Incidental Mutation 'R9068:Zfp541'
ID 689370
Institutional Source Beutler Lab
Gene Symbol Zfp541
Ensembl Gene ENSMUSG00000078796
Gene Name zinc finger protein 541
Synonyms EG666528
MMRRC Submission 068892-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.750) question?
Stock # R9068 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 15795739-15830259 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 15812376 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 343 (E343G)
Ref Sequence ENSEMBL: ENSMUSP00000104149 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000108509] [ENSMUST00000209369] [ENSMUST00000210805]
AlphaFold Q0GGX2
Predicted Effect probably damaging
Transcript: ENSMUST00000108509
AA Change: E343G

PolyPhen 2 Score 0.963 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000104149
Gene: ENSMUSG00000078796
AA Change: E343G

DomainStartEndE-ValueType
low complexity region 48 65 N/A INTRINSIC
ZnF_C2H2 140 162 2.24e-3 SMART
ZnF_C2H2 168 190 4.47e-3 SMART
ZnF_C2H2 196 221 2.36e-2 SMART
low complexity region 249 260 N/A INTRINSIC
low complexity region 362 374 N/A INTRINSIC
low complexity region 444 465 N/A INTRINSIC
low complexity region 473 484 N/A INTRINSIC
low complexity region 594 609 N/A INTRINSIC
low complexity region 659 670 N/A INTRINSIC
ZnF_C2H2 838 860 3.72e0 SMART
low complexity region 953 958 N/A INTRINSIC
ELM2 1065 1122 4.46e-14 SMART
SANT 1171 1219 8.38e-7 SMART
low complexity region 1252 1263 N/A INTRINSIC
ZnF_C2H2 1301 1323 1.01e-1 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000209369
AA Change: E343G

PolyPhen 2 Score 0.963 (Sensitivity: 0.78; Specificity: 0.95)
Predicted Effect probably benign
Transcript: ENSMUST00000210805
AA Change: E343G

