Incidental Mutation 'R9037:Slc15a2'
ID 687496
Institutional Source Beutler Lab
Gene Symbol Slc15a2
Ensembl Gene ENSMUSG00000022899
Gene Name solute carrier family 15 (H+/peptide transporter), member 2
Synonyms Pept2, 8430408C16Rik
MMRRC Submission 068969-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.118) question?
Stock # R9037 (G1)
Quality Score 225.009
Status Validated
Chromosome 16
Chromosomal Location 36570539-36605324 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 36582725 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 252 (M252K)
Ref Sequence ENSEMBL: ENSMUSP00000023616 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023616] [ENSMUST00000165380] [ENSMUST00000165531]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000023616
AA Change: M252K

PolyPhen 2 Score 0.109 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000023616
Gene: ENSMUSG00000022899
AA Change: M252K

DomainStartEndE-ValueType
low complexity region 35 47 N/A INTRINSIC
Pfam:PTR2 122 500 1.7e-122 PFAM
Pfam:PTR2 593 686 2.5e-14 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000165380
SMART Domains Protein: ENSMUSP00000131395
Gene: ENSMUSG00000022899

DomainStartEndE-ValueType
low complexity region 35 47 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000165531
AA Change: M221K

PolyPhen 2 Score 0.029 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000132663
Gene: ENSMUSG00000022899
AA Change: M221K

DomainStartEndE-ValueType
low complexity region 35 47 N/A INTRINSIC
Pfam:PTR2 99 469 2.4e-105 PFAM
PDB:2XUT|C 583 642 3e-10 PDB
transmembrane domain 655 677 N/A INTRINSIC
Meta Mutation Damage Score 0.0846 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 97.9%
Validation Efficiency 100% (66/66)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The mammalian kidney expresses a proton-coupled peptide transporter that is responsible for the absorption of small peptides, as well as beta-lactam antibiotics and other peptide-like drugs, from the tubular filtrate. This transporter, SLC15A2, belongs to the same gene family as SLC15A1 (MIM 600544), the proton-coupled peptide transporter found in the small intestine (Liu et al, 1995 [PubMed 7756356]).[supplied by OMIM, Feb 2011]
PHENOTYPE: Homozygous mutant mice have impairments of dipeptide transportion, however, show no gross defects. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ablim3 T A 18: 61,952,066 (GRCm39) I432F probably benign Het
Aco2 C G 15: 81,756,620 (GRCm39) probably benign Het
Adcy1 A G 11: 7,087,325 (GRCm39) T400A possibly damaging Het
Afap1l2 A T 19: 56,918,403 (GRCm39) probably benign Het
Anapc4 C A 5: 53,021,843 (GRCm39) Q642K probably benign Het
Ano8 A G 8: 71,937,088 (GRCm39) F160S probably damaging Het
Apob T C 12: 8,066,501 (GRCm39) V4490A probably benign Het
Bcar1 A C 8: 112,447,522 (GRCm39) F152V probably benign Het
Cacna2d2 A G 9: 107,386,395 (GRCm39) D174G probably benign Het
Capn11 T C 17: 45,950,357 (GRCm39) K328R probably benign Het
