Incidental Mutation 'R9043:Or9k2b'
ID 687858
Institutional Source Beutler Lab
Gene Symbol Or9k2b
Ensembl Gene ENSMUSG00000059862
Gene Name olfactory receptor family 9 subfamily K member 2B
Synonyms MOR210-2, GA_x6K02T2PULF-11851623-11850682, Olfr826
MMRRC Submission 068870-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.078) question?
Stock # R9043 (G1)
Quality Score 225.009
Status Validated
Chromosome 10
Chromosomal Location 130015806-130016747 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 130016154 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Glutamine at position 198 (H198Q)
Ref Sequence ENSEMBL: ENSMUSP00000149119 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078322] [ENSMUST00000203720] [ENSMUST00000216661]
AlphaFold Q8VFU6
Predicted Effect probably benign
Transcript: ENSMUST00000078322
AA Change: H198Q

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000077436
Gene: ENSMUSG00000059862
AA Change: H198Q

DomainStartEndE-ValueType
Pfam:7tm_4 34 309 2.3e-52 PFAM
Pfam:7tm_1 44 291 3.7e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000203720
AA Change: H198Q

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000144755
Gene: ENSMUSG00000059862
AA Change: H198Q

DomainStartEndE-ValueType
Pfam:7tm_4 34 309 2.3e-52 PFAM
Pfam:7tm_1 44 291 3.7e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216661
AA Change: H198Q

