Incidental Mutation 'R9062:Zfp64'
ID 689020
Institutional Source Beutler Lab
Gene Symbol Zfp64
Ensembl Gene ENSMUSG00000027551
Gene Name zinc finger protein 64
Synonyms
MMRRC Submission 068888-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.828) question?
Stock # R9062 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 168735251-168797507 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 168767747 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 622 (T622A)
Ref Sequence ENSEMBL: ENSMUSP00000085285 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087971] [ENSMUST00000109162]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000087971
AA Change: T622A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000085285
Gene: ENSMUSG00000027551
AA Change: T622A

DomainStartEndE-ValueType
ZnF_C2H2 31 51 5.54e1 SMART
low complexity region 71 93 N/A INTRINSIC
ZnF_C2H2 142 167 1.68e1 SMART
ZnF_C2H2 173 195 2.24e-3 SMART
ZnF_C2H2 201 223 1.58e-3 SMART
ZnF_C2H2 229 251 2.24e-3 SMART
ZnF_C2H2 257 279 3.89e-3 SMART
ZnF_C2H2 285 308 6.32e-3 SMART
ZnF_C2H2 313 335 2.05e-2 SMART
ZnF_C2H2 341 363 1.95e-3 SMART
ZnF_C2H2 369 392 1.36e-2 SMART
ZnF_C2H2 423 445 1.47e-3 SMART
low complexity region 503 522 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000109162
SMART Domains Protein: ENSMUSP00000104790
Gene: ENSMUSG00000027551

DomainStartEndE-ValueType
ZnF_C2H2 31 51 5.54e1 SMART
low complexity region 71 93 N/A INTRINSIC
ZnF_C2H2 142 167 1.68e1 SMART
ZnF_C2H2 173 195 2.24e-3 SMART
ZnF_C2H2 201 223 1.58e-3 SMART
ZnF_C2H2 229 251 2.24e-3 SMART
ZnF_C2H2 297 322 5.2e0 SMART
ZnF_C2H2 328 350 4.17e-3 SMART
ZnF_C2H2 356 378 6.78e-3 SMART
ZnF_C2H2 384 406 2.24e-3 SMART
ZnF_C2H2 412 434 1.79e-2 SMART
ZnF_C2H2 440 463 9.58e-3 SMART
ZnF_C2H2 465 487 3.78e-1 SMART
ZnF_C2H2 493 515 3.89e-3 SMART
ZnF_C2H2 521 544 1.92e-2 SMART
ZnF_C2H2 578 600 5.34e-1 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (52/52)
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ambra1 A G 2: 91,740,662 (GRCm39) E1047G possibly damaging Het
Ankfn1 T G 11: 89,325,583 (GRCm39) I530L probably benign Het
Apob A T 12: 8,058,046 (GRCm39) Y2176F possibly damaging Het
Atp5f1a C T 18: 77,866,459 (GRCm39) R171* probably null Het
Atxn10 T C 15: 85,275,918 (GRCm39) V325A probably benign Het
B3galt1 T C 2: 67,948,890 (GRCm39) Y202H Het
Calhm1 A T 19: 47,129,828 (GRCm39) D231E possibly damaging Het
Cel C A 2: 28,451,214 (GRCm39) V48F probably benign Het
Cep78 T A 19: 15,956,318 (GRCm39) Y207F probably benign Het
Cnst T C 1: 179,434,100 (GRCm39) probably null Het
Cpeb2 C A 5: 43,391,171 (GRCm39) N122K Het
Cyth1 T C 11: 118,023,142 (GRCm39) Q432R unknown Het
Eif2ak1 T C 5: 143,803,548 (GRCm39) probably benign Het
Eif6 T C 2: 155,665,928 (GRCm39) T76A probably benign Het
Etfrf1 A T 6: 145,161,153 (GRCm39) N41I probably damaging Het