Colq C A 14: 31,279,744 (GRCm39) probably benign Het
Coro1a A C 7: 126,299,772 (GRCm39) M350R probably benign Het
Ctbp1 T A 5: 33,424,352 (GRCm39) M24L probably benign Het
Cyp2c55 T A 19: 39,030,537 (GRCm39) F456L probably damaging Het
Dnah5 A T 15: 28,248,104 (GRCm39) K747M probably benign Het
Efcab3 A G 11: 104,803,791 (GRCm39) D3048G unknown Het
Esp36 C T 17: 38,729,840 (GRCm39) G60D unknown Het
Gast A G 11: 100,227,436 (GRCm39) E43G probably damaging Het
Gm5849 T G 3: 90,685,155 (GRCm39) N10T probably benign Het
Gulp1 T C 1: 44,793,524 (GRCm39) S62P probably benign Het
Hectd1 T C 12: 51,832,665 (GRCm39) D903G possibly damaging Het
Hk2 T A 6: 82,720,339 (GRCm39) I201F probably benign Het
Ifna2 T C 4: 88,601,664 (GRCm39) D118G probably benign Het
Ift172 T C 5: 31,420,400 (GRCm39) K1079E possibly damaging Het
Igsf9 T C 1: 172,312,081 (GRCm39) V9A probably benign Het
Ints2 G A 11: 86,106,530 (GRCm39) T960I probably benign Het
Klk12 T C 7: 43,419,139 (GRCm39) W35R probably damaging Het
Ly6c1 C A 15: 74,917,300 (GRCm39) G116V probably damaging Het
Macf1 T C 4: 123,365,518 (GRCm39) N3081S probably benign Het
Mal2 A G 15: 54,434,939 (GRCm39) N12S unknown Het
Mgat1 T G 11: 49,152,256 (GRCm39) N246K probably damaging Het
Mpeg1 T A 19: 12,439,190 (GRCm39) V216E probably damaging Het
Mpo A G 11: 87,688,557 (GRCm39) probably benign Het
Mtmr9 T A 14: 63,761,532 (GRCm39) T541S possibly damaging Het
Or4a73 C T 2: 89,421,051 (GRCm39) R136Q probably benign Het
Or51b6b T A 7: 103,310,382 (GRCm39) H25L probably benign Het
Or5ak25 T C 2: 85,269,139 (GRCm39) D121G possibly damaging Het
Or8k3 G T 2: 86,059,042 (GRCm39) T91K probably benign Het
P2rx6 A G 16: 17,388,307 (GRCm39) T328A possibly damaging Het
Pcdhb12 A C 18: 37,569,229 (GRCm39) E125A probably benign Het
Pde3a C A 6: 141,416,832 (GRCm39) Q569K probably damaging Het
Pepd A T 7: 34,720,398 (GRCm39) Q227L probably benign Het
Piezo2 T A 18: 63,225,902 (GRCm39) E911D probably benign Het
Pnpla6 A T 8: 3,592,379 (GRCm39) R1241* probably null Het
Pold1 T C 7: 44,188,339 (GRCm39) D513G probably damaging Het
Polr1d A T 5: 147,015,490 (GRCm39) I58L probably benign Het
Ppif T C 14: 25,694,828 (GRCm39) L58P probably damaging Het
Preb T C 5: 31,116,590 (GRCm39) K101R probably benign Het
Psma8 G T 18: 14,854,251 (GRCm39) V44L probably benign Het
Ptf1a A G 2: 19,451,036 (GRCm39) Y122C possibly damaging Het
Ranbp6 T C 19: 29,790,317 (GRCm39) T12A probably benign Het
Rasal3 C A 17: 32,614,094 (GRCm39) R587L probably benign Het
Rnf146 T C 10: 29,223,676 (GRCm39) K70R probably benign Het
Serpinb6b G T 13: 33,161,998 (GRCm39) E266* probably null Het
Slc2a1 T C 4: 118,993,494 (GRCm39) F444L probably damaging Het
Sox9 A G 11: 112,675,650 (GRCm39) S280G probably damaging Het
Spata31e4 A G 13: 50,856,944 (GRCm39) K861E probably benign Het
Trappc8 A G 18: 20,961,539 (GRCm39) V1243A probably benign Het
Trpv2 A T 11: 62,475,231 (GRCm39) T215S probably damaging Het
Ttc39a A G 4: 109,299,981 (GRCm39) E490G probably damaging Het
