Incidental Mutation 'R9043:Zfp692'
ID 687861
Institutional Source Beutler Lab
Gene Symbol Zfp692
Ensembl Gene ENSMUSG00000037243
Gene Name zinc finger protein 692
Synonyms Zfp692-ps
MMRRC Submission 068870-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9043 (G1)
Quality Score 225.009
Status Validated
Chromosome 11
Chromosomal Location 58197895-58205453 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 58198550 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 47 (S47P)
Ref Sequence ENSEMBL: ENSMUSP00000131896 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049353] [ENSMUST00000153510]
AlphaFold Q3U381
Predicted Effect probably damaging
Transcript: ENSMUST00000049353
AA Change: S47P

PolyPhen 2 Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000131896
Gene: ENSMUSG00000037243
AA Change: S47P

DomainStartEndE-ValueType
low complexity region 10 23 N/A INTRINSIC
low complexity region 94 110 N/A INTRINSIC
low complexity region 159 175 N/A INTRINSIC
low complexity region 193 204 N/A INTRINSIC
low complexity region 215 232 N/A INTRINSIC
ZnF_C2H2 327 352 4.11e-2 SMART
ZnF_C2H2 358 382 2.05e-2 SMART
ZnF_C2H2 388 410 1.69e-3 SMART
ZnF_C2H2 416 438 1.69e-3 SMART
ZnF_C2H2 447 470 6.23e-2 SMART
low complexity region 502 520 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000153510
AA Change: S47P

PolyPhen 2 Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000126674
Gene: ENSMUSG00000037243
AA Change: S47P

