Incidental Mutation 'R9060:Or5m10'
ID 688904
Institutional Source Beutler Lab
Gene Symbol Or5m10
Ensembl Gene ENSMUSG00000050128
Gene Name olfactory receptor family 5 subfamily M member 10
Synonyms GA_x6K02T2Q125-47363965-47364900, MOR196-3, Olfr1023
MMRRC Submission 068886-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.066) question?
Stock # R9060 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 85717146-85718081 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 85717920 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 259 (Y259H)
Ref Sequence ENSEMBL: ENSMUSP00000149138 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056408] [ENSMUST00000213441]
AlphaFold A2ASU6
Predicted Effect probably benign
Transcript: ENSMUST00000056408
AA Change: Y259H

PolyPhen 2 Score 0.065 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000059849
Gene: ENSMUSG00000050128
AA Change: Y259H

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 2.6e-52 PFAM
Pfam:7TM_GPCR_Srsx 35 304 2.6e-7 PFAM
Pfam:7tm_1 41 290 2.4e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213441
AA Change: Y259H

PolyPhen 2 Score 0.065 (Sensitivity: 0.94; Specificity: 0.84)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 98% (54/55)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acat3 A C 17: 13,145,293 (GRCm39) V295G Het
Agfg1 T C 1: 82,872,254 (GRCm39) V529A possibly damaging Het
Ap1g2 G A 14: 55,337,887 (GRCm39) P667L probably benign Het
Arhgap29 T A 3: 121,783,973 (GRCm39) S176T probably damaging Het
Casq2 A G 3: 102,052,619 (GRCm39) D377G unknown Het
Ccdc14 T C 16: 34,517,486 (GRCm39) L104P probably benign Het
Cep104 T C 4: 154,074,281 (GRCm39) I511T probably damaging Het
Cgn A G 3: 94,687,165 (GRCm39) Y46H probably damaging Het
Cilp T C 9: 65,186,302 (GRCm39) V799A probably benign Het
Col6a1 A G 10: 76,557,711 (GRCm39) V175A probably benign Het
Dclk1 C A 3: 55,163,575 (GRCm39) D222E probably benign Het
Dnah10 G T 5: 124,905,141 (GRCm39) C4058F probably damaging Het
Dnai4 A T 4: 102,947,750 (GRCm39) D175E probably benign Het
Elmod3 A T 6: 72,543,790 (GRCm39) Y334N probably damaging Het
Enah C A 1: 181,749,817 (GRCm39) A341S probably damaging Het
Eomes T C 9: 118,311,364 (GRCm39) *396Q probably null Het
Epb41l1 T A 2: 156,345,679 (GRCm39) Y227* probably null Het
Epha5 A T 5: 84,218,977 (GRCm39) D765E probably benign Het
Fat3 T C 9: 15,910,782 (GRCm39) N1740S possibly damaging Het
Fhip2a C T 19: 57,361,450 (GRCm39) H125Y probably damaging Het
Galnt9 G A 5: 110,737,710 (GRCm39) R222H possibly damaging Het
Gm19410 A G 8: 36,269,480 (GRCm39) D1105G probably damaging Het
Hoxa13 T A 6: 52,236,897 (GRCm39) Y121F probably damaging Het
Hps4 G A 5: 112,525,905 (GRCm39) S642N possibly damaging Het
Jag1 T G 2: 136,931,204 (GRCm39) T643P probably damaging Het
Limd1 T A 9: 123,309,514 (GRCm39) S404R probably benign Het
Micall2 A T 5: 139,705,035 (GRCm39) S100T probably damaging Het
Miga2 T A 2: 30,271,735 (GRCm39) L419Q probably damaging Het
Ms4a13 A C 19: 11,168,950 (GRCm39) I25S Het
Nnmt T C 9: 48,503,367 (GRCm39) T220A probably benign Het
Nrg3 G A 14: 38,734,052 (GRCm39) T278I probably damaging Het
Nup98 A G 7: 101,783,895 (GRCm39) W1146R probably damaging Het
