Incidental Mutation 'R9039:Zfp324'
ID 687611
Institutional Source Beutler Lab
Gene Symbol Zfp324
Ensembl Gene ENSMUSG00000004500
Gene Name zinc finger protein 324
Synonyms D430030K24Rik, ZF5128
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.067) question?
Stock # R9039 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 12699765-12707749 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 12705455 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Valine at position 548 (G548V)
Ref Sequence ENSEMBL: ENSMUSP00000041944 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038701] [ENSMUST00000124387] [ENSMUST00000128293] [ENSMUST00000210619]
AlphaFold Q78F42
Predicted Effect probably benign
Transcript: ENSMUST00000038701
AA Change: G548V

PolyPhen 2 Score 0.185 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000041944
Gene: ENSMUSG00000004500
AA Change: G548V

DomainStartEndE-ValueType
KRAB 31 91 8.89e-30 SMART
ZnF_C2H2 291 313 2.95e-3 SMART
ZnF_C2H2 319 341 1.82e-3 SMART
ZnF_C2H2 347 369 6.88e-4 SMART
ZnF_C2H2 375 397 1.95e-3 SMART
ZnF_C2H2 403 425 2.71e-2 SMART
ZnF_C2H2 431 453 2.95e-3 SMART
ZnF_C2H2 459 481 2.75e-3 SMART
ZnF_C2H2 487 509 1.25e-1 SMART
ZnF_C2H2 515 537 7.37e-4 SMART
low complexity region 564 579 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000124387
Predicted Effect probably benign
Transcript: ENSMUST00000128293
SMART Domains Protein: ENSMUSP00000124620
Gene: ENSMUSG00000004500

