCCCTCGAGTGCCCCAGCCCCATGCTAAATTTCC	CCTAAATTTCC	6: 48,965,074 (GRCm39)		probably benign	Het
Arfgef1	A	T	1: 10,259,055 (GRCm39)	S681T	probably benign	Het
Arhgef19	A	G	4: 140,976,549 (GRCm39)	D437G	probably damaging	Het
Arhgef25	A	G	10: 127,019,089 (GRCm39)	V576A	probably benign	Het
Arl5b	T	C	2: 15,073,012 (GRCm39)		probably null	Het
Atg10	T	A	13: 91,189,071 (GRCm39)	T80S	probably benign	Het
BC034090	A	G	1: 155,117,419 (GRCm39)	V233A	possibly damaging	Het
Bicdl2	C	T	17: 23,887,158 (GRCm39)	R482C	probably damaging	Het
Ccdc63	G	A	5: 122,247,346 (GRCm39)	P500S	probably benign	Het
Ccn2	A	T	10: 24,472,647 (GRCm39)	T186S	probably benign	Het
Ccng1	A	T	11: 40,643,078 (GRCm39)	I123K	possibly damaging	Het
Ccp110	C	T	7: 118,324,680 (GRCm39)	S734F	probably damaging	Het
Cds2	T	C	2: 132,139,614 (GRCm39)		probably null	Het
Cenpw	G	A	10: 30,074,523 (GRCm39)	T58I	probably benign	Het
Cfap61	T	A	2: 145,850,839 (GRCm39)	L326I	probably benign	Het
Cgn	T	A	3: 94,674,551 (GRCm39)	Q862L	possibly damaging	Het
Cntrl	T	A	2: 35,016,071 (GRCm39)	D362E	probably damaging	Het
Col22a1	C	T	15: 71,762,431 (GRCm39)	G76E	probably damaging	Het
Cplane1	C	T	15: 8,252,622 (GRCm39)	T1948I	possibly damaging	Het
Crip2	A	G	12: 113,108,030 (GRCm39)	T140A	probably benign	Het
Csde1	T	C	3: 102,950,976 (GRCm39)	V229A	probably damaging	Het
Cyp2d34	A	G	15: 82,500,523 (GRCm39)	F439L	probably damaging	Het
Dync2h1	A	T	9: 7,051,495 (GRCm39)	F3147I	probably damaging	Het
Dynlt1f	T	C	17: 6,916,707 (GRCm39)	T101A	probably benign	Het
Efcab3	A	G	11: 104,927,601 (GRCm39)	H4790R	probably benign	Het
Efcab8	G	A	2: 153,622,888 (GRCm39)	S19N		Het
Eno2	A	T	6: 124,740,091 (GRCm39)	I315K	possibly damaging	Het
Erich3	A	G	3: 154,468,886 (GRCm39)	T1113A	unknown	Het
Fam217a	A	T	13: 35,095,007 (GRCm39)	Y251N	possibly damaging	Het
Fcrlb	A	T	1: 170,734,938 (GRCm39)	H396Q	probably benign	Het
Fcsk	A	G	8: 111,614,064 (GRCm39)	V693A	probably benign	Het
Fgd5	A	T	6: 92,046,447 (GRCm39)	K1397*	probably null	Het
Frem1	C	A	4: 82,831,785 (GRCm39)	L2010F	probably benign	Het
Fzd8	A	G	18: 9,214,661 (GRCm39)	Y581C	probably damaging	Het
Gcc2	T	C	10: 58,106,411 (GRCm39)	V549A	possibly damaging	Het
Gcnt4	G	A	13: 97,083,042 (GRCm39)	V113I	probably benign	Het
Gldn	A	G	9: 54,245,747 (GRCm39)	I433V	probably benign	Het
Gm3336	A	G	8: 71,173,069 (GRCm39)	D27G	unknown	Het
Gm6133	T	A	18: 78,393,146 (GRCm39)	Y47N	probably damaging	Het
Gm8257	A	T	14: 44,893,877 (GRCm39)	N62K	probably benign	Het
Gpr18	T	G	14: 122,149,667 (GRCm39)	R119S	probably damaging	Het
Grm5	A	T	7: 87,685,397 (GRCm39)	I505F	possibly damaging	Het
Hdgfl1	T	C	13: 26,953,428 (GRCm39)	E215G	probably benign	Het
Heg1	T	A	16: 33,527,339 (GRCm39)	C100S	probably benign	Het
Isg20l2	T	C	3: 87,839,302 (GRCm39)	V171A	probably benign	Het
