Mutagenetix > Incidental Mutation

Incidental Mutation 'R8932:Vmn1r209'

690252

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r209

Ensembl Gene

ENSMUSG00000071491

Gene Name

vomeronasal 1 receptor 209

Synonyms

Gm11315

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.091) question?

Stock #

R8932 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

22800629-22809682 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 22806173 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tryptophan to Arginine at position 116 (W116R)

Ref Sequence

ENSEMBL: ENSMUSP00000093657 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000095961] [ENSMUST00000227038] [ENSMUST00000227265]

AlphaFold

Q5NC97

Predicted Effect

probably damaging
Transcript: ENSMUST00000095961
AA Change: W116R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000093657
Gene: ENSMUSG00000071491
AA Change: W116R

Domain	Start	End	E-Value	Type
Pfam:TAS2R	2	294	9.8e-9	PFAM
Pfam:V1R	34	297	3e-36	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000227265
AA Change: W116R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.0%

Validation Efficiency

100% (67/67)

Allele List at MGI

Other mutations in this stock

Total: 72 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2410089E03Rik	A	G	15: 8,194,375	Y874C	probably damaging	Het
Adam34	G	T	8: 43,652,155	T151K	probably benign	Het
Adnp2	C	T	18: 80,142,678	G27S	probably damaging	Het
Ank3	A	G	10: 69,824,462	M265V	probably benign	Het
Apoe	T	C	7: 19,696,672	D215G	possibly damaging	Het
Atp5b	A	G	10: 128,088,981	I438V	probably benign	Het
Bckdha	A	G	7: 25,631,011	S387P	probably damaging	Het
Camkk1	T	C	11: 73,033,908	F316L	probably damaging	Het
Carmil1	A	G	13: 24,013,196	Y158H		Het
Ccdc148	T	C	2: 59,004,042	R29G	probably benign	Het
Ccdc39	A	G	3: 33,830,125	V356A	probably benign	Het
Cdan1	G	A	2: 120,731,087	Q66*	probably null	Het
Ckap4	A	T	10: 84,528,426	S258T	probably benign	Het
Col5a2	T	C	1: 45,380,146	D1258G	probably benign	Het
Col6a1	G	A	10: 76,716,759	P431L	unknown	Het
Csn1s2a	A	G	5: 87,785,305	I138V	probably benign	Het
Cyp19a1	C	T	9: 54,176,577	G176D	probably benign	Het
Dnah10	A	G	5: 124,800,951	E2700G	possibly damaging	Het
Doxl2	G	A	6: 48,975,494	E118K	probably damaging	Het
Eif3l	T	A	15: 79,075,806	Y23*	probably null	Het
Fam72a	A	G	1: 131,528,764	K22E	probably benign	Het
Golim4	A	G	3: 75,898,044	V258A	probably benign	Het
Gtf2ird2	C	T	5: 134,208,898	A272V	probably benign	Het
Hpse	T	C	5: 100,699,006	T186A	possibly damaging	Het
Ift140	A	T	17: 25,086,888	Q816H	probably benign	Het
Iqca	A	T	1: 90,140,028	I167N	probably damaging	Het
Iqgap1	A	T	7: 80,751,393	F515L	probably benign	Het
Itgb4	G	A	11: 115,988,469	R558H	probably benign	Het
Kcna10	G	A	3: 107,194,103	D17N	probably damaging	Het
Kcnj16	A	G	11: 111,025,003	I164V	probably damaging	Het
Lrrc55	G	T	2: 85,196,271	N136K	probably damaging	Het
Mdm4	A	T	1: 133,012,644	M50K	probably benign	Het
Mfge8	A	G	7: 79,136,782	S290P	probably damaging	Het
Mindy4	G	A	6: 55,224,130	D267N	probably benign	Het
Mllt10	T	A	2: 18,123,806	S199R	probably benign	Het
Mms22l	T	C	4: 24,533,029	S436P	probably damaging	Het
Mpped2	A	G	2: 106,867,050	N290S	possibly damaging	Het
Mrgpra2a	A	G	7: 47,426,697	L271P	probably benign	Het
Myrf	T	A	19: 10,223,567	E247D	probably benign	Het
Ndrg3	A	G	2: 156,940,379	I189T	possibly damaging	Het
Nenf	C	T	1: 191,317,951	E48K	probably benign	Het
Nlgn2	T	A	11: 69,828,168	N232Y	probably damaging	Het
Olfr824	A	T	10: 130,126,762	N98K	probably benign	Het
Oog2	G	T	4: 144,194,115	M39I	probably benign	Het
Osbpl3	A	T	6: 50,327,391	N461K	probably benign	Het
P4ha1	A	G	10: 59,339,308	D30G	possibly damaging	Het
Pappa2	A	T	1: 158,763,192	C1631S	probably damaging	Het
Pigk	A	G	3: 152,740,234	M161V	possibly damaging	Het
Prdm1	G	T	10: 44,441,339	S496Y	probably damaging	Het
Prkg2	T	C	5: 98,947,440	N624S	possibly damaging	Het
Rgs6	A	G	12: 83,065,959	D181G	probably damaging	Het
Sbf2	A	G	7: 110,440,948		probably null	Het
Sbno2	A	C	10: 80,062,208	L728W	probably damaging	Het
Selenbp2	A	T	3: 94,702,486	I310F	probably damaging	Het
Shank3	T	A	15: 89,548,783	W1244R	possibly damaging	Het
Slc17a2	A	C	13: 23,820,201	I395L	probably benign	Het
Slf1	A	T	13: 77,046,574	D877E	probably damaging	Het
Smtn	T	C	11: 3,522,908	S255G	probably benign	Het
Tbx2	T	A	11: 85,834,707	D161E	probably damaging	Het
Tex14	C	A	11: 87,433,849	L26M	possibly damaging	Het
Traf7	A	G	17: 24,512,312	F249S	probably damaging	Het
Trpm6	A	G	19: 18,838,002	K1151E	possibly damaging	Het
Ttc7b	A	G	12: 100,301,763	V773A	probably benign	Het
Ttn	G	A	2: 76,772,510	T18456I	probably damaging	Het
Ttn	G	C	2: 76,878,827	L8703V	unknown	Het
Ttn	G	A	2: 76,917,568	T4379I	probably benign	Het
Ubb	T	A	11: 62,552,153	I3N	probably damaging	Het
Vmn1r75	A	G	7: 11,880,911	D190G	probably damaging	Het
Wdr12	T	A	1: 60,091,043	M70L	probably benign	Het
Wdr48	C	A	9: 119,911,076	T317K	probably damaging	Het
Zbtb5	A	G	4: 44,993,962	V474A	probably benign	Het
Zfp128	C	T	7: 12,891,186	R494C	possibly damaging	Het

