Incidental Mutation 'R9056:Lyn'
ID |
688674 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Lyn
|
Ensembl Gene |
ENSMUSG00000042228 |
Gene Name |
LYN proto-oncogene, Src family tyrosine kinase |
Synonyms |
Hck-2, Yamaguchi sarcoma viral (v-yes-1) oncogene homolog |
MMRRC Submission |
068882-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R9056 (G1)
|
Quality Score |
162.009 |
Status
|
Not validated
|
Chromosome |
4 |
Chromosomal Location |
3676865-3791612 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to T
at 3780925 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Methionine to Leucine
at position 355
(M355L)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000038838
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000041377]
[ENSMUST00000103010]
|
AlphaFold |
P25911 |
PDB Structure |
Lyn Tyrosine Kinase Domain, apo form [X-RAY DIFFRACTION]
Lyn Tyrosine Kinase Domain-AMP-PNP complex [X-RAY DIFFRACTION]
Lyn Tyrosine Kinase Domain-PP2 complex [X-RAY DIFFRACTION]
Lyn Tyrosine Kinase Domain-Dasatinib complex [X-RAY DIFFRACTION]
Structure of unliganded Lyn SH2 domain [X-RAY DIFFRACTION]
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000041377
AA Change: M355L
PolyPhen 2
Score 0.893 (Sensitivity: 0.82; Specificity: 0.94)
|
SMART Domains |
Protein: ENSMUSP00000038838 Gene: ENSMUSG00000042228 AA Change: M355L
Domain | Start | End | E-Value | Type |
SH3
|
66 |
122 |
9.24e-21 |
SMART |
SH2
|
127 |
217 |
5.38e-33 |
SMART |
TyrKc
|
247 |
497 |
3.25e-137 |
SMART |
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000103010
AA Change: M334L
PolyPhen 2
Score 0.474 (Sensitivity: 0.89; Specificity: 0.90)
|
SMART Domains |
Protein: ENSMUSP00000100075 Gene: ENSMUSG00000042228 AA Change: M334L
Domain | Start | End | E-Value | Type |
SH3
|
45 |
101 |
5.8e-23 |
SMART |
SH2
|
106 |
196 |
3.3e-35 |
SMART |
TyrKc
|
226 |
476 |
1.6e-139 |
SMART |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.5%
- 20x: 98.0%
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011] PHENOTYPE: Homozygotes for targeted null mutations exhibit splenomegaly, reduced numbers of peripheral B cells, impaired immune responses, IgM hyperglobulinemia, autoimmunity with glomerulonephritis, and monocyte/macrophage tumors. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 64 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Abca13 |
T |
C |
11: 9,414,921 (GRCm39) |
I3996T |
probably damaging |
Het |
Adgra1 |
A |
G |
7: 139,432,492 (GRCm39) |
N110S |
probably damaging |
Het |
Arhgap31 |
T |
C |
16: 38,427,017 (GRCm39) |
T612A |
probably benign |
Het |
Atp13a4 |
C |
T |
16: 29,290,706 (GRCm39) |
|
probably null |
Het |
C1rb |
T |
C |
6: 124,553,984 (GRCm39) |
S352P |
probably damaging |
Het |
Cc2d2b |
T |
C |
19: 40,784,216 (GRCm39) |
