Incidental Mutation 'R9042:Parp11'
ID 687776
Institutional Source Beutler Lab
Gene Symbol Parp11
Ensembl Gene ENSMUSG00000037997
Gene Name poly (ADP-ribose) polymerase family, member 11
Synonyms 5330431N24Rik, HIN1L
MMRRC Submission 068869-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9042 (G1)
Quality Score 225.009
Status Validated
Chromosome 6
Chromosomal Location 127423803-127471224 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to A at 127448615 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 77 (Y77*)
Ref Sequence ENSEMBL: ENSMUSP00000036127 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039680] [ENSMUST00000112191] [ENSMUST00000112193] [ENSMUST00000112195] [ENSMUST00000144115]
AlphaFold Q8CFF0
Predicted Effect probably null
Transcript: ENSMUST00000039680
AA Change: Y77*
SMART Domains Protein: ENSMUSP00000036127
Gene: ENSMUSG00000037997
AA Change: Y77*

DomainStartEndE-ValueType
Pfam:WWE 25 99 1.4e-18 PFAM
Pfam:PARP 129 331 4.1e-51 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000112191
SMART Domains Protein: ENSMUSP00000107810
Gene: ENSMUSG00000037997

DomainStartEndE-ValueType
Pfam:PARP 46 248 4e-51 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000112193
AA Change: Y77*
SMART Domains Protein: ENSMUSP00000107812
Gene: ENSMUSG00000037997
AA Change: Y77*

DomainStartEndE-ValueType
Pfam:WWE 22 99 4.5e-12 PFAM
Pfam:PARP 129 176 2.3e-8 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000112195
AA Change: Y77*
SMART Domains Protein: ENSMUSP00000107814
Gene: ENSMUSG00000037997
AA Change: Y77*

