Incidental Mutation 'R9070:Or2b2b'
ID 689501
Institutional Source Beutler Lab
Gene Symbol Or2b2b
Ensembl Gene ENSMUSG00000108534
Gene Name olfactory receptor family 2 subfamily B member 2B
Synonyms MOR256-10, MOR256-35, GA_x6K02T2QHY8-11561962-11562903, Olfr1360
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.116) question?
Stock # R9070 (G1)
Quality Score 225.009
Status Not validated
Chromosome 13
Chromosomal Location 21858171-21859150 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 21858985 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 43 (M43K)
Ref Sequence ENSEMBL: ENSMUSP00000146159 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079135] [ENSMUST00000205788] [ENSMUST00000216083]
AlphaFold K9J6X0
Predicted Effect probably benign
Transcript: ENSMUST00000079135
AA Change: M43K

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000074361
Gene: ENSMUSG00000108534
AA Change: M43K

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 3e-55 PFAM
Pfam:7tm_1 41 290 1.1e-30 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000205788
AA Change: M43K

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
Predicted Effect probably benign
Transcript: ENSMUST00000216083
AA Change: M43K

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (45/45)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adcy5 T C 16: 35,100,770 (GRCm39) L774P probably damaging Het
Aldh2 T C 5: 121,707,032 (GRCm39) E495G probably damaging Het
Als2cl T C 9: 110,718,288 (GRCm39) V343A probably benign Het
Antxrl T A 14: 33,793,671 (GRCm39) C466* probably null Het
Aoc1l3 A G 6: 48,965,329 (GRCm39) N446D possibly damaging Het
Arc A G 15: 74,543,833 (GRCm39) L130P probably damaging Het
Barhl1 C A 2: 28,805,423 (GRCm39) R90L probably benign Het
Baz2a A G 10: 127,958,931 (GRCm39) M1149V probably benign Het
Bsn G A 9: 107,987,295 (GRCm39) S106L Het
Calu A G 6: 29,356,567 (GRCm39) E31G probably benign Het
Cdh23 T G 10: 60,173,539 (GRCm39) I1650L probably benign Het
Ceacam9 T C 7: 16,457,787 (GRCm39) V100A possibly damaging Het
Dnaaf9 A T 2: 130,654,793 (GRCm39) S159R possibly damaging Het
Dpyd T G 3: 118,792,892 (GRCm39) I533S probably damaging Het
Fam184a T C 10: 53,514,373 (GRCm39) D1016G possibly damaging Het
Fv1 T A 4: 147,954,414 (GRCm39) W327R probably damaging Het
Gbp7 A G 3: 142,249,762 (GRCm39) D411G probably benign Het
Gldc A T 19: 30,080,404 (GRCm39) D885E probably damaging Het
H4c3 A G 13: 23,882,170 (GRCm39) V88A probably damaging Het
Hdgfl2 T C 17: 56,389,371 (GRCm39) W82R possibly damaging Het
Hif1an A G 19: 44,551,458 (GRCm39) S48G probably benign Het
Itgal C T 7: 126,927,873 (GRCm39) R1023W probably null Het
Kif13a C A 13: 46,905,934 (GRCm39) A1618S probably benign Het
Lrrc57 A G 2: 120,436,565 (GRCm39) L181P probably damaging Het
Mptx2 T A 1: 173,102,119 (GRCm39) D190V probably benign Het
Mroh5 A G 15: 73,656,688 (GRCm39) F590L probably damaging Het
Net1 A G 13: 3,936,103 (GRCm39) I381T probably damaging Het
Nipbl T A 15: 8,368,215 (GRCm39) K1169I possibly damaging Het
Nop9 G A 14: 55,990,757 (GRCm39) R563H probably damaging Het
Obscn A T 11: 59,013,457 (GRCm39) L1130Q probably damaging Het
Or1j13 A T 2: 36,369,268 (GRCm39) S291R probably damaging Het
Pcgf1 T A 6: 83,057,076 (GRCm39) H202Q probably damaging Het
Pcnx3 A G 19: 5,715,601 (GRCm39) L1883P probably benign Het
Pde4b T C 4: 102,458,994 (GRCm39) S505P probably damaging Het
Pitpnm2 C A 5: 124,259,375 (GRCm39) R1320L probably damaging Het
Plscr4 C A 9: 92,372,281 (GRCm39) probably benign Het
Pot1a C T 6: 25,744,629 (GRCm39) R625Q Het
Pou4f1 A G 14: 104,704,067 (GRCm39) S122P probably damaging Het
Ppl A G 16: 4,907,208 (GRCm39) V1029A probably benign Het
Prex1 A G 2: 166,427,707 (GRCm39) F982L probably damaging Het
Prr27 C A 5: 87,990,994 (GRCm39) P202Q probably benign Het
Rbks A G 5: 31,854,890 (GRCm39) V19A probably benign Het
Rps18-ps5 A G 13: 28,441,902 (GRCm39) Y95C probably benign Het
Rps20 A T 4: 3,835,280 (GRCm39) D5E probably benign Het
Sacs C A 14: 61,447,751 (GRCm39) P3266T probably benign Het
Septin7 A G 9: 25,175,507 (GRCm39) probably benign Het
Slc28a2b A G 2: 122,352,154 (GRCm39) T331A probably damaging Het
Tasor T C 14: 27,194,484 (GRCm39) V1228A probably benign Het
Trdv5 T C 14: 54,386,258 (GRCm39) D69G probably damaging Het
Treml4 G T 17: 48,576,781 (GRCm39) G180C probably damaging Het
Other mutations in Or2b2b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01736:Or2b2b APN 13 21,858,787 (GRCm39) missense probably benign 0.12
IGL02886:Or2b2b APN 13 21,859,122 (GRCm39) utr 5 prime probably benign
IGL03157:Or2b2b APN 13 21,859,112 (GRCm39) start codon destroyed probably null 0.48
R1540:Or2b2b UTSW 13 21,858,700 (GRCm39) missense probably benign 0.11
R1756:Or2b2b UTSW 13 21,858,865 (GRCm39) missense probably benign 0.00
R1843:Or2b2b UTSW 13 21,858,842 (GRCm39) missense probably benign 0.00
R3793:Or2b2b UTSW 13 21,859,153 (GRCm39) splice site probably null
R5707:Or2b2b UTSW 13 21,858,769 (GRCm39) missense probably damaging 1.00
R7566:Or2b2b UTSW 13 21,858,737 (GRCm39) missense possibly damaging 0.61
R8781:Or2b2b UTSW 13 21,859,013 (GRCm39) missense probably damaging 1.00
R8849:Or2b2b UTSW 13 21,858,226 (GRCm39) missense possibly damaging 0.67
R9462:Or2b2b UTSW 13 21,859,015 (GRCm39) missense probably benign 0.19
Z1177:Or2b2b UTSW 13 21,859,324 (GRCm39) start gained probably benign
Predicted Primers PCR Primer
(F):5'- AATGAAAAGCTGGGCCACAC -3'
(R):5'- TCACTTCATAACTAGCTGACACATC -3'

Sequencing Primer
(F):5'- GCCACACAGCCACCATAG -3'
(R):5'- TAGCTGACACATCCAATAAGCATGTC -3'
Posted On 2021-11-19