Incidental Mutation 'R9046:Xpot'
ID 688058
Institutional Source Beutler Lab
Gene Symbol Xpot
Ensembl Gene ENSMUSG00000034667
Gene Name exportin, tRNA (nuclear export receptor for tRNAs)
Synonyms EXPORTIN-T, 1110004L07Rik, C79645
Accession Numbers
Essential gene? Probably essential (E-score: 0.949) question?
Stock # R9046 (G1)
Quality Score 225.009
Status Validated
Chromosome 10
Chromosomal Location 121423285-121462237 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 121432149 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Stop codon at position 916 (C916*)
Ref Sequence ENSEMBL: ENSMUSP00000043488 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039810] [ENSMUST00000218004]
AlphaFold Q9CRT8
Predicted Effect probably null
Transcript: ENSMUST00000039810
AA Change: C916*
SMART Domains Protein: ENSMUSP00000043488
Gene: ENSMUSG00000034667
AA Change: C916*

DomainStartEndE-ValueType
IBN_N 21 89 1.37e-3 SMART
Pfam:Xpo1 98 248 5.1e-42 PFAM
low complexity region 386 399 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000218004
AA Change: C915*
Predicted Effect probably benign
Transcript: ENSMUST00000219334
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.8%
Validation Efficiency 99% (66/67)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and GTP-bound RAN. [provided by RefSeq, Jul 2008]
Allele List at MGI

All alleles(22) : Targeted, other(2) Gene trapped(20)

Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 T C 11: 9,243,525 (GRCm39) V1796A probably benign Het
Abca3 A G 17: 24,617,477 (GRCm39) D1058G probably damaging Het
Adgrg6 A G 10: 14,323,858 (GRCm39) V431A probably benign Het
Amdhd1 C T 10: 93,363,087 (GRCm39) D334N probably damaging Het
Ankrd50 A T 3: 38,506,642 (GRCm39) M252K probably benign Het
Anxa3 G A 5: 96,976,626 (GRCm39) R204Q probably damaging Het
Apmap T C 2: 150,426,093 (GRCm39) T352A probably benign Het
Arhgef4 A G 1: 34,850,846 (GRCm39) E464G possibly damaging Het
Atp11b T A 3: 35,852,740 (GRCm39) probably benign Het
Brwd1 T A 16: 95,829,402 (GRCm39) S1100C probably damaging Het
Ccm2l T A 2: 152,916,720 (GRCm39) I317N probably damaging Het
Ccr9 C T 9: 123,608,831 (GRCm39) T171I probably benign Het
Cdh23 A T 10: 60,218,303 (GRCm39) probably benign Het
Dact1 A G 12: 71,365,534 (GRCm39) I735V probably benign Het
Dok6 C A 18: 89,787,221 (GRCm39) V14L probably benign Het
Dthd1 A T 5: 62,984,603 (GRCm39) Y436F possibly damaging Het
Fndc9 G T 11: 46,128,889 (GRCm39) W136L probably damaging Het
Gal3st1 G A 11: 3,948,278 (GRCm39) V162I probably benign Het
Gart A G 16: 91,418,561 (GRCm39) S973P probably damaging Het
H2-T5 A T 17: 36,476,035 (GRCm39) probably null Het
Hsp90ab1 G A 17: 45,879,969 (GRCm39) P516S probably damaging Het
Htr1a G C 13: 105,581,816 (GRCm39) G352A probably damaging Het
Hycc2 T C 1: 58,568,945 (GRCm39) T545A probably damaging Het
Isg20 A T 7: 78,569,823 (GRCm39) R265* probably null Het
Kcmf1 C T 6: 72,825,455 (GRCm39) A213T probably damaging Het
