Incidental Mutation 'R9071:Card6'
ID 689560
Institutional Source Beutler Lab
Gene Symbol Card6
Ensembl Gene ENSMUSG00000041849
Gene Name caspase recruitment domain family, member 6
Synonyms
MMRRC Submission 068893-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9071 (G1)
Quality Score 210.458
Status Not validated
Chromosome 15
Chromosomal Location 5125463-5138021 bp(-) (GRCm39)
Type of Mutation small deletion (10 aa in frame mutation)
DNA Base Change (assembly) TTGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGCGGATGAGAGGGCTTAGCATGGGAGGACTG to TTGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGCGGATGAGAGGGCTTAGCATGGGAGGACTG at 5128173 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000112833 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000118365]
AlphaFold E9PWH2
Predicted Effect probably benign
Transcript: ENSMUST00000118365
SMART Domains Protein: ENSMUSP00000112833
Gene: ENSMUSG00000041849

DomainStartEndE-ValueType
CARD 3 89 2.13e-5 SMART
low complexity region 237 245 N/A INTRINSIC
low complexity region 257 273 N/A INTRINSIC
Blast:PGAM 278 656 7e-45 BLAST
low complexity region 919 935 N/A INTRINSIC
low complexity region 946 961 N/A INTRINSIC
internal_repeat_1 962 1041 6.5e-13 PROSPERO
internal_repeat_1 1039 1101 6.5e-13 PROSPERO
low complexity region 1107 1132 N/A INTRINSIC
Meta Mutation Damage Score 0.0846 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.4%
Validation Efficiency 100% (52/52)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that contains a caspase recruitment domain (CARD), an antiparallel six-helical bundle that mediates homotypic protein-protein interactions. The encoded protein is a microtubule-associated protein that has been shown to interact with receptor-interacting protein kinases and positively modulate signal transduction pathways converging on activation of the inducible transcription factor NF-kB. [provided by RefSeq, Jul 2008]
PHENOTYPE: Knockout mice are viable and grossly normal with no deficits in thymocytes, granulocytes, macrophages, NK cells or T- and B-cell subsets. Various signaling pathways mediating innate and adaptive immune responses appear unaltered. Mice are normally resistant to infection by a wide range of pathogens. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610021A01Rik G T 7: 41,274,783 (GRCm39) R162L probably benign Het
Alpi A G 1: 87,026,584 (GRCm39) V469A probably damaging Het
Amotl2 G T 9: 102,595,892 (GRCm39) probably benign Het
Ano3 T A 2: 110,625,418 (GRCm39) probably null Het
Atg16l1 G T 1: 87,683,907 (GRCm39) probably benign Het
Atg2b C A 12: 105,625,099 (GRCm39) E626* probably null Het
B3galt9 T C 2: 34,728,435 (GRCm39) V78A probably benign Het
Ccdc162 G A 10: 41,457,174 (GRCm39) Q1588* probably null Het
Cd3d A T 9: 44,896,340 (GRCm39) H43L probably benign Het
Cenpk C T 13: 104,378,870 (GRCm39) Q164* probably null Het
Clybl C A 14: 122,608,697 (GRCm39) D96E probably benign Het
Cog1 T C 11: 113,546,939 (GRCm39) V511A probably damaging Het
Crhr1 T A 11: 104,064,133 (GRCm39) I282N probably damaging Het
Crybg2 A G 4: 133,818,542 (GRCm39) N1433D probably damaging Het
Cspp1 A T 1: 10,159,121 (GRCm39) I516F possibly damaging Het
Cul9 T C 17: 46,837,379 (GRCm39) T1030A probably benign Het
Cyp2d10 T C 15: 82,288,361 (GRCm39) T313A probably damaging Het
