Incidental Mutation 'R9063:Gas2l3'
ID 689101
Institutional Source Beutler Lab
Gene Symbol Gas2l3
Ensembl Gene ENSMUSG00000074802
Gene Name growth arrest-specific 2 like 3
Synonyms LOC237436, 8430435B07Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.195) question?
Stock # R9063 (G1)
Quality Score 225.009
Status Not validated
Chromosome 10
Chromosomal Location 89244685-89279829 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 89249558 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 520 (I520T)
Ref Sequence ENSEMBL: ENSMUSP00000096973 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099374] [ENSMUST00000105298] [ENSMUST00000220128]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000099374
AA Change: I520T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000096973
Gene: ENSMUSG00000074802
AA Change: I520T

DomainStartEndE-ValueType
CH 52 166 1.71e-9 SMART
low complexity region 179 194 N/A INTRINSIC
Pfam:GAS2 215 284 1.8e-29 PFAM
low complexity region 446 460 N/A INTRINSIC
low complexity region 630 643 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000105298
AA Change: I520T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000100935
Gene: ENSMUSG00000074802
AA Change: I520T

DomainStartEndE-ValueType
CH 52 166 1.71e-9 SMART
low complexity region 179 194 N/A INTRINSIC
Pfam:GAS2 213 286 1.5e-31 PFAM
low complexity region 446 460 N/A INTRINSIC
low complexity region 630 643 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000220128
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a null allele display partial postnatal lethality with none surviving past 4 months, dilated cardiomyopathy, cardiac interstitial fibrosis, and premature binucleation of cardiomyocytes. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110004F10Rik T G 7: 115,703,660 (GRCm39) S178A probably benign Het
Add3 T C 19: 53,222,302 (GRCm39) L303P probably damaging Het
Agr2 T A 12: 36,053,898 (GRCm39) *176K probably null Het
Apobr C T 7: 126,185,920 (GRCm39) T477I probably benign Het
Cdca7l G A 12: 117,838,536 (GRCm39) V336M probably damaging Het
Cep63 T G 9: 102,496,227 (GRCm39) H18P unknown Het
Copa A G 1: 171,944,529 (GRCm39) D838G probably benign Het
Cspg4 G T 9: 56,795,687 (GRCm39) V1141L probably benign Het
D930020B18Rik A G 10: 121,497,002 (GRCm39) T146A probably benign Het
Dapk1 A T 13: 60,866,264 (GRCm39) I206L probably benign Het
Emsy C T 7: 98,295,684 (GRCm39) D73N probably damaging Het
Esr2 A T 12: 76,168,590 (GRCm39) Y540N probably benign Het
Exoc7 C A 11: 116,180,101 (GRCm39) V668L probably benign Het
Fcgbp C T 7: 27,791,277 (GRCm39) T846I probably damaging Het
Fhod3 A G 18: 25,153,772 (GRCm39) E418G probably damaging Het
Fryl G A 5: 73,238,346 (GRCm39) R1467C possibly damaging Het
Gfod1 A G 13: 43,354,280 (GRCm39) C232R probably benign Het
Gpr61 T C 3: 108,057,555 (GRCm39) R369G probably benign Het
Hk1 T C 10: 62,122,429 (GRCm39) Y423C probably damaging Het
Itpr3 G A 17: 27,337,651 (GRCm39) probably benign Het
Jmy T C 13: 93,635,580 (GRCm39) R79G probably benign Het
Kcnn4 T A 7: 24,076,934 (GRCm39) V161E probably damaging Het
Kif15 T A 9: 122,833,706 (GRCm39) I1040N probably damaging Het
Kif2b A G 11: 91,466,654 (GRCm39) L543S probably damaging Het
Kpna2 A G 11: 106,883,489 (GRCm39) I81T probably benign Het
Krt12 A G 11: 99,307,757 (GRCm39) S444P probably benign Het