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.0%
Validation Efficiency 99% (87/88)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 85 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933402J07Rik T A 8: 88,309,238 (GRCm39) S134T possibly damaging Het
Aadacl4 T A 4: 144,349,790 (GRCm39) L349Q probably damaging Het
Ankrd29 T C 18: 12,428,970 (GRCm39) N33S probably damaging Het
Arid3b T C 9: 57,699,900 (GRCm39) S536G possibly damaging Het
Art5 A C 7: 101,748,699 (GRCm39) M1R probably null Het
Arvcf T A 16: 18,218,452 (GRCm39) C545S probably damaging Het
Atpsckmt A G 15: 31,617,101 (GRCm39) T189A probably benign Het
Axin2 T A 11: 108,833,794 (GRCm39) N580K probably benign Het
Cdh23 T G 10: 60,151,478 (GRCm39) D2469A probably benign Het
Cep350 T A 1: 155,773,228 (GRCm39) T1781S probably damaging Het
Cfap65 T A 1: 74,943,847 (GRCm39) T1555S possibly damaging Het
Chga G A 12: 102,529,054 (GRCm39) E344K possibly damaging Het
Ckap2l A T 2: 129,126,892 (GRCm39) L429M probably damaging Het
Cpne7 C T 8: 123,856,951 (GRCm39) P402L probably damaging Het
Cyp2g1 A G 7: 26,509,256 (GRCm39) N110S probably benign Het
Cyp3a11 T C 5: 145,805,995 (GRCm39) D124G probably benign Het
Dgkq A T 5: 108,801,061 (GRCm39) V527D probably damaging Het
Dnah3 T C 7: 119,551,272 (GRCm39) I37V probably benign Het
Dnah9 T A 11: 65,845,680 (GRCm39) E3068V Het
Dusp23 T C 1: 172,460,184 (GRCm39) E89G probably null Het
Fam187a A G 11: 102,776,685 (GRCm39) Y163C possibly damaging Het
Gabrg2 T A 11: 41,865,662 (GRCm39) I106F probably damaging Het
Gpc2 A G 5: 138,277,193 (GRCm39) I78T probably benign Het
Gpr149 A C 3: 62,511,360 (GRCm39) L213R probably damaging Het
Grm1 A T 10: 10,565,056 (GRCm39) L1084* probably null Het
Gypa A G 8: 81,222,946 (GRCm39) T17A unknown Het
Gys2 A T 6: 142,376,059 (GRCm39) F534L probably damaging Het
Iqce A T 5: 140,651,810 (GRCm39) M721K probably benign Het
Klrc2 T A 6: 129,635,741 (GRCm39) Y129F probably damaging Het
Krt14 T C 11: 100,095,464 (GRCm39) S314G possibly damaging Het
L3mbtl3 T C 10: 26,156,152 (GRCm39) Q685R unknown Het
Lamb3 A T 1: 193,007,919 (GRCm39) K206* probably null Het
Lgr5 A G 10: 115,314,343 (GRCm39) I198T probably damaging Het
Mapk10 A T 5: 103,074,025 (GRCm39) probably benign Het
Mcm6 C T 1: 128,271,231 (GRCm39) D463N probably damaging Het
Med15 A T 16: 17,470,582 (GRCm39) W742R probably benign Het
Meis1 T A 11: 18,831,916 (GRCm39) Q374L possibly damaging Het
Nrxn3 T C 12: 89,227,252 (GRCm39) C296R probably damaging Het
Ntaq1 A G 15: 58,014,004 (GRCm39) Y67C possibly damaging Het
Oaf C T 9: 43,135,308 (GRCm39) A157T probably damaging Het
Oca2 T A 7: 55,927,189 (GRCm39) probably null Het
Or5b110-ps1 A T 19: 13,260,074 (GRCm39) M116K probably damaging Het
Or5b12 T A 19: 12,897,667 (GRCm39) E2V probably benign Het
Or5d36 T A 2: 87,900,983 (GRCm39) T248S possibly damaging Het
Pacs1 A G 19: 5,188,964 (GRCm39) I806T probably benign Het
Pax2 T A 19: 44,804,499 (GRCm39) S257T probably benign Het
Pbxip1 A T 3: 89,350,794 (GRCm39) T72S probably benign Het
Pcdhb14 T C 18: 37,581,851 (GRCm39) I319T probably damaging Het
Pcdhga2 C A 18: 37,802,963 (GRCm39) A269E possibly damaging Het
Pdzph1 A C 17: 59,280,535 (GRCm39) N582K probably benign Het
Plk2 A T 13: 110,533,194 (GRCm39) I186F probably damaging Het
Pzp A T 6: 128,471,742 (GRCm39) C895S probably damaging Het
Rasa2 A T 9: 96,484,770 (GRCm39) V148D probably damaging Het
Rgsl1 A T 1: 153,717,567 (GRCm39) I14N possibly damaging Het
Rhox3c C T X: 36,651,303 (GRCm39) probably benign Het
Rnf213 A G 11: 119,349,739 (GRCm39) R3867G Het
