Incidental Mutation 'R9042:Or8k3b'
ID 687767
Institutional Source Beutler Lab
Gene Symbol Or8k3b
Ensembl Gene ENSMUSG00000075174
Gene Name olfactory receptor family 8 subfamily K member 3B
Synonyms Olfr1087, GA_x6K02T2Q125-48182406-48181465, MOR188-5
MMRRC Submission 068869-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.186) question?
Stock # R9042 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 86520376-86521317 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 86521139 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 60 (Y60C)
Ref Sequence ENSEMBL: ENSMUSP00000149439 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099877] [ENSMUST00000214141]
AlphaFold Q7TR63
Predicted Effect probably damaging
Transcript: ENSMUST00000099877
AA Change: Y60C

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000097462
Gene: ENSMUSG00000075174
AA Change: Y60C

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 5.5e-49 PFAM
Pfam:7tm_1 41 290 1.7e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214141
AA Change: Y60C

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
Meta Mutation Damage Score 0.2636 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 100% (49/49)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts12 A G 15: 11,152,134 (GRCm39) K208R probably benign Het
Amh T C 10: 80,642,443 (GRCm39) M242T possibly damaging Het
Anpep T C 7: 79,488,510 (GRCm39) Y440C probably damaging Het
Atf7ip G T 6: 136,538,263 (GRCm39) E499* probably null Het
Clasp2 A G 9: 113,735,065 (GRCm39) I967V probably benign Het
Cpa6 T C 1: 10,407,515 (GRCm39) T341A probably benign Het
Cyp26b1 T A 6: 84,553,590 (GRCm39) Y263F probably benign Het
Ecm2 C A 13: 49,682,439 (GRCm39) Y489* probably null Het
Gpr22 C A 12: 31,759,853 (GRCm39) V90L probably benign Het
Grip1 G A 10: 119,836,438 (GRCm39) V516M probably benign Het
Ipo5 C T 14: 121,160,547 (GRCm39) S188L probably benign Het
Kcnh6 T A 11: 105,908,464 (GRCm39) I360N possibly damaging Het
Lrp1b C A 2: 41,392,029 (GRCm39) D512Y Het
Lrpprc C T 17: 85,059,736 (GRCm39) probably null Het
Lta4h A G 10: 93,318,850 (GRCm39) K547R probably benign Het
Nacad G C 11: 6,548,948 (GRCm39) P1340R possibly damaging Het
Ncapd2 T C 6: 125,156,301 (GRCm39) K495E probably benign Het
Ndufaf7 A T 17: 79,245,968 (GRCm39) probably null Het
Nsrp1 A G 11: 76,941,477 (GRCm39) V77A probably benign Het
Or1f19 A T 16: 3,411,132 (GRCm39) S291C probably damaging Het
P2ry12 A G 3: 59,125,456 (GRCm39) V73A probably damaging Het
Pafah1b1 G A 11: 74,574,493 (GRCm39) T231I probably benign Het
Parp11 C A 6: 127,448,615 (GRCm39) Y77* probably null Het
Phc3 T A 3: 30,983,916 (GRCm39) T712S unknown Het
Pkm T A 9: 59,579,220 (GRCm39) I335N probably damaging Het
Pmpca A G 2: 26,283,581 (GRCm39) T417A probably benign Het
Pot1b C T 17: 56,006,991 (GRCm39) probably null Het
Prrc1 T A 18: 57,507,764 (GRCm39) probably null Het
Psg18 A T 7: 18,083,047 (GRCm39) N369K probably benign Het
Pum3 T A 19: 27,399,791 (GRCm39) Y214F probably damaging Het
Reln G A 5: 22,253,036 (GRCm39) T637M probably damaging Het
Rpe65 A T 3: 159,321,292 (GRCm39) Y368F probably damaging Het
Serpina3a A G 12: 104,082,362 (GRCm39) D45G probably benign Het
Serpinb3c T A 1: 107,199,731 (GRCm39) L263F probably damaging Het
Slc25a23 C T 17: 57,352,553 (GRCm39) V444I probably damaging Het
Slc40a1 C T 1: 45,948,621 (GRCm39) G553D probably benign Het
Spata31e5 T C 1: 28,816,037 (GRCm39) Q665R possibly damaging Het
Spata31h1 A G 10: 82,123,185 (GRCm39) I3275T probably benign Het
Taf7 C A 18: 37,776,223 (GRCm39) D115Y probably damaging Het
Tanc1 G C 2: 59,673,766 (GRCm39) A1624P probably benign Het
Tmed4 T C 11: 6,224,405 (GRCm39) D85G probably benign Het
Tmed6 A G 8: 107,790,385 (GRCm39) V138A probably benign Het
Tmem63b T C 17: 45,977,517 (GRCm39) T370A probably benign Het
Ttc38 A G 15: 85,720,310 (GRCm39) T91A probably benign Het
Ube4b C G 4: 149,444,833 (GRCm39) A476P probably benign Het
Vmn2r53 A G 7: 12,315,435 (GRCm39) C795R probably benign Het
Other mutations in Or8k3b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01747:Or8k3b APN 2 86,521,045 (GRCm39) missense possibly damaging 0.90
IGL02300:Or8k3b APN 2 86,520,996 (GRCm39) missense probably benign 0.43
IGL03259:Or8k3b APN 2 86,520,894 (GRCm39) missense probably benign 0.00
IGL03404:Or8k3b APN 2 86,520,372 (GRCm39) utr 3 prime probably benign
R1430:Or8k3b UTSW 2 86,520,866 (GRCm39) missense possibly damaging 0.91
R1513:Or8k3b UTSW 2 86,521,141 (GRCm39) missense possibly damaging 0.60
R1529:Or8k3b UTSW 2 86,520,677 (GRCm39) missense possibly damaging 0.69
R1767:Or8k3b UTSW 2 86,520,728 (GRCm39) missense probably benign 0.01
R1869:Or8k3b UTSW 2 86,520,735 (GRCm39) missense probably damaging 0.98
R3056:Or8k3b UTSW 2 86,520,896 (GRCm39) missense possibly damaging 0.91
R5002:Or8k3b UTSW 2 86,520,429 (GRCm39) missense possibly damaging 0.95
R7303:Or8k3b UTSW 2 86,521,166 (GRCm39) missense probably benign 0.05
R8335:Or8k3b UTSW 2 86,520,512 (GRCm39) missense probably benign 0.38
R9364:Or8k3b UTSW 2 86,520,575 (GRCm39) missense possibly damaging 0.66
X0063:Or8k3b UTSW 2 86,520,887 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GGTCATAGGACATTGCAGACAG -3'
(R):5'- CGATCACATGTTGGGTATTTGC -3'

Sequencing Primer
(F):5'- TTGCAGACAGAATCAAAAGCTC -3'
(R):5'- TGCTCTTTGATGTTACTGTAATGTAC -3'
Posted On 2021-11-19