Ddx11 T A 17: 66,450,736 (GRCm39) N549K probably damaging Het
Ddx41 A G 13: 55,680,219 (GRCm39) V391A probably damaging Het
Eif3a T C 19: 60,751,634 (GRCm39) D1227G unknown Het
Fam83f T C 15: 80,576,206 (GRCm39) Y286H probably damaging Het
Fasn T C 11: 120,708,324 (GRCm39) D647G probably damaging Het
Fat4 T C 3: 39,037,598 (GRCm39) V3750A probably benign Het
Golga2 T C 2: 32,178,364 (GRCm39) S14P probably damaging Het
Hgsnat A G 8: 26,436,302 (GRCm39) V584A possibly damaging Het
Ifi207 A T 1: 173,557,764 (GRCm39) F325I unknown Het
Igfals A T 17: 25,099,670 (GRCm39) I254F probably damaging Het
Matr3 T C 18: 35,705,803 (GRCm39) Y243H possibly damaging Het
Mki67 G C 7: 135,301,205 (GRCm39) D1276E probably benign Het
Moap1 T A 12: 102,709,364 (GRCm39) K62* probably null Het
Msto1 C A 3: 88,812,414 (GRCm39) probably benign Het
Myt1 A T 2: 181,448,420 (GRCm39) D697V possibly damaging Het
Nampt T A 12: 32,892,781 (GRCm39) V356E probably damaging Het
Nell2 T A 15: 95,244,682 (GRCm39) K472* probably null Het
Nfe2l3 A C 6: 51,434,243 (GRCm39) S268R probably benign Het
Or8b43 T C 9: 38,361,032 (GRCm39) I288T possibly damaging Het
Osbpl10 G T 9: 114,890,908 (GRCm39) V99L probably benign Het
Plod2 A G 9: 92,485,048 (GRCm39) I537M probably benign Het
Prdm4 A G 10: 85,729,076 (GRCm39) L770P probably benign Het
Prr27 C A 5: 87,990,994 (GRCm39) P202Q probably benign Het
Scaper T C 9: 55,771,803 (GRCm39) D371G probably benign Het
Sema3e A G 5: 14,282,154 (GRCm39) K430R probably benign Het
Sez6l A T 5: 112,573,603 (GRCm39) probably benign Het
Slco1a5 A T 6: 142,196,052 (GRCm39) I317N possibly damaging Het
Spata4 T G 8: 55,055,742 (GRCm39) F211C probably damaging Het
Sspo A G 6: 48,433,982 (GRCm39) E929G probably benign Het
Sult1e1 A C 5: 87,735,681 (GRCm39) probably benign Het
Tas2r125 A T 6: 132,887,400 (GRCm39) N263Y probably benign Het
Ugt3a1 T A 15: 9,370,224 (GRCm39) L456* probably null Het
Wdr20rt G A 12: 65,274,222 (GRCm39) V562I probably benign Het
Zc3h7b T C 15: 81,677,964 (GRCm39) *983Q probably null Het
Zfp28 T A 7: 6,397,544 (GRCm39) C660S probably damaging Het
Other mutations in Card6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00755:Card6 APN 15 5,128,423 (GRCm39) missense possibly damaging 0.93
IGL01307:Card6 APN 15 5,129,484 (GRCm39) missense possibly damaging 0.93
IGL02016:Card6 APN 15 5,137,738 (GRCm39) missense probably damaging 1.00
IGL02976:Card6 APN 15 5,129,310 (GRCm39) nonsense probably null
IGL03328:Card6 APN 15 5,134,927 (GRCm39) splice site probably benign
IGL03356:Card6 APN 15 5,129,723 (GRCm39) missense probably benign 0.00
Mark UTSW 15 5,128,173 (GRCm39) small deletion probably benign
sharps UTSW 15 5,129,378 (GRCm39) nonsense probably null
PIT4131001:Card6 UTSW 15 5,137,788 (GRCm39) missense probably damaging 1.00
PIT4142001:Card6 UTSW 15 5,128,113 (GRCm39) missense unknown
PIT4458001:Card6 UTSW 15 5,128,173 (GRCm39) small deletion probably benign
R0562:Card6 UTSW 15 5,134,648 (GRCm39) missense probably damaging 1.00
R0943:Card6 UTSW 15 5,129,768 (GRCm39) missense probably damaging 1.00
R1654:Card6 UTSW 15 5,128,214 (GRCm39) missense probably benign 0.00
R3892:Card6 UTSW 15 5,128,778 (GRCm39) missense probably benign 0.01
R4408:Card6 UTSW 15 5,130,536 (GRCm39) missense probably damaging 0.97
