Incidental Mutation 'R9042:Vmn2r53'
ID 687778
Institutional Source Beutler Lab
Gene Symbol Vmn2r53
Ensembl Gene ENSMUSG00000096002
Gene Name vomeronasal 2, receptor 53
Synonyms EG637908
MMRRC Submission 068869-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.106) question?
Stock # R9042 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 12315397-12342583 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 12315435 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Arginine at position 795 (C795R)
Ref Sequence ENSEMBL: ENSMUSP00000126979 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000170412]
AlphaFold A0A3B2W4A7
Predicted Effect probably benign
Transcript: ENSMUST00000170412
AA Change: C795R

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000126979
Gene: ENSMUSG00000096002
AA Change: C795R

DomainStartEndE-ValueType
Pfam:ANF_receptor 5 397 3.6e-58 PFAM
Pfam:NCD3G 442 495 2.2e-19 PFAM
Pfam:7tm_3 526 763 3.1e-53 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 100% (49/49)
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts12 A G 15: 11,152,134 (GRCm39) K208R probably benign Het
Amh T C 10: 80,642,443 (GRCm39) M242T possibly damaging Het
Anpep T C 7: 79,488,510 (GRCm39) Y440C probably damaging Het
Atf7ip G T 6: 136,538,263 (GRCm39) E499* probably null Het
Clasp2 A G 9: 113,735,065 (GRCm39) I967V probably benign Het
Cpa6 T C 1: 10,407,515 (GRCm39) T341A probably benign Het
Cyp26b1 T A 6: 84,553,590 (GRCm39) Y263F probably benign Het
Ecm2 C A 13: 49,682,439 (GRCm39) Y489* probably null Het
Gpr22 C A 12: 31,759,853 (GRCm39) V90L probably benign Het
Grip1 G A 10: 119,836,438 (GRCm39) V516M probably benign Het
Ipo5 C T 14: 121,160,547 (GRCm39) S188L probably benign Het
Kcnh6 T A 11: 105,908,464 (GRCm39) I360N possibly damaging Het
Lrp1b C A 2: 41,392,029 (GRCm39) D512Y Het
Lrpprc C T 17: 85,059,736 (GRCm39) probably null Het
Lta4h A G 10: 93,318,850 (GRCm39) K547R probably benign Het
Nacad G C 11: 6,548,948 (GRCm39) P1340R possibly damaging Het
Ncapd2 T C 6: 125,156,301 (GRCm39) K495E probably benign Het
Ndufaf7 A T 17: 79,245,968 (GRCm39) probably null Het
Nsrp1 A G 11: 76,941,477 (GRCm39) V77A probably benign Het
Or1f19 A T 16: 3,411,132 (GRCm39) S291C probably damaging Het
Or8k3b T C 2: 86,521,139 (GRCm39) Y60C probably damaging Het
P2ry12 A G 3: 59,125,456 (GRCm39) V73A probably damaging Het
Pafah1b1 G A 11: 74,574,493 (GRCm39) T231I probably benign Het
Parp11 C A 6: 127,448,615 (GRCm39) Y77* probably null Het
Phc3 T A 3: 30,983,916 (GRCm39) T712S unknown Het
Pkm T A 9: 59,579,220 (GRCm39) I335N probably damaging Het
Pmpca A G 2: 26,283,581 (GRCm39) T417A probably benign Het
Pot1b C T 17: 56,006,991 (GRCm39) probably null Het
Prrc1 T A 18: 57,507,764 (GRCm39) probably null Het
Psg18 A T 7: 18,083,047 (GRCm39) N369K probably benign Het
Pum3 T A 19: 27,399,791 (GRCm39) Y214F probably damaging Het
Reln G A 5: 22,253,036 (GRCm39) T637M probably damaging Het