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 97% (57/59)
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aass T C 6: 23,075,828 (GRCm39) I770V probably benign Het
Abtb3 C A 10: 85,223,762 (GRCm39) N190K unknown Het
Actr10 T C 12: 70,989,073 (GRCm39) L64S probably damaging Het
Adam22 T C 5: 8,177,343 (GRCm39) T589A probably benign Het
Akr1b7 T C 6: 34,395,977 (GRCm39) S160P probably damaging Het
Ankrd52 C T 10: 128,217,850 (GRCm39) H277Y probably damaging Het
Cc2d1b T A 4: 108,482,062 (GRCm39) L112Q probably damaging Het
Cd200r3 T A 16: 44,773,750 (GRCm39) probably benign Het
Clec3a A G 8: 115,152,375 (GRCm39) D127G probably damaging Het
Cnnm3 T C 1: 36,551,962 (GRCm39) L324P probably damaging Het
Cspp1 T C 1: 10,147,469 (GRCm39) probably null Het
Cwf19l1 C T 19: 44,124,274 (GRCm39) probably benign Het
Cyp26b1 G A 6: 84,551,379 (GRCm39) T470I probably damaging Het
Dedd2 A G 7: 24,917,092 (GRCm39) V110A probably benign Het
Dnah8 A G 17: 30,975,729 (GRCm39) I2866M possibly damaging Het
Dpp10 T C 1: 123,360,667 (GRCm39) Y286C probably damaging Het
Efna2 C T 10: 80,024,524 (GRCm39) P177L probably damaging Het
Fbxo46 A G 7: 18,869,325 (GRCm39) probably benign Het
Gdpd5 A T 7: 99,108,048 (GRCm39) T542S probably benign Het
Gm136 T G 4: 34,750,928 (GRCm39) D115A possibly damaging Het
Gm7356 T A 17: 14,221,687 (GRCm39) K114I possibly damaging Het
Gpr180 G T 14: 118,385,658 (GRCm39) E157* probably null Het
Grk4 T C 5: 34,905,653 (GRCm39) I466T Het
Hic1 A G 11: 75,060,332 (GRCm39) M5T unknown Het
Hmcn2 C A 2: 31,303,685 (GRCm39) N3058K probably benign Het
Htr5a T A 5: 28,055,799 (GRCm39) H263Q probably benign Het
Lrrc7 T C 3: 157,946,138 (GRCm39) K187R probably benign Het
Map3k8 A T 18: 4,340,557 (GRCm39) H252Q probably benign Het
Muc4 CAC CACTAC 16: 32,575,367 (GRCm39) probably benign Het
Naa16 A T 14: 79,612,289 (GRCm39) M233K probably benign Het
Napsa A T 7: 44,235,223 (GRCm39) D336V probably damaging Het
Neurod1 T A 2: 79,285,218 (GRCm39) N55I possibly damaging Het
Or10d5 A T 9: 39,862,087 (GRCm39) probably benign Het
Or4c115 A T 2: 88,927,369 (GRCm39) C301S probably benign Het
Or5an9 T C 19: 12,187,703 (GRCm39) F258L probably damaging Het
Or8b12 T A 9: 37,657,963 (GRCm39) C178S probably damaging Het
Pcdha8 G T 18: 37,127,323 (GRCm39) G602C probably damaging Het
Peg10 T TCCG 6: 4,756,451 (GRCm39) probably benign Het
Pigr G A 1: 130,774,231 (GRCm39) V404M probably damaging Het
Plch1 G A 3: 63,612,036 (GRCm39) P803L probably damaging Het
Ppp4r3b T A 11: 29,159,396 (GRCm39) F583L probably benign Het
Rit2 A T 18: 31,108,468 (GRCm39) D172E possibly damaging Het
Skint4 C T 4: 112,022,932 (GRCm39) P476S possibly damaging Het
Slco2b1 A G 7: 99,320,171 (GRCm39) V353A probably benign Het
Slit3 A G 11: 35,574,917 (GRCm39) D1077G probably damaging Het
Sun2 A G 15: 79,612,252 (GRCm39) F478L probably benign Het
Syt6 C A 3: 103,494,825 (GRCm39) C263* probably null Het
Tfpi C A 2: 84,273,235 (GRCm39) L229F unknown Het
Tmem131l A T 3: 83,817,775 (GRCm39) C1242S probably benign Het
Ttc3 T A 16: 94,204,219 (GRCm39) W280R probably damaging Het
Uncx A G 5: 139,532,573 (GRCm39) K213E possibly damaging Het
Usp24 T C 4: 106,232,875 (GRCm39) L887P probably benign Het
Vmn1r178 A T 7: 23,593,404 (GRCm39) I151F probably damaging Het
Vmn2r50 G T 7: 9,772,061 (GRCm39) Q547K possibly damaging Het
Vwf A G 6: 125,625,792 (GRCm39) probably benign Het
Wdfy3 A T 5: 102,000,451 (GRCm39) V2973D probably benign Het
Zbtb49 T C 5: 38,358,289 (GRCm39) M655V probably benign Het
Zc3h3 C T 15: 75,711,499 (GRCm39) A321T probably benign Het
Zeb2 T A 2: 45,000,040 (GRCm39) R65W possibly damaging Het
Zfp775 C A 6: 48,597,151 (GRCm39) R342S probably damaging Het
