Incidental Mutation 'R9051:Ncapg'
ID 688355
Institutional Source Beutler Lab
Gene Symbol Ncapg
Ensembl Gene ENSMUSG00000015880
Gene Name non-SMC condensin I complex, subunit G
Synonyms MFT.M05.13, Hcapg, 5730507H05Rik
MMRRC Submission 068877-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.952) question?
Stock # R9051 (G1)
Quality Score 225.009
Status Not validated
Chromosome 5
Chromosomal Location 45827261-45857888 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 45853140 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Methionine at position 869 (L869M)
Ref Sequence ENSEMBL: ENSMUSP00000112871 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000045586] [ENSMUST00000117396] [ENSMUST00000121573] [ENSMUST00000190036]
AlphaFold E9PWG6
Predicted Effect probably benign
Transcript: ENSMUST00000045586
SMART Domains Protein: ENSMUSP00000042677
Gene: ENSMUSG00000015882

DomainStartEndE-ValueType
low complexity region 234 253 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000117396
AA Change: L869M

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000112871
Gene: ENSMUSG00000015880
AA Change: L869M

DomainStartEndE-ValueType
Pfam:Cnd3 557 863 7.4e-87 PFAM
low complexity region 864 874 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000121573
SMART Domains Protein: ENSMUSP00000112416
Gene: ENSMUSG00000015882

DomainStartEndE-ValueType
low complexity region 151 170 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000190036
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.9%
  • 20x: 99.6%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a subunit of the condensin complex, which is responsible for the condensation and stabilization of chromosomes during mitosis and meiosis. Phosphorylation of the encoded protein activates the condensin complex. There are pseudogenes for this gene on chromosomes 8 and 15. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Allele List at MGI
Other mutations in this stock
Total: 92 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 A T 11: 9,285,232 (GRCm39) T3289S probably damaging Het
Actr1b G T 1: 36,740,534 (GRCm39) Q240K probably benign Het
Adamts19 T C 18: 59,034,048 (GRCm39) V341A probably damaging Het
Akirin2 C A 4: 34,551,148 (GRCm39) S35* probably null Het
Alg3 G T 16: 20,427,765 (GRCm39) Q90K probably benign Het
Alox12 C T 11: 70,138,153 (GRCm39) R394H possibly damaging Het
Ankrd17 A C 5: 90,411,134 (GRCm39) M1387R probably damaging Het
Anp32b T G 4: 46,468,592 (GRCm39) F121V possibly damaging Het
Atp2b2 A G 6: 113,740,566 (GRCm39) V815A probably damaging Het
Atxn7l1 T C 12: 33,417,420 (GRCm39) L527S probably benign Het
B9d2 C T 7: 25,385,462 (GRCm39) L91F possibly damaging Het
Bcl2l11 T A 2: 128,000,221 (GRCm39) I188N probably damaging Het
Bnc2 A C 4: 84,210,138 (GRCm39) S744A probably benign Het
Casr T G 16: 36,330,414 (GRCm39) M307L probably benign Het
Cd109 CATTTATTTATTTATTTATTTATTTATTTATTTAT CATTTATTTATTTATTTATTTATTTATTTATTTATTTAT 9: 78,619,782 (GRCm39) probably benign Het