R4856:Card6 UTSW 15 5,134,623 (GRCm39) splice site probably null
R4886:Card6 UTSW 15 5,134,623 (GRCm39) splice site probably null
R4998:Card6 UTSW 15 5,129,564 (GRCm39) missense probably benign 0.00
R5050:Card6 UTSW 15 5,129,858 (GRCm39) missense probably benign 0.00
R5365:Card6 UTSW 15 5,134,888 (GRCm39) missense possibly damaging 0.53
R5518:Card6 UTSW 15 5,134,696 (GRCm39) missense probably damaging 0.99
R5686:Card6 UTSW 15 5,130,435 (GRCm39) missense probably damaging 0.99
R6088:Card6 UTSW 15 5,134,501 (GRCm39) missense possibly damaging 0.56
R6194:Card6 UTSW 15 5,127,926 (GRCm39) missense unknown
R6336:Card6 UTSW 15 5,128,646 (GRCm39) nonsense probably null
R6539:Card6 UTSW 15 5,134,873 (GRCm39) missense probably damaging 0.99
R6560:Card6 UTSW 15 5,128,367 (GRCm39) missense probably damaging 1.00
R7132:Card6 UTSW 15 5,128,173 (GRCm39) small deletion probably benign
R7157:Card6 UTSW 15 5,129,591 (GRCm39) missense probably benign 0.07
R7174:Card6 UTSW 15 5,128,173 (GRCm39) small deletion probably benign
R7186:Card6 UTSW 15 5,128,173 (GRCm39) small deletion probably benign
R7338:Card6 UTSW 15 5,129,354 (GRCm39) missense probably benign 0.09
R7430:Card6 UTSW 15 5,128,682 (GRCm39) missense probably benign 0.00
R7579:Card6 UTSW 15 5,128,173 (GRCm39) small deletion probably benign
R7677:Card6 UTSW 15 5,127,926 (GRCm39) missense unknown
R7718:Card6 UTSW 15 5,129,269 (GRCm39) missense possibly damaging 0.54
R7720:Card6 UTSW 15 5,127,905 (GRCm39) missense unknown
R7756:Card6 UTSW 15 5,129,378 (GRCm39) nonsense probably null
R7758:Card6 UTSW 15 5,129,378 (GRCm39) nonsense probably null
R7762:Card6 UTSW 15 5,134,820 (GRCm39) missense probably benign
R7786:Card6 UTSW 15 5,128,173 (GRCm39) small deletion probably benign
R7808:Card6 UTSW 15 5,128,954 (GRCm39) missense probably benign 0.00
R7817:Card6 UTSW 15 5,128,173 (GRCm39) small deletion probably benign
R7822:Card6 UTSW 15 5,128,347 (GRCm39) missense possibly damaging 0.82
R7902:Card6 UTSW 15 5,128,173 (GRCm39) small deletion probably benign
R7977:Card6 UTSW 15 5,130,007 (GRCm39) missense probably damaging 1.00
R7987:Card6 UTSW 15 5,130,007 (GRCm39) missense probably damaging 1.00
R8295:Card6 UTSW 15 5,128,173 (GRCm39) small deletion probably benign
R8303:Card6 UTSW 15 5,134,847 (GRCm39) missense probably benign 0.13
R8431:Card6 UTSW 15 5,129,758 (GRCm39) missense probably damaging 0.98
R8691:Card6 UTSW 15 5,129,078 (GRCm39) missense possibly damaging 0.76
R8937:Card6 UTSW 15 5,128,173 (GRCm39) small deletion probably benign
R8978:Card6 UTSW 15 5,128,173 (GRCm39) small deletion probably benign
R9009:Card6 UTSW 15 5,128,173 (GRCm39) small deletion probably benign
R9441:Card6 UTSW 15 5,128,173 (GRCm39) small deletion probably benign
R9558:Card6 UTSW 15 5,128,173 (GRCm39) small deletion probably benign
R9565:Card6 UTSW 15 5,128,173 (GRCm39) small deletion probably benign
R9771:Card6 UTSW 15 5,129,693 (GRCm39) missense probably benign 0.01
R9800:Card6 UTSW 15 5,128,702 (GRCm39) missense probably benign 0.00
RF013:Card6 UTSW 15 5,129,624 (GRCm39) missense probably benign 0.19
Predicted Primers PCR Primer
(F):5'- TGGGTCTCGGTTGAAAAGGC -3'
(R):5'- TGCTAAACCTTCTCATCAGAATCC -3'

Sequencing Primer
(F):5'- GCCTTACACTGAGTAGACTGG -3'
(R):5'- TCAGAATCCCTCTCATGCTAAC -3'
Posted On 2021-11-19