Incidental Mutation 'R9075:Tmprss15'
ID 689757
Institutional Source Beutler Lab
Gene Symbol Tmprss15
Ensembl Gene ENSMUSG00000022857
Gene Name transmembrane protease, serine 15
Synonyms Prss7, enterokinase, enteropeptidase, A130097D21Rik
MMRRC Submission 068896-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9075 (G1)
Quality Score 225.009
Status Validated
Chromosome 16
Chromosomal Location 78749896-78887985 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 78754259 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 998 (Y998C)
Ref Sequence ENSEMBL: ENSMUSP00000023566 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023566] [ENSMUST00000060402]
AlphaFold P97435
Predicted Effect probably damaging
Transcript: ENSMUST00000023566
AA Change: Y998C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000023566
Gene: ENSMUSG00000022857
AA Change: Y998C

DomainStartEndE-ValueType
transmembrane domain 21 43 N/A INTRINSIC
SEA 52 172 1.62e-22 SMART
LDLa 228 268 1.74e-4 SMART
CUB 270 379 1.54e-11 SMART
MAM 387 549 7.33e-54 SMART
low complexity region 551 567 N/A INTRINSIC
CUB 569 679 1.72e-32 SMART
LDLa 687 724 7.32e-12 SMART
SR 723 813 3.12e-5 SMART
Tryp_SPc 829 1064 1.48e-95 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000060402
AA Change: Y983C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000052034
Gene: ENSMUSG00000022857
AA Change: Y983C

DomainStartEndE-ValueType
transmembrane domain 21 43 N/A INTRINSIC
SEA 52 172 1.62e-22 SMART
LDLa 213 253 1.74e-4 SMART
CUB 255 364 1.54e-11 SMART
MAM 372 534 7.33e-54 SMART
low complexity region 536 552 N/A INTRINSIC
CUB 554 664 1.72e-32 SMART
LDLa 672 709 7.32e-12 SMART
SR 708 798 3.12e-5 SMART
Tryp_SPc 814 1049 1.48e-95 SMART
Meta Mutation Damage Score 0.0789 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (50/50)
MGI Phenotype FUNCTION: This gene encodes an enzyme that proteolytically activates the pancreatic proenzyme trypsinogen, converting it into trypsin. The encoded protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3110009E18Rik T G 1: 120,097,014 (GRCm39) S137A Het
Actl6a G T 3: 32,769,641 (GRCm39) C152F possibly damaging Het
Adam26b A T 8: 43,973,405 (GRCm39) D532E probably benign Het
Adamts6 A G 13: 104,598,793 (GRCm39) N878S probably benign Het
Ap1b1 T C 11: 4,975,597 (GRCm39) S387P possibly damaging Het
Cdh23 A G 10: 60,153,541 (GRCm39) S2350P probably damaging Het
Cdh4 A G 2: 179,501,940 (GRCm39) D300G probably damaging Het
Cngb1 T C 8: 95,979,993 (GRCm39) Y969C probably damaging Het
Cog8 C T 8: 107,779,208 (GRCm39) M356I probably damaging Het
Fam168a T A 7: 100,484,582 (GRCm39) V224D probably damaging Het
Fam210a C T 18: 68,405,693 (GRCm39) V177M probably damaging Het
Flnc A T 6: 29,447,646 (GRCm39) I1150F probably damaging Het
Frmd4a G T 2: 4,608,765 (GRCm39) G878W probably damaging Het