Other mutations in Vmn1r209

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01773:Vmn1r209	APN	13	22806280	missense	probably damaging	1.00
IGL01788:Vmn1r209	APN	13	22805662	missense	probably damaging	0.97
IGL02738:Vmn1r209	APN	13	22806120	nonsense	probably null
IGL03177:Vmn1r209	APN	13	22805854	missense	possibly damaging	0.46
IGL03199:Vmn1r209	APN	13	22806050	missense	possibly damaging	0.89
R0437:Vmn1r209	UTSW	13	22806356	missense	probably benign	0.01
R0497:Vmn1r209	UTSW	13	22805948	missense	probably damaging	1.00
R0506:Vmn1r209	UTSW	13	22805944	missense	probably damaging	0.98
R1496:Vmn1r209	UTSW	13	22805764	missense	probably damaging	1.00
R1644:Vmn1r209	UTSW	13	22806482	missense	possibly damaging	0.52
R1829:Vmn1r209	UTSW	13	22806239	missense	possibly damaging	0.95
R2360:Vmn1r209	UTSW	13	22805666	missense	probably damaging	1.00
R3434:Vmn1r209	UTSW	13	22806097	missense	probably benign	0.04
R3435:Vmn1r209	UTSW	13	22806097	missense	probably benign	0.04
R4082:Vmn1r209	UTSW	13	22805615	missense	probably null	0.15
R4451:Vmn1r209	UTSW	13	22806498	missense	probably benign	0.02
R4616:Vmn1r209	UTSW	13	22805965	missense	probably damaging	1.00
R4618:Vmn1r209	UTSW	13	22806449	missense	possibly damaging	0.87
R4801:Vmn1r209	UTSW	13	22805656	missense	probably damaging	1.00
R4802:Vmn1r209	UTSW	13	22805656	missense	probably damaging	1.00
R6035:Vmn1r209	UTSW	13	22806032	missense	probably benign	0.02
R6035:Vmn1r209	UTSW	13	22806032	missense	probably benign	0.02
R6908:Vmn1r209	UTSW	13	22806230	missense	possibly damaging	0.60
R7162:Vmn1r209	UTSW	13	22805958	missense	probably damaging	1.00
R7772:Vmn1r209	UTSW	13	22806494	missense	possibly damaging	0.77
R8328:Vmn1r209	UTSW	13	22806473	missense	probably benign	0.00
R8335:Vmn1r209	UTSW	13	22805807	missense	probably damaging	1.00
R8903:Vmn1r209	UTSW	13	22806514	missense	probably benign	0.00
R8919:Vmn1r209	UTSW	13	22806053	missense	probably benign
R9307:Vmn1r209	UTSW	13	22805902	missense	probably damaging	0.98
R9343:Vmn1r209	UTSW	13	22806376	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TGAAACACTGCATCTCTCAGG -3'
(R):5'- CTTACAAAAGGATTGCCAAAGACAG -3'

Sequencing Primer
(F):5'- CATCTCTCAGGACCATGAGAGTG -3'
(R):5'- TGCCAAAGACAGTAGCAGCTTTTG -3'

Posted On

2021-11-19