Mutagenetix > Incidental Mutation

Incidental Mutation 'R9080:Vmn2r72'

689959

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r72

Ensembl Gene

ENSMUSG00000051877

Gene Name

vomeronasal 2, receptor 72

Synonyms

Vmn2r72-ps, EG244114

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.139) question?

Stock #

R9080 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

85737784-85754981 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 85738256 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Serine at position 700 (I700S)

Ref Sequence

ENSEMBL: ENSMUSP00000133014 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000063425]

AlphaFold

D3Z4N8

Predicted Effect

probably damaging
Transcript: ENSMUST00000063425
AA Change: I700S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000133014
Gene: ENSMUSG00000051877
AA Change: I700S

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	82	469	2.3e-28	PFAM
Pfam:NCD3G	512	564	1.2e-18	PFAM
Pfam:7tm_3	594	832	4e-53	PFAM

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.4%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 59 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
5730596B20Rik	T	C	6: 52,178,993	I13T	unknown	Het
Adad1	G	T	3: 37,065,249	V160L	probably benign	Het
Adamts6	T	A	13: 104,312,919	M279K	probably damaging	Het
Adgra2	T	C	8: 27,114,501	S535P	probably benign	Het
Akr1c13	C	T	13: 4,191,173		probably benign	Het
Anapc1	A	G	2: 128,622,506	I1690T	possibly damaging	Het
Ccdc138	A	G	10: 58,562,062	M575V	probably damaging	Het
Cfap100	T	C	6: 90,406,201	N330S	unknown	Het
Col12a1	T	C	9: 79,609,851	D2849G	probably benign	Het
Cox11	G	A	11: 90,644,420	M232I	probably damaging	Het
Cpne7	C	T	8: 123,130,212	P402L	probably damaging	Het
Cspp1	G	A	1: 10,113,694	S848N	probably benign	Het
Cxcr5	A	G	9: 44,513,266	S365P	probably damaging	Het
Dclre1c	A	T	2: 3,457,552	M389L	probably benign	Het
Dlc1	T	C	8: 36,584,852	D124G	probably benign	Het
Dtx3	A	T	10: 127,191,268	S346T	possibly damaging	Het
E330021D16Rik	T	A	6: 136,400,722	D370V	probably damaging	Het
Exosc10	A	G	4: 148,564,664	D337G	probably damaging	Het
Fpr1	G	A	17: 17,876,950	A259V	probably benign	Het
Gm11232	A	T	4: 71,757,833	M25K	probably benign	Het
Gm4950	A	G	18: 51,865,850	V11A	possibly damaging	Het
Gsap	C	T	5: 21,194,412	T37I	possibly damaging	Het
Igfbp2	T	A	1: 72,851,998	C252S	probably damaging	Het
Ing2	T	C	8: 47,668,773	T247A	possibly damaging	Het
Ints1	C	T	5: 139,753,545	V2028M	probably benign	Het
Itfg1	A	G	8: 85,740,245	F400L	possibly damaging	Het
Itga6	A	G	2: 71,843,289	Y889C	probably benign	Het
Kcnh3	A	G	15: 99,241,786	E882G	probably damaging	Het
Limch1	T	A	5: 67,017,649	C515S	probably benign	Het
Lrrc74a	G	T	12: 86,749,134	V294F	possibly damaging	Het
Megf8	A	G	7: 25,341,706	E1120G	probably damaging	Het
Nbea	A	T	3: 56,005,095	Y1090*	probably null	Het
Nckap1	A	G	2: 80,520,382	Y794H	probably damaging	Het
Nfib	T	C	4: 82,705,517	M25V		Het
Ogfod2	A	G	5: 124,114,944	E339G	probably damaging	Het
Olah	T	A	2: 3,348,352	E64V	probably damaging	Het
Olfr237-ps1	T	A	6: 43,153,896	V197D	possibly damaging	Het
Olfr460	T	A	6: 40,571,629	L81H	probably damaging	Het
Pdcd6ip	T	A	9: 113,691,556	K120M	probably damaging	Het
Pex1	A	G	5: 3,605,476	I134V	probably damaging	Het
Plekhm2	T	C	4: 141,631,728	H576R	probably damaging	Het
Ptpn13	T	A	5: 103,489,628	H127Q	probably damaging	Het
Rmnd5b	C	T	11: 51,624,228		probably null	Het
Rsf1	A	AAGGCGACGG	7: 97,579,904		probably null	Het
Sec16b	C	A	1: 157,565,730	Q995K	probably benign	Het
Serpinb6d	T	A	13: 33,671,124	S260R	probably benign	Het
Slc47a1	C	T	11: 61,373,393	G67S	possibly damaging	Het
Slco6d1	T	C	1: 98,421,258	V18A	probably benign	Het
Tfcp2	GGTAATCCAAAGAGATGGACTGGTGGCTGTCCTGCTGCTGAGTAATCCAAAGAGATGGACTGGTGGCTGTCCTGCTGCTGAGTAATCCAAAGAGATGGACTGGTGGCTGTCCTGCTGCTGAGTAATCCAAAGAGATGGACTGGTGGCTGTCCTGCTGCTGA	GGTAATCCAAAGAGATGGACTGGTGGCTGTCCTGCTGCTGAGTAATCCAAAGAGATGGACTGGTGGCTGTCCTGCTGCTGAGTAATCCAAAGAGATGGACTGGTGGCTGTCCTGCTGCTGA	15: 100,498,087		probably null	Het
Tiam2	T	G	17: 3,414,244	C83G	probably benign	Het
Tln2	C	T	9: 67,346,561	G743R	probably damaging	Het
Tmem136	C	T	9: 43,111,369	R230Q	probably benign	Het
Tnks	CCCGCCGCCGCCGCCGCCGCCG	CCCGCCGCCGCCGCCGCCG	8: 34,965,312		probably benign	Het
Ttn	G	A	2: 76,706,499	T34994I	probably benign	Het
Uggt2	T	A	14: 119,057,605	E536D	probably benign	Het
Usp54	T	C	14: 20,562,240	E836G	probably damaging	Het
Vmn1r41	C	T	6: 89,747,156	T63M	unknown	Het
Xrcc4	T	C	13: 90,000,978	N141S	probably damaging	Het
Zfp638	T	C	6: 83,867,173	V6A	unknown	Het