I671T |
unknown |
Het |
Cmas |
A |
G |
6: 142,710,105 (GRCm39) |
D116G |
probably damaging |
Het |
Col24a1 |
T |
C |
3: 145,021,009 (GRCm39) |
V460A |
probably damaging |
Het |
Cracdl |
G |
A |
1: 37,663,553 (GRCm39) |
R782C |
possibly damaging |
Het |
Cubn |
T |
G |
2: 13,461,466 (GRCm39) |
D687A |
probably damaging |
Het |
Cul9 |
A |
C |
17: 46,854,696 (GRCm39) |
V2G |
probably damaging |
Het |
Elp3 |
T |
C |
14: 65,797,582 (GRCm39) |
Y382C |
probably damaging |
Het |
Fbxo11 |
A |
T |
17: 88,310,249 (GRCm39) |
I443K |
|
Het |
Fdps |
G |
A |
3: 89,006,639 (GRCm39) |
R84W |
probably benign |
Het |
Helz |
C |
T |
11: 107,547,019 (GRCm39) |
A1112V |
possibly damaging |
Het |
Herc1 |
T |
A |
9: 66,380,782 (GRCm39) |
M3553K |
probably benign |
Het |
Hspa12a |
T |
C |
19: 58,813,720 (GRCm39) |
Y135C |
probably damaging |
Het |
Hspa1l |
A |
G |
17: 35,196,849 (GRCm39) |
Y296C |
probably benign |
Het |
Ifna12 |
T |
G |
4: 88,521,079 (GRCm39) |
E156A |
possibly damaging |
Het |
Ilf3 |
C |
T |
9: 21,314,434 (GRCm39) |
Q689* |
probably null |
Het |
Ints1 |
A |
G |
5: 139,760,041 (GRCm39) |
|
probably null |
Het |
Itga8 |
T |
A |
2: 12,235,019 (GRCm39) |
D413V |
possibly damaging |
Het |
Kcnd3 |
C |
T |
3: 105,574,290 (GRCm39) |
L492F |
possibly damaging |
Het |
Kcnh5 |
T |
C |
12: 74,944,774 (GRCm39) |
K825R |
probably benign |
Het |
Kcnma1 |
A |
G |
14: 23,700,214 (GRCm39) |
I194T |
possibly damaging |
Het |
Kmo |
A |
G |
1: 175,465,108 (GRCm39) |
R30G |
probably damaging |
Het |
Krtap19-4 |
C |
A |
16: 88,681,801 (GRCm39) |
G52C |
unknown |
Het |
Ksr1 |
A |
G |
11: 78,918,465 (GRCm39) |
V563A |
possibly damaging |
Het |
Med13 |
A |
T |
11: 86,189,660 (GRCm39) |
L1083* |
probably null |
Het |
Mfsd13a |
A |
G |
19: 46,354,900 (GRCm39) |
T26A |
probably benign |
Het |
Mup14 |
T |
C |
4: 61,259,430 (GRCm39) |
I41V |
probably benign |
Het |
Myo9b |
T |
A |
8: 71,804,906 (GRCm39) |
S1466T |
probably benign |
Het |
Nampt |
T |
C |
12: 32,888,458 (GRCm39) |
|
probably null |
Het |
Nbeal1 |
T |
C |
1: 60,317,885 (GRCm39) |
Y1941H |
probably damaging |
Het |
Nyap2 |
C |
T |
1: 81,314,314 (GRCm39) |
A670V |
probably benign |
Het |
Or10h28 |
A |
G |
17: 33,487,794 (GRCm39) |
Y32C |
probably damaging |
Het |
Or2aj6 |
A |
G |
16: 19,443,791 (GRCm39) |
S20P |
probably benign |
Het |
Or4k44 |
T |
C |
2: 111,368,488 (GRCm39) |
I49V |
probably benign |
Het |
Or4m1 |
T |
C |
14: 50,557,999 (GRCm39) |
I98V |
probably damaging |
Het |
Or8g31-ps1 |
T |
C |
9: 39,276,416 (GRCm39) |
V187A |
unknown |
Het |
Pcdh15 |
A |
G |
10: 74,221,731 (GRCm39) |
D677G |
probably damaging |
Het |
Pogz |
T |
A |
3: 94,787,530 (GRCm39) |
S1373T |
probably benign |
Het |
Ptprj |
T |
C |
2: 90,288,613 (GRCm39) |
D691G |
probably benign |
Het |
Qpctl |
