Incidental Mutation 'R9072:Zfp735'
| ID |
689616 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp735
|
| Ensembl Gene |
ENSMUSG00000060630 |
| Gene Name |
zinc finger protein 735 |
| Synonyms |
1700012C15Rik |
| MMRRC Submission |
068894-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.069)
|
| Stock # |
R9072 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
11 |
| Chromosomal Location |
73579604-73604624 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 73603060 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 668
(V668A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000079269
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000080407]
|
| AlphaFold |
B1ARH2 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000080407
AA Change: V668A
PolyPhen 2
Score 0.210 (Sensitivity: 0.92; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000079269
Gene: ENSMUSG00000060630
AA Change: V668A
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
8 |
68 |
2.2e-34 |
SMART |
|
ZnF_C2H2
|
483 |
505 |
4.38e1 |
SMART |
|
ZnF_C2H2
|
511 |
533 |
2.67e-1 |
SMART |
|
ZnF_C2H2
|
539 |
561 |
1.81e1 |
SMART |
|
ZnF_C2H2
|
567 |
589 |
1.5e-4 |
SMART |
|
ZnF_C2H2
|
595 |
617 |
4.87e-4 |
SMART |
|
ZnF_C2H2
|
623 |
645 |
4.24e-4 |
SMART |
|
ZnF_C2H2
|
651 |
673 |
2.27e-4 |
SMART |
|
ZnF_C2H2
|
679 |
701 |
7.49e-5 |
SMART |
|
ZnF_C2H2
|
707 |
729 |
4.87e-4 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 73 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aak1 |
T |
A |
6: 86,921,374 (GRCm39) |
Y190* |
probably null |
Het |
| Agbl3 |
T |
C |
6: 34,776,387 (GRCm39) |
C298R |
probably damaging |
Het |
| Ankrd26 |
T |
A |
6: 118,500,350 (GRCm39) |
K1040N |
probably damaging |
Het |
| Ano3 |
T |
A |
2: 110,576,243 (GRCm39) |
T93S |
probably benign |
Het |
| Apoc3 |
T |
A |
9: 46,144,532 (GRCm39) |
I97F |
probably benign |
Het |
| Arid5a |
A |
G |
1: 36,358,626 (GRCm39) |
E401G |
probably benign |
Het |
| Atxn3 |
T |
C |
12: 101,903,730 (GRCm39) |
|
probably null |
Het |
| Brca1 |
C |
T |
11: 101,393,306 (GRCm39) |
|
probably null |
Het |
| C1ql3 |
T |
A |
2: 13,015,198 (GRCm39) |
N154I |
probably damaging |
Het |
| Ccdc110 |
A |
T |
8: 46,395,875 (GRCm39) |
M589L |
probably benign |
Het |
| Ccnb2 |
A |
T |
9: 70,318,095 (GRCm39) |
F226I |
possibly damaging |
Het |
| Commd8 |
TTGTCATCT |
TT |
5: 72,318,327 (GRCm39) |
|
probably null |
Het |
| Dis3 |
T |
C |
14: 99,332,647 (GRCm39) |
T262A |
probably benign |
Het |
| Eif4a2 |
G |
A |
16: 22,929,403 (GRCm39) |
R234Q |
probably benign |
Het |
| Ephx2 |
G |
A |
14: 66,323,688 (GRCm39) |
R481* |
probably null |
Het |
| Fbxo15 |
T |
C |
18: 84,983,645 (GRCm39) |
I331T |
possibly damaging |
Het |
| Gfra2 |
A |
G |
14: 71,138,935 (GRCm39) |
E121G |
possibly damaging |
Het |
| Git1 |
G |
A |
11: 77,389,901 (GRCm39) |
A55T |
probably benign |
Het |
| Hfm1 |
T |
C |
5: 107,046,146 (GRCm39) |
I553V |
probably benign |
Het |
| Hydin |
G |
A |
8: 110,994,083 (GRCm39) |
|
probably null |
Het |
| Iqgap3 |
A |
G |
3: 88,016,773 (GRCm39) |
N1085S |
|
Het |
| Kbtbd12 |
T |
C |
6: 88,595,422 (GRCm39) |
Y136C |
probably damaging |
Het |
| Kcng3 |
A |
G |
17: 83,938,423 (GRCm39) |
Y209H |
possibly damaging |
Het |
| Kcnj2 |
A |
T |
11: 110,962,664 (GRCm39) |
M19L |
possibly damaging |
Het |
| Lonrf2 |
A |
T |
1: 38,850,867 (GRCm39) |
F232I |
probably damaging |
Het |
| Lrrc31 |
T |
C |
3: 30,753,859 (GRCm39) |
D14G |
probably benign |
Het |
| Ly6l |
G |
A |
15: 75,321,585 (GRCm39) |
V62I |
possibly damaging |
