Incidental Mutation 'R9082:Grk5'
ID 690109
Institutional Source Beutler Lab
Gene Symbol Grk5
Ensembl Gene ENSMUSG00000003228
Gene Name G protein-coupled receptor kinase 5
Synonyms Gprk5
MMRRC Submission 068901-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9082 (G1)
Quality Score 225.009
Status Validated
Chromosome 19
Chromosomal Location 60878187-61084406 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 61034567 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 105 (I105T)
Ref Sequence ENSEMBL: ENSMUSP00000003313 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000003313]
AlphaFold Q8VEB1
Predicted Effect possibly damaging
Transcript: ENSMUST00000003313
AA Change: I105T

PolyPhen 2 Score 0.953 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000003313
Gene: ENSMUSG00000003228
AA Change: I105T

DomainStartEndE-ValueType
low complexity region 18 31 N/A INTRINSIC
RGS 52 171 1.21e-35 SMART
S_TKc 186 448 9.44e-84 SMART
S_TK_X 449 528 1.08e-9 SMART
low complexity region 561 590 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 100% (55/55)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs). [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous mutation of this gene results in a decrease in thermal pain sensation. Mice homozygous for a knock-out allele exhibit decreased response of heart to induced stress. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Afm G T 5: 90,698,095 (GRCm39) C499F probably damaging Het
Agap2 A G 10: 126,918,911 (GRCm39) E429G probably damaging Het
Ankrd22 A T 19: 34,126,662 (GRCm39) V56D probably damaging Het
Apol11b C T 15: 77,524,771 (GRCm39) E5K possibly damaging Het
Ccdc168 G A 1: 44,099,874 (GRCm39) S408L unknown Het
Cdk4 T A 10: 126,900,732 (GRCm39) L128Q probably damaging Het
Clu T C 14: 66,217,153 (GRCm39) S329P probably damaging Het
Cntnap5c A G 17: 58,637,335 (GRCm39) N1071D probably damaging Het
Col5a1 T C 2: 27,852,122 (GRCm39) S540P possibly damaging Het
Cpne2 A C 8: 95,295,237 (GRCm39) I441L probably benign Het
Ctu2 T C 8: 123,203,952 (GRCm39) S87P probably damaging Het
Dhodh G T 8: 110,322,734 (GRCm39) N211K probably damaging Het
Dtnb G A 12: 3,822,740 (GRCm39) A570T possibly damaging Het
Eif3m A T 2: 104,836,217 (GRCm39) V209E probably damaging Het
Fbxo31 G A 8: 122,281,136 (GRCm39) R337C probably damaging Het
Fktn T C 4: 53,720,010 (GRCm39) V8A unknown Het
Ftdc1 T C 16: 58,437,294 (GRCm39) R5G probably benign Het
Gcnt1 G T 19: 17,307,559 (GRCm39) S55R probably benign Het
Gm11011 G T 2: 169,426,424 (GRCm39) P63Q Het
Gskip G A 12: 105,665,009 (GRCm39) S16N probably benign Het
Gys1 C A 7: 45,088,917 (GRCm39) N169K probably benign Het
Itgb2 T C 10: 77,384,503 (GRCm39) L208P probably damaging Het
Kcnh7 A G 2: 62,607,878 (GRCm39) C568R probably damaging Het
Krt84 C T 15: 101,440,814 (GRCm39) G126D unknown Het
Lrrc26 T A 2: 25,180,344 (GRCm39) F115Y probably damaging Het
Mul1 T C 4: 138,166,945 (GRCm39) I338T probably damaging Het
Ncam2 T A 16: 81,412,660 (GRCm39) L716H probably damaging Het
Ncoa1 C T 12: 4,346,106 (GRCm39) V414I probably benign Het
Negr1 C A 3: 156,774,876 (GRCm39) C197* probably null Het
Nisch G T 14: 30,899,331 (GRCm39) A438E unknown Het
Nsun5 T C 5: 135,402,828 (GRCm39) L174P probably damaging Het