Lrrc49	A	T	9: 60,495,150 (GRCm39)	C694S	probably benign	Het
Map7d1	A	T	4: 126,133,911 (GRCm39)	I217N	probably damaging	Het
Mbnl2	A	T	14: 120,562,712 (GRCm39)	Q21L	probably benign	Het
Mfsd10	A	T	5: 34,792,751 (GRCm39)	F220Y	probably benign	Het
Mmp1b	A	C	9: 7,387,909 (GRCm39)	N28K	probably null	Het
Muc16	A	T	9: 18,555,975 (GRCm39)	N3439K	unknown	Het
Myef2l	C	A	3: 10,157,341 (GRCm39)	Q495K	unknown	Het
Myo9a	A	T	9: 59,687,584 (GRCm39)	K230*	probably null	Het
Mysm1	T	C	4: 94,835,294 (GRCm39)	T790A	probably benign	Het
Nell2	C	T	15: 95,194,117 (GRCm39)	C532Y	probably damaging	Het
Nmnat1	T	A	4: 149,553,482 (GRCm39)	N210I	probably damaging	Het
Or14j7	T	G	17: 38,235,168 (GRCm39)	V237G	probably benign	Het
Or2aj6	A	T	16: 19,443,295 (GRCm39)	L185*	probably null	Het
Or4k41	T	C	2: 111,280,343 (GRCm39)	I286T	probably damaging	Het
Or7g16	G	A	9: 18,727,569 (GRCm39)	T7I	probably damaging	Het
Pabpc6	T	C	17: 9,888,281 (GRCm39)	D90G	probably damaging	Het
Pacs2	A	T	12: 113,026,104 (GRCm39)	I554F	possibly damaging	Het
Padi3	C	A	4: 140,523,004 (GRCm39)	V323L	probably benign	Het
Piezo1	G	A	8: 123,215,090 (GRCm39)	P1484L		Het
Pogk	A	G	1: 166,227,254 (GRCm39)	I299T	possibly damaging	Het
Ptprk	A	G	10: 28,461,928 (GRCm39)	I1164V	probably benign	Het
Raph1	A	G	1: 60,542,124 (GRCm39)	M278T	unknown	Het
Rasa3	T	A	8: 13,645,851 (GRCm39)	Q163L	probably benign	Het
Rbm6	T	A	9: 107,660,911 (GRCm39)	K884I	probably damaging	Het
Rtl1	A	G	12: 109,559,691 (GRCm39)	V716A	probably benign	Het
Sag	A	G	1: 87,749,054 (GRCm39)	K151R	probably damaging	Het
Scara5	G	A	14: 66,000,197 (GRCm39)	V456M	probably benign	Het
Selplg	GTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCT	GTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCT	5: 113,957,756 (GRCm39)		probably benign	Het
Slc4a1	A	T	11: 102,243,279 (GRCm39)	V784D	probably damaging	Het
Sstr1	T	C	12: 58,259,569 (GRCm39)	I64T	possibly damaging	Het
Steap1	A	G	5: 5,790,708 (GRCm39)	I80T	probably benign	Het
Tbc1d24	T	A	17: 24,427,491 (GRCm39)	D157V	probably benign	Het
Thsd7a	T	C	6: 12,418,249 (GRCm39)	E660G		Het
Trappc3l	A	G	10: 33,932,786 (GRCm39)		probably benign	Het
Tsc22d2	T	C	3: 58,323,497 (GRCm39)	S130P	probably benign	Het
Tti2	T	A	8: 31,645,814 (GRCm39)	I376N	probably damaging	Het
Ttll2	C	A	17: 7,619,054 (GRCm39)	W291L	probably benign	Het
Ttll3	G	A	6: 113,376,657 (GRCm39)	V345I	possibly damaging	Het
Ttn	A	G	2: 76,565,046 (GRCm39)	Y28394H	probably damaging	Het
Usp45	A	G	4: 21,832,201 (GRCm39)	Y684C	probably damaging	Het
Vdr	A	G	15: 97,765,089 (GRCm39)	S217P	probably benign	Het
Xpot	A	G	10: 121,447,580 (GRCm39)	L105P	probably damaging	Het
Zan	A	G	5: 137,464,206 (GRCm39)	I533T	probably damaging	Het
Zbtb8a	T	C	4: 129,248,059 (GRCm39)	E404G	probably benign	Het
