Incidental Mutation 'R9064:Or10j3b'
ID 689133
Institutional Source Beutler Lab
Gene Symbol Or10j3b
Ensembl Gene ENSMUSG00000049456
Gene Name olfactory receptor family 10 subfamily J member 3B
Synonyms GA_x6K02T2R7CC-630397-629456, Olfr1404, MOR267-2
MMRRC Submission 068889-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.505) question?
Stock # R9064 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 173043174-173044207 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 173044060 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Phenylalanine at position 281 (L281F)
Ref Sequence ENSEMBL: ENSMUSP00000150122 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049706] [ENSMUST00000056592] [ENSMUST00000193017] [ENSMUST00000216556] [ENSMUST00000217374]
AlphaFold Q8VGE1
Predicted Effect probably benign
Transcript: ENSMUST00000049706
SMART Domains Protein: ENSMUSP00000056882
Gene: ENSMUSG00000005339

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
IG 34 108 1.08e-8 SMART
IG 116 193 1.37e-1 SMART
transmembrane domain 200 222 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000056592
AA Change: L281F

PolyPhen 2 Score 0.667 (Sensitivity: 0.86; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000050406
Gene: ENSMUSG00000049456
AA Change: L281F

DomainStartEndE-ValueType
Pfam:7tm_4 32 309 7.9e-55 PFAM
Pfam:7tm_1 42 291 1e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000193017
SMART Domains Protein: ENSMUSP00000141932
Gene: ENSMUSG00000005339

DomainStartEndE-ValueType
IG_like 9 52 4.8e-1 SMART
IG 60 137 5.7e-4 SMART
transmembrane domain 144 166 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000216556
AA Change: L281F

PolyPhen 2 Score 0.667 (Sensitivity: 0.86; Specificity: 0.91)
Predicted Effect possibly damaging
Transcript: ENSMUST00000217374
AA Change: L281F