DomainStartEndE-ValueType
low complexity region 10 23 N/A INTRINSIC
low complexity region 94 110 N/A INTRINSIC
low complexity region 159 175 N/A INTRINSIC
low complexity region 193 204 N/A INTRINSIC
low complexity region 215 232 N/A INTRINSIC
ZnF_C2H2 327 352 4.11e-2 SMART
ZnF_C2H2 358 382 2.05e-2 SMART
ZnF_C2H2 388 410 1.69e-3 SMART
ZnF_C2H2 416 438 1.69e-3 SMART
ZnF_C2H2 447 470 6.23e-2 SMART
low complexity region 502 520 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.0%
Validation Efficiency 99% (87/88)
Allele List at MGI
Other mutations in this stock
Total: 85 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933402J07Rik T A 8: 88,309,238 (GRCm39) S134T possibly damaging Het
Aadacl4 T A 4: 144,349,790 (GRCm39) L349Q probably damaging Het
Ankrd29 T C 18: 12,428,970 (GRCm39) N33S probably damaging Het
Arid3b T C 9: 57,699,900 (GRCm39) S536G possibly damaging Het
Art5 A C 7: 101,748,699 (GRCm39) M1R probably null Het
Arvcf T A 16: 18,218,452 (GRCm39) C545S probably damaging Het
Atpsckmt A G 15: 31,617,101 (GRCm39) T189A probably benign Het
Axin2 T A 11: 108,833,794 (GRCm39) N580K probably benign Het
Cdh23 T G 10: 60,151,478 (GRCm39) D2469A probably benign Het
Cep350 T A 1: 155,773,228 (GRCm39) T1781S probably damaging Het
Cfap65 T A 1: 74,943,847 (GRCm39) T1555S possibly damaging Het
Chga G A 12: 102,529,054 (GRCm39) E344K possibly damaging Het
Ckap2l A T 2: 129,126,892 (GRCm39) L429M probably damaging Het
Cpne7 C T 8: 123,856,951 (GRCm39) P402L probably damaging Het
Cyp2g1 A G 7: 26,509,256 (GRCm39) N110S probably benign Het
Cyp3a11 T C 5: 145,805,995 (GRCm39) D124G probably benign Het
Dgkq A T 5: 108,801,061 (GRCm39) V527D probably damaging Het
Dnah3 T C 7: 119,551,272 (GRCm39) I37V probably benign Het
Dnah9 T A 11: 65,845,680 (GRCm39) E3068V Het
Dusp23 T C 1: 172,460,184 (GRCm39) E89G probably null Het
Fam187a A G 11: 102,776,685 (GRCm39) Y163C possibly damaging Het
Gabrg2 T A 11: 41,865,662 (GRCm39) I106F probably damaging Het
Gpc2 A G 5: 138,277,193 (GRCm39) I78T probably benign Het
Gpr149 A C 3: 62,511,360 (GRCm39) L213R probably damaging Het
Grm1 A T 10: 10,565,056 (GRCm39) L1084* probably null Het
Gypa A G 8: 81,222,946 (GRCm39) T17A unknown Het
Gys2 A T 6: 142,376,059 (GRCm39) F534L probably damaging Het
Iqce A T 5: 140,651,810 (GRCm39) M721K probably benign Het
Klrc2 T A 6: 129,635,741 (GRCm39) Y129F probably damaging Het
Krt14 T C 11: 100,095,464 (GRCm39) S314G possibly damaging Het
L3mbtl3 T C 10: 26,156,152 (GRCm39) Q685R unknown Het
Lamb3 A T 1: 193,007,919 (GRCm39) K206* probably null Het
Lgr5 A G 10: 115,314,343 (GRCm39) I198T probably damaging Het
Mapk10 A T 5: 103,074,025 (GRCm39) probably benign Het
Mcm6 C T 1: 128,271,231 (GRCm39) D463N probably damaging Het
Med15 A T 16: 17,470,582 (GRCm39) W742R probably benign Het
Meis1 T A 11: 18,831,916 (GRCm39) Q374L possibly damaging Het
Nrxn3 T C 12: 89,227,252 (GRCm39) C296R probably damaging Het
Ntaq1 A G 15: 58,014,004 (GRCm39) Y67C possibly damaging Het
Oaf C T 9: 43,135,308 (GRCm39) A157T probably damaging Het
Oca2 T A 7: 55,927,189 (GRCm39) probably null Het
Or5b110-ps1 A T 19: 13,260,074 (GRCm39) M116K probably damaging Het
Or5b12 T A 19: 12,897,667 (GRCm39) E2V probably benign Het
Or5d36 T A 2: 87,900,983 (GRCm39) T248S possibly damaging Het
Or9k2b A T 10: 130,016,154 (GRCm39) H198Q probably benign Het
Pacs1 A G 19: 5,188,964 (GRCm39) I806T probably benign Het
Pax2 T A 19: 44,804,499 (GRCm39) S257T probably benign Het
Pbxip1 A T 3: 89,350,794 (GRCm39) T72S probably benign Het
Pcdhb14 T C 18: 37,581,851 (GRCm39) I319T probably damaging Het
Pcdhga2 C A 18: 37,802,963 (GRCm39) A269E possibly damaging Het
Pdzph1 A C 17: 59,280,535 (GRCm39) N582K probably benign Het
Plk2 A T 13: 110,533,194 (GRCm39) I186F probably damaging Het
Pzp A T 6: 128,471,742 (GRCm39) C895S probably damaging Het
Rasa2 A T 9: 96,484,770 (GRCm39) V148D probably damaging Het
Rgsl1 A T 1: 153,717,567 (GRCm39) I14N possibly damaging Het
Rhox3c C T X: 36,651,303 (GRCm39) probably benign Het
Rnf213 A G 11: 119,349,739 (GRCm39) R3867G Het
Rpap3 A G 15: 97,584,443 (GRCm39) Y334H possibly damaging Het
Scara3 A C 14: 66,169,070 (GRCm39) N182K probably damaging Het
Sh3bp1 A G 15: 78,791,449 (GRCm39) E412G possibly damaging Het
Sh3tc2 T A 18: 62,122,961 (GRCm39) I574N possibly damaging Het
Slc16a11 T C 11: 70,106,520 (GRCm39) Y253H probably damaging Het
Slc38a4 A T 15: 96,906,805 (GRCm39) V311E possibly damaging Het