Ush2a A T 1: 187,995,487 (GRCm39) D86V possibly damaging Het
Usp24 A G 4: 106,236,251 (GRCm39) T980A probably damaging Het
Vwa7 T C 17: 35,236,268 (GRCm39) V74A probably benign Het
Zan A G 5: 137,452,578 (GRCm39) V1501A unknown Het
Zfp105 A G 9: 122,758,836 (GRCm39) E169G possibly damaging Het
Zfp788 C T 7: 41,298,315 (GRCm39) T317I probably damaging Het
Other mutations in Slc15a2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00505:Slc15a2 APN 16 36,574,137 (GRCm39) missense probably benign 0.00
IGL00703:Slc15a2 APN 16 36,578,153 (GRCm39) missense probably benign 0.00
IGL00937:Slc15a2 APN 16 36,572,242 (GRCm39) nonsense probably null
IGL01511:Slc15a2 APN 16 36,605,088 (GRCm39) missense probably damaging 0.99
IGL01739:Slc15a2 APN 16 36,576,592 (GRCm39) missense probably benign
IGL02069:Slc15a2 APN 16 36,579,613 (GRCm39) missense probably benign 0.02
IGL02076:Slc15a2 APN 16 36,582,743 (GRCm39) missense probably damaging 1.00
IGL02254:Slc15a2 APN 16 36,580,449 (GRCm39) missense possibly damaging 0.93
IGL02387:Slc15a2 APN 16 36,572,137 (GRCm39) splice site probably null
IGL02507:Slc15a2 APN 16 36,602,021 (GRCm39) missense possibly damaging 0.87
IGL02829:Slc15a2 APN 16 36,577,555 (GRCm39) missense possibly damaging 0.92
IGL03114:Slc15a2 APN 16 36,572,267 (GRCm39) missense probably damaging 1.00
IGL03227:Slc15a2 APN 16 36,576,410 (GRCm39) critical splice donor site probably null
PIT4581001:Slc15a2 UTSW 16 36,592,405 (GRCm39) missense probably benign
R0058:Slc15a2 UTSW 16 36,574,909 (GRCm39) missense probably benign 0.08
R0058:Slc15a2 UTSW 16 36,574,909 (GRCm39) missense probably benign 0.08
R0083:Slc15a2 UTSW 16 36,602,645 (GRCm39) missense probably damaging 1.00
R0099:Slc15a2 UTSW 16 36,573,398 (GRCm39) missense probably damaging 1.00
R0104:Slc15a2 UTSW 16 36,594,997 (GRCm39) missense possibly damaging 0.79
R0402:Slc15a2 UTSW 16 36,595,960 (GRCm39) missense probably benign 0.00
R0619:Slc15a2 UTSW 16 36,579,669 (GRCm39) missense probably damaging 1.00
R0963:Slc15a2 UTSW 16 36,594,935 (GRCm39) missense probably damaging 1.00
R0972:Slc15a2 UTSW 16 36,577,501 (GRCm39) missense probably benign 0.00
R1440:Slc15a2 UTSW 16 36,605,005 (GRCm39) splice site probably benign
R1471:Slc15a2 UTSW 16 36,574,153 (GRCm39) missense probably damaging 0.99
R1569:Slc15a2 UTSW 16 36,576,745 (GRCm39) missense probably benign 0.00
R1616:Slc15a2 UTSW 16 36,574,843 (GRCm39) missense probably benign
R2246:Slc15a2 UTSW 16 36,582,723 (GRCm39) missense probably damaging 1.00
R2405:Slc15a2 UTSW 16 36,572,199 (GRCm39) nonsense probably null
R3834:Slc15a2 UTSW 16 36,592,490 (GRCm39) nonsense probably null
R3835:Slc15a2 UTSW 16 36,592,490 (GRCm39) nonsense probably null
R3885:Slc15a2 UTSW 16 36,602,666 (GRCm39) missense probably damaging 1.00
R3887:Slc15a2 UTSW 16 36,602,666 (GRCm39) missense probably damaging 1.00
R3888:Slc15a2 UTSW 16 36,602,666 (GRCm39) missense probably damaging 1.00
R3889:Slc15a2 UTSW 16 36,602,666 (GRCm39) missense probably damaging 1.00