Het |
| Marchf8 |
T |
C |
6: 116,378,884 (GRCm39) |
F273L |
probably benign |
Het |
| Masp1 |
A |
C |
16: 23,288,671 (GRCm39) |
S710A |
probably benign |
Het |
| Mcm10 |
G |
A |
2: 5,013,414 (GRCm39) |
R73C |
possibly damaging |
Het |
| Mcm5 |
G |
A |
8: 75,852,934 (GRCm39) |
R682H |
probably damaging |
Het |
| Mink1 |
C |
T |
11: 70,499,207 (GRCm39) |
T684I |
possibly damaging |
Het |
| Mocos |
A |
T |
18: 24,797,089 (GRCm39) |
Q83L |
probably damaging |
Het |
| Nags |
T |
C |
11: 102,038,347 (GRCm39) |
L351P |
probably damaging |
Het |
| Nalcn |
G |
A |
14: 123,532,863 (GRCm39) |
T1299I |
possibly damaging |
Het |
| Nlrp4b |
A |
G |
7: 10,459,870 (GRCm39) |
D824G |
probably benign |
Het |
| Nwd1 |
A |
T |
8: 73,422,046 (GRCm39) |
M1031L |
probably benign |
Het |
| Or11g27 |
C |
T |
14: 50,771,211 (GRCm39) |
T114I |
probably benign |
Het |
| Or4c101 |
A |
C |
2: 88,390,658 (GRCm39) |
I271L |
probably benign |
Het |
| Or4k40 |
A |
T |
2: 111,250,705 (GRCm39) |
I197N |
possibly damaging |
Het |
| Or56b1 |
C |
T |
7: 104,285,291 (GRCm39) |
R137C |
probably benign |
Het |
| Or5b112 |
A |
G |
19: 13,319,238 (GRCm39) |
T39A |
possibly damaging |
Het |
| Or5d37 |
T |
A |
2: 87,924,172 (GRCm39) |
Q36L |
probably benign |
Het |
| Pan2 |
T |
C |
10: 128,151,050 (GRCm39) |
M807T |
probably damaging |
Het |
| Parp8 |
A |
T |
13: 117,047,951 (GRCm39) |
I222N |
probably damaging |
Het |
| Pmm1 |
C |
T |
15: 81,839,896 (GRCm39) |
R143H |
probably damaging |
Het |
| Pou1f1 |
T |
C |
16: 65,328,833 (GRCm39) |
L186P |
|
Het |
| Ppargc1b |
G |
A |
18: 61,443,730 (GRCm39) |
R494W |
probably damaging |
Het |
| Prg4 |
G |
T |
1: 150,331,288 (GRCm39) |
P462T |
unknown |
Het |
| Ptcd1 |
T |
A |
5: 145,091,525 (GRCm39) |
I525L |
probably benign |
Het |
| Ptchd4 |
A |
T |
17: 42,813,650 (GRCm39) |
Y517F |
probably damaging |
Het |
| Pum1 |
T |
C |
4: 130,480,172 (GRCm39) |
F693S |
probably damaging |
Het |
| Ribc2 |
A |
C |
15: 85,022,163 (GRCm39) |
Q186P |
probably damaging |
Het |
| Sesn2 |
C |
A |
4: 132,224,195 (GRCm39) |
|
probably null |
Het |
| Sgf29 |
G |
A |
7: 126,271,826 (GRCm39) |
V284M |
probably damaging |
Het |
| Skap2 |
C |
T |
6: 51,856,750 (GRCm39) |
|
probably null |
Het |
| Smap1 |
T |
A |
1: 23,961,154 (GRCm39) |
E28V |
probably damaging |
Het |
| Smc3 |
A |
G |
19: 53,617,200 (GRCm39) |
N538D |
probably benign |
Het |
| Spen |
T |
C |
4: 141,203,702 (GRCm39) |
T1642A |
unknown |
Het |
| Spred3 |
G |
A |
7: 28,865,955 (GRCm39) |
R115* |
probably null |
Het |
| Sugt1 |
T |
A |
14: 79,866,293 (GRCm39) |
M304K |
possibly damaging |
Het |
| Sval1 |
T |
C |
6: 41,928,606 (GRCm39) |
I6T |
possibly damaging |
Het |
| Svil |
T |
C |
18: 5,097,500 (GRCm39) |
I1574T |
probably benign |
Het |
| Tinag |
T |
A |
9: 76,904,300 (GRCm39) |
|
probably null |
Het |
| Trak1 |
T |
C |
9: 121,289,554 (GRCm39) |
L622P |
probably damaging |
Het |
| Ttn |
C |
T |
2: 76,586,218 (GRCm39) |
D21838N |
probably damaging |
Het |
| Ttn |
ATATCTCTCCAGAGCCTCCCCTGGAGGAGTGGAGTATCTCTCCAGAGCCTCCCCTGGAGGAGTGGAGTATCTCTCCAGAGCCTCCCCTG |
ATATCTCTCCAGAGCCTCCCCTGGAGGAGTGGAGTATCTCTCCAGAGCCTCCCCTG |
2: 76,746,150 (GRCm39) |
|
probably benign |
Het |
| Vmn1r43 |
G |
A |
6: 89,846,877 (GRCm39) |
T203M |
probably damaging |
Het |
| Vmn1r73 |
C |
T |
7: 11,490,203 (GRCm39) |
A7V |
probably benign |
Het |
| Yy1 |
G |
T |
12: 108,759,921 (GRCm39) |
G195C |
probably benign |
Het |
| Zbtb17 |
T |
A |
4: 141,193,676 (GRCm39) |
C607S |
possibly damaging |
Het |
| Zfp819 |
C |
A |