Zfp106	T	A	2: 120,369,906 (GRCm39)	I62F	probably damaging	Het
Zfp451	A	T	1: 33,815,562 (GRCm39)	F796Y	probably damaging	Het

Other mutations in Dync1h1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01291:Dync1h1	APN	12	110,615,538 (GRCm39)	missense	probably benign	0.31
IGL01299:Dync1h1	APN	12	110,580,541 (GRCm39)	missense	probably benign	0.04
IGL01321:Dync1h1	APN	12	110,592,041 (GRCm39)	splice site	probably benign
IGL01324:Dync1h1	APN	12	110,593,299 (GRCm39)	missense	probably damaging	0.99
IGL01327:Dync1h1	APN	12	110,583,126 (GRCm39)	splice site	probably benign
IGL01371:Dync1h1	APN	12	110,605,285 (GRCm39)	missense	probably benign	0.05
IGL01598:Dync1h1	APN	12	110,624,562 (GRCm39)	missense	probably damaging	0.99
IGL01782:Dync1h1	APN	12	110,581,374 (GRCm39)	missense	probably damaging	1.00
IGL01791:Dync1h1	APN	12	110,625,364 (GRCm39)	missense	probably damaging	0.99
IGL01797:Dync1h1	APN	12	110,618,630 (GRCm39)	critical splice donor site	probably null
IGL02040:Dync1h1	APN	12	110,603,558 (GRCm39)	missense	probably benign	0.21
IGL02096:Dync1h1	APN	12	110,599,254 (GRCm39)	missense	possibly damaging	0.68
IGL02164:Dync1h1	APN	12	110,628,993 (GRCm39)	missense	probably damaging	1.00
IGL02216:Dync1h1	APN	12	110,629,436 (GRCm39)	missense	probably damaging	0.98
IGL02298:Dync1h1	APN	12	110,607,322 (GRCm39)	missense	probably damaging	1.00
IGL02422:Dync1h1	APN	12	110,606,644 (GRCm39)	missense	possibly damaging	0.68
IGL02610:Dync1h1	APN	12	110,625,666 (GRCm39)	nonsense	probably null
IGL02643:Dync1h1	APN	12	110,625,706 (GRCm39)	unclassified	probably benign
IGL03076:Dync1h1	APN	12	110,624,327 (GRCm39)	missense	probably damaging	1.00
IGL03292:Dync1h1	APN	12	110,632,989 (GRCm39)	splice site	probably null
IGL03293:Dync1h1	APN	12	110,595,168 (GRCm39)	missense	probably benign	0.12
IGL03299:Dync1h1	APN	12	110,585,644 (GRCm39)	missense	possibly damaging	0.49
chinashop	UTSW	12	110,624,568 (GRCm39)	missense	probably damaging	1.00
Gesund	UTSW	12	110,582,838 (GRCm39)	missense	probably benign	0.35
gymnast	UTSW	12	110,584,802 (GRCm39)	missense	probably damaging	1.00
Lightfoot	UTSW	12	110,584,354 (GRCm39)	missense	probably damaging	1.00
Lissom	UTSW	12	110,599,254 (GRCm39)	missense	possibly damaging	0.68
Strong	UTSW	12	110,624,560 (GRCm39)	missense	probably damaging	1.00
waters	UTSW	12	110,596,113 (GRCm39)	missense	probably damaging	1.00
ANU05:Dync1h1	UTSW	12	110,615,538 (GRCm39)	missense	probably benign	0.31
H8562:Dync1h1	UTSW	12	110,583,241 (GRCm39)	missense	probably benign	0.01
R0082:Dync1h1	UTSW	12	110,602,880 (GRCm39)	missense	probably benign
R0110:Dync1h1	UTSW	12	110,606,378 (GRCm39)	missense	probably benign	0.42
R0130:Dync1h1	UTSW	12	110,585,108 (GRCm39)	missense	probably benign	0.16
