Mutagenetix > Incidental Mutation

Incidental Mutation 'R9056:Vmn2r68'

688690

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r68

Ensembl Gene

ENSMUSG00000096861

Gene Name

vomeronasal 2, receptor 68

Synonyms

EG620697, Vmn2r68-ps

MMRRC Submission

068882-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.085) question?

Stock #

R9056 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

84870726-84886912 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 84871420 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 621 (V621A)

Ref Sequence

ENSEMBL: ENSMUSP00000129411 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000061074]

AlphaFold

L7N2B3

Predicted Effect

possibly damaging
Transcript: ENSMUST00000061074
AA Change: V621A

PolyPhen 2 Score 0.710 (Sensitivity: 0.86; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000129411
Gene: ENSMUSG00000096861
AA Change: V621A

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	77	463	4.5e-28	PFAM
Pfam:NCD3G	507	559	1.1e-18	PFAM
Pfam:7tm_3	589	827	3.7e-53	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.5%
20x: 98.0%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 64 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	T	C	11: 9,414,921 (GRCm39)	I3996T	probably damaging	Het
Adgra1	A	G	7: 139,432,492 (GRCm39)	N110S	probably damaging	Het
Arhgap31	T	C	16: 38,427,017 (GRCm39)	T612A	probably benign	Het
Atp13a4	C	T	16: 29,290,706 (GRCm39)		probably null	Het
C1rb	T	C	6: 124,553,984 (GRCm39)	S352P	probably damaging	Het
Cc2d2b	T	C	19: 40,784,216 (GRCm39)	I671T	unknown	Het
Cmas	A	G	6: 142,710,105 (GRCm39)	D116G	probably damaging	Het
Col24a1	T	C	3: 145,021,009 (GRCm39)	V460A	probably damaging	Het
Cracdl	G	A	1: 37,663,553 (GRCm39)	R782C	possibly damaging	Het
Cubn	T	G	2: 13,461,466 (GRCm39)	D687A	probably damaging	Het
Cul9	A	C	17: 46,854,696 (GRCm39)	V2G	probably damaging	Het
Elp3	T	C	14: 65,797,582 (GRCm39)	Y382C	probably damaging	Het
Fbxo11	A	T	17: 88,310,249 (GRCm39)	I443K		Het
Fdps	G	A	3: 89,006,639 (GRCm39)	R84W	probably benign	Het
Helz	C	T	11: 107,547,019 (GRCm39)	A1112V	possibly damaging	Het
Herc1	T	A	9: 66,380,782 (GRCm39)	M3553K	probably benign	Het
Hspa12a	T	C	19: 58,813,720 (GRCm39)	Y135C	probably damaging	Het
Hspa1l	A	G	17: 35,196,849 (GRCm39)	Y296C	probably benign	Het
Ifna12	T	G	4: 88,521,079 (GRCm39)	E156A	possibly damaging	Het
Ilf3	C	T	9: 21,314,434 (GRCm39)	Q689*	probably null	Het
Ints1	A	G	5: 139,760,041 (GRCm39)		probably null	Het
Itga8	T	A	2: 12,235,019 (GRCm39)	D413V	possibly damaging	Het
