Incidental Mutation 'R9058:Nlrc5'
ID 688819
Institutional Source Beutler Lab
Gene Symbol Nlrc5
Ensembl Gene ENSMUSG00000074151
Gene Name NLR family, CARD domain containing 5
Synonyms AI451557
MMRRC Submission 068884-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9058 (G1)
Quality Score 225.009
Status Not validated
Chromosome 8
Chromosomal Location 95160984-95253900 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 95238938 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 1459 (T1459S)
Ref Sequence ENSEMBL: ENSMUSP00000138322 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053085] [ENSMUST00000211816]
AlphaFold C3VPR6
PDB Structure The solution NMR structure of the NLRC5 caspase recruitment domain (CARD) [SOLUTION NMR]
Predicted Effect possibly damaging
Transcript: ENSMUST00000053085
AA Change: T1459S

PolyPhen 2 Score 0.863 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000138322
Gene: ENSMUSG00000074151
AA Change: T1459S

DomainStartEndE-ValueType
low complexity region 136 151 N/A INTRINSIC
Pfam:NACHT 223 386 1.8e-32 PFAM
LRR 716 743 6.89e1 SMART
LRR 744 771 9.86e1 SMART
LRR 772 796 1.22e2 SMART
LRR 844 870 2.16e2 SMART
LRR 871 898 1.76e-1 SMART
LRR 1006 1033 1.9e0 SMART
LRR 1034 1061 4.51e1 SMART
low complexity region 1141 1169 N/A INTRINSIC
LRR 1240 1267 2.67e1 SMART
LRR 1273 1295 1.22e1 SMART
low complexity region 1341 1351 N/A INTRINSIC
LRR 1519 1546 5.48e1 SMART
LRR 1547 1574 3.36e1 SMART
LRR 1575 1602 1.69e1 SMART
LRR 1603 1630 8.99e-1 SMART
LRR 1631 1654 5.26e0 SMART
LRR 1659 1686 2.81e0 SMART
LRR 1687 1714 1.6e-4 SMART
LRR 1715 1742 1.06e0 SMART
LRR 1743 1768 8e0 SMART
LRR 1793 1820 2.06e1 SMART
LRR 1821 1848 5.42e-2 SMART
LRR 1849 1876 3.54e0 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000211816
AA Change: T1459S

PolyPhen 2 Score 0.863 (Sensitivity: 0.83; Specificity: 0.93)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the caspase recruitment domain-containing NLR family. This gene plays a role in cytokine response and antiviral immunity through its inhibition of NF-kappa-B activation and negative regulation of type I interferon signaling pathways. [provided by RefSeq, Oct 2011]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit normal cytokine production induced by virus and bacteria infection. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acox1 T C 11: 116,080,268 (GRCm39) T135A possibly damaging Het
Adrm1b A T 3: 92,335,559 (GRCm39) M283K probably benign Het
Aldh8a1 T C 10: 21,258,344 (GRCm39) I147T possibly damaging Het
Alkbh5 T C 11: 60,444,548 (GRCm39) L288S probably benign Het
Bpifb5 A G 2: 154,080,817 (GRCm39) D478G possibly damaging Het
Cacna1s A T 1: 135,998,436 (GRCm39) K155* probably null Het
Ccser1 T C 6: 61,350,976 (GRCm39) L511P probably damaging Het
Cebpz A T 17: 79,243,227 (GRCm39) N142K probably benign Het
Cfap299 A T 5: 98,932,400 (GRCm39) D200V probably damaging Het
Clip1 G T 5: 123,752,645 (GRCm39) R379S Het
Cpne8 T A 15: 90,381,276 (GRCm39) I513F probably damaging Het