R4105:Slc15a2 UTSW 16 36,602,755 (GRCm39) intron probably benign
R4108:Slc15a2 UTSW 16 36,602,755 (GRCm39) intron probably benign
R4254:Slc15a2 UTSW 16 36,574,852 (GRCm39) missense probably benign 0.04
R4352:Slc15a2 UTSW 16 36,592,390 (GRCm39) missense probably benign 0.08
R4684:Slc15a2 UTSW 16 36,578,211 (GRCm39) missense probably damaging 1.00
R4747:Slc15a2 UTSW 16 36,592,498 (GRCm39) missense probably damaging 0.98
R4774:Slc15a2 UTSW 16 36,602,057 (GRCm39) nonsense probably null
R5151:Slc15a2 UTSW 16 36,572,659 (GRCm39) missense probably damaging 1.00
R5503:Slc15a2 UTSW 16 36,582,747 (GRCm39) missense probably damaging 1.00
R5649:Slc15a2 UTSW 16 36,592,472 (GRCm39) nonsense probably null
R6003:Slc15a2 UTSW 16 36,574,910 (GRCm39) missense probably benign 0.00
R6261:Slc15a2 UTSW 16 36,581,973 (GRCm39) missense probably benign 0.25
R6329:Slc15a2 UTSW 16 36,572,144 (GRCm39) missense possibly damaging 0.94
R6409:Slc15a2 UTSW 16 36,582,232 (GRCm39) missense probably benign 0.00
R6523:Slc15a2 UTSW 16 36,572,683 (GRCm39) missense probably benign 0.17
R7125:Slc15a2 UTSW 16 36,602,660 (GRCm39) missense probably damaging 1.00
R7208:Slc15a2 UTSW 16 36,576,643 (GRCm39) missense probably benign 0.02
R7234:Slc15a2 UTSW 16 36,578,173 (GRCm39) missense probably benign 0.05
R7374:Slc15a2 UTSW 16 36,572,207 (GRCm39) missense probably benign 0.01
R7545:Slc15a2 UTSW 16 36,595,964 (GRCm39) missense probably damaging 1.00
R7559:Slc15a2 UTSW 16 36,572,259 (GRCm39) missense probably benign
R7611:Slc15a2 UTSW 16 36,576,673 (GRCm39) missense probably benign 0.18
R7787:Slc15a2 UTSW 16 36,572,228 (GRCm39) missense probably benign 0.02
R7825:Slc15a2 UTSW 16 36,573,396 (GRCm39) missense possibly damaging 0.94
R8324:Slc15a2 UTSW 16 36,579,669 (GRCm39) missense probably damaging 1.00
R9035:Slc15a2 UTSW 16 36,602,719 (GRCm39) missense possibly damaging 0.82
R9212:Slc15a2 UTSW 16 36,602,053 (GRCm39) nonsense probably null
R9273:Slc15a2 UTSW 16 36,574,090 (GRCm39) missense probably benign 0.01
R9363:Slc15a2 UTSW 16 36,572,672 (GRCm39) missense possibly damaging 0.91
R9368:Slc15a2 UTSW 16 36,574,080 (GRCm39) missense probably benign 0.00
R9488:Slc15a2 UTSW 16 36,579,651 (GRCm39) missense probably benign 0.02
T0722:Slc15a2 UTSW 16 36,772,445 (GRCm38) missense probably benign
V8831:Slc15a2 UTSW 16 36,772,445 (GRCm38) missense probably benign
X0066:Slc15a2 UTSW 16 36,574,151 (GRCm39) nonsense probably null
Z1088:Slc15a2 UTSW 16 36,772,445 (GRCm38) missense probably benign
Z1176:Slc15a2 UTSW 16 36,772,445 (GRCm38) missense probably benign
Z1176:Slc15a2 UTSW 16 36,579,678 (GRCm39) critical splice acceptor site probably null
Z1177:Slc15a2 UTSW 16 36,605,049 (GRCm39) frame shift probably null
Z1177:Slc15a2 UTSW 16 36,772,445 (GRCm38) missense probably benign
Predicted Primers PCR Primer
(F):5'- ACTCAGTTTGTCAAAAGGTAGGC -3'
(R):5'- GGGGCAGAAATGACTTCAATCTC -3'

Sequencing Primer
(F):5'- CAGTTTGTCAAAAGGTAGGCTCATAG -3'
(R):5'- ATCCCTTGAAGGTCTCCATGAG -3'
Posted On 2021-11-19