DomainStartEndE-ValueType
KRAB 31 75 3.83e-11 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000210619
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 100% (68/68)
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik T C 12: 71,213,849 (GRCm39) V692A possibly damaging Het
Aco2 C G 15: 81,756,620 (GRCm39) probably benign Het
Adcy10 T C 1: 165,345,914 (GRCm39) I321T probably damaging Het
Agbl2 C T 2: 90,645,730 (GRCm39) T821I probably benign Het
Alpk1 A G 3: 127,473,192 (GRCm39) L937P probably damaging Het
Atp5f1b A G 10: 127,919,767 (GRCm39) D45G probably benign Het
C8a C T 4: 104,679,200 (GRCm39) R530H probably benign Het
Cacna1s T C 1: 136,016,057 (GRCm39) S694P probably benign Het
Cdca7 T A 2: 72,312,856 (GRCm39) D162E probably benign Het
Cep78 G T 19: 15,936,907 (GRCm39) Q600K probably benign Het
Cert1 C T 13: 96,679,717 (GRCm39) P16S probably benign Het
Coq8b A C 7: 26,950,011 (GRCm39) R363S probably benign Het
Cpne3 A T 4: 19,540,770 (GRCm39) C202S probably damaging Het
Csmd3 G T 15: 47,483,308 (GRCm39) probably benign Het
Cyp4a14 A T 4: 115,344,461 (GRCm39) V468E probably damaging Het
Dchs1 A T 7: 105,405,215 (GRCm39) D2442E probably benign Het
Dip2a T C 10: 76,163,553 (GRCm39) Y49C probably benign Het
Dop1a A G 9: 86,382,870 (GRCm39) R268G probably damaging Het
Eid3 C T 10: 82,703,565 (GRCm39) S342L possibly damaging Het
Ezh2 A G 6: 47,528,671 (GRCm39) L296P possibly damaging Het
Fgfrl1 G C 5: 108,853,439 (GRCm39) probably null Het
Flg2 A G 3: 93,110,899 (GRCm39) R976G unknown Het
Fsip2 C A 2: 82,828,545 (GRCm39) Q6781K probably benign Het
Golga3 C T 5: 110,352,799 (GRCm39) H857Y probably benign Het
Hmcn2 T A 2: 31,244,646 (GRCm39) V701E probably damaging Het
Il21 A T 3: 37,286,602 (GRCm39) I38N probably benign Het
Ip6k2 G T 9: 108,681,807 (GRCm39) G246V probably damaging Het
Ipo13 T C 4: 117,758,185 (GRCm39) Q726R probably damaging Het
Itsn1 A T 16: 91,703,658 (GRCm39) N1521Y unknown Het
Kif2b A G 11: 91,467,131 (GRCm39) V384A possibly damaging Het
L3mbtl1 G T 2: 162,807,988 (GRCm39) R541L probably damaging Het
Lama3 T A 18: 12,614,120 (GRCm39) C1296* probably null Het
Lars1 T C 18: 42,390,234 (GRCm39) D11G probably damaging Het
Ly6c1 C A 15: 74,917,300 (GRCm39) G116V probably damaging Het
Mmp27 C A 9: 7,581,250 (GRCm39) F478L probably benign Het
Moxd1 T A 10: 24,155,251 (GRCm39) probably benign Het
Naaa T A 5: 92,420,300 (GRCm39) probably benign Het
Nav1 T A 1: 135,371,487 (GRCm39) Q1746L unknown Het
Nedd9 T C 13: 41,471,984 (GRCm39) Y165C probably damaging Het
Neurod1 T C 2: 79,284,720 (GRCm39) Y221C probably damaging Het
Or2q1 A T 6: 42,794,545 (GRCm39) I47F probably damaging Het
Or4c122 G T 2: 89,079,545 (GRCm39) F152L probably benign Het
Or5al6 T C 2: 85,976,625 (GRCm39) Y151C probably damaging Het
Or9m1 T C 2: 87,733,907 (GRCm39) T38A probably damaging Het
Orm3 A G 4: 63,274,533 (GRCm39) N33D possibly damaging Het
Ppp1r3a G A 6: 14,754,525 (GRCm39) P241S probably damaging Het
Ppp1r9a A G 6: 5,134,657 (GRCm39) T949A probably benign Het
Prdx6 A T 1: 161,078,619 (GRCm39) I23N probably damaging Het
Prkd3 A T 17: 79,280,003 (GRCm39) V334E probably benign Het
Prr12 A T 7: 44,684,146 (GRCm39) D1631E probably damaging Het
Ptpn22 A G 3: 103,819,551 (GRCm39) probably benign Het
Pum2 T G 12: 8,794,430 (GRCm39) D773E probably damaging Het
Sidt2 A G 9: 45,856,648 (GRCm39) C451R probably benign Het
Slc37a2 A G 9: 37,148,658 (GRCm39) S275P probably benign Het
Slmap G T 14: 26,254,519 (GRCm39) N54K probably benign Het
Susd4 A G 1: 182,681,597 (GRCm39) D146G probably benign Het
Tekt3 G A 11: 62,972,169 (GRCm39) R275H possibly damaging Het
Tkfc A G 19: 10,573,612 (GRCm39) L242P probably damaging Het
Tm9sf2 T A 14: 122,363,576 (GRCm39) L99I probably benign Het
Triqk A T 4: 12,980,490 (GRCm39) D78V probably damaging Het
Trmo T C 4: 46,382,322 (GRCm39) D258G probably benign Het
Tsc2 A G 17: 24,826,489 (GRCm39) V920A probably benign Het
Tspan17 C T 13: 54,943,991 (GRCm39) Q257* probably null Het
Tube1 T A 10: 39,011,017 (GRCm39) F45I probably damaging Het
Vmn1r4 A G 6: 56,933,822 (GRCm39) T109A possibly damaging Het
Vmn2r14 A T 5: 109,367,902 (GRCm39) Y363* probably null Het
Zpld2 C A 4: 133,922,858 (GRCm39) V492F probably damaging Het
Other mutations in Zfp324
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01109:Zfp324 APN 7 12,703,362 (GRCm39) missense probably benign 0.02
IGL01943:Zfp324 APN 7 12,702,713 (GRCm39) splice site probably benign
IGL02668:Zfp324 APN 7 12,704,773 (GRCm39) missense probably damaging 1.00
R0883:Zfp324 UTSW 7 12,704,951 (GRCm39) missense probably damaging 1.00
R0931:Zfp324 UTSW 7 12,700,185 (GRCm39) missense probably benign 0.05
R1164:Zfp324 UTSW 7 12,705,551 (GRCm39) missense probably benign 0.02
R1587:Zfp324 UTSW 7 12,704,570 (GRCm39) missense possibly damaging 0.63
R1837:Zfp324 UTSW 7 12,704,156 (GRCm39) missense probably benign 0.15
R1982:Zfp324 UTSW 7 12,705,145 (GRCm39) missense probably damaging 1.00
R2333:Zfp324 UTSW 7 12,705,172 (GRCm39) missense possibly damaging 0.93
R3155:Zfp324 UTSW 7 12,702,817 (GRCm39) missense probably damaging 1.00
R4050:Zfp324 UTSW 7 12,704,794 (GRCm39) missense probably damaging 1.00
R4784:Zfp324 UTSW 7 12,705,233 (GRCm39) missense probably damaging 1.00
R4992:Zfp324 UTSW 7 12,703,300 (GRCm39) missense probably benign 0.02
R5970:Zfp324 UTSW 7 12,703,293 (GRCm39) missense probably benign 0.28
R6767:Zfp324 UTSW 7 12,704,527 (GRCm39) missense probably null 0.13
R7007:Zfp324 UTSW 7 12,705,142 (GRCm39) missense probably damaging 1.00
R7152:Zfp324 UTSW 7 12,700,198 (GRCm39) missense probably benign 0.07
R7164:Zfp324 UTSW 7 12,702,810 (GRCm39) missense probably damaging 0.97
R7233:Zfp324 UTSW 7 12,704,524 (GRCm39) nonsense probably null
R9172:Zfp324 UTSW 7 12,704,689 (GRCm39) missense probably damaging 1.00
X0062:Zfp324 UTSW 7 12,705,316 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACACCGGAGAGAAGCCTTTC -3'
(R):5'- AACACAGGCTCTTCCACAGTG -3'

Sequencing Primer
(F):5'- ATCAGCTGCTGCACACG -3'
(R):5'- ACAGTGAGTGAAAGGGATTTCAG -3'
Posted On 2021-11-19