Ctnnb1 T A 9: 120,780,476 (GRCm39) C213* probably null Het
Dnah7b A G 1: 46,282,575 (GRCm39) K2903E probably damaging Het
Dnah7c G T 1: 46,805,816 (GRCm39) G3422W probably damaging Het
Dnhd1 T A 7: 105,333,270 (GRCm39) H247Q probably benign Het
Efna2 A G 10: 80,022,720 (GRCm39) Y88C probably damaging Het
Eppk1 C T 15: 75,992,265 (GRCm39) G1539R probably benign Het
Exoc3l2 A T 7: 19,203,821 (GRCm39) K138* probably null Het
Fam47e A G 5: 92,719,367 (GRCm39) probably benign Het
Frmpd1 T A 4: 45,283,948 (GRCm39) M923K probably damaging Het
Gbe1 A G 16: 70,324,059 (GRCm39) E558G possibly damaging Het
Gm5431 T C 11: 48,786,049 (GRCm39) T109A probably benign Het
Gm9508 G A 10: 77,532,620 (GRCm39) P150S unknown Het
Grep1 T C 17: 23,935,016 (GRCm39) N63S probably benign Het
Hps4 G A 5: 112,525,905 (GRCm39) S642N possibly damaging Het
Hrob T C 11: 102,146,386 (GRCm39) S221P probably benign Het
Hsfy2 A T 1: 56,676,504 (GRCm39) V11D probably benign Het
Kif13a T C 13: 46,944,941 (GRCm39) N887D probably damaging Het
Kirrel1 A G 3: 86,992,442 (GRCm39) V541A probably benign Het
Klk15 C T 7: 43,587,790 (GRCm39) H73Y possibly damaging Het
Lamc3 G A 2: 31,798,653 (GRCm39) R453H probably benign Het
Mideas A G 12: 84,220,642 (GRCm39) M104T probably damaging Het
Muc6 G C 7: 141,218,154 (GRCm39) T2173S possibly damaging Het
Neb T C 2: 52,075,341 (GRCm39) N208S probably benign Het
Npy1r T C 8: 67,156,600 (GRCm39) S7P probably benign Het
Nr4a2 T C 2: 57,002,255 (GRCm39) N66S probably benign Het
Nr5a1 T C 2: 38,584,034 (GRCm39) T462A probably damaging Het
Ntng2 A G 2: 29,094,202 (GRCm39) C390R probably benign Het
Or4p23 A C 2: 88,577,030 (GRCm39) D67E Het
Or5b119 G A 19: 13,456,956 (GRCm39) T202I possibly damaging Het
Or7g12 T A 9: 18,900,222 (GRCm39) *313R probably null Het
Pecam1 G T 11: 106,590,675 (GRCm39) P33Q probably damaging Het
Phc2 T A 4: 128,616,769 (GRCm39) F347L probably benign Het
Phldb2 T A 16: 45,592,604 (GRCm39) H938L possibly damaging Het
Pkd1l3 GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA 8: 110,350,827 (GRCm39) probably benign Het
Prkch G T 12: 73,822,308 (GRCm39) probably null Het
Prr5 A G 15: 84,641,241 (GRCm39) N169S probably benign Het
Puf60 C T 15: 75,942,425 (GRCm39) D483N probably benign Het
Puf60 C T 15: 75,944,382 (GRCm39) M133I probably benign Het
Rmnd1 T C 10: 4,363,398 (GRCm39) H284R probably benign Het
Scaper T C 9: 55,722,762 (GRCm39) E682G probably damaging Het
Sds A G 5: 120,618,779 (GRCm39) E111G possibly damaging Het
Sec23b T A 2: 144,424,010 (GRCm39) I553N probably damaging Het
Serpina1a A T 12: 103,820,001 (GRCm39) I415K possibly damaging Het
Slc14a1 T A 18: 78,145,785 (GRCm39) probably null Het
Socs1 G A 16: 10,602,692 (GRCm39) P15L probably benign Het
Sv2b A T 7: 74,789,822 (GRCm39) probably null Het
Sync T C 4: 129,187,217 (GRCm39) I83T probably damaging Het
Syt16 T A 12: 74,282,019 (GRCm39) L381Q probably damaging Het
Tbx20 T C 9: 24,681,019 (GRCm39) R158G probably damaging Het
Tmco1 C T 1: 167,136,132 (GRCm39) probably benign Het