T |
A |
7: 18,880,961 (GRCm39) |
D157V |
probably damaging |
Het |
Rbbp8 |
T |
C |
18: 11,810,677 (GRCm39) |
F60L |
possibly damaging |
Het |
Ripor1 |
T |
A |
8: 106,344,072 (GRCm39) |
L402Q |
possibly damaging |
Het |
Rptn |
C |
T |
3: 93,304,412 (GRCm39) |
H582Y |
probably benign |
Het |
Rusc1 |
T |
A |
3: 88,996,990 (GRCm39) |
Q611L |
probably damaging |
Het |
Ryr2 |
A |
G |
13: 11,610,817 (GRCm39) |
V4003A |
possibly damaging |
Het |
Siglech |
T |
A |
7: 55,422,294 (GRCm39) |
W300R |
probably benign |
Het |
Slc25a51 |
T |
C |
4: 45,399,494 (GRCm39) |
D232G |
probably damaging |
Het |
Slc6a11 |
T |
A |
6: 114,220,905 (GRCm39) |
C479S |
probably benign |
Het |
Spata31h1 |
T |
C |
10: 82,127,101 (GRCm39) |
T1970A |
probably benign |
Het |
Sspo |
G |
T |
6: 48,450,608 (GRCm39) |
G2599V |
probably damaging |
Het |
Tfpt |
T |
A |
7: 3,627,604 (GRCm39) |
E116V |
probably null |
Het |
Tmem260 |
T |
A |
14: 48,717,774 (GRCm39) |
V121E |
probably benign |
Het |
Tmem54 |
T |
C |
4: 129,002,120 (GRCm39) |
F45L |
probably benign |
Het |
Trim2 |
T |
A |
3: 84,080,128 (GRCm39) |
N631I |
probably damaging |
Het |
Tshr |
C |
T |
12: 91,474,563 (GRCm39) |
T179I |
probably damaging |
Het |
Vmn1r40 |
A |
G |
6: 89,691,198 (GRCm39) |
N5S |
probably benign |
Het |
Vmn2r68 |
A |
G |
7: 84,871,420 (GRCm39) |
V621A |
possibly damaging |
Het |
Zc2hc1c |
TTTATCC |
T |
12: 85,343,230 (GRCm39) |
|
probably benign |
Het |
Zfp644 |
G |
A |
5: 106,783,944 (GRCm39) |
Q837* |
probably null |
Het |
Zfp773 |
A |
T |
7: 7,135,989 (GRCm39) |
N202K |
probably damaging |
Het |
|
Other mutations in Lyn |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01752:Lyn
|
APN |
4 |
3,743,286 (GRCm39) |
missense |
probably benign |
|
IGL02744:Lyn
|
APN |
4 |
3,738,808 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02860:Lyn
|
APN |
4 |
3,745,594 (GRCm39) |
missense |
possibly damaging |
0.77 |
IGL03328:Lyn
|
APN |
4 |
3,745,327 (GRCm39) |
missense |
probably benign |
0.01 |
IGL03370:Lyn
|
APN |
4 |
3,780,931 (GRCm39) |
missense |
possibly damaging |
0.81 |
bibb
|
UTSW |
4 |
3,783,055 (GRCm39) |
missense |
probably damaging |
1.00 |
butterhead
|
UTSW |
4 |
3,748,765 (GRCm39) |
missense |
probably benign |
0.11 |
Cress
|
UTSW |
4 |
3,789,908 (GRCm39) |
nonsense |
probably null |
|
Friede
|
UTSW |
4 |
3,789,834 (GRCm39) |
nonsense |
probably null |
|
Kohlrabi
|
UTSW |
4 |
3,783,089 (GRCm39) |
missense |
possibly damaging |
0.74 |
lechuga
|
UTSW |
4 |
3,783,050 (GRCm39) |
missense |
probably damaging |
1.00 |
Lemon
|
UTSW |
4 |
3,746,768 (GRCm39) |
missense |
probably damaging |
1.00 |
Pacific
|
UTSW |
4 |
3,745,330 (GRCm39) |
missense |
probably damaging |
1.00 |
water
|
UTSW |
4 |
3,748,787 (GRCm39) |
missense |
possibly damaging |
0.93 |
R0079:Lyn
|
UTSW |