Zwilch A G 9: 64,075,942 (GRCm39) F27L probably benign Het
Other mutations in Zfp541
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02162:Zfp541 APN 7 15,813,393 (GRCm39) missense possibly damaging 0.80
IGL02262:Zfp541 APN 7 15,813,620 (GRCm39) missense probably damaging 1.00
IGL02347:Zfp541 APN 7 15,817,390 (GRCm39) missense probably damaging 1.00
IGL02516:Zfp541 APN 7 15,816,918 (GRCm39) splice site probably null
R0101:Zfp541 UTSW 7 15,811,968 (GRCm39) missense probably damaging 1.00
R0412:Zfp541 UTSW 7 15,816,099 (GRCm39) missense possibly damaging 0.88
R0627:Zfp541 UTSW 7 15,829,607 (GRCm39) splice site probably benign
R0784:Zfp541 UTSW 7 15,816,917 (GRCm39) intron probably benign
R1083:Zfp541 UTSW 7 15,812,637 (GRCm39) missense probably benign 0.16
R1541:Zfp541 UTSW 7 15,812,437 (GRCm39) missense probably benign 0.04
R1575:Zfp541 UTSW 7 15,812,640 (GRCm39) missense possibly damaging 0.94
R1730:Zfp541 UTSW 7 15,811,898 (GRCm39) missense probably damaging 0.99
R1783:Zfp541 UTSW 7 15,811,898 (GRCm39) missense probably damaging 0.99
R1966:Zfp541 UTSW 7 15,812,996 (GRCm39) missense probably benign 0.02
R2022:Zfp541 UTSW 7 15,816,110 (GRCm39) missense probably damaging 1.00
R2048:Zfp541 UTSW 7 15,812,252 (GRCm39) missense possibly damaging 0.94
R2436:Zfp541 UTSW 7 15,810,373 (GRCm39) missense possibly damaging 0.94
R3973:Zfp541 UTSW 7 15,806,147 (GRCm39) missense probably damaging 1.00
R4081:Zfp541 UTSW 7 15,806,060 (GRCm39) missense probably benign 0.16
R4589:Zfp541 UTSW 7 15,817,261 (GRCm39) missense probably benign 0.35
R4724:Zfp541 UTSW 7 15,815,612 (GRCm39) missense probably damaging 0.99
R4812:Zfp541 UTSW 7 15,813,035 (GRCm39) missense probably benign 0.01
R4817:Zfp541 UTSW 7 15,824,307 (GRCm39) missense probably damaging 1.00
R5232:Zfp541 UTSW 7 15,829,104 (GRCm39) missense probably damaging 1.00
R5331:Zfp541 UTSW 7 15,829,683 (GRCm39) missense probably damaging 1.00
R5551:Zfp541 UTSW 7 15,824,786 (GRCm39) missense probably damaging 1.00
R5976:Zfp541 UTSW 7 15,810,344 (GRCm39) missense probably benign 0.34
R6259:Zfp541 UTSW 7 15,829,451 (GRCm39) missense probably benign 0.02
R6523:Zfp541 UTSW 7 15,829,445 (GRCm39) missense probably damaging 1.00
R6826:Zfp541 UTSW 7 15,812,907 (GRCm39) missense probably damaging 0.96
R7319:Zfp541 UTSW 7 15,813,294 (GRCm39) missense probably benign 0.21
R7428:Zfp541 UTSW 7 15,826,793 (GRCm39) missense probably damaging 1.00
R7594:Zfp541 UTSW 7 15,810,311 (GRCm39) missense probably damaging 0.96
R7724:Zfp541 UTSW 7 15,805,919 (GRCm39) missense probably damaging 1.00
R8276:Zfp541 UTSW 7 15,813,009 (GRCm39) missense possibly damaging 0.87
R8433:Zfp541 UTSW 7 15,805,999 (GRCm39) missense probably benign 0.16
R9086:Zfp541 UTSW 7 15,824,329 (GRCm39) missense probably damaging 1.00
R9132:Zfp541 UTSW 7 15,816,966 (GRCm39) missense probably benign 0.45
R9261:Zfp541 UTSW 7 15,816,029 (GRCm39) missense possibly damaging 0.94
R9408:Zfp541 UTSW 7 15,806,139 (GRCm39) missense probably damaging 1.00
R9518:Zfp541 UTSW 7 15,813,036 (GRCm39) missense possibly damaging 0.80
R9621:Zfp541 UTSW 7 15,805,892 (GRCm39) missense possibly damaging 0.94
Z1088:Zfp541 UTSW 7 15,813,720 (GRCm39) missense probably benign 0.16
Z1176:Zfp541 UTSW 7 15,812,191 (GRCm39) missense probably damaging 1.00
Z1177:Zfp541 UTSW 7 15,816,092 (GRCm39) missense probably damaging 0.98
Z1177:Zfp541 UTSW 7 15,812,954 (GRCm39) missense probably benign 0.26
Z1177:Zfp541 UTSW 7 15,812,688 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCATCGTCCACCAGAAGATTC -3'
(R):5'- CACTGGAAGTTGTGGCTGGAAG -3'

Sequencing Primer
(F):5'- GAAGATTCCTTCTCCTGGCCCAG -3'
(R):5'- CTGGAAGGCTGGGATCCTGAG -3'
Posted On 2021-11-19