Tmem19 C A 10: 115,198,031 (GRCm39) probably benign Het
Trpa1 A C 1: 14,959,618 (GRCm39) N689K probably damaging Het
Ube3b C A 5: 114,553,300 (GRCm39) H891N probably benign Het
Vmn2r19 T A 6: 123,313,021 (GRCm39) M697K possibly damaging Het
Zfp142 A T 1: 74,608,955 (GRCm39) C1613* probably null Het
Zfp7 T A 15: 76,764,981 (GRCm39) M1K probably null Het
Zfp936 A T 7: 42,839,196 (GRCm39) Q221L probably benign Het
Other mutations in Nlrc5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00158:Nlrc5 APN 8 95,228,839 (GRCm39) splice site probably benign
IGL00232:Nlrc5 APN 8 95,211,251 (GRCm39) critical splice donor site probably null
IGL00324:Nlrc5 APN 8 95,248,107 (GRCm39) missense probably damaging 1.00
IGL02715:Nlrc5 APN 8 95,201,296 (GRCm39) missense probably damaging 1.00
IGL02992:Nlrc5 APN 8 95,233,201 (GRCm39) missense possibly damaging 0.69
IGL03095:Nlrc5 APN 8 95,248,536 (GRCm39) splice site probably benign
IGL03389:Nlrc5 APN 8 95,248,102 (GRCm39) missense probably damaging 1.00
IGL03406:Nlrc5 APN 8 95,203,483 (GRCm39) missense probably benign 0.01
cassis UTSW 8 95,203,021 (GRCm39) nonsense probably null
cowberry UTSW 8 95,218,153 (GRCm39) missense possibly damaging 0.83
lingon UTSW 8 95,208,488 (GRCm39) missense probably damaging 1.00
R0037:Nlrc5 UTSW 8 95,216,163 (GRCm39) missense probably benign 0.00
R0048:Nlrc5 UTSW 8 95,201,284 (GRCm39) missense possibly damaging 0.81
R0092:Nlrc5 UTSW 8 95,216,222 (GRCm39) splice site probably benign
R0506:Nlrc5 UTSW 8 95,219,753 (GRCm39) splice site probably benign
R0548:Nlrc5 UTSW 8 95,248,411 (GRCm39) missense probably null 0.09
R2014:Nlrc5 UTSW 8 95,252,138 (GRCm39) splice site probably benign
R3051:Nlrc5 UTSW 8 95,203,343 (GRCm39) missense probably benign 0.01
R3776:Nlrc5 UTSW 8 95,199,467 (GRCm39) missense possibly damaging 0.48
R3837:Nlrc5 UTSW 8 95,237,929 (GRCm39) splice site probably benign
R4012:Nlrc5 UTSW 8 95,202,620 (GRCm39) missense possibly damaging 0.92
R4367:Nlrc5 UTSW 8 95,203,192 (GRCm39) missense probably damaging 1.00
R4400:Nlrc5 UTSW 8 95,220,981 (GRCm39) missense probably benign 0.08
R4469:Nlrc5 UTSW 8 95,247,467 (GRCm39) missense probably damaging 1.00
R4561:Nlrc5 UTSW 8 95,203,774 (GRCm39) missense probably damaging 1.00
R4584:Nlrc5 UTSW 8 95,203,903 (GRCm39) missense probably damaging 0.96
R4758:Nlrc5 UTSW 8 95,238,956 (GRCm39) missense possibly damaging 0.70
R4834:Nlrc5 UTSW 8 95,232,113 (GRCm39) missense probably benign 0.00
R4896:Nlrc5 UTSW 8 95,247,844 (GRCm39) unclassified probably benign
R5004:Nlrc5 UTSW 8 95,247,844 (GRCm39) unclassified probably benign
R5018:Nlrc5 UTSW 8 95,252,080 (GRCm39) missense probably damaging 1.00
R5115:Nlrc5 UTSW 8 95,203,447 (GRCm39) missense possibly damaging 0.67
R5116:Nlrc5 UTSW 8 95,208,488 (GRCm39) missense probably damaging 1.00
R5126:Nlrc5 UTSW 8 95,201,299 (GRCm39) missense possibly damaging 0.95
R5148:Nlrc5 UTSW 8 95,203,321 (GRCm39) missense probably damaging 1.00
R5224:Nlrc5 UTSW 8 95,220,944 (GRCm39) missense probably benign 0.26