Gm11555 C T 11: 99,540,694 (GRCm39) C95Y Het
Gns A G 10: 121,226,542 (GRCm39) N397S probably benign Het
Grin2b CA C 6: 135,709,509 (GRCm39) probably null Het
Ifi204 T A 1: 173,589,282 (GRCm39) N50Y possibly damaging Het
Iqub T A 6: 24,446,124 (GRCm39) I767F probably damaging Het
Lama2 A T 10: 26,857,588 (GRCm39) L3087Q probably damaging Het
Mars2 A G 1: 55,278,154 (GRCm39) T586A probably damaging Het
Mrps28 G T 3: 8,867,312 (GRCm39) S185R probably benign Het
Nphp4 T C 4: 152,591,905 (GRCm39) Y363H probably damaging Het
Nploc4 T C 11: 120,304,526 (GRCm39) T232A possibly damaging Het
Pate3 A G 9: 35,557,893 (GRCm39) probably null Het
Pcdh18 G A 3: 49,699,339 (GRCm39) A1041V probably benign Het
Plpp5 T A 8: 26,210,379 (GRCm39) Y50N probably benign Het
Ppp4r4 G T 12: 103,570,290 (GRCm39) G755* probably null Het
Psmd14 T A 2: 61,607,021 (GRCm39) V156D probably damaging Het
Ptch1 G A 13: 63,681,335 (GRCm39) R651C possibly damaging Het
Rai14 T C 15: 10,589,403 (GRCm39) E265G probably damaging Het
Rbmx G A X: 56,432,717 (GRCm39) P301L probably benign Het
Rimbp2 T A 5: 128,851,312 (GRCm39) D878V probably damaging Het
Sarm1 T C 11: 78,374,023 (GRCm39) K668R probably benign Het
Slc10a2 C A 8: 5,155,267 (GRCm39) probably benign Het
Slc15a3 T C 19: 10,826,094 (GRCm39) S262P probably damaging Het
Slf2 T C 19: 44,930,860 (GRCm39) Y646H probably damaging Het
Smpd4 C T 16: 17,457,849 (GRCm39) P406S unknown Het
Sv2b A G 7: 74,789,845 (GRCm39) V396A possibly damaging Het
Swt1 A G 1: 151,246,245 (GRCm39) probably benign Het
Sympk A G 7: 18,776,563 (GRCm39) E485G probably benign Het
Tbc1d9 T C 8: 83,982,501 (GRCm39) V762A probably benign Het
Thbs2 T A 17: 14,900,587 (GRCm39) H540L probably benign Het
Tie1 C A 4: 118,341,356 (GRCm39) G275V possibly damaging Het
Trappc10 A T 10: 78,040,130 (GRCm39) V607E possibly damaging Het
Trim69 A T 2: 122,009,264 (GRCm39) R441S probably benign Het
Trio G T 15: 27,774,022 (GRCm39) S1814* probably null Het
Vmn1r192 C T 13: 22,371,333 (GRCm39) V296I probably benign Het
Vmn1r223 A G 13: 23,433,600 (GRCm39) S65G possibly damaging Het
Vmn1r43 G A 6: 89,846,877 (GRCm39) T203M probably damaging Het
Vmn2r41 A G 7: 8,141,250 (GRCm39) V738A probably benign Het
Zfp408 A G 2: 91,476,065 (GRCm39) V363A possibly damaging Het
Zfp583 A T 7: 6,319,870 (GRCm39) C381S probably damaging Het
Other mutations in Tmprss15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00331:Tmprss15 APN 16 78,782,882 (GRCm39) missense possibly damaging 0.87
IGL00477:Tmprss15 APN 16 78,818,301 (GRCm39) missense probably damaging 1.00
IGL01583:Tmprss15 APN 16 78,868,149 (GRCm39) missense probably benign
IGL01896:Tmprss15 APN 16 78,887,678 (GRCm39) missense probably benign 0.22
IGL02052:Tmprss15 APN 16 78,884,394 (GRCm39) missense probably damaging 1.00
IGL02374:Tmprss15 APN 16 78,832,056 (GRCm39) missense probably benign 0.00
