Incidental Mutation 'R9066:Ncr1'
ID 689261
Institutional Source Beutler Lab
Gene Symbol Ncr1
Ensembl Gene ENSMUSG00000062524
Gene Name natural cytotoxicity triggering receptor 1
Synonyms Ly94, NKp46, MAR1 (mouse activating receptor 1), Cd335
MMRRC Submission 068891-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.050) question?
Stock # R9066 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 4340723-4348163 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 4347552 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 276 (D276G)
Ref Sequence ENSEMBL: ENSMUSP00000006792 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000006792] [ENSMUST00000126417]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000006792
AA Change: D276G

PolyPhen 2 Score 0.130 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000006792
Gene: ENSMUSG00000062524
AA Change: D276G

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
IG 34 118 5.21e-2 SMART
IG 129 211 1.49e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000126417
AA Change: D239G

PolyPhen 2 Score 0.130 (Sensitivity: 0.93; Specificity: 0.86)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 96% (46/48)
MGI Phenotype PHENOTYPE: Mutations in this gene lead to alterations in susceptibility to viral infection induced morbidity/mortality, NK cell number, NK cell cytolysis, and T cell responses. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca7 A G 10: 79,849,188 (GRCm39) T1858A probably damaging Het
Atp1a1 A G 3: 101,489,338 (GRCm39) I758T probably damaging Het
Atp2c1 T C 9: 105,330,845 (GRCm39) E225G probably damaging Het
Clec7a A C 6: 129,444,491 (GRCm39) S115A probably benign Het
Cnbd1 T C 4: 19,098,181 (GRCm39) T80A probably benign Het
Ctu1 A G 7: 43,326,019 (GRCm39) H226R possibly damaging Het
Dctn4 T C 18: 60,659,387 (GRCm39) F29L probably damaging Het
Dnajb2 A G 1: 75,217,874 (GRCm39) T169A Het
Efcab3 T A 11: 104,631,688 (GRCm39) probably benign Het
Esf1 A T 2: 139,990,693 (GRCm39) M597K probably benign Het
Fzd7 C T 1: 59,521,991 (GRCm39) probably benign Het
Gapvd1 C A 2: 34,617,297 (GRCm39) Q349H probably damaging Het
Garin5b T C 7: 4,773,518 (GRCm39) probably benign Het
Gata5 A G 2: 179,968,761 (GRCm39) F371S Het
Gm572 A T 4: 148,751,278 (GRCm39) Q217L possibly damaging Het
Igkv14-130 T A 6: 67,768,219 (GRCm39) M26K probably damaging Het
Jchain T G 5: 88,675,638 (GRCm39) M1L probably benign Het
Kcnj14 G A 7: 45,469,073 (GRCm39) T144M probably damaging Het
Kirrel2 C A 7: 30,153,454 (GRCm39) A302S probably damaging Het
Klhl29 C T 12: 5,260,114 (GRCm39) V35I probably benign Het
Kndc1 C T 7: 139,507,708 (GRCm39) S1222F possibly damaging Het
Lgi4 A C 7: 30,759,446 (GRCm39) M1L probably benign Het
Nfatc3 T A 8: 106,825,782 (GRCm39) M619K probably benign Het
Nudcd1 A T 15: 44,243,588 (GRCm39) F441I probably damaging Het
Nxt2 C T X: 141,020,747 (GRCm39) A118V possibly damaging Het
Or10a3n A T 7: 108,493,253 (GRCm39) Y125* probably null Het
Or8b12 T G 9: 37,657,871 (GRCm39) V147G possibly damaging Het
Pop1 A T 15: 34,516,060 (GRCm39) Q586L possibly damaging Het
Prss3b C T 6: 41,008,640 (GRCm39) G225R probably benign Het
Rcbtb1 T G 14: 59,462,206 (GRCm39) I279S possibly damaging Het