R0233:Dync1h1	UTSW	12	110,607,414 (GRCm39)	missense	probably benign	0.45
R0233:Dync1h1	UTSW	12	110,607,414 (GRCm39)	missense	probably benign	0.45
R0242:Dync1h1	UTSW	12	110,616,285 (GRCm39)	missense	possibly damaging	0.67
R0242:Dync1h1	UTSW	12	110,616,285 (GRCm39)	missense	possibly damaging	0.67
R0408:Dync1h1	UTSW	12	110,598,126 (GRCm39)	missense	probably benign
R0450:Dync1h1	UTSW	12	110,606,378 (GRCm39)	missense	probably benign	0.42
R0611:Dync1h1	UTSW	12	110,599,222 (GRCm39)	missense	probably damaging	0.97
R0612:Dync1h1	UTSW	12	110,582,930 (GRCm39)	missense	probably damaging	1.00
R0624:Dync1h1	UTSW	12	110,618,181 (GRCm39)	unclassified	probably benign
R0685:Dync1h1	UTSW	12	110,623,626 (GRCm39)	missense	probably damaging	1.00
R0747:Dync1h1	UTSW	12	110,595,718 (GRCm39)	missense	probably damaging	0.99
R0747:Dync1h1	UTSW	12	110,578,845 (GRCm39)	missense	probably benign
R0843:Dync1h1	UTSW	12	110,631,647 (GRCm39)	missense	possibly damaging	0.81
R0970:Dync1h1	UTSW	12	110,602,943 (GRCm39)	missense	probably benign	0.04
R1161:Dync1h1	UTSW	12	110,602,943 (GRCm39)	missense	probably benign	0.04
R1211:Dync1h1	UTSW	12	110,602,943 (GRCm39)	missense	probably benign	0.04
R1214:Dync1h1	UTSW	12	110,602,943 (GRCm39)	missense	probably benign	0.04
R1215:Dync1h1	UTSW	12	110,602,943 (GRCm39)	missense	probably benign	0.04
R1227:Dync1h1	UTSW	12	110,602,943 (GRCm39)	missense	probably benign	0.04
R1230:Dync1h1	UTSW	12	110,602,943 (GRCm39)	missense	probably benign	0.04
R1232:Dync1h1	UTSW	12	110,602,943 (GRCm39)	missense	probably benign	0.04
R1237:Dync1h1	UTSW	12	110,632,393 (GRCm39)	missense	probably benign	0.00
R1274:Dync1h1	UTSW	12	110,602,943 (GRCm39)	missense	probably benign	0.04
R1275:Dync1h1	UTSW	12	110,602,943 (GRCm39)	missense	probably benign	0.04
R1289:Dync1h1	UTSW	12	110,602,943 (GRCm39)	missense	probably benign	0.04
R1290:Dync1h1	UTSW	12	110,602,943 (GRCm39)	missense	probably benign	0.04
R1331:Dync1h1	UTSW	12	110,615,698 (GRCm39)	missense	probably damaging	0.98
R1340:Dync1h1	UTSW	12	110,602,943 (GRCm39)	missense	probably benign	0.04
R1383:Dync1h1	UTSW	12	110,602,943 (GRCm39)	missense	probably benign	0.04
R1394:Dync1h1	UTSW	12	110,602,943 (GRCm39)	missense	probably benign	0.04
R1396:Dync1h1	UTSW	12	110,602,943 (GRCm39)	missense	probably benign	0.04
R1397:Dync1h1	UTSW	12	110,602,943 (GRCm39)	missense	probably benign	0.04
R1413:Dync1h1	UTSW	12	110,602,943 (GRCm39)	missense	probably benign	0.04
R1432:Dync1h1	UTSW	12	110,602,943 (GRCm39)	missense	probably benign	0.04
R1500:Dync1h1	UTSW	12	110,602,943 (GRCm39)	missense	probably benign	0.04
R1661:Dync1h1	UTSW	12	110,622,791 (GRCm39)	missense	probably damaging	1.00
R1678:Dync1h1	UTSW	12	110,632,096 (GRCm39)	critical splice acceptor site	probably null