Cd109 TTATA TTATATATA 9: 78,619,813 (GRCm39) probably benign Het
Cd22 A G 7: 30,575,449 (GRCm39) S198P probably benign Het
Cd37 C A 7: 44,886,622 (GRCm39) V99L probably benign Het
Cdkn1c A G 7: 143,013,964 (GRCm39) S161P possibly damaging Het
Chi3l1 G T 1: 134,111,919 (GRCm39) probably null Het
Col4a2 T C 8: 11,498,198 (GRCm39) F1669S probably damaging Het
Dchs2 A T 3: 83,261,493 (GRCm39) H2587L probably benign Het
Ddx19a A T 8: 111,710,228 (GRCm39) M124K probably benign Het
Dnhd1 A T 7: 105,341,933 (GRCm39) H1244L possibly damaging Het
Dnpep G A 1: 75,292,329 (GRCm39) P165L probably damaging Het
Dpp3 T C 19: 4,973,172 (GRCm39) R141G probably benign Het
Dpysl3 T C 18: 43,462,814 (GRCm39) D521G probably damaging Het
Dusp4 T A 8: 35,284,345 (GRCm39) M220K probably damaging Het
Duxf4 G A 10: 58,071,711 (GRCm39) P168S probably damaging Het
Edc4 T A 8: 106,613,833 (GRCm39) L391Q probably damaging Het
Edrf1 A C 7: 133,273,207 (GRCm39) I1221L probably benign Het
Elavl2 A G 4: 91,199,847 (GRCm39) L12P probably benign Het
Fastkd3 T A 13: 68,733,071 (GRCm39) V464D probably damaging Het
Flt4 C A 11: 49,527,598 (GRCm39) N920K probably benign Het
Gimap3 T C 6: 48,742,259 (GRCm39) T224A probably benign Het
Gm9772 T A 17: 22,225,565 (GRCm39) K112* probably null Het
Gp5 C A 16: 30,127,976 (GRCm39) V233L Het
Gpr25 A T 1: 136,188,026 (GRCm39) W196R probably benign Het
Hs3st4 G A 7: 123,582,680 (GRCm39) G93S probably damaging Het
Igsf10 A G 3: 59,236,668 (GRCm39) L1171S probably benign Het
Itgb7 C T 15: 102,126,359 (GRCm39) G526S possibly damaging Het
Kcnh8 G A 17: 53,141,642 (GRCm39) C295Y probably damaging Het
Klhl8 A G 5: 104,015,709 (GRCm39) probably null Het
Krt1c T A 15: 101,726,317 (GRCm39) I74F unknown Het
Lamp5 G T 2: 135,911,054 (GRCm39) M262I probably benign Het
Lrp5 G T 19: 3,680,156 (GRCm39) R443S possibly damaging Het
Lrrc66 G T 5: 73,765,267 (GRCm39) A592E probably benign Het
Lrrc66 C T 5: 73,765,268 (GRCm39) A592T probably benign Het
Mettl23 T A 11: 116,744,865 (GRCm39) V93D unknown Het
Mier2 G A 10: 79,384,274 (GRCm39) R166W probably damaging Het
Mkrn2os G A 6: 115,562,325 (GRCm39) R213W probably benign Het
Mrps36 T A 13: 100,877,715 (GRCm39) I22L probably damaging Het
Msantd5f4 A G 4: 73,557,185 (GRCm39) N6S possibly damaging Het
Myocd T C 11: 65,077,795 (GRCm39) R667G probably benign Het
Ndst3 T C 3: 123,465,549 (GRCm39) N141S probably benign Het
Neu2 A T 1: 87,524,965 (GRCm39) R317* probably null Het
Nf1 G T 11: 79,364,168 (GRCm39) V1533F probably damaging Het
Npy4r T A 14: 33,869,083 (GRCm39) R68S possibly damaging Het
Nr1h5 T C 3: 102,853,427 (GRCm39) H360R probably null Het
Or1x6 G A 11: 50,938,938 (GRCm39) M1I probably null Het
Or4f14c T C 2: 111,941,441 (GRCm39) D52G probably damaging Het
Or9s15 T C 1: 92,524,978 (GRCm39) S246P probably damaging Het
Osmr A C 15: 6,882,027 (GRCm39) V39G probably damaging Het
Plekhm2 T C 4: 141,359,732 (GRCm39) D345G possibly damaging Het
Prkaa2 G T 4: 104,906,600 (GRCm39) S165* probably null Het
Qser1 A T 2: 104,593,292 (GRCm39) F1575Y possibly damaging Het