R5527:Nlrc5 UTSW 8 95,217,044 (GRCm39) missense probably damaging 1.00
R5640:Nlrc5 UTSW 8 95,202,421 (GRCm39) missense probably benign 0.02
R5705:Nlrc5 UTSW 8 95,202,385 (GRCm39) missense probably benign 0.00
R5778:Nlrc5 UTSW 8 95,206,154 (GRCm39) missense possibly damaging 0.66
R5830:Nlrc5 UTSW 8 95,199,542 (GRCm39) missense probably damaging 1.00
R5850:Nlrc5 UTSW 8 95,247,675 (GRCm39) missense probably benign 0.00
R5978:Nlrc5 UTSW 8 95,215,221 (GRCm39) missense probably damaging 0.98
R6335:Nlrc5 UTSW 8 95,228,902 (GRCm39) missense probably benign 0.01
R6372:Nlrc5 UTSW 8 95,206,378 (GRCm39) missense probably damaging 0.98
R6486:Nlrc5 UTSW 8 95,247,927 (GRCm39) splice site probably null
R6765:Nlrc5 UTSW 8 95,216,996 (GRCm39) missense probably benign 0.20
R6861:Nlrc5 UTSW 8 95,247,857 (GRCm39) unclassified probably benign
R6869:Nlrc5 UTSW 8 95,248,583 (GRCm39) missense probably benign 0.00
R7134:Nlrc5 UTSW 8 95,206,350 (GRCm39) missense probably damaging 0.99
R7204:Nlrc5 UTSW 8 95,218,153 (GRCm39) missense possibly damaging 0.83
R7231:Nlrc5 UTSW 8 95,248,433 (GRCm39) critical splice donor site probably null
R7309:Nlrc5 UTSW 8 95,200,670 (GRCm39) missense probably benign 0.01
R7368:Nlrc5 UTSW 8 95,203,021 (GRCm39) nonsense probably null
R7497:Nlrc5 UTSW 8 95,248,598 (GRCm39) missense probably damaging 1.00
R7606:Nlrc5 UTSW 8 95,203,745 (GRCm39) missense possibly damaging 0.67
R7611:Nlrc5 UTSW 8 95,239,276 (GRCm39) critical splice donor site probably null
R7685:Nlrc5 UTSW 8 95,248,028 (GRCm39) splice site probably null
R7810:Nlrc5 UTSW 8 95,231,772 (GRCm39) missense possibly damaging 0.85
R7829:Nlrc5 UTSW 8 95,248,397 (GRCm39) missense probably damaging 1.00
R7910:Nlrc5 UTSW 8 95,219,720 (GRCm39) missense probably benign 0.00
R7921:Nlrc5 UTSW 8 95,214,292 (GRCm39) missense probably damaging 1.00
R8131:Nlrc5 UTSW 8 95,208,420 (GRCm39) missense probably damaging 1.00
R8237:Nlrc5 UTSW 8 95,252,753 (GRCm39) missense unknown
R8493:Nlrc5 UTSW 8 95,249,848 (GRCm39) missense probably damaging 1.00
R8888:Nlrc5 UTSW 8 95,252,118 (GRCm39) missense probably benign 0.04
R8964:Nlrc5 UTSW 8 95,232,116 (GRCm39) missense possibly damaging 0.54
R9053:Nlrc5 UTSW 8 95,217,013 (GRCm39) missense probably benign 0.00
R9161:Nlrc5 UTSW 8 95,213,274 (GRCm39) missense probably damaging 0.97
R9278:Nlrc5 UTSW 8 95,237,908 (GRCm39) missense probably benign 0.00
R9285:Nlrc5 UTSW 8 95,199,604 (GRCm39) missense probably damaging 1.00
R9405:Nlrc5 UTSW 8 95,199,652 (GRCm39) missense probably damaging 0.98
R9591:Nlrc5 UTSW 8 95,249,309 (GRCm39) missense probably damaging 1.00
R9620:Nlrc5 UTSW 8 95,203,034 (GRCm39) missense probably benign 0.44
RF021:Nlrc5 UTSW 8 95,203,516 (GRCm39) missense probably benign 0.16
Z1088:Nlrc5 UTSW 8 95,231,092 (GRCm39) missense possibly damaging 0.48
Z1177:Nlrc5 UTSW 8 95,233,208 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- TTCCCAGTGGGTCTTGTAAC -3'
(R):5'- ATGCTGAACACACCTCAGGG -3'

Sequencing Primer
(F):5'- GGTCTTGTAACTGGGTAGTAAACTC -3'
(R):5'- TGACAGAAGGTCCCTCTAAGAGC -3'
Posted On 2021-11-19