Etl4 T G 2: 20,748,616 (GRCm39) L318R probably damaging Het
Fam151a G T 4: 106,605,306 (GRCm39) W556L probably benign Het
Gas2l1 A G 11: 5,011,497 (GRCm39) V444A probably benign Het
Gbp8 A G 5: 105,179,124 (GRCm39) I125T possibly damaging Het
Jrkl A G 9: 13,245,338 (GRCm39) F108L probably benign Het
Kif13a G T 13: 46,941,536 (GRCm39) D980E possibly damaging Het
Leng9 C T 7: 4,151,666 (GRCm39) A337T probably damaging Het
Lipo3 A C 19: 33,757,714 (GRCm39) C252G probably damaging Het
Lrp4 C A 2: 91,303,925 (GRCm39) D113E possibly damaging Het
Mapk8ip1 T C 2: 92,217,527 (GRCm39) Y265C probably damaging Het
Mios A T 6: 8,233,221 (GRCm39) I790F probably benign Het
Mlf2 G A 6: 124,911,334 (GRCm39) silent Het
Mycbp2 T A 14: 103,479,796 (GRCm39) Y1226F probably benign Het
Ncoa6 T A 2: 155,263,348 (GRCm39) Q362L probably benign Het
Notch3 T C 17: 32,341,692 (GRCm39) D2020G possibly damaging Het
Or4a73 T C 2: 89,420,923 (GRCm39) M179V probably benign Het
Or4c111 T A 2: 88,843,548 (GRCm39) T287S probably damaging Het
Or52z1 T A 7: 103,437,155 (GRCm39) I110L probably benign Het
Or8d1b A T 9: 38,887,421 (GRCm39) I150F probably benign Het
Otop2 C A 11: 115,214,465 (GRCm39) A74E probably benign Het
Pgm1 T C 4: 99,843,954 (GRCm39) I579T probably damaging Het
Preb A G 5: 31,116,196 (GRCm39) V137A probably benign Het
Psap G T 10: 60,131,738 (GRCm39) V244L possibly damaging Het
Setbp1 A G 18: 78,900,266 (GRCm39) S1134P probably benign Het
Skp2 G T 15: 9,113,821 (GRCm39) P399Q probably damaging Het
Slc47a1 T G 11: 61,253,924 (GRCm39) I222L probably benign Het
Spata31h1 A G 10: 82,126,945 (GRCm39) W2022R probably benign Het
Spef2 A G 15: 9,601,717 (GRCm39) L1515S unknown Het
Sri T C 5: 8,106,625 (GRCm39) Y13H unknown Het
Tcf25 T C 8: 124,116,448 (GRCm39) F248L Het
Tdrd12 T C 7: 35,179,694 (GRCm39) T885A unknown Het
Ttn T C 2: 76,600,944 (GRCm39) T18813A probably damaging Het
Usp42 A G 5: 143,703,740 (GRCm39) V441A possibly damaging Het
Vwa1 A T 4: 155,854,820 (GRCm39) S405T probably benign Het
Zbbx A T 3: 74,989,124 (GRCm39) H326Q possibly damaging Het
Zfp677 T G 17: 21,612,815 (GRCm39) probably null Het
Other mutations in Zfp64
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00155:Zfp64 APN 2 168,768,601 (GRCm39) missense probably benign 0.06
IGL01479:Zfp64 APN 2 168,793,599 (GRCm39) missense probably damaging 1.00
IGL02320:Zfp64 APN 2 168,768,118 (GRCm39) missense probably damaging 0.98
IGL03411:Zfp64 APN 2 168,793,462 (GRCm39) splice site probably null
PIT4362001:Zfp64 UTSW 2 168,767,735 (GRCm39) missense probably benign 0.23
R0033:Zfp64 UTSW 2 168,767,635 (GRCm39) missense possibly damaging 0.94
R0033:Zfp64 UTSW 2 168,767,635 (GRCm39) missense possibly damaging 0.94
R0230:Zfp64 UTSW 2 168,754,150 (GRCm39) splice site probably benign
R0325:Zfp64 UTSW 2 168,767,960 (GRCm39) missense probably benign 0.00