DomainStartEndE-ValueType
Pfam:WWE 22 99 4.5e-12 PFAM
Pfam:PARP 129 176 2.3e-8 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000144115
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 100% (49/49)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired male fertility and teratozoospermia associated with sperm head malformations and nuclear envelope defects during the nuclear reshaping process of spermatid elongation and condensation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts12 A G 15: 11,152,134 (GRCm39) K208R probably benign Het
Amh T C 10: 80,642,443 (GRCm39) M242T possibly damaging Het
Anpep T C 7: 79,488,510 (GRCm39) Y440C probably damaging Het
Atf7ip G T 6: 136,538,263 (GRCm39) E499* probably null Het
Clasp2 A G 9: 113,735,065 (GRCm39) I967V probably benign Het
Cpa6 T C 1: 10,407,515 (GRCm39) T341A probably benign Het
Cyp26b1 T A 6: 84,553,590 (GRCm39) Y263F probably benign Het
Ecm2 C A 13: 49,682,439 (GRCm39) Y489* probably null Het
Gpr22 C A 12: 31,759,853 (GRCm39) V90L probably benign Het
Grip1 G A 10: 119,836,438 (GRCm39) V516M probably benign Het
Ipo5 C T 14: 121,160,547 (GRCm39) S188L probably benign Het
Kcnh6 T A 11: 105,908,464 (GRCm39) I360N possibly damaging Het
Lrp1b C A 2: 41,392,029 (GRCm39) D512Y Het
Lrpprc C T 17: 85,059,736 (GRCm39) probably null Het
Lta4h A G 10: 93,318,850 (GRCm39) K547R probably benign Het
Nacad G C 11: 6,548,948 (GRCm39) P1340R possibly damaging Het
Ncapd2 T C 6: 125,156,301 (GRCm39) K495E probably benign Het
Ndufaf7 A T 17: 79,245,968 (GRCm39) probably null Het
Nsrp1 A G 11: 76,941,477 (GRCm39) V77A probably benign Het
Or1f19 A T 16: 3,411,132 (GRCm39) S291C probably damaging Het
Or8k3b T C 2: 86,521,139 (GRCm39) Y60C probably damaging Het
P2ry12 A G 3: 59,125,456 (GRCm39) V73A probably damaging Het
Pafah1b1 G A 11: 74,574,493 (GRCm39) T231I probably benign Het
Phc3 T A 3: 30,983,916 (GRCm39) T712S unknown Het
Pkm T A 9: 59,579,220 (GRCm39) I335N probably damaging Het
Pmpca A G 2: 26,283,581 (GRCm39) T417A probably benign Het
Pot1b C T 17: 56,006,991 (GRCm39) probably null Het
Prrc1 T A 18: 57,507,764 (GRCm39) probably null Het
Psg18 A T 7: 18,083,047 (GRCm39) N369K probably benign Het
Pum3 T A 19: 27,399,791 (GRCm39) Y214F probably damaging Het
Reln G A 5: 22,253,036 (GRCm39) T637M probably damaging Het
Rpe65 A T 3: 159,321,292 (GRCm39) Y368F probably damaging Het
Serpina3a A G 12: 104,082,362 (GRCm39) D45G probably benign Het
Serpinb3c T A 1: 107,199,731 (GRCm39) L263F probably damaging Het
Slc25a23 C T 17: 57,352,553 (GRCm39) V444I probably damaging Het
Slc40a1 C T 1: 45,948,621 (GRCm39) G553D probably benign Het
Spata31e5 T C 1: 28,816,037 (GRCm39) Q665R possibly damaging Het
Spata31h1 A G 10: 82,123,185 (GRCm39) I3275T probably benign Het
Taf7 C A 18: 37,776,223 (GRCm39) D115Y probably damaging Het
Tanc1 G C 2: 59,673,766 (GRCm39) A1624P probably benign Het
Tmed4 T C 11: 6,224,405 (GRCm39) D85G probably benign Het
Tmed6 A G 8: 107,790,385 (GRCm39) V138A probably benign Het
Tmem63b T C 17: 45,977,517 (GRCm39) T370A probably benign Het
Ttc38 A G 15: 85,720,310 (GRCm39) T91A probably benign Het
Ube4b C G 4: 149,444,833 (GRCm39) A476P probably benign Het
Vmn2r53 A G 7: 12,315,435 (GRCm39) C795R probably benign Het
Other mutations in Parp11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01358:Parp11 APN 6 127,448,526 (GRCm39) nonsense probably null
IGL01548:Parp11 APN 6 127,468,562 (GRCm39) missense probably damaging 1.00
IGL01638:Parp11 APN 6 127,468,492 (GRCm39) missense probably benign 0.13
IGL01688:Parp11 APN 6 127,448,569 (GRCm39) missense probably benign 0.00
IGL03201:Parp11 APN 6 127,466,981 (GRCm39) missense possibly damaging 0.80
IGL03297:Parp11 APN 6 127,467,045 (GRCm39) splice site probably benign
H8786:Parp11 UTSW 6 127,448,598 (GRCm39) missense probably damaging 1.00
R1514:Parp11 UTSW 6 127,451,256 (GRCm39) missense possibly damaging 0.89
R1817:Parp11 UTSW 6 127,467,008 (GRCm39) missense probably damaging 1.00
R1868:Parp11 UTSW 6 127,447,740 (GRCm39) missense probably damaging 1.00
R1942:Parp11 UTSW 6 127,447,663 (GRCm39) critical splice acceptor site probably null
R2011:Parp11 UTSW 6 127,454,854 (GRCm39) missense probably benign 0.02
R4483:Parp11 UTSW 6 127,448,568 (GRCm39) missense probably benign
R4507:Parp11 UTSW 6 127,451,246 (GRCm39) missense probably damaging 1.00
R4593:Parp11 UTSW 6 127,451,262 (GRCm39) missense probably benign 0.03
R5024:Parp11 UTSW 6 127,448,599 (GRCm39) missense probably damaging 1.00
R5371:Parp11 UTSW 6 127,447,755 (GRCm39) missense probably damaging 1.00
R6608:Parp11 UTSW 6 127,454,811 (GRCm39) missense possibly damaging 0.93
R7606:Parp11 UTSW 6 127,447,723 (GRCm39) missense probably benign 0.06
R8772:Parp11 UTSW 6 127,468,667 (GRCm39) missense probably damaging 1.00
R8772:Parp11 UTSW 6 127,447,726 (GRCm39) missense possibly damaging 0.77
Predicted Primers PCR Primer
(F):5'- CATTCTCTGTCACTGGGAGC -3'
(R):5'- AACATGCTTTTATCAATGGCAGGG -3'

Sequencing Primer
(F):5'- TCTGTCACTGGGAGCTCAGC -3'
(R):5'- GCTGCTCAAGAGTTGACAGTGC -3'
Posted On 2021-11-19