Rsf1 CGGCGGCGG CGGCGGCGGGGGCGGCGG 7: 97,229,118 (GRCm39) probably benign Het
Serpine3 A G 14: 62,929,555 (GRCm39) D401G probably damaging Het
Slc25a4 A G 8: 46,662,115 (GRCm39) V181A probably damaging Het
Slc26a2 T G 18: 61,335,130 (GRCm39) I108L probably benign Het
Slc27a5 A C 7: 12,722,530 (GRCm39) V648G possibly damaging Het
Slc2a7 T C 4: 150,250,872 (GRCm39) F431S probably damaging Het
Sox11 T C 12: 27,391,422 (GRCm39) H329R possibly damaging Het
Speg G A 1: 75,361,654 (GRCm39) G223R probably damaging Het
Synpo2 G A 3: 122,911,133 (GRCm39) H171Y possibly damaging Het
Tle6 G T 10: 81,430,212 (GRCm39) N323K possibly damaging Het
Ugt3a1 A T 15: 9,367,384 (GRCm39) M376L possibly damaging Het
Unc13d T C 11: 115,957,561 (GRCm39) K798R probably benign Het
Vasp A T 7: 18,998,433 (GRCm39) H80Q probably damaging Het
Vmn2r28 T C 7: 5,491,596 (GRCm39) D217G probably damaging Het
Vps41 T C 13: 19,008,018 (GRCm39) S284P probably damaging Het
Zer1 A C 2: 30,000,686 (GRCm39) L245R probably damaging Het
Zfp516 G T 18: 82,973,964 (GRCm39) R54L probably damaging Het
Zfp868 T C 8: 70,064,292 (GRCm39) K348E probably damaging Het
Other mutations in Ncr1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00832:Ncr1 APN 7 4,344,287 (GRCm39) missense possibly damaging 0.50
IGL01994:Ncr1 APN 7 4,344,253 (GRCm39) missense probably benign 0.16
IGL02163:Ncr1 APN 7 4,344,262 (GRCm39) missense possibly damaging 0.86
IGL02610:Ncr1 APN 7 4,341,132 (GRCm39) missense probably benign 0.42
IGL02885:Ncr1 APN 7 4,341,225 (GRCm39) missense probably damaging 1.00
IGL03082:Ncr1 APN 7 4,344,241 (GRCm39) splice site probably benign
R0196:Ncr1 UTSW 7 4,343,972 (GRCm39) missense probably damaging 1.00
R1172:Ncr1 UTSW 7 4,341,120 (GRCm39) missense probably benign 0.19
R1758:Ncr1 UTSW 7 4,343,807 (GRCm39) missense probably benign 0.40
R2065:Ncr1 UTSW 7 4,341,206 (GRCm39) missense probably benign 0.00
R2135:Ncr1 UTSW 7 4,343,756 (GRCm39) splice site probably benign
R2397:Ncr1 UTSW 7 4,341,260 (GRCm39) missense probably benign 0.22
R5389:Ncr1 UTSW 7 4,343,932 (GRCm39) missense probably benign 0.01
R5648:Ncr1 UTSW 7 4,347,519 (GRCm39) missense probably damaging 0.97
R5690:Ncr1 UTSW 7 4,341,296 (GRCm39) missense probably damaging 1.00
R5817:Ncr1 UTSW 7 4,343,894 (GRCm39) missense possibly damaging 0.59
R5847:Ncr1 UTSW 7 4,347,573 (GRCm39) missense probably benign 0.04
R7033:Ncr1 UTSW 7 4,341,144 (GRCm39) missense possibly damaging 0.59
R7391:Ncr1 UTSW 7 4,347,470 (GRCm39) missense possibly damaging 0.86
R7395:Ncr1 UTSW 7 4,341,150 (GRCm39) missense probably damaging 1.00
R7680:Ncr1 UTSW 7 4,341,123 (GRCm39) missense possibly damaging 0.52
R8163:Ncr1 UTSW 7 4,343,828 (GRCm39) missense probably damaging 1.00
R8472:Ncr1 UTSW 7 4,341,120 (GRCm39) missense probably benign 0.19
R8782:Ncr1 UTSW 7 4,340,763 (GRCm39) missense probably benign 0.01
R8880:Ncr1 UTSW 7 4,341,336 (GRCm39) missense probably benign 0.00
R9789:Ncr1 UTSW 7 4,344,300 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- TAGTCTCTGGGGAAGGTACAGG -3'
(R):5'- ATCCAGGGTACAGCATAGAGC -3'

Sequencing Primer
(F):5'- TAGGGACATCCTTGTGACAAG -3'
(R):5'- CTCACAAGGCCCCAGGAGTTG -3'
Posted On 2021-11-19