Other mutations in Vmn2r72

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00931:Vmn2r72	APN	7	85749646	missense	probably benign	0.01
IGL01019:Vmn2r72	APN	7	85738334	missense	probably benign	0.26
IGL01445:Vmn2r72	APN	7	85749646	missense	probably benign	0.06
IGL02076:Vmn2r72	APN	7	85738367	missense	probably damaging	1.00
IGL02082:Vmn2r72	APN	7	85738166	missense	probably benign	0.00
IGL02086:Vmn2r72	APN	7	85738166	missense	probably benign	0.00
IGL02089:Vmn2r72	APN	7	85738166	missense	probably benign	0.00
IGL02125:Vmn2r72	APN	7	85750711	missense	probably benign	0.00
IGL02146:Vmn2r72	APN	7	85737962	missense	probably damaging	1.00
IGL02272:Vmn2r72	APN	7	85750693	missense	probably benign
IGL02514:Vmn2r72	APN	7	85738699	missense	possibly damaging	0.90
IGL02662:Vmn2r72	APN	7	85738183	missense	probably benign	0.26
IGL02697:Vmn2r72	APN	7	85738671	missense	probably benign	0.36
IGL02733:Vmn2r72	APN	7	85751813	missense	probably benign	0.05
IGL03070:Vmn2r72	APN	7	85752041	splice site	probably benign
IGL03150:Vmn2r72	APN	7	85751176	missense	probably damaging	1.00
IGL03159:Vmn2r72	APN	7	85754954	missense	probably benign	0.05
IGL03333:Vmn2r72	APN	7	85750867	missense	probably benign	0.10
R0081:Vmn2r72	UTSW	7	85751836	missense	probably benign	0.01
R0090:Vmn2r72	UTSW	7	85754876	missense	probably benign
R0655:Vmn2r72	UTSW	7	85738111	nonsense	probably null
R0778:Vmn2r72	UTSW	7	85749739	missense	probably benign	0.00
R1169:Vmn2r72	UTSW	7	85751309	missense	probably benign	0.01
R1172:Vmn2r72	UTSW	7	85751944	missense	probably damaging	1.00
R1173:Vmn2r72	UTSW	7	85751944	missense	probably damaging	1.00
R1175:Vmn2r72	UTSW	7	85751944	missense	probably damaging	1.00
R1248:Vmn2r72	UTSW	7	85749188	missense	probably benign	0.02
R1302:Vmn2r72	UTSW	7	85738257	missense	probably damaging	1.00
R1506:Vmn2r72	UTSW	7	85749211	missense	probably benign
R1632:Vmn2r72	UTSW	7	85751792	missense	probably benign	0.13
R1775:Vmn2r72	UTSW	7	85738170	missense	probably benign	0.01
R1962:Vmn2r72	UTSW	7	85749161	missense	probably benign	0.00
R2201:Vmn2r72	UTSW	7	85738236	missense	probably benign	0.12
R2290:Vmn2r72	UTSW	7	85738341	missense	probably damaging	1.00
R2327:Vmn2r72	UTSW	7	85738256	missense	probably damaging	1.00
R2424:Vmn2r72	UTSW	7	85750953	missense	probably damaging	1.00
R2655:Vmn2r72	UTSW	7	85751269	missense	possibly damaging	0.95
R2860:Vmn2r72	UTSW	7	85750836	missense	probably damaging	0.99
R2861:Vmn2r72	UTSW	7	85750836	missense	probably damaging	0.99
R2862:Vmn2r72	UTSW	7	85750836	missense	probably damaging	0.99
R3009:Vmn2r72	UTSW	7	85749642	missense	probably benign	0.00
R3797:Vmn2r72	UTSW	7	85738077	missense	probably benign	0.44
R3798:Vmn2r72	UTSW	7	85738077	missense	probably benign	0.44
R3902:Vmn2r72	UTSW	7	85749735	missense	possibly damaging	0.52
R3959:Vmn2r72	UTSW	7	85751131	missense	probably benign	0.36
R3974:Vmn2r72	UTSW	7	85749809	missense	probably damaging	1.00