R1698:Dync1h1	UTSW	12	110,593,426 (GRCm39)	missense	possibly damaging	0.88
R1767:Dync1h1	UTSW	12	110,602,943 (GRCm39)	missense	probably benign	0.04
R1776:Dync1h1	UTSW	12	110,599,362 (GRCm39)	splice site	probably benign
R1812:Dync1h1	UTSW	12	110,629,334 (GRCm39)	missense	possibly damaging	0.46
R1831:Dync1h1	UTSW	12	110,580,493 (GRCm39)	missense	probably damaging	1.00
R1832:Dync1h1	UTSW	12	110,580,493 (GRCm39)	missense	probably damaging	1.00
R1856:Dync1h1	UTSW	12	110,602,943 (GRCm39)	missense	probably benign	0.04
R1857:Dync1h1	UTSW	12	110,629,059 (GRCm39)	missense	probably damaging	0.96
R1879:Dync1h1	UTSW	12	110,591,070 (GRCm39)	missense	probably benign	0.04
R1892:Dync1h1	UTSW	12	110,612,738 (GRCm39)	missense	probably damaging	1.00
R1909:Dync1h1	UTSW	12	110,629,063 (GRCm39)	missense	probably damaging	1.00
R1962:Dync1h1	UTSW	12	110,602,943 (GRCm39)	missense	probably benign	0.04
R1974:Dync1h1	UTSW	12	110,592,166 (GRCm39)	missense	possibly damaging	0.80
R1999:Dync1h1	UTSW	12	110,632,857 (GRCm39)	critical splice donor site	probably null
R2073:Dync1h1	UTSW	12	110,581,026 (GRCm39)	missense	probably damaging	1.00
R2091:Dync1h1	UTSW	12	110,616,022 (GRCm39)	missense	probably benign	0.07
R2113:Dync1h1	UTSW	12	110,596,420 (GRCm39)	missense	probably damaging	1.00
R2128:Dync1h1	UTSW	12	110,607,316 (GRCm39)	missense	probably damaging	1.00
R2134:Dync1h1	UTSW	12	110,623,065 (GRCm39)	missense	possibly damaging	0.68
R2496:Dync1h1	UTSW	12	110,607,654 (GRCm39)	missense	possibly damaging	0.65
R2680:Dync1h1	UTSW	12	110,609,681 (GRCm39)	missense	probably damaging	1.00
R2890:Dync1h1	UTSW	12	110,583,325 (GRCm39)	missense	probably damaging	1.00
R2964:Dync1h1	UTSW	12	110,607,460 (GRCm39)	critical splice donor site	probably null
R3705:Dync1h1	UTSW	12	110,607,020 (GRCm39)	missense	possibly damaging	0.80
R3708:Dync1h1	UTSW	12	110,609,563 (GRCm39)	missense	probably damaging	0.96
R3735:Dync1h1	UTSW	12	110,598,109 (GRCm39)	missense	probably benign
R3736:Dync1h1	UTSW	12	110,598,109 (GRCm39)	missense	probably benign
R3882:Dync1h1	UTSW	12	110,595,492 (GRCm39)	missense	probably benign	0.41
R3971:Dync1h1	UTSW	12	110,632,399 (GRCm39)	missense	probably benign	0.00
R4017:Dync1h1	UTSW	12	110,609,624 (GRCm39)	missense	probably damaging	1.00
R4032:Dync1h1	UTSW	12	110,584,483 (GRCm39)	nonsense	probably null
R4355:Dync1h1	UTSW	12	110,599,333 (GRCm39)	missense	possibly damaging	0.55
R4514:Dync1h1	UTSW	12	110,623,573 (GRCm39)	missense	possibly damaging	0.76
R4586:Dync1h1	UTSW	12	110,615,917 (GRCm39)	missense	probably benign	0.30
R4619:Dync1h1	UTSW	12	110,605,278 (GRCm39)	missense	probably benign	0.09
R4659:Dync1h1	UTSW	12	110,595,201 (GRCm39)	missense	possibly damaging	0.50
R4676:Dync1h1	UTSW	12	110,628,975 (GRCm39)	missense	probably damaging	0.99