IGL02505:Tmprss15 APN 16 78,784,629 (GRCm39) missense probably benign 0.00
IGL02632:Tmprss15 APN 16 78,782,790 (GRCm39) missense probably damaging 0.98
IGL02674:Tmprss15 APN 16 78,798,682 (GRCm39) missense possibly damaging 0.72
beached UTSW 16 78,821,736 (GRCm39) missense possibly damaging 0.62
Cellulite UTSW 16 78,754,259 (GRCm39) missense probably damaging 1.00
lolling UTSW 16 78,800,298 (GRCm39) missense probably benign 0.26
miniature UTSW 16 78,854,497 (GRCm39) critical splice donor site probably null
PIT1430001:Tmprss15 UTSW 16 78,821,640 (GRCm39) critical splice donor site probably null
R0106:Tmprss15 UTSW 16 78,800,277 (GRCm39) missense probably damaging 0.99
R0106:Tmprss15 UTSW 16 78,800,277 (GRCm39) missense probably damaging 0.99
R0195:Tmprss15 UTSW 16 78,831,222 (GRCm39) missense probably benign 0.05
R0335:Tmprss15 UTSW 16 78,821,630 (GRCm39) splice site probably benign
R0514:Tmprss15 UTSW 16 78,765,155 (GRCm39) missense probably benign 0.05
R0552:Tmprss15 UTSW 16 78,821,637 (GRCm39) splice site probably null
R0675:Tmprss15 UTSW 16 78,782,838 (GRCm39) missense probably damaging 0.98
R0739:Tmprss15 UTSW 16 78,821,736 (GRCm39) missense possibly damaging 0.62
R1435:Tmprss15 UTSW 16 78,818,342 (GRCm39) missense probably benign 0.03
R1446:Tmprss15 UTSW 16 78,875,846 (GRCm39) missense probably benign 0.01
R1572:Tmprss15 UTSW 16 78,887,717 (GRCm39) missense probably benign 0.00
R1708:Tmprss15 UTSW 16 78,850,958 (GRCm39) missense possibly damaging 0.95
R1893:Tmprss15 UTSW 16 78,868,306 (GRCm39) missense probably benign
R2403:Tmprss15 UTSW 16 78,854,578 (GRCm39) missense probably damaging 1.00
R2866:Tmprss15 UTSW 16 78,832,121 (GRCm39) missense possibly damaging 0.65
R2913:Tmprss15 UTSW 16 78,759,078 (GRCm39) missense probably benign 0.45
R2914:Tmprss15 UTSW 16 78,759,078 (GRCm39) missense probably benign 0.45
R3425:Tmprss15 UTSW 16 78,800,321 (GRCm39) missense possibly damaging 0.83
R3703:Tmprss15 UTSW 16 78,851,030 (GRCm39) critical splice acceptor site probably null
R3916:Tmprss15 UTSW 16 78,782,884 (GRCm39) missense probably damaging 1.00
R3950:Tmprss15 UTSW 16 78,870,074 (GRCm39) missense probably benign 0.04
R4332:Tmprss15 UTSW 16 78,831,222 (GRCm39) missense probably benign 0.15
R4392:Tmprss15 UTSW 16 78,821,326 (GRCm39) missense probably damaging 1.00
R4515:Tmprss15 UTSW 16 78,754,244 (GRCm39) missense probably benign 0.00
R4619:Tmprss15 UTSW 16 78,818,358 (GRCm39) missense probably damaging 1.00
R4620:Tmprss15 UTSW 16 78,818,358 (GRCm39) missense probably damaging 1.00
R4754:Tmprss15 UTSW 16 78,851,012 (GRCm39) missense probably damaging 0.98
R4853:Tmprss15 UTSW 16 78,757,479 (GRCm39) missense probably benign
R5159:Tmprss15 UTSW 16 78,800,298 (GRCm39) missense probably benign 0.26