Kcnd3	C	T	3: 105,574,290 (GRCm39)	L492F	possibly damaging	Het
Kcnh5	T	C	12: 74,944,774 (GRCm39)	K825R	probably benign	Het
Kcnma1	A	G	14: 23,700,214 (GRCm39)	I194T	possibly damaging	Het
Kmo	A	G	1: 175,465,108 (GRCm39)	R30G	probably damaging	Het
Krtap19-4	C	A	16: 88,681,801 (GRCm39)	G52C	unknown	Het
Ksr1	A	G	11: 78,918,465 (GRCm39)	V563A	possibly damaging	Het
Lyn	A	T	4: 3,780,925 (GRCm39)	M355L	possibly damaging	Het
Med13	A	T	11: 86,189,660 (GRCm39)	L1083*	probably null	Het
Mfsd13a	A	G	19: 46,354,900 (GRCm39)	T26A	probably benign	Het
Mup14	T	C	4: 61,259,430 (GRCm39)	I41V	probably benign	Het
Myo9b	T	A	8: 71,804,906 (GRCm39)	S1466T	probably benign	Het
Nampt	T	C	12: 32,888,458 (GRCm39)		probably null	Het
Nbeal1	T	C	1: 60,317,885 (GRCm39)	Y1941H	probably damaging	Het
Nyap2	C	T	1: 81,314,314 (GRCm39)	A670V	probably benign	Het
Or10h28	A	G	17: 33,487,794 (GRCm39)	Y32C	probably damaging	Het
Or2aj6	A	G	16: 19,443,791 (GRCm39)	S20P	probably benign	Het
Or4k44	T	C	2: 111,368,488 (GRCm39)	I49V	probably benign	Het
Or4m1	T	C	14: 50,557,999 (GRCm39)	I98V	probably damaging	Het
Or8g31-ps1	T	C	9: 39,276,416 (GRCm39)	V187A	unknown	Het
Pcdh15	A	G	10: 74,221,731 (GRCm39)	D677G	probably damaging	Het
Pogz	T	A	3: 94,787,530 (GRCm39)	S1373T	probably benign	Het
Ptprj	T	C	2: 90,288,613 (GRCm39)	D691G	probably benign	Het
Qpctl	T	A	7: 18,880,961 (GRCm39)	D157V	probably damaging	Het
Rbbp8	T	C	18: 11,810,677 (GRCm39)	F60L	possibly damaging	Het
Ripor1	T	A	8: 106,344,072 (GRCm39)	L402Q	possibly damaging	Het
Rptn	C	T	3: 93,304,412 (GRCm39)	H582Y	probably benign	Het
Rusc1	T	A	3: 88,996,990 (GRCm39)	Q611L	probably damaging	Het
Ryr2	A	G	13: 11,610,817 (GRCm39)	V4003A	possibly damaging	Het
Siglech	T	A	7: 55,422,294 (GRCm39)	W300R	probably benign	Het
Slc25a51	T	C	4: 45,399,494 (GRCm39)	D232G	probably damaging	Het
Slc6a11	T	A	6: 114,220,905 (GRCm39)	C479S	probably benign	Het
Spata31h1	T	C	10: 82,127,101 (GRCm39)	T1970A	probably benign	Het
Sspo	G	T	6: 48,450,608 (GRCm39)	G2599V	probably damaging	Het
Tfpt	T	A	7: 3,627,604 (GRCm39)	E116V	probably null	Het
Tmem260	T	A	14: 48,717,774 (GRCm39)	V121E	probably benign	Het
Tmem54	T	C	4: 129,002,120 (GRCm39)	F45L	probably benign	Het
Trim2	T	A	3: 84,080,128 (GRCm39)	N631I	probably damaging	Het
Tshr	C	T	12: 91,474,563 (GRCm39)	T179I	probably damaging	Het
Vmn1r40	A	G	6: 89,691,198 (GRCm39)	N5S	probably benign	Het
Zc2hc1c	TTTATCC	T	12: 85,343,230 (GRCm39)		probably benign	Het
Zfp644	G	A	5: 106,783,944 (GRCm39)	Q837*	probably null	Het
Zfp773	A	T	7: 7,135,989 (GRCm39)	N202K	probably damaging	Het

