Mutagenetix > Incidental Mutations

Incidental Mutation 'R9041:Klf17'

687711

Institutional Source

Beutler Lab

Gene Symbol

Klf17

Ensembl Gene

ENSMUSG00000048626

Gene Name

Kruppel-like factor 17

Synonyms

D4Ertd561e, 7420700M05Rik, Zfp393

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

R9041 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

117757836-117765648 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 117760359 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 267 (Y267C)

Ref Sequence

ENSEMBL: ENSMUSP00000052316 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000062747]

AlphaFold

Q8CFA7

Predicted Effect

probably damaging
Transcript: ENSMUST00000062747
AA Change: Y267C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000052316
Gene: ENSMUSG00000048626
AA Change: Y267C

Domain	Start	End	E-Value	Type
low complexity region	21	34	N/A	INTRINSIC
low complexity region	142	157	N/A	INTRINSIC
low complexity region	202	213	N/A	INTRINSIC
ZnF_C2H2	256	280	4.47e-3	SMART
ZnF_C2H2	286	310	1.92e-2	SMART
ZnF_C2H2	316	338	1.1e-2	SMART

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.8%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 60 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700113H08Rik	T	C	10: 87,226,192	I168T	probably benign	Het
Adcy8	A	T	15: 64,737,438	I874N	probably benign	Het
Angptl1	G	T	1: 156,858,429	D362Y	probably damaging	Het
Arc	A	G	15: 74,672,047	V109A	probably damaging	Het
Asphd2	T	A	5: 112,391,902	T22S	probably benign	Het
Caprin2	A	T	6: 148,869,532	N321K	probably benign	Het
Carmil1	T	C	13: 24,098,810	D547G	possibly damaging	Het
Cd163l1	T	C	7: 140,228,590	C805R	probably damaging	Het
Cd38	G	A	5: 43,901,557		probably null	Het
Cd3g	A	G	9: 44,973,520	V142A	possibly damaging	Het
Chrna6	A	T	8: 27,406,895	I318N	probably damaging	Het
Cmah	T	C	13: 24,457,021		probably null	Het
Cmklr1	G	C	5: 113,613,982	H319Q	probably benign	Het
Cplx4	T	C	18: 65,970,026	M8V	probably damaging	Het
Dnajc19	T	C	3: 34,080,133	K27R	probably damaging	Het
E2f3	C	A	13: 29,909,956	D441Y	probably damaging	Het
Erap1	A	G	13: 74,674,699	K777R	probably benign	Het
Fastkd1	C	T	2: 69,702,371	V551I	probably benign	Het
Fgd5	A	G	6: 91,987,446	E220G	probably benign	Het
Gal3st2	T	C	1: 93,872,484	V19A	possibly damaging	Het
Ghr	T	C	15: 3,328,048	E246G	probably benign	Het
Gm10228	A	T	16: 89,041,225	Y64N	unknown	Het
Gm4737	T	G	16: 46,154,105	D303A	possibly damaging	Het
Gm9833	T	C	3: 10,092,293	*499Q	probably null	Het
Gsdmc4	T	C	15: 63,902,737	N65S	probably benign	Het
Heatr5b	C	A	17: 78,796,432	A1105S	probably benign	Het
Hipk2	A	T	6: 38,747,974	L376*	probably null	Het
Il6st	A	G	13: 112,475,097	T18A	probably benign	Het
Kif3b	T	C	2: 153,317,548	I423T	probably benign	Het
Kntc1	A	G	5: 123,789,030	T1183A	probably benign	Het
Lrrc71	A	G	3: 87,743,353	S201P	probably damaging	Het
Mrgprb5	A	T	7: 48,168,761	D75E	probably damaging	Het
Myf6	A	G	10: 107,493,364	V240A	probably benign	Het
Ncoa6	T	C	2: 155,415,530	M698V	possibly damaging	Het
Nox4	G	A	7: 87,376,240	R525Q	probably benign	Het
Nynrin	T	C	14: 55,871,296	S1287P	possibly damaging	Het
Olfr509	A	G	7: 108,646,382	S65P	probably damaging	Het
Otud4	T	A	8: 79,673,812	S1052T	probably damaging	Het
Pcsk5	A	T	19: 17,560,768	C898*	probably null	Het
Pdcd1	T	C	1: 94,041,366	T76A	probably benign	Het
Plin2	T	A	4: 86,660,267	M198L	probably benign	Het
Prmt7	T	A	8: 106,236,828	V180D	possibly damaging	Het
R3hdm2	T	C	10: 127,484,536	Y549H	probably damaging	Het
Rad54l2	A	G	9: 106,722,819	S80P	possibly damaging	Het
Ryr3	T	A	2: 112,957,201	E235D	probably damaging	Het
Serpina9	A	T	12: 104,001,478	S219R		Het
Sesn2	G	A	4: 132,497,961	T298I	probably benign	Het
Sf3b2	A	T	19: 5,274,844	V838E	possibly damaging	Het
Sfpq	C	A	4: 127,021,503	H29Q	unknown	Het
Smchd1	A	G	17: 71,394,715		probably null	Het
Sprr1b	A	G	3: 92,437,170	V133A	probably benign	Het
Srgap3	T	C	6: 112,777,093	Y243C	probably damaging	Het
Thop1	C	T	10: 81,081,394	A577V	possibly damaging	Het
Tmprss3	T	A	17: 31,191,040	D200V	probably benign	Het
Treh	A	T	9: 44,685,380	K512M	probably damaging	Het
Trip11	A	G	12: 101,878,868	V1537A	probably benign	Het
Trp63	A	G	16: 25,763,333	T44A	probably benign	Het
Vmn1r225	T	A	17: 20,502,315	M6K	possibly damaging	Het
Vmn2r90	A	C	17: 17,734,024	M817L	probably benign	Het
Zfp68	A	T	5: 138,606,437	Y541*	probably null	Het

Other mutations in Klf17

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00331:Klf17	APN	4	117761038	missense	probably benign	0.06
IGL01399:Klf17	APN	4	117759159	missense	probably damaging	1.00
R0047:Klf17	UTSW	4	117761032	missense	probably benign	0.00
R0051:Klf17	UTSW	4	117760392	missense	probably damaging	1.00
R0051:Klf17	UTSW	4	117760392	missense	probably damaging	1.00
R1513:Klf17	UTSW	4	117760935	missense	probably damaging	0.96
R3103:Klf17	UTSW	4	117760608	missense	possibly damaging	0.72
R4112:Klf17	UTSW	4	117760701	missense	possibly damaging	0.85
R4180:Klf17	UTSW	4	117759186	missense	probably benign	0.14
R4669:Klf17	UTSW	4	117760371	missense	probably damaging	1.00
R4715:Klf17	UTSW	4	117760536	missense	probably benign	0.44
R5063:Klf17	UTSW	4	117760659	missense	possibly damaging	0.85
R7578:Klf17	UTSW	4	117760719	missense	possibly damaging	0.85
R7765:Klf17	UTSW	4	117760615	missense	probably benign	0.08
Z1176:Klf17	UTSW	4	117760351	missense	probably benign	0.06

Predicted Primers

PCR Primer
(F):5'- GAGATCCAAACCTTCTTCTGGTC -3'
(R):5'- ATTGCTACCTTTAGACTCCCAAG -3'

Sequencing Primer
(F):5'- AAACCTTCTTCTGGTCTCTGTGGG -3'
(R):5'- GCTACCTTTAGACTCCCAAGATTCAC -3'

Posted On

2021-11-19