Rpe65 A T 3: 159,321,292 (GRCm39) Y368F probably damaging Het
Serpina3a A G 12: 104,082,362 (GRCm39) D45G probably benign Het
Serpinb3c T A 1: 107,199,731 (GRCm39) L263F probably damaging Het
Slc25a23 C T 17: 57,352,553 (GRCm39) V444I probably damaging Het
Slc40a1 C T 1: 45,948,621 (GRCm39) G553D probably benign Het
Spata31e5 T C 1: 28,816,037 (GRCm39) Q665R possibly damaging Het
Spata31h1 A G 10: 82,123,185 (GRCm39) I3275T probably benign Het
Taf7 C A 18: 37,776,223 (GRCm39) D115Y probably damaging Het
Tanc1 G C 2: 59,673,766 (GRCm39) A1624P probably benign Het
Tmed4 T C 11: 6,224,405 (GRCm39) D85G probably benign Het
Tmed6 A G 8: 107,790,385 (GRCm39) V138A probably benign Het
Tmem63b T C 17: 45,977,517 (GRCm39) T370A probably benign Het
Ttc38 A G 15: 85,720,310 (GRCm39) T91A probably benign Het
Ube4b C G 4: 149,444,833 (GRCm39) A476P probably benign Het
Other mutations in Vmn2r53
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01090:Vmn2r53 APN 7 12,334,835 (GRCm39) missense possibly damaging 0.70
IGL01997:Vmn2r53 APN 7 12,316,373 (GRCm39) missense possibly damaging 0.54
IGL02442:Vmn2r53 APN 7 12,315,656 (GRCm39) missense probably damaging 1.00
IGL02449:Vmn2r53 APN 7 12,316,288 (GRCm39) missense probably damaging 1.00
IGL02589:Vmn2r53 APN 7 12,315,872 (GRCm39) missense possibly damaging 0.93
IGL02986:Vmn2r53 APN 7 12,315,393 (GRCm39) unclassified probably benign
IGL03064:Vmn2r53 APN 7 12,334,937 (GRCm39) missense possibly damaging 0.89
IGL03093:Vmn2r53 APN 7 12,334,791 (GRCm39) missense probably benign 0.03
IGL03244:Vmn2r53 APN 7 12,340,435 (GRCm39) missense probably damaging 1.00
IGL03252:Vmn2r53 APN 7 12,340,318 (GRCm39) missense probably damaging 1.00
IGL03264:Vmn2r53 APN 7 12,315,819 (GRCm39) missense possibly damaging 0.95
IGL03293:Vmn2r53 APN 7 12,332,349 (GRCm39) missense probably benign 0.34
R0109:Vmn2r53 UTSW 7 12,315,993 (GRCm39) missense probably damaging 1.00
R0453:Vmn2r53 UTSW 7 12,316,338 (GRCm39) missense probably damaging 1.00
R0735:Vmn2r53 UTSW 7 12,315,707 (GRCm39) missense probably benign
R0881:Vmn2r53 UTSW 7 12,334,859 (GRCm39) missense probably benign 0.01
R0894:Vmn2r53 UTSW 7 12,335,141 (GRCm39) missense probably benign 0.00
R0973:Vmn2r53 UTSW 7 12,335,319 (GRCm39) missense probably damaging 1.00
R0973:Vmn2r53 UTSW 7 12,335,319 (GRCm39) missense probably damaging 1.00
R0974:Vmn2r53 UTSW 7 12,335,319 (GRCm39) missense probably damaging 1.00
R0990:Vmn2r53 UTSW 7 12,315,429 (GRCm39) missense probably benign
R1102:Vmn2r53 UTSW 7 12,332,410 (GRCm39) missense possibly damaging 0.94
R1141:Vmn2r53 UTSW 7 12,334,673 (GRCm39) missense possibly damaging 0.54
R1263:Vmn2r53 UTSW 7 12,315,533 (GRCm39) missense probably benign 0.41
R1343:Vmn2r53 UTSW 7 12,318,701 (GRCm39) missense probably benign 0.08
R1750:Vmn2r53 UTSW 7 12,315,632 (GRCm39) missense probably damaging 1.00
R1836:Vmn2r53 UTSW 7 12,334,812 (GRCm39) missense probably damaging 1.00
R2035:Vmn2r53 UTSW 7 12,332,438 (GRCm39) missense possibly damaging 0.76