R4688:Dync1h1	UTSW	12	110,621,962 (GRCm39)	missense	probably damaging	0.99
R4732:Dync1h1	UTSW	12	110,615,941 (GRCm39)	nonsense	probably null
R4733:Dync1h1	UTSW	12	110,615,941 (GRCm39)	nonsense	probably null
R4780:Dync1h1	UTSW	12	110,627,630 (GRCm39)	missense	probably damaging	1.00
R4846:Dync1h1	UTSW	12	110,624,560 (GRCm39)	missense	probably damaging	1.00
R4861:Dync1h1	UTSW	12	110,624,560 (GRCm39)	missense	probably damaging	1.00
R4861:Dync1h1	UTSW	12	110,624,560 (GRCm39)	missense	probably damaging	1.00
R4865:Dync1h1	UTSW	12	110,606,235 (GRCm39)	missense	possibly damaging	0.84
R4872:Dync1h1	UTSW	12	110,624,560 (GRCm39)	missense	probably damaging	1.00
R4873:Dync1h1	UTSW	12	110,624,560 (GRCm39)	missense	probably damaging	1.00
R4874:Dync1h1	UTSW	12	110,624,560 (GRCm39)	missense	probably damaging	1.00
R4875:Dync1h1	UTSW	12	110,624,560 (GRCm39)	missense	probably damaging	1.00
R4927:Dync1h1	UTSW	12	110,629,289 (GRCm39)	missense	possibly damaging	0.82
R4949:Dync1h1	UTSW	12	110,624,560 (GRCm39)	missense	probably damaging	1.00
R4954:Dync1h1	UTSW	12	110,624,560 (GRCm39)	missense	probably damaging	1.00
R4956:Dync1h1	UTSW	12	110,624,560 (GRCm39)	missense	probably damaging	1.00
R4957:Dync1h1	UTSW	12	110,624,560 (GRCm39)	missense	probably damaging	1.00
R4958:Dync1h1	UTSW	12	110,624,560 (GRCm39)	missense	probably damaging	1.00
R4984:Dync1h1	UTSW	12	110,624,560 (GRCm39)	missense	probably damaging	1.00
R4985:Dync1h1	UTSW	12	110,624,560 (GRCm39)	missense	probably damaging	1.00
R4988:Dync1h1	UTSW	12	110,624,560 (GRCm39)	missense	probably damaging	1.00
R5029:Dync1h1	UTSW	12	110,584,444 (GRCm39)	missense	possibly damaging	0.46
R5032:Dync1h1	UTSW	12	110,593,326 (GRCm39)	nonsense	probably null
R5036:Dync1h1	UTSW	12	110,596,969 (GRCm39)	missense	probably damaging	1.00
R5037:Dync1h1	UTSW	12	110,607,341 (GRCm39)	missense	probably benign	0.09
R5105:Dync1h1	UTSW	12	110,584,366 (GRCm39)	missense	probably damaging	0.99
R5122:Dync1h1	UTSW	12	110,596,114 (GRCm39)	missense	probably damaging	1.00
R5156:Dync1h1	UTSW	12	110,595,264 (GRCm39)	missense	probably benign	0.00
R5290:Dync1h1	UTSW	12	110,581,502 (GRCm39)	missense	probably benign	0.03
R5453:Dync1h1	UTSW	12	110,599,099 (GRCm39)	missense	probably benign	0.12
R5540:Dync1h1	UTSW	12	110,627,384 (GRCm39)	missense	probably benign	0.00
R5613:Dync1h1	UTSW	12	110,599,254 (GRCm39)	missense	possibly damaging	0.68
R5626:Dync1h1	UTSW	12	110,607,575 (GRCm39)	missense	probably benign	0.01
R5652:Dync1h1	UTSW	12	110,632,422 (GRCm39)	missense	possibly damaging	0.70
R5655:Dync1h1	UTSW	12	110,595,496 (GRCm39)	missense	probably benign	0.03
R5686:Dync1h1	UTSW	12	110,582,838 (GRCm39)	missense	probably benign	0.35
R5772:Dync1h1	UTSW	12	110,612,707 (GRCm39)	nonsense	probably null