Or13a28 T G 7: 140,217,695 (GRCm39) L27R Het
Pacsin3 T C 2: 91,091,557 (GRCm39) F85L probably benign Het
Padi4 T A 4: 140,477,953 (GRCm39) D465V probably damaging Het
Pakap A G 4: 57,855,412 (GRCm39) E247G probably damaging Het
Pclo A T 5: 14,726,599 (GRCm39) Y1819F unknown Het
Pitpnm1 C A 19: 4,156,869 (GRCm39) T464N probably damaging Het
Rnf214 T C 9: 45,809,772 (GRCm39) probably benign Het
Rrs1 G A 1: 9,616,677 (GRCm39) G310D probably damaging Het
Rsf1 CGGCGGCGG CGGCGGCGGGGGCGGCGG 7: 97,229,130 (GRCm39) probably benign Het
Slc35e3 A G 10: 117,581,688 (GRCm39) probably null Het
Slc47a2 T C 11: 61,227,699 (GRCm39) I142V probably benign Het
Slc8a3 G A 12: 81,260,852 (GRCm39) R626C probably benign Het
Spart T C 3: 55,032,275 (GRCm39) S370P probably benign Het
Spata31e1 G A 13: 49,940,087 (GRCm39) S541F probably damaging Het
Spmap2 G T 10: 79,420,571 (GRCm39) L189I probably damaging Het
Tle3 T A 9: 61,282,821 (GRCm39) M67K probably damaging Het
Tmco1 C T 1: 167,136,132 (GRCm39) probably benign Het
Ubr3 T A 2: 69,839,489 (GRCm39) Y1534* probably null Het
Usp13 T C 3: 32,965,812 (GRCm39) probably null Het
Vmn2r97 T C 17: 19,134,585 (GRCm39) M1T probably null Het
Zc3h7a G A 16: 10,969,047 (GRCm39) T438I probably damaging Het
Zfhx2 A G 14: 55,311,803 (GRCm39) V297A probably benign Het
Other mutations in Or5m10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01536:Or5m10 APN 2 85,717,944 (GRCm39) missense probably damaging 1.00
IGL01622:Or5m10 APN 2 85,717,306 (GRCm39) missense probably benign 0.01
IGL01623:Or5m10 APN 2 85,717,306 (GRCm39) missense probably benign 0.01
IGL01977:Or5m10 APN 2 85,717,711 (GRCm39) missense probably damaging 1.00
IGL02057:Or5m10 APN 2 85,717,275 (GRCm39) missense probably benign 0.00
IGL02555:Or5m10 APN 2 85,717,742 (GRCm39) missense probably benign 0.34
IGL03133:Or5m10 APN 2 85,717,478 (GRCm39) missense probably damaging 1.00
IGL03180:Or5m10 APN 2 85,717,740 (GRCm39) missense probably benign 0.00
R0415:Or5m10 UTSW 2 85,717,782 (GRCm39) missense possibly damaging 0.94
R1476:Or5m10 UTSW 2 85,717,592 (GRCm39) nonsense probably null
R1544:Or5m10 UTSW 2 85,717,615 (GRCm39) missense probably damaging 1.00
R2058:Or5m10 UTSW 2 85,717,296 (GRCm39) missense possibly damaging 0.48
R4096:Or5m10 UTSW 2 85,717,767 (GRCm39) missense probably damaging 0.98
R5055:Or5m10 UTSW 2 85,717,585 (GRCm39) missense probably benign 0.12
R5703:Or5m10 UTSW 2 85,717,783 (GRCm39) missense probably benign 0.06
R6297:Or5m10 UTSW 2 85,717,159 (GRCm39) missense probably benign 0.35
R7041:Or5m10 UTSW 2 85,717,965 (GRCm39) missense probably benign 0.01
R7070:Or5m10 UTSW 2 85,718,034 (GRCm39) missense probably benign 0.13
R7563:Or5m10 UTSW 2 85,717,482 (GRCm39) missense probably damaging 0.98
R7777:Or5m10 UTSW 2 85,717,951 (GRCm39) missense possibly damaging 0.83
R7913:Or5m10 UTSW 2 85,718,074 (GRCm39) missense probably damaging 0.96
R9789:Or5m10 UTSW 2 85,717,338 (GRCm39) missense probably damaging 1.00
S24628:Or5m10 UTSW 2 85,717,782 (GRCm39) missense possibly damaging 0.94
Predicted Primers PCR Primer
(F):5'- GTAGCTGGCTTTACTCTCTCAAG -3'
(R):5'- ACCAAGTTCTTTATCCAGCACATTG -3'

Sequencing Primer
(F):5'- GGCTTTACTCTCTCAAGTTCCC -3'
(R):5'- CCAGCACATTGTATCAGAAATGATC -3'
Posted On 2021-11-19