Incidental Mutation 'R9038:Wdr90'
ID 687569
Institutional Source Beutler Lab
Gene Symbol Wdr90
Ensembl Gene ENSMUSG00000073434
Gene Name WD repeat domain 90
Synonyms 3230401M21Rik
MMRRC Submission 068866-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.101) question?
Stock # R9038 (G1)
Quality Score 194.009
Status Not validated
Chromosome 17
Chromosomal Location 26063745-26080475 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 26076200 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Aspartic acid at position 86 (N86D)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079461] [ENSMUST00000176923]
AlphaFold Q6ZPG2
Predicted Effect probably benign
Transcript: ENSMUST00000079461
AA Change: N498D

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000078426
Gene: ENSMUSG00000073434
AA Change: N498D

DomainStartEndE-ValueType
low complexity region 32 53 N/A INTRINSIC
Pfam:DUF667 60 183 5e-26 PFAM
Pfam:DUF667 210 271 3.7e-9 PFAM
low complexity region 381 396 N/A INTRINSIC
WD40 478 519 5.94e0 SMART
WD40 522 565 3.2e0 SMART
WD40 572 612 3.3e1 SMART
WD40 687 725 1.15e1 SMART
WD40 728 766 5.75e-1 SMART
WD40 768 808 9.24e-4 SMART
WD40 811 850 4.13e0 SMART
WD40 853 892 4.62e-1 SMART
WD40 950 993 1.07e1 SMART
WD40 996 1035 5.75e-1 SMART
WD40 1040 1077 1.58e-2 SMART
WD40 1290 1334 5.23e-3 SMART
WD40 1337 1378 1.27e-1 SMART
WD40 1384 1419 1.83e2 SMART
WD40 1422 1469 3.08e0 SMART
WD40 1472 1509 9.9e0 SMART
WD40 1568 1607 9.02e-7 SMART
WD40 1610 1655 5.75e-1 SMART
WD40 1659 1697 2.98e-1 SMART
WD40 1700 1749 6.14e1 SMART
WD40 1850 1888 1.92e-1 SMART
Predicted Effect
Predicted Effect probably benign
Transcript: ENSMUST00000176923
AA Change: N480D

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000135420
Gene: ENSMUSG00000073434
AA Change: N480D

DomainStartEndE-ValueType
low complexity region 32 53 N/A INTRINSIC
Pfam:DUF667 60 252 5.1e-14 PFAM
low complexity region 363 378 N/A INTRINSIC
WD40 460 501 5.94e0 SMART
WD40 504 547 3.2e0 SMART
WD40 554 594 3.3e1 SMART
WD40 669 707 1.15e1 SMART
WD40 710 748 5.75e-1 SMART
WD40 750 790 9.24e-4 SMART
WD40 793 832 4.13e0 SMART
WD40 835 874 4.62e-1 SMART
WD40 932 975 1.07e1 SMART
WD40 978 1017 5.75e-1 SMART
WD40 1022 1059 1.58e-2 SMART
WD40 1272 1316 5.23e-3 SMART
WD40 1319 1360 1.27e-1 SMART
WD40 1366 1401 1.83e2 SMART
WD40 1404 1451 3.08e0 SMART
WD40 1454 1491 9.9e0 SMART
WD40 1550 1589 9.02e-7 SMART
WD40 1592 1637 5.75e-1 SMART
WD40 1641 1679 2.98e-1 SMART
WD40 1682 1731 6.14e1 SMART
WD40 1832 1870 1.92e-1 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.8%
  • 10x: 98.9%
  • 20x: 95.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb5 A T 12: 118,895,651 (GRCm39) C382S probably benign Het
Abcf2 A G 5: 24,776,191 (GRCm39) V296A possibly damaging Het
Aco2 C G 15: 81,756,620 (GRCm39) probably benign Het
Acvrl1 A G 15: 101,039,011 (GRCm39) D436G possibly damaging Het
Adamts7 A G 9: 90,056,692 (GRCm39) I254V Het
Arhgef18 A G 8: 3,503,257 (GRCm39) I888V probably benign Het
Arhgef40 C A 14: 52,235,072 (GRCm39) A1083D probably damaging Het
Arnt2 C A 7: 83,954,059 (GRCm39) A275S probably benign Het