R5806:Dync1h1	UTSW	12	110,618,087 (GRCm39)	missense	probably damaging	1.00
R5891:Dync1h1	UTSW	12	110,580,654 (GRCm39)	critical splice donor site	probably null
R5921:Dync1h1	UTSW	12	110,584,802 (GRCm39)	missense	probably damaging	1.00
R5965:Dync1h1	UTSW	12	110,599,212 (GRCm39)	missense	probably benign
R6113:Dync1h1	UTSW	12	110,586,848 (GRCm39)	missense	probably benign
R6119:Dync1h1	UTSW	12	110,594,440 (GRCm39)	missense	possibly damaging	0.82
R6154:Dync1h1	UTSW	12	110,584,427 (GRCm39)	missense	probably damaging	1.00
R6339:Dync1h1	UTSW	12	110,612,639 (GRCm39)	missense	probably damaging	0.97
R6522:Dync1h1	UTSW	12	110,583,171 (GRCm39)	missense	probably damaging	0.99
R6531:Dync1h1	UTSW	12	110,584,354 (GRCm39)	missense	probably damaging	1.00
R6554:Dync1h1	UTSW	12	110,616,282 (GRCm39)	missense	probably benign	0.06
R6672:Dync1h1	UTSW	12	110,624,568 (GRCm39)	missense	probably damaging	1.00
R6746:Dync1h1	UTSW	12	110,618,087 (GRCm39)	missense	probably damaging	1.00
R6785:Dync1h1	UTSW	12	110,596,113 (GRCm39)	missense	probably damaging	1.00
R6857:Dync1h1	UTSW	12	110,624,981 (GRCm39)	missense	possibly damaging	0.94
R6863:Dync1h1	UTSW	12	110,618,614 (GRCm39)	missense	probably benign	0.07
R6881:Dync1h1	UTSW	12	110,590,995 (GRCm39)	missense	probably damaging	1.00
R6892:Dync1h1	UTSW	12	110,605,335 (GRCm39)	missense	probably benign	0.00
R7015:Dync1h1	UTSW	12	110,632,521 (GRCm39)	nonsense	probably null
R7096:Dync1h1	UTSW	12	110,623,512 (GRCm39)	missense	probably damaging	0.99
R7173:Dync1h1	UTSW	12	110,568,173 (GRCm39)	missense	probably benign
R7224:Dync1h1	UTSW	12	110,584,196 (GRCm39)	missense	possibly damaging	0.93
R7295:Dync1h1	UTSW	12	110,631,183 (GRCm39)	critical splice donor site	probably null
R7308:Dync1h1	UTSW	12	110,631,596 (GRCm39)	missense	possibly damaging	0.91
R7346:Dync1h1	UTSW	12	110,602,076 (GRCm39)	missense	probably damaging	1.00
R7359:Dync1h1	UTSW	12	110,591,036 (GRCm39)	missense	probably benign	0.00
R7405:Dync1h1	UTSW	12	110,600,654 (GRCm39)	missense	probably damaging	1.00
R7439:Dync1h1	UTSW	12	110,602,887 (GRCm39)	missense	probably damaging	1.00
R7441:Dync1h1	UTSW	12	110,602,887 (GRCm39)	missense	probably damaging	1.00
R7472:Dync1h1	UTSW	12	110,632,109 (GRCm39)	missense	probably damaging	0.99
R7532:Dync1h1	UTSW	12	110,618,011 (GRCm39)	missense	probably benign	0.00
R7543:Dync1h1	UTSW	12	110,580,541 (GRCm39)	missense	probably benign	0.04
R7555:Dync1h1	UTSW	12	110,597,059 (GRCm39)	missense	probably benign	0.03
R7632:Dync1h1	UTSW	12	110,627,327 (GRCm39)	missense	probably benign	0.10
R7701:Dync1h1	UTSW	12	110,585,080 (GRCm39)	missense	probably damaging	1.00
R7704:Dync1h1	UTSW	12	110,632,200 (GRCm39)	missense	probably damaging	1.00