R5441:Tmprss15 UTSW 16 78,868,335 (GRCm39) critical splice acceptor site probably null
R5824:Tmprss15 UTSW 16 78,831,201 (GRCm39) missense probably damaging 0.99
R5970:Tmprss15 UTSW 16 78,854,547 (GRCm39) missense probably benign 0.00
R6224:Tmprss15 UTSW 16 78,821,266 (GRCm39) missense probably benign 0.08
R6257:Tmprss15 UTSW 16 78,769,113 (GRCm39) missense probably damaging 1.00
R6313:Tmprss15 UTSW 16 78,759,058 (GRCm39) missense probably benign 0.16
R6368:Tmprss15 UTSW 16 78,802,945 (GRCm39) splice site probably null
R6525:Tmprss15 UTSW 16 78,800,266 (GRCm39) missense probably damaging 0.97
R6587:Tmprss15 UTSW 16 78,868,317 (GRCm39) missense probably benign
R6894:Tmprss15 UTSW 16 78,872,702 (GRCm39) nonsense probably null
R7018:Tmprss15 UTSW 16 78,821,741 (GRCm39) missense possibly damaging 0.78
R7180:Tmprss15 UTSW 16 78,764,886 (GRCm39) missense probably damaging 0.97
R7324:Tmprss15 UTSW 16 78,758,907 (GRCm39) missense probably damaging 1.00
R7337:Tmprss15 UTSW 16 78,868,164 (GRCm39) missense probably benign 0.01
R7558:Tmprss15 UTSW 16 78,800,302 (GRCm39) missense possibly damaging 0.55
R7732:Tmprss15 UTSW 16 78,800,308 (GRCm39) missense probably benign 0.11
R7792:Tmprss15 UTSW 16 78,800,275 (GRCm39) missense probably damaging 1.00
R7829:Tmprss15 UTSW 16 78,784,538 (GRCm39) missense probably benign 0.02
R7998:Tmprss15 UTSW 16 78,798,731 (GRCm39) missense possibly damaging 0.79
R8009:Tmprss15 UTSW 16 78,887,751 (GRCm39) missense probably damaging 0.96
R8145:Tmprss15 UTSW 16 78,757,473 (GRCm39) missense probably damaging 1.00
R8183:Tmprss15 UTSW 16 78,884,400 (GRCm39) missense probably benign 0.04
R8221:Tmprss15 UTSW 16 78,821,223 (GRCm39) missense probably damaging 0.99
R8294:Tmprss15 UTSW 16 78,868,176 (GRCm39) missense probably benign
R8537:Tmprss15 UTSW 16 78,884,403 (GRCm39) missense probably damaging 0.99
R8735:Tmprss15 UTSW 16 78,798,702 (GRCm39) missense possibly damaging 0.88
R8858:Tmprss15 UTSW 16 78,854,497 (GRCm39) critical splice donor site probably null
R8869:Tmprss15 UTSW 16 78,750,834 (GRCm39) nonsense probably null
R8884:Tmprss15 UTSW 16 78,821,657 (GRCm39) missense probably benign 0.00
R9014:Tmprss15 UTSW 16 78,872,691 (GRCm39) missense probably benign 0.04
R9351:Tmprss15 UTSW 16 78,832,086 (GRCm39) missense probably damaging 1.00
R9393:Tmprss15 UTSW 16 78,754,211 (GRCm39) missense probably benign 0.01
R9747:Tmprss15 UTSW 16 78,884,400 (GRCm39) missense probably benign 0.04
R9767:Tmprss15 UTSW 16 78,875,977 (GRCm39) missense probably damaging 1.00
R9783:Tmprss15 UTSW 16 78,887,890 (GRCm39) start gained probably benign
RF005:Tmprss15 UTSW 16 78,750,689 (GRCm39) makesense probably null
Predicted Primers PCR Primer
(F):5'- CAAGTGGCTCGCCTAAAGTC -3'
(R):5'- CTTGAAAGTGCAAGGTTGGTAG -3'

Sequencing Primer
(F):5'- GTCACTCATTCTCAACGTGAAAGGG -3'
(R):5'- CCACATAGTACTTGATAATGAGAGC -3'
Posted On 2021-11-19