Lmnb2 C T 10: 80,742,005 (GRCm39) V29M probably benign Het
Lmod2 T C 6: 24,603,364 (GRCm39) V113A probably benign Het
Lrp1b T C 2: 41,231,838 (GRCm39) T1211A Het
Lrrc8d T C 5: 105,961,959 (GRCm39) S790P probably damaging Het
Map3k4 A G 17: 12,482,878 (GRCm39) V613A probably damaging Het
Marveld2 T C 13: 100,748,653 (GRCm39) N142S probably benign Het
Mgll G A 6: 88,802,690 (GRCm39) V282I possibly damaging Het
Mief2 G A 11: 60,622,314 (GRCm39) E295K probably damaging Het
Mmrn2 A T 14: 34,120,567 (GRCm39) H479L probably benign Het
Myh15 T A 16: 48,913,118 (GRCm39) N358K probably benign Het
Mzf1 T G 7: 12,787,005 (GRCm39) K101Q probably damaging Het
Ncbp3 T A 11: 72,964,253 (GRCm39) L401Q probably damaging Het
Nck2 T C 1: 43,593,503 (GRCm39) C237R possibly damaging Het
Nlrp9a T G 7: 26,273,291 (GRCm39) N976K possibly damaging Het
Nol11 A G 11: 107,064,240 (GRCm39) V524A probably benign Het
Nol11 T C 11: 107,069,857 (GRCm39) Y331C possibly damaging Het
Nsmf A T 2: 24,952,622 (GRCm39) H149L probably benign Het
Olfm3 T C 3: 114,914,582 (GRCm39) V231A probably benign Het
Or1l4b A T 2: 37,036,646 (GRCm39) M141L probably benign Het
Or51a6 A G 7: 102,604,446 (GRCm39) S121P probably benign Het
Or55b4 T C 7: 102,133,931 (GRCm39) Y132C probably damaging Het
Pcdhgb5 T A 18: 37,864,739 (GRCm39) F178Y probably damaging Het
Plk2 T A 13: 110,532,920 (GRCm39) S160R possibly damaging Het
Plk5 C G 10: 80,193,830 (GRCm39) R40G probably damaging Het
Ppp1cc A G 5: 122,306,279 (GRCm39) N33D probably benign Het
Ptpn23 T C 9: 110,218,693 (GRCm39) E499G possibly damaging Het
Pwp1 A G 10: 85,720,431 (GRCm39) H356R probably benign Het
Rbsn G T 6: 92,171,000 (GRCm39) T307K probably benign Het
Rnf19a G A 15: 36,265,615 (GRCm39) Q161* probably null Het
Scin T C 12: 40,134,336 (GRCm39) D236G possibly damaging Het
Setd1a G A 7: 127,385,558 (GRCm39) R755H possibly damaging Het
Sik3 C T 9: 46,123,735 (GRCm39) T1178I probably benign Het
Slc49a3 A G 5: 108,590,103 (GRCm39) L433P probably damaging Het
Tex26 C T 5: 149,393,826 (GRCm39) R272C probably damaging Het
Trim60 T A 8: 65,453,465 (GRCm39) K261N possibly damaging Het
Tspan9 A G 6: 127,944,072 (GRCm39) I76T probably damaging Het
Ttn T A 2: 76,588,833 (GRCm39) Y21412F probably damaging Het
Ttn A T 2: 76,710,907 (GRCm39) I8409N unknown Het
Unc80 T C 1: 66,645,816 (GRCm39) probably null Het
Ush2a A T 1: 187,995,457 (GRCm39) Q76L probably benign Het
Usp1 G A 4: 98,819,389 (GRCm39) V284I probably benign Het
Usp31 A G 7: 121,306,466 (GRCm39) V4A probably benign Het
Vmn2r88 G A 14: 51,648,329 (GRCm39) probably benign Het
Zfp959 G A 17: 56,204,221 (GRCm39) R86K probably benign Het
Other mutations in Gas2l3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00321:Gas2l3 APN 10 89,249,489 (GRCm39) missense probably benign 0.00
IGL01148:Gas2l3 APN 10 89,249,366 (GRCm39) missense probably benign 0.25
R0472:Gas2l3 UTSW 10 89,262,339 (GRCm39) missense probably damaging 1.00
R0578:Gas2l3 UTSW 10 89,252,937 (GRCm39) missense probably damaging 1.00
R0720:Gas2l3 UTSW 10 89,249,805 (GRCm39) missense probably benign 0.00
R1386:Gas2l3 UTSW 10 89,250,215 (GRCm39) missense possibly damaging 0.77
R1470:Gas2l3 UTSW 10 89,249,796 (GRCm39) missense probably benign
R1470:Gas2l3 UTSW 10 89,249,796 (GRCm39) missense probably benign
R1530:Gas2l3 UTSW 10 89,269,631 (GRCm39) missense probably benign 0.02
R1733:Gas2l3 UTSW 10 89,250,127 (GRCm39) missense probably damaging 1.00