R0689:Zfp64 UTSW 2 168,777,121 (GRCm39) splice site probably benign
R1741:Zfp64 UTSW 2 168,768,238 (GRCm39) missense probably benign 0.05
R2054:Zfp64 UTSW 2 168,767,728 (GRCm39) missense probably damaging 1.00
R2133:Zfp64 UTSW 2 168,782,663 (GRCm39) missense probably damaging 1.00
R2254:Zfp64 UTSW 2 168,768,662 (GRCm39) missense probably damaging 0.96
R4093:Zfp64 UTSW 2 168,767,855 (GRCm39) missense probably benign 0.00
R4094:Zfp64 UTSW 2 168,767,855 (GRCm39) missense probably benign 0.00
R4257:Zfp64 UTSW 2 168,768,298 (GRCm39) missense probably damaging 1.00
R4630:Zfp64 UTSW 2 168,768,463 (GRCm39) missense possibly damaging 0.94
R4642:Zfp64 UTSW 2 168,776,851 (GRCm39) missense probably benign 0.22
R4817:Zfp64 UTSW 2 168,768,032 (GRCm39) missense probably benign
R4880:Zfp64 UTSW 2 168,736,297 (GRCm39) missense probably damaging 1.00
R5051:Zfp64 UTSW 2 168,768,304 (GRCm39) missense probably damaging 0.98
R5155:Zfp64 UTSW 2 168,748,885 (GRCm39) missense probably benign 0.17
R5562:Zfp64 UTSW 2 168,767,642 (GRCm39) missense probably benign 0.00
R5619:Zfp64 UTSW 2 168,741,735 (GRCm39) missense probably damaging 0.97
R5619:Zfp64 UTSW 2 168,741,734 (GRCm39) missense probably damaging 0.99
R5620:Zfp64 UTSW 2 168,741,888 (GRCm39) missense possibly damaging 0.70
R5919:Zfp64 UTSW 2 168,768,419 (GRCm39) missense probably benign 0.05
R6156:Zfp64 UTSW 2 168,768,088 (GRCm39) missense probably benign 0.34
R6364:Zfp64 UTSW 2 168,754,186 (GRCm39) missense probably damaging 1.00
R6488:Zfp64 UTSW 2 168,777,129 (GRCm39) critical splice donor site probably null
R6512:Zfp64 UTSW 2 168,735,997 (GRCm39) missense probably benign 0.00
R6588:Zfp64 UTSW 2 168,768,827 (GRCm39) missense probably damaging 1.00
R7103:Zfp64 UTSW 2 168,768,357 (GRCm39) missense probably benign 0.00
R7313:Zfp64 UTSW 2 168,741,810 (GRCm39) missense probably damaging 1.00
R7470:Zfp64 UTSW 2 168,767,731 (GRCm39) missense probably damaging 1.00
R7529:Zfp64 UTSW 2 168,735,992 (GRCm39) missense probably benign
R7560:Zfp64 UTSW 2 168,767,585 (GRCm39) missense probably damaging 1.00
R7963:Zfp64 UTSW 2 168,793,538 (GRCm39) missense probably benign 0.32
R8037:Zfp64 UTSW 2 168,741,932 (GRCm39) missense probably damaging 1.00
R8038:Zfp64 UTSW 2 168,741,932 (GRCm39) missense probably damaging 1.00
R8825:Zfp64 UTSW 2 168,793,552 (GRCm39) missense probably benign
R8840:Zfp64 UTSW 2 168,768,635 (GRCm39) missense probably benign
R8891:Zfp64 UTSW 2 168,797,083 (GRCm39) start codon destroyed probably null 0.37
R9592:Zfp64 UTSW 2 168,768,118 (GRCm39) missense probably damaging 1.00
R9681:Zfp64 UTSW 2 168,793,680 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CAGACTAATCAGGAATGGAGTCAGC -3'
(R):5'- TTCGCCAGGTCAGTCTCATTG -3'

Sequencing Primer
(F):5'- TCAGCGGGACAGAGCAG -3'
(R):5'- TGAGTCAGCCAACTGTCCTG -3'
Posted On 2021-11-19