Slc4a7 T C 14: 14,775,048 (GRCm38) L826P probably damaging Het
Spag9 T G 11: 93,951,085 (GRCm39) V83G Het
Sspo T G 6: 48,470,214 (GRCm39) V4560G probably benign Het
Stxbp2 T A 8: 3,684,478 (GRCm39) F144I Het
Tafa2 T C 10: 123,540,294 (GRCm39) V50A probably damaging Het
Tdh T C 14: 63,730,278 (GRCm39) I334V probably benign Het
Tesk2 C A 4: 116,660,148 (GRCm39) S451Y probably benign Het
Tjp1 A T 7: 64,962,679 (GRCm39) V1166E probably benign Het
Tmeff2 G A 1: 51,018,779 (GRCm39) V254M unknown Het
Tmem126a A G 7: 90,100,749 (GRCm39) probably null Het
Togaram2 C G 17: 71,993,699 (GRCm39) P2A probably benign Het
Trappc14 G A 5: 138,259,889 (GRCm39) T389I possibly damaging Het
Tssk4 C T 14: 55,889,211 (GRCm39) R246W probably damaging Het
Tubal3 C T 13: 3,982,708 (GRCm39) R163* probably null Het
Usp48 G A 4: 137,340,996 (GRCm39) G332E probably benign Het
Vezt T C 10: 93,820,027 (GRCm39) N446S probably damaging Het
Vim A T 2: 13,579,249 (GRCm39) T3S unknown Het
Vmn2r45 A G 7: 8,474,904 (GRCm39) L708P possibly damaging Het
Yes1 A G 5: 32,810,312 (GRCm39) Y157C probably damaging Het
Zfp358 A G 8: 3,545,810 (GRCm39) T131A probably benign Het
Zfp426 C T 9: 20,386,308 (GRCm39) V58M probably damaging Het
Zfp719 A T 7: 43,239,605 (GRCm39) T398S possibly damaging Het
Other mutations in Zfp692
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00978:Zfp692 APN 11 58,200,824 (GRCm39) missense possibly damaging 0.92
IGL00978:Zfp692 APN 11 58,204,855 (GRCm39) missense possibly damaging 0.94
IGL01667:Zfp692 APN 11 58,202,379 (GRCm39) missense probably damaging 1.00
IGL02209:Zfp692 APN 11 58,204,824 (GRCm39) nonsense probably null
IGL02873:Zfp692 APN 11 58,199,765 (GRCm39) missense probably damaging 1.00
R0255:Zfp692 UTSW 11 58,201,229 (GRCm39) splice site probably benign
R0267:Zfp692 UTSW 11 58,205,140 (GRCm39) missense possibly damaging 0.64
R0506:Zfp692 UTSW 11 58,199,881 (GRCm39) nonsense probably null
R0554:Zfp692 UTSW 11 58,205,053 (GRCm39) missense probably damaging 1.00
R0628:Zfp692 UTSW 11 58,200,449 (GRCm39) missense probably damaging 1.00
R0712:Zfp692 UTSW 11 58,205,140 (GRCm39) missense probably benign 0.00
R1112:Zfp692 UTSW 11 58,202,388 (GRCm39) missense probably damaging 1.00
R1493:Zfp692 UTSW 11 58,204,866 (GRCm39) missense probably damaging 1.00
R1768:Zfp692 UTSW 11 58,201,002 (GRCm39) splice site probably benign
R1853:Zfp692 UTSW 11 58,200,805 (GRCm39) missense possibly damaging 0.69
R3551:Zfp692 UTSW 11 58,200,254 (GRCm39) missense possibly damaging 0.52
R3552:Zfp692 UTSW 11 58,200,254 (GRCm39) missense possibly damaging 0.52
R4281:Zfp692 UTSW 11 58,205,091 (GRCm39) missense probably damaging 1.00
R4784:Zfp692 UTSW 11 58,200,997 (GRCm39) missense probably null 0.12
R5150:Zfp692 UTSW 11 58,198,413 (GRCm39) start codon destroyed probably null 0.77
R7035:Zfp692 UTSW 11 58,200,268 (GRCm39) critical splice donor site probably null
R7343:Zfp692 UTSW 11 58,202,331 (GRCm39) missense probably damaging 1.00
R7896:Zfp692 UTSW 11 58,205,062 (GRCm39) missense probably damaging 1.00
R8071:Zfp692 UTSW 11 58,198,560 (GRCm39) missense probably damaging 0.96
R8163:Zfp692 UTSW 11 58,201,199 (GRCm39) splice site probably null
R9487:Zfp692 UTSW 11 58,199,765 (GRCm39) missense probably damaging 1.00
R9777:Zfp692 UTSW 11 58,199,638 (GRCm39) missense probably benign 0.14
Z1186:Zfp692 UTSW 11 58,200,844 (GRCm39) missense probably benign
Z1186:Zfp692 UTSW 11 58,199,859 (GRCm39) missense probably benign 0.02
Z1187:Zfp692 UTSW 11 58,200,844 (GRCm39) missense probably benign
Z1187:Zfp692 UTSW 11 58,199,859 (GRCm39) missense probably benign 0.02
Z1188:Zfp692 UTSW 11 58,200,844 (GRCm39) missense probably benign
Z1188:Zfp692 UTSW 11 58,199,859 (GRCm39) missense probably benign 0.02
Z1189:Zfp692 UTSW 11 58,200,844 (GRCm39) missense probably benign
Z1189:Zfp692 UTSW 11 58,199,859 (GRCm39) missense probably benign 0.02
Z1190:Zfp692 UTSW 11 58,200,844 (GRCm39) missense probably benign
Z1190:Zfp692 UTSW 11 58,199,859 (GRCm39) missense probably benign 0.02
Z1191:Zfp692 UTSW 11 58,200,844 (GRCm39) missense probably benign
Z1191:Zfp692 UTSW 11 58,199,859 (GRCm39) missense probably benign 0.02
Z1192:Zfp692 UTSW 11 58,200,844 (GRCm39) missense probably benign
Z1192:Zfp692 UTSW 11 58,199,859 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- ATTCATTGCAGACGGAGCGAG -3'
(R):5'- GCACTCACACACTTACAGGG -3'

Sequencing Primer
(F):5'- TGTGTCTGTCCCGAAAGC -3'
(R):5'- TCACACACTTACAGGGCCAAC -3'
Posted On 2021-11-19