R4399:Vmn2r72	UTSW	7	85738500	missense	probably damaging	1.00
R4421:Vmn2r72	UTSW	7	85738500	missense	probably damaging	1.00
R4426:Vmn2r72	UTSW	7	85737828	nonsense	probably null
R4522:Vmn2r72	UTSW	7	85751926	missense	probably benign	0.44
R4523:Vmn2r72	UTSW	7	85751926	missense	probably benign	0.44
R4533:Vmn2r72	UTSW	7	85751926	missense	probably benign	0.44
R4691:Vmn2r72	UTSW	7	85737911	nonsense	probably null
R4781:Vmn2r72	UTSW	7	85737861	missense	probably benign	0.14
R4863:Vmn2r72	UTSW	7	85750598	missense	possibly damaging	0.91
R4952:Vmn2r72	UTSW	7	85751109	missense	probably benign
R4991:Vmn2r72	UTSW	7	85751130	missense	probably damaging	0.99
R4995:Vmn2r72	UTSW	7	85738485	missense	probably damaging	1.00
R5095:Vmn2r72	UTSW	7	85737853	missense	probably damaging	0.98
R5174:Vmn2r72	UTSW	7	85737840	missense	probably benign	0.00
R5276:Vmn2r72	UTSW	7	85738254	missense	possibly damaging	0.90
R5395:Vmn2r72	UTSW	7	85750897	missense	possibly damaging	0.71
R5560:Vmn2r72	UTSW	7	85751942	missense	probably damaging	0.96
R5933:Vmn2r72	UTSW	7	85737850	missense	probably benign	0.05
R6033:Vmn2r72	UTSW	7	85737929	missense	probably damaging	1.00
R6033:Vmn2r72	UTSW	7	85737929	missense	probably damaging	1.00
R6354:Vmn2r72	UTSW	7	85750539	critical splice donor site	probably null
R6362:Vmn2r72	UTSW	7	85751174	missense	probably damaging	1.00
R6594:Vmn2r72	UTSW	7	85749684	missense	probably benign	0.32
R6794:Vmn2r72	UTSW	7	85737996	missense	probably damaging	1.00
R7113:Vmn2r72	UTSW	7	85749803	splice site	probably null
R7189:Vmn2r72	UTSW	7	85754917	missense	probably benign	0.36
R7266:Vmn2r72	UTSW	7	85738274	nonsense	probably null
R7323:Vmn2r72	UTSW	7	85750563	missense	probably benign
R7426:Vmn2r72	UTSW	7	85751140	missense	probably benign
R7606:Vmn2r72	UTSW	7	85751154	missense	possibly damaging	0.91
R7651:Vmn2r72	UTSW	7	85751938	missense	probably damaging	1.00
R7688:Vmn2r72	UTSW	7	85754890	missense	probably benign	0.32
R7753:Vmn2r72	UTSW	7	85750626	missense	probably damaging	1.00
R7843:Vmn2r72	UTSW	7	85749630	missense	probably benign	0.01
R8157:Vmn2r72	UTSW	7	85751233	missense	probably benign	0.09
R8254:Vmn2r72	UTSW	7	85751019	missense	probably damaging	1.00
R8389:Vmn2r72	UTSW	7	85751960	missense	probably damaging	0.99
R8444:Vmn2r72	UTSW	7	85738175	missense	probably benign
R8989:Vmn2r72	UTSW	7	85754926	missense	probably benign	0.10
R9015:Vmn2r72	UTSW	7	85749180	missense	probably benign	0.01
R9269:Vmn2r72	UTSW	7	85751203	missense	probably benign	0.03
R9317:Vmn2r72	UTSW	7	85754814	missense	probably benign	0.04
R9509:Vmn2r72	UTSW	7	85754867	missense	probably benign
Z1176:Vmn2r72	UTSW	7	85749191	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- TGAATGTATCAGGCAGGTTCC -3'
(R):5'- ATTGGTCATCCCACTACGGTC -3'

Sequencing Primer
(F):5'- GGTTCCTGGCCAAGAAAGCTAC -3'
(R):5'- GGTCATCTGTATCCTGCAGCAG -3'

Posted On

2021-11-19