Other mutations in Vmn2r68

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01391:Vmn2r68	APN	7	84,886,819 (GRCm39)	missense	probably benign
IGL01477:Vmn2r68	APN	7	84,882,691 (GRCm39)	missense	probably damaging	1.00
IGL01600:Vmn2r68	APN	7	84,871,468 (GRCm39)	missense	probably benign	0.39
IGL01979:Vmn2r68	APN	7	84,871,325 (GRCm39)	missense	probably benign
IGL01999:Vmn2r68	APN	7	84,871,439 (GRCm39)	missense	probably damaging	1.00
IGL02269:Vmn2r68	APN	7	84,870,947 (GRCm39)	missense	possibly damaging	0.84
IGL02517:Vmn2r68	APN	7	84,871,153 (GRCm39)	nonsense	probably null
IGL02827:Vmn2r68	APN	7	84,886,800 (GRCm39)	missense	probably damaging	1.00
IGL02852:Vmn2r68	APN	7	84,882,595 (GRCm39)	missense	probably damaging	1.00
IGL02982:Vmn2r68	APN	7	84,883,649 (GRCm39)	missense	probably benign	0.12
IGL03099:Vmn2r68	APN	7	84,871,448 (GRCm39)	nonsense	probably null
IGL03166:Vmn2r68	APN	7	84,871,331 (GRCm39)	missense	probably benign	0.01
IGL03168:Vmn2r68	APN	7	84,870,972 (GRCm39)	missense	probably damaging	1.00
IGL03243:Vmn2r68	APN	7	84,882,963 (GRCm39)	missense	possibly damaging	0.66
F5770:Vmn2r68	UTSW	7	84,871,088 (GRCm39)	missense	probably benign	0.01
R0280:Vmn2r68	UTSW	7	84,882,466 (GRCm39)	critical splice donor site	probably null
R0280:Vmn2r68	UTSW	7	84,882,457 (GRCm39)	splice site	probably benign
R0281:Vmn2r68	UTSW	7	84,882,466 (GRCm39)	critical splice donor site	probably null
R0281:Vmn2r68	UTSW	7	84,882,457 (GRCm39)	splice site	probably benign
R0348:Vmn2r68	UTSW	7	84,870,884 (GRCm39)	missense	possibly damaging	0.50
R0390:Vmn2r68	UTSW	7	84,882,466 (GRCm39)	critical splice donor site	probably null
R0390:Vmn2r68	UTSW	7	84,882,457 (GRCm39)	splice site	probably benign
R0722:Vmn2r68	UTSW	7	84,870,794 (GRCm39)	missense	possibly damaging	0.95
R1129:Vmn2r68	UTSW	7	84,886,712 (GRCm39)	splice site	probably null
R1136:Vmn2r68	UTSW	7	84,871,549 (GRCm39)	missense	possibly damaging	0.81
R1319:Vmn2r68	UTSW	7	84,881,700 (GRCm39)	missense	probably damaging	0.96
R1614:Vmn2r68	UTSW	7	84,870,946 (GRCm39)	missense	possibly damaging	0.93
R1682:Vmn2r68	UTSW	7	84,882,574 (GRCm39)	missense	possibly damaging	0.68
R1837:Vmn2r68	UTSW	7	84,882,886 (GRCm39)	missense	probably damaging	0.96
R1893:Vmn2r68	UTSW	7	84,883,867 (GRCm39)	nonsense	probably null
R1908:Vmn2r68	UTSW	7	84,883,260 (GRCm39)	missense	probably benign	0.09
R1909:Vmn2r68	UTSW	7	84,883,260 (GRCm39)	missense	probably benign	0.09
R1951:Vmn2r68	UTSW	7	84,883,102 (GRCm39)	missense	probably damaging	1.00
R2177:Vmn2r68	UTSW	7	84,871,123 (GRCm39)	missense	probably benign	0.01
R2178:Vmn2r68	UTSW	7	84,870,758 (GRCm39)	frame shift	probably null
R2185:Vmn2r68	UTSW	7	84,882,901 (GRCm39)	nonsense	probably null
R2188:Vmn2r68	UTSW	7	84,870,758 (GRCm39)	frame shift	probably null
R2282:Vmn2r68	UTSW	7	84,870,859 (GRCm39)	missense	possibly damaging	0.65
R2567:Vmn2r68	UTSW	7	84,883,803 (GRCm39)	missense	probably benign
R2869:Vmn2r68	UTSW	7	84,882,834 (GRCm39)	missense	probably benign	0.25
R2869:Vmn2r68	UTSW	7	84,882,834 (GRCm39)	missense	probably benign	0.25
R2870:Vmn2r68	UTSW	7	84,882,834 (GRCm39)	missense	probably benign	0.25
R2870:Vmn2r68	UTSW	7	84,882,834 (GRCm39)	missense	probably benign	0.25
R2871:Vmn2r68	UTSW	7	84,882,834 (GRCm39)	missense	probably benign	0.25
R2871:Vmn2r68	UTSW	7	84,882,834 (GRCm39)	missense	probably benign	0.25
R2873:Vmn2r68	UTSW	7	84,882,834 (GRCm39)	missense	probably benign	0.25
R2874:Vmn2r68	UTSW	7	84,882,834 (GRCm39)	missense	probably benign	0.25
R3149:Vmn2r68	UTSW	7	84,886,875 (GRCm39)	missense	probably benign	0.00