R7808:Dync1h1	UTSW	12	110,621,893 (GRCm39)	missense	possibly damaging	0.53
R7891:Dync1h1	UTSW	12	110,609,590 (GRCm39)	missense	probably benign	0.02
R7895:Dync1h1	UTSW	12	110,582,891 (GRCm39)	missense	probably damaging	1.00
R7913:Dync1h1	UTSW	12	110,595,168 (GRCm39)	missense	probably benign	0.12
R8164:Dync1h1	UTSW	12	110,582,794 (GRCm39)	missense	possibly damaging	0.91
R8257:Dync1h1	UTSW	12	110,602,908 (GRCm39)	missense	probably damaging	1.00
R8346:Dync1h1	UTSW	12	110,632,226 (GRCm39)	missense	probably benign	0.21
R8432:Dync1h1	UTSW	12	110,584,576 (GRCm39)	missense	probably benign	0.00
R8510:Dync1h1	UTSW	12	110,583,177 (GRCm39)	missense	possibly damaging	0.94
R8731:Dync1h1	UTSW	12	110,607,018 (GRCm39)	missense	possibly damaging	0.93
R8739:Dync1h1	UTSW	12	110,581,014 (GRCm39)	missense	probably damaging	1.00
R8756:Dync1h1	UTSW	12	110,583,261 (GRCm39)	missense	probably benign	0.06
R8855:Dync1h1	UTSW	12	110,602,333 (GRCm39)	missense	probably damaging	1.00
R8866:Dync1h1	UTSW	12	110,602,333 (GRCm39)	missense	probably damaging	1.00
R8885:Dync1h1	UTSW	12	110,583,172 (GRCm39)	missense	probably damaging	1.00
R8893:Dync1h1	UTSW	12	110,608,477 (GRCm39)	missense	probably damaging	1.00
R8913:Dync1h1	UTSW	12	110,624,602 (GRCm39)	missense	probably benign	0.14
R8937:Dync1h1	UTSW	12	110,584,471 (GRCm39)	missense	probably damaging	1.00
R8958:Dync1h1	UTSW	12	110,586,805 (GRCm39)	missense	probably benign	0.00
R9000:Dync1h1	UTSW	12	110,606,397 (GRCm39)	missense	probably benign
R9090:Dync1h1	UTSW	12	110,583,310 (GRCm39)	missense	probably benign	0.06
R9108:Dync1h1	UTSW	12	110,622,706 (GRCm39)	intron	probably benign
R9161:Dync1h1	UTSW	12	110,625,023 (GRCm39)	missense	probably benign	0.01
R9185:Dync1h1	UTSW	12	110,601,937 (GRCm39)	missense	probably benign	0.33
R9271:Dync1h1	UTSW	12	110,583,310 (GRCm39)	missense	probably benign	0.06
R9436:Dync1h1	UTSW	12	110,582,975 (GRCm39)	missense	probably damaging	1.00
R9478:Dync1h1	UTSW	12	110,625,137 (GRCm39)	missense	probably benign	0.02
R9547:Dync1h1	UTSW	12	110,624,805 (GRCm39)	missense	probably damaging	1.00
R9561:Dync1h1	UTSW	12	110,615,533 (GRCm39)	missense	probably damaging	0.99
R9586:Dync1h1	UTSW	12	110,582,975 (GRCm39)	missense	probably damaging	1.00
R9609:Dync1h1	UTSW	12	110,607,362 (GRCm39)	missense	probably benign	0.01
Z1088:Dync1h1	UTSW	12	110,596,351 (GRCm39)	frame shift	probably null
Z1177:Dync1h1	UTSW	12	110,624,951 (GRCm39)	nonsense	probably null
Z1177:Dync1h1	UTSW	12	110,607,611 (GRCm39)	frame shift	probably null
Z1177:Dync1h1	UTSW	12	110,603,988 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TCCCACAGTTACAGGTTAGCG -3'
(R):5'- ATCAGGATGGTTGGCATTGTAC -3'

Sequencing Primer
(F):5'- GTTAGCGTAGATGGAAACCCCCTC -3'
(R):5'- GTTGGCATTGTACTGCGCCAC -3'

Posted On

2021-11-19