4 |
3,746,768 (GRCm39) |
missense |
probably damaging |
1.00 |
R0089:Lyn
|
UTSW |
4 |
3,748,768 (GRCm39) |
missense |
probably benign |
0.23 |
R0582:Lyn
|
UTSW |
4 |
3,743,296 (GRCm39) |
missense |
probably damaging |
1.00 |
R0747:Lyn
|
UTSW |
4 |
3,745,638 (GRCm39) |
splice site |
probably benign |
|
R1460:Lyn
|
UTSW |
4 |
3,789,908 (GRCm39) |
nonsense |
probably null |
|
R1615:Lyn
|
UTSW |
4 |
3,748,765 (GRCm39) |
missense |
probably benign |
0.11 |
R1654:Lyn
|
UTSW |
4 |
3,789,912 (GRCm39) |
missense |
probably damaging |
0.99 |
R1703:Lyn
|
UTSW |
4 |
3,738,867 (GRCm39) |
splice site |
probably null |
|
R2301:Lyn
|
UTSW |
4 |
3,780,959 (GRCm39) |
missense |
probably damaging |
1.00 |
R2421:Lyn
|
UTSW |
4 |
3,748,787 (GRCm39) |
missense |
possibly damaging |
0.93 |
R2512:Lyn
|
UTSW |
4 |
3,745,542 (GRCm39) |
missense |
probably benign |
0.01 |
R3418:Lyn
|
UTSW |
4 |
3,746,833 (GRCm39) |
missense |
probably damaging |
0.97 |
R3419:Lyn
|
UTSW |
4 |
3,746,833 (GRCm39) |
missense |
probably damaging |
0.97 |
R3701:Lyn
|
UTSW |
4 |
3,742,455 (GRCm39) |
missense |
probably benign |
|
R3702:Lyn
|
UTSW |
4 |
3,742,455 (GRCm39) |
missense |
probably benign |
|
R3736:Lyn
|
UTSW |
4 |
3,745,330 (GRCm39) |
missense |
probably damaging |
1.00 |
R4350:Lyn
|
UTSW |
4 |
3,789,796 (GRCm39) |
missense |
probably damaging |
0.99 |
R4351:Lyn
|
UTSW |
4 |
3,789,796 (GRCm39) |
missense |
probably damaging |
0.99 |
R4352:Lyn
|
UTSW |
4 |
3,789,796 (GRCm39) |
missense |
probably damaging |
0.99 |
R4649:Lyn
|
UTSW |
4 |
3,738,850 (GRCm39) |
missense |
probably benign |
|
R5738:Lyn
|
UTSW |
4 |
3,782,987 (GRCm39) |
missense |
probably damaging |
1.00 |
R5875:Lyn
|
UTSW |
4 |
3,745,631 (GRCm39) |
splice site |
probably null |
|
R6375:Lyn
|
UTSW |
4 |
3,745,527 (GRCm39) |
missense |
probably damaging |
1.00 |
R7029:Lyn
|
UTSW |
4 |
3,782,996 (GRCm39) |
missense |
probably damaging |
0.98 |
R7621:Lyn
|
UTSW |
4 |
3,789,834 (GRCm39) |
nonsense |
probably null |
|
R7726:Lyn
|
UTSW |
4 |
3,756,428 (GRCm39) |
nonsense |
probably null |
|
R7940:Lyn
|
UTSW |
4 |
3,783,089 (GRCm39) |
missense |
possibly damaging |
0.74 |
R8169:Lyn
|
UTSW |
4 |
3,783,050 (GRCm39) |
missense |
probably damaging |
1.00 |
R8341:Lyn
|
UTSW |
4 |
3,743,304 (GRCm39) |
critical splice donor site |
probably null |
|
R8782:Lyn
|
UTSW |
4 |
3,783,055 (GRCm39) |
missense |
probably damaging |
1.00 |
R9353:Lyn
|
UTSW |
4 |
3,746,804 (GRCm39) |
missense |
possibly damaging |
0.71 |
R9567:Lyn
|
UTSW |
4 |
3,746,757 (GRCm39) |
missense |
probably benign |
0.00 |
|
Predicted Primers |
PCR Primer
(F):5'- TCATCATTGTAGATGTTAGGGACAG -3'
(R):5'- CACAAGCCTGCAGTGAGATG -3'
Sequencing Primer
(F):5'- AGGATTCTAAGGGTGACTTTAGCAC -3'
(R):5'- CTGCAGTGAGATGGCCTCTG -3'
|
Posted On |
2021-11-19 |