Kdm3a A G 6: 71,572,540 (GRCm39) V1007A probably damaging Het
Klhl25 A G 7: 75,515,337 (GRCm39) E81G probably damaging Het
Klhl6 C A 16: 19,765,803 (GRCm39) V600F probably damaging Het
Kmt2b A G 7: 30,285,479 (GRCm39) V471A probably benign Het
Lap3 A G 5: 45,652,562 (GRCm39) T53A probably damaging Het
Lmntd1 A T 6: 145,365,565 (GRCm39) I188N probably damaging Het
Lrba A G 3: 86,302,543 (GRCm39) I1868V possibly damaging Het
Mef2d A T 3: 88,074,825 (GRCm39) Y337F probably benign Het
Mgat4e T C 1: 134,474,742 (GRCm39) T7A possibly damaging Het
Myo3a G T 2: 22,448,367 (GRCm39) L985F probably damaging Het
Myof T C 19: 37,923,112 (GRCm39) probably benign Het
Ncapg2 G A 12: 116,376,145 (GRCm39) G77S probably benign Het
Nostrin G T 2: 68,975,123 (GRCm39) V13L probably benign Het
Nup155 TGGG TGG 15: 8,157,919 (GRCm39) probably null Het
Or14j6 A G 17: 38,215,145 (GRCm39) K236R probably damaging Het
Or3a10 T C 11: 73,935,284 (GRCm39) D272G probably damaging Het
Or4a75 C T 2: 89,448,496 (GRCm39) probably benign Het
Or5b101 T C 19: 13,005,115 (GRCm39) N193D probably benign Het
Parp4 A C 14: 56,864,927 (GRCm39) K1025T probably damaging Het
Parvb T C 15: 84,174,639 (GRCm39) I144T probably benign Het
Peg10 GC GCTCC 6: 4,756,452 (GRCm39) probably benign Het
Phf10 A G 17: 15,175,160 (GRCm39) V195A probably damaging Het
Prpf18 A T 2: 4,640,464 (GRCm39) M257K possibly damaging Het
Ptcd3 A T 6: 71,870,364 (GRCm39) probably null Het
Ptprt G A 2: 161,372,361 (GRCm39) T1437M possibly damaging Het
Ptx3 T C 3: 66,132,153 (GRCm39) F225L probably damaging Het
Rpl3l A G 17: 24,947,435 (GRCm39) K50E probably damaging Het
Rubcn T C 16: 32,661,940 (GRCm39) N427D probably benign Het
Serpinb8 G A 1: 107,530,563 (GRCm39) A114T possibly damaging Het
Sgsm1 A G 5: 113,436,725 (GRCm39) V35A probably damaging Het
Slc22a2 G A 17: 12,834,234 (GRCm39) A501T probably null Het
Slu7 G A 11: 43,335,629 (GRCm39) C455Y probably damaging Het
Src C A 2: 157,307,795 (GRCm39) H235N probably damaging Het
Svopl T A 6: 37,998,531 (GRCm39) M248L probably benign Het
Tbx6 G A 7: 126,381,120 (GRCm39) probably null Het
Tprg1l A T 4: 154,242,913 (GRCm39) I239N probably damaging Het
Trafd1 A G 5: 121,513,189 (GRCm39) F350L probably benign Het
Trpv3 A G 11: 73,176,698 (GRCm39) Y359C probably damaging Het
Vmn1r46 T C 6: 89,953,585 (GRCm39) S145P probably damaging Het
Vmn2r11 A T 5: 109,202,850 (GRCm39) F76I probably benign Het
Zfp236 C T 18: 82,637,042 (GRCm39) E1415K possibly damaging Het
Other mutations in Xpot
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00340:Xpot APN 10 121,441,549 (GRCm39) missense probably benign
IGL01286:Xpot APN 10 121,438,243 (GRCm39) missense probably benign 0.03
IGL01364:Xpot APN 10 121,440,399 (GRCm39) missense probably benign 0.08
IGL01370:Xpot APN 10 121,440,399 (GRCm39) missense probably benign 0.08
IGL01516:Xpot APN 10 121,426,127 (GRCm39) splice site probably null
IGL01530:Xpot APN 10 121,447,433 (GRCm39) missense probably damaging 0.99