R2202:Vmn2r53 UTSW 7 12,335,366 (GRCm39) missense probably damaging 1.00
R3707:Vmn2r53 UTSW 7 12,315,981 (GRCm39) missense possibly damaging 0.95
R4372:Vmn2r53 UTSW 7 12,315,656 (GRCm39) missense probably damaging 0.98
R4615:Vmn2r53 UTSW 7 12,316,229 (GRCm39) missense probably damaging 1.00
R4655:Vmn2r53 UTSW 7 12,315,932 (GRCm39) missense possibly damaging 0.83
R4663:Vmn2r53 UTSW 7 12,334,901 (GRCm39) missense probably benign 0.21
R4708:Vmn2r53 UTSW 7 12,335,129 (GRCm39) missense probably benign
R4710:Vmn2r53 UTSW 7 12,335,129 (GRCm39) missense probably benign
R4774:Vmn2r53 UTSW 7 12,334,692 (GRCm39) nonsense probably null
R4859:Vmn2r53 UTSW 7 12,335,330 (GRCm39) missense probably damaging 1.00
R5061:Vmn2r53 UTSW 7 12,315,741 (GRCm39) missense probably benign 0.01
R5561:Vmn2r53 UTSW 7 12,335,347 (GRCm39) missense probably damaging 1.00
R5729:Vmn2r53 UTSW 7 12,334,733 (GRCm39) missense probably damaging 1.00
R6004:Vmn2r53 UTSW 7 12,316,328 (GRCm39) missense probably benign 0.12
R6083:Vmn2r53 UTSW 7 12,315,808 (GRCm39) missense probably benign
R6312:Vmn2r53 UTSW 7 12,332,566 (GRCm39) critical splice acceptor site probably null
R6700:Vmn2r53 UTSW 7 12,315,633 (GRCm39) missense probably damaging 0.96
R6783:Vmn2r53 UTSW 7 12,335,360 (GRCm39) missense probably damaging 1.00
R6852:Vmn2r53 UTSW 7 12,340,441 (GRCm39) missense probably damaging 0.99
R6889:Vmn2r53 UTSW 7 12,335,069 (GRCm39) missense probably benign 0.10
R6940:Vmn2r53 UTSW 7 12,316,343 (GRCm39) missense probably benign 0.19
R7100:Vmn2r53 UTSW 7 12,315,513 (GRCm39) nonsense probably null
R7174:Vmn2r53 UTSW 7 12,315,628 (GRCm39) missense probably benign 0.01
R7213:Vmn2r53 UTSW 7 12,334,983 (GRCm39) missense probably benign 0.17
R7276:Vmn2r53 UTSW 7 12,340,359 (GRCm39) missense probably damaging 0.99
R7515:Vmn2r53 UTSW 7 12,315,846 (GRCm39) missense probably benign 0.05
R7678:Vmn2r53 UTSW 7 12,332,425 (GRCm39) missense probably benign 0.04
R7714:Vmn2r53 UTSW 7 12,340,418 (GRCm39) missense probably damaging 1.00
R7843:Vmn2r53 UTSW 7 12,316,026 (GRCm39) missense probably damaging 1.00
R8208:Vmn2r53 UTSW 7 12,335,322 (GRCm39) missense probably damaging 1.00
R8211:Vmn2r53 UTSW 7 12,315,843 (GRCm39) missense probably benign 0.01
R8478:Vmn2r53 UTSW 7 12,340,281 (GRCm39) missense probably benign 0.01
R8853:Vmn2r53 UTSW 7 12,315,737 (GRCm39) missense probably damaging 1.00
R8924:Vmn2r53 UTSW 7 12,334,752 (GRCm39) missense probably benign 0.17
R8963:Vmn2r53 UTSW 7 12,315,926 (GRCm39) missense probably damaging 1.00
R9076:Vmn2r53 UTSW 7 12,340,231 (GRCm39) missense probably damaging 1.00
R9407:Vmn2r53 UTSW 7 12,335,124 (GRCm39) missense probably damaging 0.99
R9690:Vmn2r53 UTSW 7 12,315,912 (GRCm39) missense probably damaging 1.00
Z1176:Vmn2r53 UTSW 7 12,335,231 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTTTGCGCACTTTGGCATTG -3'
(R):5'- GTGGCTGTAGAGATCTTTTCCATCC -3'

Sequencing Primer
(F):5'- TTGACATGCTCACTGGCAAG -3'
(R):5'- GTAGAGATCTTTTCCATCCTGGCC -3'
Posted On 2021-11-19