|Institutional Source||Beutler Lab|
|Gene Name||calcium/calmodulin-dependent protein kinase IV|
|Synonyms||D18Bwg0362e, CaMKIV/Gr, CaMKIV, Ca2+/calmodulin-dependent protein kinase type IV/Gr, A430110E23Rik|
|Is this an essential gene?||Probably non essential (E-score: 0.083)|
|Stock #||R9038 (G1)|
|Chromosomal Location||32939041-33195767 bp(+) (GRCm38)|
|Type of Mutation||nonsense|
|DNA Base Change (assembly)||C to A at 33158900 bp|
|Amino Acid Change||Cysteine to Stop codon at position 204 (C204*)|
|Ref Sequence||ENSEMBL: ENSMUSP00000046539 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000042868]|
|AlphaFold||no structure available at present|
|Predicted Effect||probably null
AA Change: C204*
AA Change: C204*
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for different targeted mutations show variable phenotypes, including reduced viability, male and/or female sterility, and mild to severe neurological and spatial memory disorders. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Camk4||
(F):5'- ACTGGGTCAGGAGTCAACAG -3'
(R):5'- ACACAGGTGTCCTACATTCCATG -3'
(F):5'- GTCAGGAGTCAACAGATACATTTG -3'
(R):5'- ACATTCCATGTCACTGAGGC -3'