Brd10 A T 19: 29,731,900 (GRCm39) Y371N possibly damaging Het
Brip1 C T 11: 86,080,599 (GRCm39) V156I probably benign Het
Camk4 C A 18: 33,291,953 (GRCm39) C204* probably null Het
Cenpe A G 3: 134,923,797 (GRCm39) T161A probably benign Het
Chd2 G A 7: 73,105,358 (GRCm39) H1256Y probably damaging Het
Chd9 G A 8: 91,716,233 (GRCm39) V936I unknown Het
D6Ertd527e A G 6: 87,089,233 (GRCm39) *465W probably null Het
Dcaf11 T A 14: 55,803,114 (GRCm39) D309E probably damaging Het
Dtna A G 18: 23,743,553 (GRCm39) N373S probably benign Het
Eif2b2 A G 12: 85,266,897 (GRCm39) D104G probably benign Het
Fras1 A T 5: 96,874,742 (GRCm39) T2302S probably benign Het
Gga1 A G 15: 78,768,321 (GRCm39) K114E probably damaging Het
Gm12887 A G 4: 121,473,616 (GRCm39) probably null Het
Gss A T 2: 155,406,794 (GRCm39) I396N Het
H2-M5 T C 17: 37,299,422 (GRCm39) I199M possibly damaging Het
Hjurp GT GTT 1: 88,194,246 (GRCm39) probably null Het
Ift172 G T 5: 31,441,399 (GRCm39) T245K possibly damaging Het
Ift70a2 G A 2: 75,808,215 (GRCm39) T99I probably benign Het
Iqck A G 7: 118,498,881 (GRCm39) D173G probably damaging Het
Itga11 A G 9: 62,675,039 (GRCm39) N857S possibly damaging Het
Kdm1b C A 13: 47,202,770 (GRCm39) S68R probably benign Het
Ly6c1 C A 15: 74,917,300 (GRCm39) G116V probably damaging Het
Myo6 G T 9: 80,162,285 (GRCm39) V341L unknown Het
Nfkbie C A 17: 45,870,183 (GRCm39) A176E probably damaging Het
Nlrp2 C T 7: 5,330,478 (GRCm39) M639I probably benign Het
Or10g3 T A 14: 52,609,716 (GRCm39) S265C probably damaging Het
Or10j2 T A 1: 173,098,147 (GRCm39) I135N possibly damaging Het
Or56a41 T C 7: 104,740,433 (GRCm39) I138V probably benign Het
Or5w16 A G 2: 87,577,125 (GRCm39) N195S probably damaging Het
Or6c215 T C 10: 129,637,564 (GRCm39) T277A probably damaging Het
Or8k40 A T 2: 86,584,354 (GRCm39) S243T probably damaging Het
Pak4 G A 7: 28,264,263 (GRCm39) T213M probably damaging Het
Pan2 C T 10: 128,153,810 (GRCm39) Q1003* probably null Het
Pde4c G C 8: 71,179,550 (GRCm39) V34L probably benign Het
Pi4k2a G A 19: 42,089,235 (GRCm39) V199M probably damaging Het
Platr25 T C 13: 62,848,007 (GRCm39) E285G probably damaging Het
Polr3e T C 7: 120,536,906 (GRCm39) V356A possibly damaging Het
Prcp A G 7: 92,567,017 (GRCm39) D243G probably benign Het
Qsox2 T C 2: 26,115,246 (GRCm39) T161A probably damaging Het
Rhoj A G 12: 75,355,700 (GRCm39) T35A Het
Scn9a T A 2: 66,325,147 (GRCm39) M1336L probably damaging Het
Sel1l2 G T 2: 140,117,384 (GRCm39) N162K probably damaging Het
Slc15a3 T C 19: 10,820,866 (GRCm39) L161P probably damaging Het
Slc4a11 G A 2: 130,533,663 (GRCm39) A100V probably damaging Het
Sp1 A G 15: 102,316,320 (GRCm39) S41G probably benign Het
Tbx15 A G 3: 99,222,085 (GRCm39) M183V probably benign Het
Tfip11 A G 5: 112,481,214 (GRCm39) T397A possibly damaging Het
Themis T C 10: 28,657,749 (GRCm39) S259P probably damaging Het
Tm7sf2 T C 19: 6,117,172 (GRCm39) Y77C probably damaging Het
Tnnt2 C A 1: 135,774,484 (GRCm39) P81H possibly damaging Het
Trpc7 T C 13: 57,035,886 (GRCm39) T16A probably benign Het
Ttn T A 2: 76,745,056 (GRCm39) Y5331F possibly damaging Het