Rasl11a C A 5: 146,782,107 (GRCm39) D27E probably benign Het
Ret A T 6: 118,142,888 (GRCm39) Y929* probably null Het
Samd9l T A 6: 3,373,493 (GRCm39) E1256V probably benign Het
Scnn1g A G 7: 121,341,566 (GRCm39) I243V possibly damaging Het
Slc6a3 C T 13: 73,718,031 (GRCm39) R514* probably null Het
Sorcs3 C T 19: 48,194,809 (GRCm39) A64V probably benign Het
Sos1 G T 17: 80,715,723 (GRCm39) N1011K probably benign Het
Srbd1 C A 17: 86,428,115 (GRCm39) A373S possibly damaging Het
Tas1r1 C T 4: 152,122,833 (GRCm39) W4* probably null Het
Tcf15 C T 2: 151,985,690 (GRCm39) R49C probably damaging Het
Tex30 A G 1: 44,127,136 (GRCm39) V124A possibly damaging Het
Tgif1 T C 17: 71,151,882 (GRCm39) D243G Het
Tgtp1 T G 11: 48,877,916 (GRCm39) D263A probably damaging Het
Themis3 T A 17: 66,862,864 (GRCm39) T365S probably benign Het
Thoc2l C A 5: 104,666,818 (GRCm39) P447T probably benign Het
Tprg1 A T 16: 25,231,662 (GRCm39) I213F probably damaging Het
Traf4 A T 11: 78,052,005 (GRCm39) C160S probably damaging Het
Trio T C 15: 27,732,770 (GRCm39) E3037G possibly damaging Het
Ttbk2 G T 2: 120,575,911 (GRCm39) S1022* probably null Het
Ttc6 T C 12: 57,783,949 (GRCm39) Y1803H probably damaging Het
Ttn A C 2: 76,549,452 (GRCm39) Y31742D probably benign Het
Ttn G T 2: 76,617,595 (GRCm39) P16292Q probably damaging Het
Ubr5 A G 15: 38,002,503 (GRCm39) V1510A Het
Vac14 A G 8: 111,379,869 (GRCm39) D389G probably benign Het
Vwa8 A G 14: 79,324,150 (GRCm39) D1151G probably benign Het
Zfp608 T C 18: 55,032,266 (GRCm39) N558S probably damaging Het
Other mutations in Ncapg
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00662:Ncapg APN 5 45,850,502 (GRCm39) missense possibly damaging 0.53
IGL00777:Ncapg APN 5 45,853,107 (GRCm39) missense possibly damaging 0.93
IGL00857:Ncapg APN 5 45,833,927 (GRCm39) splice site probably null
IGL00916:Ncapg APN 5 45,828,534 (GRCm39) missense probably benign 0.37
IGL01293:Ncapg APN 5 45,839,196 (GRCm39) missense probably benign 0.01
IGL01360:Ncapg APN 5 45,831,727 (GRCm39) nonsense probably null
IGL01462:Ncapg APN 5 45,828,477 (GRCm39) missense probably benign 0.02
IGL01527:Ncapg APN 5 45,829,726 (GRCm39) missense possibly damaging 0.71
IGL01732:Ncapg APN 5 45,851,195 (GRCm39) missense probably damaging 1.00
IGL01788:Ncapg APN 5 45,828,423 (GRCm39) missense probably damaging 0.97
IGL01871:Ncapg APN 5 45,845,923 (GRCm39) missense probably benign 0.09
IGL03106:Ncapg APN 5 45,853,010 (GRCm39) missense probably damaging 1.00
IGL03124:Ncapg APN 5 45,828,551 (GRCm39) missense probably benign
R0086:Ncapg UTSW 5 45,834,086 (GRCm39) splice site probably null
R0109:Ncapg UTSW 5 45,851,090 (GRCm39) splice site probably null
R0110:Ncapg UTSW 5 45,850,489 (GRCm39) unclassified probably benign
R0377:Ncapg UTSW 5 45,851,159 (GRCm39) missense probably benign
R0432:Ncapg UTSW 5 45,829,770 (GRCm39) missense probably damaging 0.99
R0637:Ncapg UTSW 5 45,844,666 (GRCm39) missense probably damaging 1.00
R0835:Ncapg UTSW 5 45,838,790 (GRCm39) missense probably damaging 0.96
R0894:Ncapg UTSW 5 45,837,236 (GRCm39) missense probably null 0.24