IGL02047:Xpot APN 10 121,437,267 (GRCm39) unclassified probably benign
IGL02207:Xpot APN 10 121,449,485 (GRCm39) missense probably damaging 1.00
IGL02340:Xpot APN 10 121,451,109 (GRCm39) missense probably damaging 1.00
IGL02408:Xpot APN 10 121,439,070 (GRCm39) missense probably damaging 1.00
IGL03150:Xpot APN 10 121,445,091 (GRCm39) missense probably benign 0.00
IGL03210:Xpot APN 10 121,451,132 (GRCm39) splice site probably benign
3-1:Xpot UTSW 10 121,449,264 (GRCm39) missense probably benign 0.00
R0077:Xpot UTSW 10 121,441,544 (GRCm39) missense probably benign 0.09
R1750:Xpot UTSW 10 121,438,932 (GRCm39) critical splice donor site probably null
R1806:Xpot UTSW 10 121,443,543 (GRCm39) splice site probably benign
R1950:Xpot UTSW 10 121,455,053 (GRCm39) missense probably benign
R2227:Xpot UTSW 10 121,458,765 (GRCm39) missense probably damaging 0.98
R2304:Xpot UTSW 10 121,447,488 (GRCm39) missense probably benign 0.02
R3914:Xpot UTSW 10 121,440,443 (GRCm39) missense possibly damaging 0.72
R4784:Xpot UTSW 10 121,450,968 (GRCm39) splice site probably null
R4884:Xpot UTSW 10 121,442,713 (GRCm39) missense probably damaging 1.00
R4904:Xpot UTSW 10 121,453,083 (GRCm39) missense probably benign 0.00
R5218:Xpot UTSW 10 121,455,043 (GRCm39) missense probably damaging 0.99
R5361:Xpot UTSW 10 121,436,765 (GRCm39) missense possibly damaging 0.71
R5651:Xpot UTSW 10 121,440,454 (GRCm39) missense probably damaging 0.99
R5894:Xpot UTSW 10 121,449,551 (GRCm39) missense probably damaging 1.00
R5915:Xpot UTSW 10 121,450,998 (GRCm39) missense probably damaging 0.97
R6139:Xpot UTSW 10 121,447,613 (GRCm39) missense probably benign 0.41
R6182:Xpot UTSW 10 121,442,163 (GRCm39) missense probably damaging 1.00
R6896:Xpot UTSW 10 121,449,390 (GRCm39) critical splice donor site probably null
R7024:Xpot UTSW 10 121,438,304 (GRCm39) missense probably benign 0.35
R7146:Xpot UTSW 10 121,442,678 (GRCm39) missense probably damaging 1.00
R7272:Xpot UTSW 10 121,453,094 (GRCm39) critical splice acceptor site probably null
R7556:Xpot UTSW 10 121,449,411 (GRCm39) missense probably benign 0.01
R7882:Xpot UTSW 10 121,454,996 (GRCm39) critical splice donor site probably null
R7916:Xpot UTSW 10 121,458,848 (GRCm39) start gained probably benign
R8087:Xpot UTSW 10 121,437,232 (GRCm39) missense probably benign
R8224:Xpot UTSW 10 121,443,513 (GRCm39) missense probably damaging 1.00
R8303:Xpot UTSW 10 121,447,405 (GRCm39) nonsense probably null
R9036:Xpot UTSW 10 121,447,580 (GRCm39) missense probably damaging 1.00
R9393:Xpot UTSW 10 121,445,600 (GRCm39) critical splice donor site probably null
R9716:Xpot UTSW 10 121,447,392 (GRCm39) missense probably benign
Z1088:Xpot UTSW 10 121,437,228 (GRCm39) missense probably damaging 0.99
Z1176:Xpot UTSW 10 121,453,079 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CAAGACAAACTGAATGCTATCTGGC -3'
(R):5'- CTACAGTCTTCAGATGGAGAGCTG -3'

Sequencing Primer
(F):5'- AACTGAATGCTATCTGGCTTTCTTG -3'
(R):5'- CTGGGGGCTTTGATTAAGTTGGTAC -3'
Posted On 2021-11-19