Obscn A T 11: 58,903,612 (GRCm39) V7454E probably benign Het
Optn A C 2: 5,059,451 (GRCm39) N22K probably damaging Het
Or5k15 C T 16: 58,709,834 (GRCm39) V250M probably damaging Het
Or6d13 G A 6: 116,517,969 (GRCm39) C185Y probably damaging Het
Pcdhb22 A G 18: 37,653,047 (GRCm39) N248S probably damaging Het
Pcnx2 A C 8: 126,613,753 (GRCm39) L566R probably damaging Het
Pdlim5 C T 3: 142,009,163 (GRCm39) V191I possibly damaging Het
Pdzrn3 C T 6: 101,146,094 (GRCm39) probably null Het
Peak1 A T 9: 56,165,504 (GRCm39) I808N probably benign Het
Pomt1 A C 2: 32,142,973 (GRCm39) Y617S probably damaging Het
Ptch2 G A 4: 116,962,297 (GRCm39) probably null Het
Rptn A G 3: 93,302,928 (GRCm39) H87R possibly damaging Het
Sez6 G A 11: 77,865,121 (GRCm39) E623K possibly damaging Het
Slc37a4 A G 9: 44,313,016 (GRCm39) T333A probably benign Het
Slc5a7 A G 17: 54,604,139 (GRCm39) V9A probably benign Het
Slc6a20a A G 9: 123,507,832 (GRCm39) F14L possibly damaging Het
Smg7 A T 1: 152,715,928 (GRCm39) M1062K probably damaging Het
Tsc22d4 T C 5: 137,749,509 (GRCm39) Y262H probably damaging Het
Vmn2r83 C T 10: 79,304,894 (GRCm39) H35Y probably benign Het
Zc3h13 CAGAGACCGGGACAGAAGGAGAGAC CAGAGAC 14: 75,569,381 (GRCm39) probably benign Het
Zeb1 C T 18: 5,772,557 (GRCm39) H949Y probably damaging Het
Zfp184 T A 13: 22,143,636 (GRCm39) H447Q probably damaging Het
Zfp551 T C 7: 12,151,004 (GRCm39) E135G probably damaging Het
Other mutations in Grk5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02565:Grk5 APN 19 61,057,809 (GRCm39) missense probably damaging 0.99
IGL03183:Grk5 APN 19 61,057,774 (GRCm39) missense probably damaging 0.99
R0257:Grk5 UTSW 19 61,065,068 (GRCm39) intron probably benign
R1565:Grk5 UTSW 19 61,078,410 (GRCm39) missense probably damaging 0.99
R1603:Grk5 UTSW 19 61,057,800 (GRCm39) missense probably benign 0.06
R1672:Grk5 UTSW 19 61,074,653 (GRCm39) splice site probably null
R1687:Grk5 UTSW 19 61,065,221 (GRCm39) missense probably damaging 1.00
R1793:Grk5 UTSW 19 61,065,200 (GRCm39) missense probably damaging 1.00
R1822:Grk5 UTSW 19 61,078,410 (GRCm39) missense probably damaging 0.99
R1824:Grk5 UTSW 19 61,078,410 (GRCm39) missense probably damaging 0.99
R1876:Grk5 UTSW 19 61,071,663 (GRCm39) missense probably damaging 1.00
R4320:Grk5 UTSW 19 61,080,383 (GRCm39) nonsense probably null
R4828:Grk5 UTSW 19 60,976,213 (GRCm39) nonsense probably null
R5085:Grk5 UTSW 19 61,065,122 (GRCm39) missense probably damaging 1.00
R6237:Grk5 UTSW 19 61,078,380 (GRCm39) missense probably damaging 1.00
R6310:Grk5 UTSW 19 61,069,349 (GRCm39) missense probably damaging 0.96
R6736:Grk5 UTSW 19 60,879,064 (GRCm39) missense probably damaging 0.99
R7061:Grk5 UTSW 19 61,034,530 (GRCm39) missense probably benign 0.00
R7248:Grk5 UTSW 19 60,879,045 (GRCm39) missense probably benign 0.05
R7583:Grk5 UTSW 19 61,071,642 (GRCm39) missense possibly damaging 0.85
R7852:Grk5 UTSW 19 61,069,383 (GRCm39) critical splice donor site probably null
R8810:Grk5 UTSW 19 61,078,432 (GRCm39) missense possibly damaging 0.69
R9729:Grk5 UTSW 19 61,078,467 (GRCm39) missense possibly damaging 0.90
Predicted Primers PCR Primer
(F):5'- TTTGTTGGACTTTGGACACCC -3'
(R):5'- TCCTTCTGATTCTGTAAGGCTGAG -3'

Sequencing Primer
(F):5'- GGCCAGGCCTTCCTTTC -3'
(R):5'- CTGTAAGGCTGAGGCATGTCTAAG -3'
Posted On 2021-11-19