Rpap3 A G 15: 97,584,443 (GRCm39) Y334H possibly damaging Het
Scara3 A C 14: 66,169,070 (GRCm39) N182K probably damaging Het
Sh3bp1 A G 15: 78,791,449 (GRCm39) E412G possibly damaging Het
Sh3tc2 T A 18: 62,122,961 (GRCm39) I574N possibly damaging Het
Slc16a11 T C 11: 70,106,520 (GRCm39) Y253H probably damaging Het
Slc38a4 A T 15: 96,906,805 (GRCm39) V311E possibly damaging Het
Slc4a7 T C 14: 14,775,048 (GRCm38) L826P probably damaging Het
Spag9 T G 11: 93,951,085 (GRCm39) V83G Het
Sspo T G 6: 48,470,214 (GRCm39) V4560G probably benign Het
Stxbp2 T A 8: 3,684,478 (GRCm39) F144I Het
Tafa2 T C 10: 123,540,294 (GRCm39) V50A probably damaging Het
Tdh T C 14: 63,730,278 (GRCm39) I334V probably benign Het
Tesk2 C A 4: 116,660,148 (GRCm39) S451Y probably benign Het
Tjp1 A T 7: 64,962,679 (GRCm39) V1166E probably benign Het
Tmeff2 G A 1: 51,018,779 (GRCm39) V254M unknown Het
Tmem126a A G 7: 90,100,749 (GRCm39) probably null Het
Togaram2 C G 17: 71,993,699 (GRCm39) P2A probably benign Het
Trappc14 G A 5: 138,259,889 (GRCm39) T389I possibly damaging Het
Tssk4 C T 14: 55,889,211 (GRCm39) R246W probably damaging Het
Tubal3 C T 13: 3,982,708 (GRCm39) R163* probably null Het
Usp48 G A 4: 137,340,996 (GRCm39) G332E probably benign Het
Vezt T C 10: 93,820,027 (GRCm39) N446S probably damaging Het
Vim A T 2: 13,579,249 (GRCm39) T3S unknown Het
Vmn2r45 A G 7: 8,474,904 (GRCm39) L708P possibly damaging Het
Yes1 A G 5: 32,810,312 (GRCm39) Y157C probably damaging Het
Zfp358 A G 8: 3,545,810 (GRCm39) T131A probably benign Het
Zfp426 C T 9: 20,386,308 (GRCm39) V58M probably damaging Het
Zfp692 T C 11: 58,198,550 (GRCm39) S47P probably damaging Het
Zfp719 A T 7: 43,239,605 (GRCm39) T398S possibly damaging Het
Other mutations in Or9k2b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00933:Or9k2b APN 10 130,016,083 (GRCm39) missense probably benign 0.06
R0627:Or9k2b UTSW 10 130,016,557 (GRCm39) missense probably damaging 1.00
R1672:Or9k2b UTSW 10 130,016,261 (GRCm39) missense probably benign 0.00
R1834:Or9k2b UTSW 10 130,016,701 (GRCm39) missense probably benign 0.01
R1957:Or9k2b UTSW 10 130,015,847 (GRCm39) missense possibly damaging 0.77
R3717:Or9k2b UTSW 10 130,016,369 (GRCm39) missense possibly damaging 0.63
R5106:Or9k2b UTSW 10 130,016,177 (GRCm39) missense probably benign 0.37
R5837:Or9k2b UTSW 10 130,016,266 (GRCm39) missense probably damaging 1.00
R6348:Or9k2b UTSW 10 130,016,166 (GRCm39) missense probably benign 0.12
R6971:Or9k2b UTSW 10 130,016,638 (GRCm39) missense possibly damaging 0.95
R7181:Or9k2b UTSW 10 130,016,626 (GRCm39) missense possibly damaging 0.78
R7394:Or9k2b UTSW 10 130,016,123 (GRCm39) missense probably damaging 1.00
R8372:Or9k2b UTSW 10 130,016,656 (GRCm39) missense probably damaging 0.99
R8429:Or9k2b UTSW 10 130,016,092 (GRCm39) missense possibly damaging 0.87
R8679:Or9k2b UTSW 10 130,016,702 (GRCm39) missense probably benign 0.01
R8746:Or9k2b UTSW 10 130,016,086 (GRCm39) missense probably damaging 1.00
R9204:Or9k2b UTSW 10 130,016,566 (GRCm39) missense probably damaging 1.00
R9254:Or9k2b UTSW 10 130,016,605 (GRCm39) missense possibly damaging 0.85
R9379:Or9k2b UTSW 10 130,016,605 (GRCm39) missense possibly damaging 0.85
R9568:Or9k2b UTSW 10 130,015,814 (GRCm39) missense probably benign
Z1176:Or9k2b UTSW 10 130,015,834 (GRCm39) missense possibly damaging 0.61
Predicted Primers PCR Primer
(F):5'- TCAGTTCAGGAAATCTGTCAGG -3'
(R):5'- ATGTCCACACGTCTCTGCAC -3'

Sequencing Primer
(F):5'- ATCTGTCAGGGGTGAGATACATG -3'
(R):5'- GTCTCTGCACTCAGCTGGTG -3'
Posted On 2021-11-19