R1069:Ncapg UTSW 5 45,833,272 (GRCm39) intron probably benign
R1216:Ncapg UTSW 5 45,857,261 (GRCm39) missense possibly damaging 0.68
R1967:Ncapg UTSW 5 45,857,252 (GRCm39) missense probably damaging 0.99
R2396:Ncapg UTSW 5 45,835,715 (GRCm39) missense probably benign 0.00
R3157:Ncapg UTSW 5 45,833,400 (GRCm39) missense probably benign
R3735:Ncapg UTSW 5 45,853,469 (GRCm39) missense probably benign 0.00
R3736:Ncapg UTSW 5 45,853,469 (GRCm39) missense probably benign 0.00
R3887:Ncapg UTSW 5 45,831,705 (GRCm39) missense probably benign
R4371:Ncapg UTSW 5 45,835,797 (GRCm39) missense probably benign
R4545:Ncapg UTSW 5 45,828,554 (GRCm39) missense probably damaging 1.00
R4546:Ncapg UTSW 5 45,828,554 (GRCm39) missense probably damaging 1.00
R4558:Ncapg UTSW 5 45,833,986 (GRCm39) missense probably benign 0.00
R4615:Ncapg UTSW 5 45,844,741 (GRCm39) missense probably benign 0.00
R4938:Ncapg UTSW 5 45,828,551 (GRCm39) missense probably benign
R5839:Ncapg UTSW 5 45,829,620 (GRCm39) missense probably damaging 0.99
R5871:Ncapg UTSW 5 45,853,039 (GRCm39) missense probably damaging 1.00
R6086:Ncapg UTSW 5 45,850,578 (GRCm39) missense probably damaging 1.00
R6418:Ncapg UTSW 5 45,839,158 (GRCm39) missense probably damaging 1.00
R6617:Ncapg UTSW 5 45,827,474 (GRCm39) missense probably benign 0.03
R7145:Ncapg UTSW 5 45,827,372 (GRCm39) missense possibly damaging 0.82
R7408:Ncapg UTSW 5 45,853,135 (GRCm39) missense probably benign 0.00
R7443:Ncapg UTSW 5 45,829,652 (GRCm39) missense probably benign 0.31
R7463:Ncapg UTSW 5 45,851,434 (GRCm39) splice site probably null
R7509:Ncapg UTSW 5 45,853,450 (GRCm39) missense probably benign 0.01
R7687:Ncapg UTSW 5 45,857,227 (GRCm39) missense probably benign 0.03
R7919:Ncapg UTSW 5 45,853,390 (GRCm39) missense probably benign 0.00
R8022:Ncapg UTSW 5 45,839,136 (GRCm39) missense probably damaging 1.00
R8177:Ncapg UTSW 5 45,851,095 (GRCm39) missense probably benign 0.00
R8261:Ncapg UTSW 5 45,844,730 (GRCm39) missense possibly damaging 0.90
R8263:Ncapg UTSW 5 45,849,134 (GRCm39) missense probably benign 0.44
R8324:Ncapg UTSW 5 45,853,010 (GRCm39) missense probably damaging 1.00
R8333:Ncapg UTSW 5 45,831,805 (GRCm39) missense probably damaging 0.96
R8742:Ncapg UTSW 5 45,851,216 (GRCm39) missense probably damaging 1.00
R9026:Ncapg UTSW 5 45,853,115 (GRCm39) missense probably benign 0.00
R9076:Ncapg UTSW 5 45,833,983 (GRCm39) missense probably benign
R9122:Ncapg UTSW 5 45,846,015 (GRCm39) missense possibly damaging 0.95
R9751:Ncapg UTSW 5 45,851,195 (GRCm39) missense probably damaging 1.00
R9776:Ncapg UTSW 5 45,829,834 (GRCm39) missense probably damaging 0.96
RF019:Ncapg UTSW 5 45,856,198 (GRCm39) missense probably benign 0.00
Z1088:Ncapg UTSW 5 45,837,222 (GRCm39) missense probably damaging 1.00
Z1177:Ncapg UTSW 5 45,829,844 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- TGAGGCAAATGAGACTTTTGC -3'
(R):5'- TCCTATCTGTTACATGCTGGGG -3'

Sequencing Primer
(F):5'- GCAAATGAGACTTTTGCAAGTTAGC -3'
(R):5'- GGGAAATGGAAAGTAAGTCATCTTTC -3'
Posted On 2021-11-19