Virma A G 4: 11,526,922 (GRCm39) Q1057R possibly damaging Het
Vmn2r118 A T 17: 55,918,649 (GRCm39) F81Y probably damaging Het
Vmn2r88 T C 14: 51,651,490 (GRCm39) V268A Het
Vmn2r93 T A 17: 18,524,471 (GRCm39) M155K probably benign Het
Vps13b G T 15: 35,875,931 (GRCm39) C2772F possibly damaging Het
Zbtb34 T C 2: 33,301,248 (GRCm39) D431G probably damaging Het
Zc3h3 G A 15: 75,711,237 (GRCm39) P408L probably benign Het
Zfp345 A G 2: 150,313,864 (GRCm39) Y558H probably benign Het
Zfp583 G A 7: 6,319,543 (GRCm39) P490S probably damaging Het
Other mutations in Wdr90
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00418:Wdr90 APN 17 26,068,338 (GRCm39) missense probably damaging 1.00
IGL01118:Wdr90 APN 17 26,073,661 (GRCm39) missense probably damaging 1.00
IGL01964:Wdr90 APN 17 26,067,383 (GRCm39) missense probably benign
IGL02116:Wdr90 APN 17 26,078,466 (GRCm39) missense probably benign 0.12
IGL02172:Wdr90 APN 17 26,069,408 (GRCm39) missense probably benign 0.22
IGL02716:Wdr90 APN 17 26,076,194 (GRCm39) missense probably damaging 0.96
IGL02961:Wdr90 APN 17 26,067,649 (GRCm39) nonsense probably null
IGL03229:Wdr90 APN 17 26,064,437 (GRCm39) splice site probably benign
IGL03367:Wdr90 APN 17 26,066,765 (GRCm39) splice site probably benign
IGL03098:Wdr90 UTSW 17 26,078,961 (GRCm39) intron probably benign
R0111:Wdr90 UTSW 17 26,067,418 (GRCm39) splice site probably benign
R0454:Wdr90 UTSW 17 26,079,023 (GRCm39) missense probably damaging 0.96
R0457:Wdr90 UTSW 17 26,079,459 (GRCm39) missense probably benign 0.00
R0488:Wdr90 UTSW 17 26,067,591 (GRCm39) missense probably damaging 1.00
R0622:Wdr90 UTSW 17 26,074,632 (GRCm39) missense probably damaging 1.00
R0671:Wdr90 UTSW 17 26,065,367 (GRCm39) missense probably benign 0.04
R0799:Wdr90 UTSW 17 26,079,104 (GRCm39) missense probably benign 0.38
R1177:Wdr90 UTSW 17 26,065,028 (GRCm39) missense possibly damaging 0.85
R1460:Wdr90 UTSW 17 26,079,422 (GRCm39) missense possibly damaging 0.82
R1468:Wdr90 UTSW 17 26,073,027 (GRCm39) missense probably damaging 1.00
R1468:Wdr90 UTSW 17 26,073,027 (GRCm39) missense probably damaging 1.00
R1544:Wdr90 UTSW 17 26,068,284 (GRCm39) missense possibly damaging 0.69
R2057:Wdr90 UTSW 17 26,074,173 (GRCm39) missense probably benign 0.05
R2087:Wdr90 UTSW 17 26,065,577 (GRCm39) missense probably damaging 1.00
R2159:Wdr90 UTSW 17 26,070,715 (GRCm39) missense probably benign
R2208:Wdr90 UTSW 17 26,079,362 (GRCm39) missense probably damaging 1.00
R2345:Wdr90 UTSW 17 26,078,136 (GRCm39) missense probably benign 0.05
R2391:Wdr90 UTSW 17 26,070,429 (GRCm39) missense probably damaging 1.00
R2394:Wdr90 UTSW 17 26,070,429 (GRCm39) missense probably damaging 1.00
R2520:Wdr90 UTSW 17 26,074,326 (GRCm39) missense probably damaging 1.00
R3798:Wdr90 UTSW 17 26,069,472 (GRCm39) missense probably benign 0.01
R3979:Wdr90 UTSW 17 26,078,252 (GRCm39) missense probably benign 0.00
R4111:Wdr90 UTSW 17 26,068,342 (GRCm39) missense possibly damaging 0.94
R4326:Wdr90 UTSW 17 26,072,705 (GRCm39) missense probably benign 0.25
R4459:Wdr90 UTSW 17 26,079,976 (GRCm39) missense possibly damaging 0.95