7: 43,266,570 (GRCm39) |
T351K |
probably damaging |
Het |
| Zfp820 |
C |
A |
17: 22,039,031 (GRCm39) |
S99I |
possibly damaging |
Het |
|
| Other mutations in Zfp735 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00492:Zfp735
|
APN |
11 |
73,602,192 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL00798:Zfp735
|
APN |
11 |
73,602,386 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
IGL01642:Zfp735
|
APN |
11 |
73,601,305 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
IGL01684:Zfp735
|
APN |
11 |
73,581,191 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL02096:Zfp735
|
APN |
11 |
73,602,254 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02238:Zfp735
|
APN |
11 |
73,601,319 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02505:Zfp735
|
APN |
11 |
73,580,626 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02740:Zfp735
|
APN |
11 |
73,601,412 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
IGL02957:Zfp735
|
APN |
11 |
73,601,755 (GRCm39) |
missense |
probably benign |
0.00 |
|
bananaquit
|
UTSW |
11 |
73,601,412 (GRCm39) |
nonsense |
probably null |
|
|
bescher
|
UTSW |
11 |
73,602,979 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
Galvanic
|
UTSW |
11 |
73,602,504 (GRCm39) |
nonsense |
probably null |
|
|
grassquit
|
UTSW |
11 |
73,603,029 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R0114:Zfp735
|
UTSW |
11 |
73,601,488 (GRCm39) |
missense |
probably benign |
0.33 |
|
R0217:Zfp735
|
UTSW |
11 |
73,602,112 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R0943:Zfp735
|
UTSW |
11 |
73,602,909 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1421:Zfp735
|
UTSW |
11 |
73,601,523 (GRCm39) |
missense |
probably benign |
|
|
R1460:Zfp735
|
UTSW |
11 |
73,603,159 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R1493:Zfp735
|
UTSW |
11 |
73,601,305 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R1517:Zfp735
|
UTSW |
11 |
73,601,470 (GRCm39) |
missense |
probably benign |
|
|
R1676:Zfp735
|
UTSW |
11 |
73,602,301 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R1709:Zfp735
|
UTSW |
11 |
73,602,589 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1871:Zfp735
|
UTSW |
11 |
73,601,412 (GRCm39) |
nonsense |
probably null |
|
|
R1931:Zfp735
|
UTSW |
11 |
73,602,677 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R2219:Zfp735
|
UTSW |
11 |
73,601,851 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R2227:Zfp735
|
UTSW |
11 |
73,602,223 (GRCm39) |
nonsense |
probably null |
|
|
R2227:Zfp735
|
UTSW |
11 |
73,602,222 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R3552:Zfp735
|
UTSW |
11 |
73,602,067 (GRCm39) |
nonsense |
probably null |
|
|
R3856:Zfp735
|
UTSW |
11 |
73,602,282 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3925:Zfp735
|
UTSW |
11 |
73,601,950 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4572:Zfp735
|
UTSW |
11 |
73,580,611 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4585:Zfp735
|
UTSW |
11 |
73,580,550 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R4586:Zfp735
|
UTSW |
11 |
73,580,550 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R4619:Zfp735
|
UTSW |
11 |
73,602,031 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4687:Zfp735
|
UTSW |
11 |
73,602,682 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4687:Zfp735
|
UTSW |
11 |
73,602,681 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5435:Zfp735
|
UTSW |
11 |
73,602,939 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R5489:Zfp735
|
UTSW |