R3401:Vmn2r68	UTSW	7	84,870,758 (GRCm39)	frame shift	probably null
R3978:Vmn2r68	UTSW	7	84,881,670 (GRCm39)	missense	probably benign	0.00
R4399:Vmn2r68	UTSW	7	84,870,758 (GRCm39)	frame shift	probably null
R4401:Vmn2r68	UTSW	7	84,870,758 (GRCm39)	frame shift	probably null
R4421:Vmn2r68	UTSW	7	84,870,758 (GRCm39)	frame shift	probably null
R4478:Vmn2r68	UTSW	7	84,870,758 (GRCm39)	frame shift	probably null
R4479:Vmn2r68	UTSW	7	84,870,758 (GRCm39)	frame shift	probably null
R4495:Vmn2r68	UTSW	7	84,870,758 (GRCm39)	frame shift	probably null
R4628:Vmn2r68	UTSW	7	84,883,673 (GRCm39)	missense	probably benign	0.00
R4649:Vmn2r68	UTSW	7	84,870,743 (GRCm39)	missense	probably benign
R4654:Vmn2r68	UTSW	7	84,882,769 (GRCm39)	nonsense	probably null
R4793:Vmn2r68	UTSW	7	84,883,648 (GRCm39)	missense	probably benign	0.01
R5007:Vmn2r68	UTSW	7	84,881,622 (GRCm39)	missense	probably benign
R5021:Vmn2r68	UTSW	7	84,882,942 (GRCm39)	missense	possibly damaging	0.62
R5082:Vmn2r68	UTSW	7	84,883,076 (GRCm39)	missense	probably benign	0.12
R5177:Vmn2r68	UTSW	7	84,871,199 (GRCm39)	missense	probably damaging	0.99
R5221:Vmn2r68	UTSW	7	84,871,085 (GRCm39)	missense	probably damaging	1.00
R5514:Vmn2r68	UTSW	7	84,886,767 (GRCm39)	missense	possibly damaging	0.92
R5521:Vmn2r68	UTSW	7	84,882,926 (GRCm39)	missense	probably benign	0.03
R5563:Vmn2r68	UTSW	7	84,871,283 (GRCm39)	missense	probably damaging	1.00
R5664:Vmn2r68	UTSW	7	84,882,978 (GRCm39)	missense	probably benign	0.02
R5829:Vmn2r68	UTSW	7	84,886,812 (GRCm39)	missense	probably benign	0.00
R6016:Vmn2r68	UTSW	7	84,871,453 (GRCm39)	missense	probably damaging	0.99
R6356:Vmn2r68	UTSW	7	84,883,048 (GRCm39)	missense	possibly damaging	0.85
R6413:Vmn2r68	UTSW	7	84,870,973 (GRCm39)	missense	probably damaging	1.00
R6418:Vmn2r68	UTSW	7	84,882,915 (GRCm39)	missense	probably benign
R6699:Vmn2r68	UTSW	7	84,881,583 (GRCm39)	missense	possibly damaging	0.58
R7287:Vmn2r68	UTSW	7	84,871,460 (GRCm39)	missense	probably benign	0.33
R7319:Vmn2r68	UTSW	7	84,883,042 (GRCm39)	missense	probably benign
R7374:Vmn2r68	UTSW	7	84,881,607 (GRCm39)	missense	possibly damaging	0.66
R7585:Vmn2r68	UTSW	7	84,881,587 (GRCm39)	missense	probably damaging	1.00
R7605:Vmn2r68	UTSW	7	84,883,116 (GRCm39)	missense	probably benign	0.01
R7892:Vmn2r68	UTSW	7	84,883,722 (GRCm39)	missense	probably benign
R7979:Vmn2r68	UTSW	7	84,883,625 (GRCm39)	critical splice donor site	probably null
R8177:Vmn2r68	UTSW	7	84,871,422 (GRCm39)	nonsense	probably null
R8349:Vmn2r68	UTSW	7	84,882,785 (GRCm39)	missense	probably damaging	1.00
R8378:Vmn2r68	UTSW	7	84,871,108 (GRCm39)	missense	probably benign	0.00
R8397:Vmn2r68	UTSW	7	84,886,722 (GRCm39)	missense	possibly damaging	0.71
R8449:Vmn2r68	UTSW	7	84,882,785 (GRCm39)	missense	probably damaging	1.00
R8543:Vmn2r68	UTSW	7	84,883,648 (GRCm39)	missense	probably benign	0.01
R8680:Vmn2r68	UTSW	7	84,871,321 (GRCm39)	missense	possibly damaging	0.68
R9342:Vmn2r68	UTSW	7	84,882,993 (GRCm39)	missense	probably benign	0.39
R9734:Vmn2r68	UTSW	7	84,882,757 (GRCm39)	missense	possibly damaging	0.54
V7581:Vmn2r68	UTSW	7	84,871,088 (GRCm39)	missense	probably benign	0.01
Z1176:Vmn2r68	UTSW	7	84,871,289 (GRCm39)	missense	probably benign	0.27
Z1176:Vmn2r68	UTSW	7	84,870,941 (GRCm39)	missense	probably damaging	1.00
Z1176:Vmn2r68	UTSW	7	84,871,307 (GRCm39)	missense	possibly damaging	0.92

Predicted Primers

PCR Primer
(F):5'- TATTTGGGTGCCCCTGACAC -3'
(R):5'- TGCAAATGAACACCATACTCTCTG -3'

Sequencing Primer
(F):5'- GTGCCCCTGACACAAGCAG -3'
(R):5'- CTGCCTCCAAAAAGTTGTGTC -3'

Posted On

2021-11-19