R4697:Wdr90 UTSW 17 26,074,337 (GRCm39) missense probably benign 0.03
R4735:Wdr90 UTSW 17 26,078,424 (GRCm39) missense probably benign
R4907:Wdr90 UTSW 17 26,079,624 (GRCm39) intron probably benign
R5070:Wdr90 UTSW 17 26,065,307 (GRCm39) missense probably damaging 1.00
R5230:Wdr90 UTSW 17 26,074,277 (GRCm39) missense probably benign 0.01
R5268:Wdr90 UTSW 17 26,069,819 (GRCm39) missense probably damaging 1.00
R5287:Wdr90 UTSW 17 26,080,441 (GRCm39) utr 5 prime probably benign
R5382:Wdr90 UTSW 17 26,064,572 (GRCm39) missense probably damaging 1.00
R5511:Wdr90 UTSW 17 26,063,995 (GRCm39) unclassified probably benign
R5545:Wdr90 UTSW 17 26,064,830 (GRCm39) missense probably damaging 1.00
R5707:Wdr90 UTSW 17 26,076,166 (GRCm39) missense probably benign 0.00
R5973:Wdr90 UTSW 17 26,065,381 (GRCm39) missense probably damaging 1.00
R5973:Wdr90 UTSW 17 26,064,107 (GRCm39) missense probably damaging 0.99
R6385:Wdr90 UTSW 17 26,067,504 (GRCm39) missense probably damaging 1.00
R6481:Wdr90 UTSW 17 26,064,885 (GRCm39) missense probably damaging 0.99
R7078:Wdr90 UTSW 17 26,068,623 (GRCm39) missense probably damaging 1.00
R7214:Wdr90 UTSW 17 26,064,367 (GRCm39) missense probably benign 0.00
R7288:Wdr90 UTSW 17 26,065,286 (GRCm39) missense probably benign 0.03
R7304:Wdr90 UTSW 17 26,070,480 (GRCm39) missense probably benign 0.10
R7309:Wdr90 UTSW 17 26,079,676 (GRCm39) missense probably benign 0.02
R7391:Wdr90 UTSW 17 26,065,502 (GRCm39) missense probably benign 0.08
R7622:Wdr90 UTSW 17 26,073,083 (GRCm39) missense probably benign 0.00
R7646:Wdr90 UTSW 17 26,079,104 (GRCm39) missense probably benign 0.38
R7772:Wdr90 UTSW 17 26,080,465 (GRCm39) start gained probably benign
R7779:Wdr90 UTSW 17 26,065,300 (GRCm39) missense probably damaging 1.00
R7780:Wdr90 UTSW 17 26,065,300 (GRCm39) missense probably damaging 1.00
R7781:Wdr90 UTSW 17 26,065,300 (GRCm39) missense probably damaging 1.00
R7782:Wdr90 UTSW 17 26,065,300 (GRCm39) missense probably damaging 1.00
R7812:Wdr90 UTSW 17 26,071,532 (GRCm39) missense probably damaging 1.00
R7870:Wdr90 UTSW 17 26,079,513 (GRCm39) missense probably damaging 0.96
R7911:Wdr90 UTSW 17 26,069,723 (GRCm39) missense probably benign 0.00
R8126:Wdr90 UTSW 17 26,067,951 (GRCm39) missense possibly damaging 0.48
R8260:Wdr90 UTSW 17 26,064,141 (GRCm39) missense probably damaging 1.00
R8315:Wdr90 UTSW 17 26,064,399 (GRCm39) missense probably benign 0.21
R8919:Wdr90 UTSW 17 26,076,146 (GRCm39) missense
R8938:Wdr90 UTSW 17 26,076,146 (GRCm39) missense
R8940:Wdr90 UTSW 17 26,076,146 (GRCm39) missense
R9079:Wdr90 UTSW 17 26,076,403 (GRCm39) missense
R9401:Wdr90 UTSW 17 26,064,750 (GRCm39) small insertion probably benign
R9471:Wdr90 UTSW 17 26,080,015 (GRCm39) missense possibly damaging 0.72
R9642:Wdr90 UTSW 17 26,072,694 (GRCm39) critical splice donor site probably null
X0064:Wdr90 UTSW 17 26,067,537 (GRCm39) missense probably damaging 1.00
Z1176:Wdr90 UTSW 17 26,079,470 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TGATGAGGCATCTCCCACTG -3'
(R):5'- CTAAGCAACCAAGAGGGACCTG -3'

Sequencing Primer
(F):5'- GCCCCTGCTGCCCTGATC -3'
(R):5'- CTAGGCCCTGTGGACCAAAGATG -3'
Posted On 2021-11-19