R1772:Gas2l3 UTSW 10 89,252,876 (GRCm39) unclassified probably benign
R1840:Gas2l3 UTSW 10 89,258,113 (GRCm39) missense possibly damaging 0.79
R2168:Gas2l3 UTSW 10 89,249,960 (GRCm39) missense probably benign 0.01
R3082:Gas2l3 UTSW 10 89,266,820 (GRCm39) small deletion probably benign
R3083:Gas2l3 UTSW 10 89,266,820 (GRCm39) small deletion probably benign
R4639:Gas2l3 UTSW 10 89,266,820 (GRCm39) small deletion probably benign
R4641:Gas2l3 UTSW 10 89,266,820 (GRCm39) small deletion probably benign
R4642:Gas2l3 UTSW 10 89,266,820 (GRCm39) small deletion probably benign
R4643:Gas2l3 UTSW 10 89,266,820 (GRCm39) small deletion probably benign
R4644:Gas2l3 UTSW 10 89,266,820 (GRCm39) small deletion probably benign
R4645:Gas2l3 UTSW 10 89,266,820 (GRCm39) small deletion probably benign
R4809:Gas2l3 UTSW 10 89,266,820 (GRCm39) small deletion probably benign
R4810:Gas2l3 UTSW 10 89,266,820 (GRCm39) small deletion probably benign
R4820:Gas2l3 UTSW 10 89,252,907 (GRCm39) missense probably damaging 1.00
R4852:Gas2l3 UTSW 10 89,266,820 (GRCm39) small deletion probably benign
R4853:Gas2l3 UTSW 10 89,266,820 (GRCm39) small deletion probably benign
R4855:Gas2l3 UTSW 10 89,266,820 (GRCm39) small deletion probably benign
R4865:Gas2l3 UTSW 10 89,266,820 (GRCm39) small deletion probably benign
R4900:Gas2l3 UTSW 10 89,266,820 (GRCm39) small deletion probably benign
R4906:Gas2l3 UTSW 10 89,266,820 (GRCm39) small deletion probably benign
R4926:Gas2l3 UTSW 10 89,266,820 (GRCm39) small deletion probably benign
R4946:Gas2l3 UTSW 10 89,249,634 (GRCm39) missense probably benign
R5072:Gas2l3 UTSW 10 89,266,820 (GRCm39) small deletion probably benign
R5073:Gas2l3 UTSW 10 89,266,820 (GRCm39) small deletion probably benign
R5074:Gas2l3 UTSW 10 89,266,820 (GRCm39) small deletion probably benign
R5137:Gas2l3 UTSW 10 89,249,837 (GRCm39) missense probably damaging 1.00
R5579:Gas2l3 UTSW 10 89,249,928 (GRCm39) missense probably benign
R5919:Gas2l3 UTSW 10 89,252,917 (GRCm39) missense probably damaging 1.00
R6573:Gas2l3 UTSW 10 89,258,072 (GRCm39) splice site probably null
R6763:Gas2l3 UTSW 10 89,249,231 (GRCm39) missense probably benign 0.00
R6961:Gas2l3 UTSW 10 89,249,153 (GRCm39) missense probably benign 0.00
R7491:Gas2l3 UTSW 10 89,249,763 (GRCm39) missense probably benign 0.02
R7707:Gas2l3 UTSW 10 89,250,220 (GRCm39) missense probably damaging 1.00
R7806:Gas2l3 UTSW 10 89,249,232 (GRCm39) missense probably benign 0.00
R8167:Gas2l3 UTSW 10 89,262,342 (GRCm39) missense probably damaging 1.00
R8781:Gas2l3 UTSW 10 89,266,841 (GRCm39) missense probably damaging 0.99
R8862:Gas2l3 UTSW 10 89,250,282 (GRCm39) missense probably damaging 0.97
R9119:Gas2l3 UTSW 10 89,249,319 (GRCm39) missense possibly damaging 0.87
R9258:Gas2l3 UTSW 10 89,262,315 (GRCm39) missense probably benign 0.18
R9574:Gas2l3 UTSW 10 89,258,135 (GRCm39) missense probably damaging 1.00
R9634:Gas2l3 UTSW 10 89,249,943 (GRCm39) missense probably benign 0.00
R9640:Gas2l3 UTSW 10 89,266,774 (GRCm39) missense probably damaging 1.00
R9702:Gas2l3 UTSW 10 89,249,943 (GRCm39) missense probably benign 0.00
R9703:Gas2l3 UTSW 10 89,249,943 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- ATTCCGGCAGACACCCTTAC -3'
(R):5'- CAAGAGATCTGTCTAAGTCCAGAC -3'

Sequencing Primer
(F):5'- GCAGACACCCTTACTCTGAGGTTG -3'
(R):5'- GTAAATCTCCTGGAAAAATGGAACC -3'
Posted On 2021-11-19