11 |
73,601,419 (GRCm39) |
nonsense |
probably null |
|
|
R5516:Zfp735
|
UTSW |
11 |
73,601,640 (GRCm39) |
missense |
probably benign |
|
|
R5654:Zfp735
|
UTSW |
11 |
73,602,964 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R5990:Zfp735
|
UTSW |
11 |
73,581,174 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R6332:Zfp735
|
UTSW |
11 |
73,602,504 (GRCm39) |
nonsense |
probably null |
|
|
R6427:Zfp735
|
UTSW |
11 |
73,581,140 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R6460:Zfp735
|
UTSW |
11 |
73,602,478 (GRCm39) |
missense |
probably benign |
0.33 |
|
R6820:Zfp735
|
UTSW |
11 |
73,579,783 (GRCm39) |
start codon destroyed |
probably null |
0.01 |
|
R6831:Zfp735
|
UTSW |
11 |
73,601,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6833:Zfp735
|
UTSW |
11 |
73,601,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6834:Zfp735
|
UTSW |
11 |
73,601,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6897:Zfp735
|
UTSW |
11 |
73,601,880 (GRCm39) |
missense |
probably benign |
0.08 |
|
R6941:Zfp735
|
UTSW |
11 |
73,581,159 (GRCm39) |
missense |
probably benign |
0.33 |
|
R7335:Zfp735
|
UTSW |
11 |
73,602,379 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R7366:Zfp735
|
UTSW |
11 |
73,602,979 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7474:Zfp735
|
UTSW |
11 |
73,602,002 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R7487:Zfp735
|
UTSW |
11 |
73,581,154 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7583:Zfp735
|
UTSW |
11 |
73,601,933 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R7866:Zfp735
|
UTSW |
11 |
73,601,629 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8005:Zfp735
|
UTSW |
11 |
73,603,140 (GRCm39) |
nonsense |
probably null |
|
|
R8500:Zfp735
|
UTSW |
11 |
73,601,811 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8551:Zfp735
|
UTSW |
11 |
73,603,122 (GRCm39) |
missense |
probably benign |
0.06 |
|
R8754:Zfp735
|
UTSW |
11 |
73,603,000 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8769:Zfp735
|
UTSW |
11 |
73,581,127 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8794:Zfp735
|
UTSW |
11 |
73,603,029 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R8835:Zfp735
|
UTSW |
11 |
73,601,692 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8869:Zfp735
|
UTSW |
11 |
73,602,510 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8969:Zfp735
|
UTSW |
11 |
73,602,699 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9073:Zfp735
|
UTSW |
11 |
73,603,060 (GRCm39) |
missense |
probably benign |
0.21 |
|
R9193:Zfp735
|
UTSW |
11 |
73,580,600 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R9355:Zfp735
|
UTSW |
11 |
73,602,362 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9414:Zfp735
|
UTSW |
11 |
73,602,023 (GRCm39) |
nonsense |
probably null |
|
|
R9456:Zfp735
|
UTSW |
11 |
73,602,403 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R9573:Zfp735
|
UTSW |
11 |
73,602,936 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R9647:Zfp735
|
UTSW |
11 |
73,580,600 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9710:Zfp735
|
UTSW |
11 |
73,601,806 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
Z1176:Zfp735
|
UTSW |
11 |
73,601,641 (GRCm39) |
missense |
probably benign |
0.02 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTCAGTACTCAGCTCTTCAAAAC -3'
(R):5'- ATCATGTAAATGATTCCCCATGC -3'
Sequencing Primer
(F):5'- TCTTCAAGTGCATCAGAGAGTCC -3'
(R):5'- GAAGTCTGTGGTGAACTTTAAGAC -3'
|
| Posted On |
2021-11-19 |
Incidental Mutation