PolyPhen 2 Score 0.667 (Sensitivity: 0.86; Specificity: 0.91)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.2%
Validation Efficiency 100% (52/52)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acss1 T C 2: 150,463,510 (GRCm39) E598G probably benign Het
Adgrb3 T C 1: 25,570,965 (GRCm39) E504G possibly damaging Het
Ank3 T C 10: 69,822,185 (GRCm39) S285P Het
Ankrd28 G A 14: 31,454,005 (GRCm39) H410Y probably damaging Het
Armh1 C A 4: 117,094,855 (GRCm39) V62L probably benign Het
Atp8b1 A G 18: 64,697,491 (GRCm39) I451T probably benign Het
C2cd3 A G 7: 100,059,608 (GRCm39) D245G Het
Calr3 T C 8: 73,188,674 (GRCm39) K151R possibly damaging Het
Cenpq G A 17: 41,243,731 (GRCm39) T39I probably benign Het
Cep126 T C 9: 8,103,341 (GRCm39) D223G possibly damaging Het
Chd2 A T 7: 73,143,279 (GRCm39) I538K possibly damaging Het
Cyp3a41b C T 5: 145,514,910 (GRCm39) R105Q probably damaging Het
Dnah6 C A 6: 73,126,156 (GRCm39) R1327L probably benign Het
Exd2 T C 12: 80,531,148 (GRCm39) probably null Het
Fam118a T C 15: 84,930,039 (GRCm39) V89A probably damaging Het
Fbxo40 A T 16: 36,791,002 (GRCm39) I36K probably damaging Het
Fntb A G 12: 76,934,640 (GRCm39) N170S probably benign Het
Frzb A G 2: 80,277,052 (GRCm39) S45P probably benign Het
Gm4841 T C 18: 60,403,961 (GRCm39) E44G probably benign Het
Hecw2 C A 1: 53,866,045 (GRCm39) A1539S probably benign Het
Jarid2 G T 13: 44,994,326 (GRCm39) V13L Het
Kcnh5 A T 12: 75,177,727 (GRCm39) C126* probably null Het
Kdm5a TAGAAGAAG TAGAAG 6: 120,403,869 (GRCm39) probably benign Het
Kremen2 A G 17: 23,961,736 (GRCm39) L257P possibly damaging Het
Mcat A C 15: 83,432,134 (GRCm39) F245V probably damaging Het
Mdm2 T C 10: 117,538,235 (GRCm39) I54M probably benign Het
Muc4 A G 16: 32,754,397 (GRCm38) T1424A possibly damaging Het
Mylk3 T C 8: 86,081,940 (GRCm39) T416A probably benign Het
Nol4 T A 18: 22,903,850 (GRCm39) D156V Het
Nxpe4 T C 9: 48,309,964 (GRCm39) V409A probably benign Het
Nxt2 C T X: 141,020,747 (GRCm39) A118V possibly damaging Het
Obscn G T 11: 58,899,935 (GRCm39) T966K Het
Or10w1 G A 19: 13,632,719 (GRCm39) V309M possibly damaging Het
Or14c42-ps1 A G 7: 86,211,371 (GRCm39) T144A unknown Het
Phip C T 9: 82,753,540 (GRCm39) V1735I probably benign Het
Pkhd1l1 A T 15: 44,426,038 (GRCm39) T3200S possibly damaging Het
Prdm4 T C 10: 85,737,678 (GRCm39) N496S probably damaging Het
Proser1 C T 3: 53,384,927 (GRCm39) L270F probably damaging Het
Psmd11 T C 11: 80,336,069 (GRCm39) V107A probably damaging Het
Rassf10 A T 7: 112,554,315 (GRCm39) E305D probably benign Het
Rbm45 T C 2: 76,202,446 (GRCm39) I123T probably damaging Het
Rpp25 G T 9: 57,411,635 (GRCm39) R39L probably damaging Het
Rreb1 A G 13: 38,115,326 (GRCm39) N895S possibly damaging Het
Sirpa A T 2: 129,458,460 (GRCm39) S359C possibly damaging Het
Slc26a9 T A 1: 131,680,703 (GRCm39) C83S probably benign Het
Spink5 T G 18: 44,100,193 (GRCm39) L70R probably damaging Het
Stil T G 4: 114,898,932 (GRCm39) N1187K probably benign Het
Sucla2 A T 14: 73,828,303 (GRCm39) E303D probably benign Het
Supt3 G A 17: 45,305,295 (GRCm39) probably null Het
Tmc5 G T 7: 118,233,270 (GRCm39) S28I probably benign Het
Vps8 T C 16: 21,288,979 (GRCm39) V444A probably damaging Het
Other mutations in Or10j3b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01295:Or10j3b APN 1 173,043,440 (GRCm39) missense probably damaging 0.99
IGL01411:Or10j3b APN 1 173,043,695 (GRCm39) missense probably benign 0.01
IGL02533:Or10j3b APN 1 173,043,628 (GRCm39) missense probably damaging 0.99
IGL02559:Or10j3b APN 1 173,044,088 (GRCm39) missense probably damaging 0.98
R0233:Or10j3b UTSW 1 173,043,868 (GRCm39) missense probably benign 0.25
R0233:Or10j3b UTSW 1 173,043,868 (GRCm39) missense probably benign 0.25
R0245:Or10j3b UTSW 1 173,043,524 (GRCm39) missense possibly damaging 0.54
R0652:Or10j3b UTSW 1 173,043,524 (GRCm39) missense possibly damaging 0.54
R1613:Or10j3b UTSW 1 173,043,434 (GRCm39) missense probably benign 0.41
R1939:Or10j3b UTSW 1 173,043,499 (GRCm39) missense probably benign 0.00
R2062:Or10j3b UTSW 1 173,043,277 (GRCm39) missense probably benign 0.00
R2074:Or10j3b UTSW 1 173,043,377 (GRCm39) missense probably damaging 0.98
R6045:Or10j3b UTSW 1 173,044,067 (GRCm39) missense possibly damaging 0.94
R6681:Or10j3b UTSW 1 173,043,973 (GRCm39) missense probably damaging 1.00
R7192:Or10j3b UTSW 1 173,043,575 (GRCm39) missense probably damaging 0.98
R7576:Or10j3b UTSW 1 173,043,538 (GRCm39) missense probably benign 0.01
R8919:Or10j3b UTSW 1 173,044,064 (GRCm39) missense probably damaging 0.97
R9369:Or10j3b UTSW 1 173,043,451 (GRCm39) missense possibly damaging 0.55
R9615:Or10j3b UTSW 1 173,044,034 (GRCm39) missense possibly damaging 0.50
Predicted Primers PCR Primer
(F):5'- ATGGGCGTGGTCTTCATCTC -3'
(R):5'- GTTATCAACTGTTAACGTGTTCTGG -3'

Sequencing Primer
(F):5'- ATGTAGTGATCATCTCCACCATC -3'
(R):5'- GTTTTGCTGATACCATAAGATAAGGC -3'
Posted On 2021-11-19