Incidental Mutation 'R8998:Or10a3b'
ID 690286
Institutional Source Beutler Lab
Gene Symbol Or10a3b
Ensembl Gene ENSMUSG00000062434
Gene Name olfactory receptor family 10 subfamily A member 3B
Synonyms GA_x6K02T2PBJ9-11176324-11175380, MOR268-2, Olfr516
MMRRC Submission 068829-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.225) question?
Stock # R8998 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 108444271-108445215 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 108445017 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Alanine at position 67 (S67A)
Ref Sequence ENSEMBL: ENSMUSP00000149160 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071410] [ENSMUST00000216092] [ENSMUST00000217279]
AlphaFold Q8VFZ5
Predicted Effect probably benign
Transcript: ENSMUST00000071410
AA Change: S67A

PolyPhen 2 Score 0.220 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000071358
Gene: ENSMUSG00000062434
AA Change: S67A

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 6.2e-60 PFAM
Pfam:7TM_GPCR_Srsx 35 305 1.9e-5 PFAM
Pfam:7tm_1 41 290 9.2e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216092
AA Change: S67A

PolyPhen 2 Score 0.220 (Sensitivity: 0.91; Specificity: 0.88)
Predicted Effect probably benign
Transcript: ENSMUST00000217279
AA Change: S67A

PolyPhen 2 Score 0.220 (Sensitivity: 0.91; Specificity: 0.88)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency 100% (41/41)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aloxe3 A G 11: 69,033,051 (GRCm39) K575R probably benign Het
Atp10b T A 11: 43,150,726 (GRCm39) *1475R probably null Het
Baz2b T C 2: 59,799,608 (GRCm39) D237G probably benign Het
Cacna2d4 A C 6: 119,219,876 (GRCm39) Q215H possibly damaging Het
Capn15 G A 17: 26,182,055 (GRCm39) R651C probably damaging Het
Cby2 T C 14: 75,820,654 (GRCm39) E357G probably damaging Het
Ccdc28b A G 4: 129,516,471 (GRCm39) V29A probably benign Het
Cyb5rl A G 4: 106,938,157 (GRCm39) T170A possibly damaging Het
D330020A13Rik A G 6: 120,271,890 (GRCm39) T189A unknown Het
Emsy C A 7: 98,268,512 (GRCm39) V524F possibly damaging Het
Eppk1 T A 15: 75,980,765 (GRCm39) N3315I probably damaging Het
Erich2 T G 2: 70,361,964 (GRCm39) probably benign Het
Fkbp15 T C 4: 62,242,365 (GRCm39) D529G probably damaging Het
Gbx2 C A 1: 89,856,745 (GRCm39) G215V possibly damaging Het
Gzmd T A 14: 56,368,144 (GRCm39) Y105F possibly damaging Het
Hpse G A 5: 100,840,109 (GRCm39) T336M probably damaging Het
Hrg A G 16: 22,772,455 (GRCm39) D88G probably damaging Het
Kif20b G A 19: 34,914,253 (GRCm39) probably benign Het
Kmt2a A G 9: 44,733,174 (GRCm39) M2381T unknown Het
Krtap5-3 T A 7: 141,755,933 (GRCm39) C257S unknown Het
Met C T 6: 17,491,534 (GRCm39) R99W probably benign Het
Nlrp4b A G 7: 10,449,629 (GRCm39) R611G probably null Het
Or4b1d C T 2: 89,969,472 (GRCm39) V4I probably benign Het
Or8b1c T C 9: 38,384,787 (GRCm39) V248A probably benign Het
Or9m1 T A 2: 87,733,189 (GRCm39) Y277F probably damaging Het
Pclo A G 5: 14,727,510 (GRCm39) I2123V unknown Het
Phf10 G C 17: 15,170,883 (GRCm39) A350G probably benign Het
Pira2 T C 7: 3,845,490 (GRCm39) Y298C probably damaging Het
Pkhd1 A T 1: 20,434,425 (GRCm39) Y2338N probably damaging Het
Psme4 C T 11: 30,788,957 (GRCm39) L1120F possibly damaging Het
Safb2 A T 17: 56,870,391 (GRCm39) H934Q possibly damaging Het
Slc4a7 T A 14: 14,775,346 (GRCm38) L884Q probably damaging Het
Smc4 A C 3: 68,934,894 (GRCm39) probably benign Het
Spag16 T C 1: 69,935,706 (GRCm39) V311A probably benign Het
Sprr2j-ps T C 3: 92,326,176 (GRCm39) V17A unknown Het
Tenm3 T C 8: 48,729,722 (GRCm39) Y1428C probably damaging Het
Tent4b A G 8: 88,977,350 (GRCm39) H384R probably benign Het
Treml2 A G 17: 48,609,775 (GRCm39) D69G possibly damaging Het
Ttn T C 2: 76,658,277 (GRCm39) K12368E unknown Het
Usp17le T C 7: 104,417,969 (GRCm39) D391G probably benign Het
Usp28 G A 9: 48,949,139 (GRCm39) R911Q probably benign Het
Wdfy3 A C 5: 101,993,058 (GRCm39) S3274R probably benign Het
Ythdc2 T C 18: 44,997,371 (GRCm39) V976A probably benign Het
Zfp334 A G 2: 165,223,408 (GRCm39) S212P possibly damaging Het
Other mutations in Or10a3b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01540:Or10a3b APN 7 108,444,887 (GRCm39) missense probably damaging 0.99
R0583:Or10a3b UTSW 7 108,444,621 (GRCm39) missense possibly damaging 0.87
R0939:Or10a3b UTSW 7 108,444,440 (GRCm39) missense probably damaging 1.00
R1037:Or10a3b UTSW 7 108,445,191 (GRCm39) missense probably benign 0.04
R1631:Or10a3b UTSW 7 108,445,064 (GRCm39) missense probably damaging 1.00
R1691:Or10a3b UTSW 7 108,444,348 (GRCm39) missense possibly damaging 0.60
R5153:Or10a3b UTSW 7 108,444,906 (GRCm39) missense probably benign 0.03
R6114:Or10a3b UTSW 7 108,444,593 (GRCm39) missense possibly damaging 0.53
R6305:Or10a3b UTSW 7 108,444,761 (GRCm39) missense possibly damaging 0.87
R6808:Or10a3b UTSW 7 108,444,747 (GRCm39) missense probably benign 0.01
R6896:Or10a3b UTSW 7 108,444,750 (GRCm39) missense probably benign
R7544:Or10a3b UTSW 7 108,444,528 (GRCm39) missense probably benign 0.39
Predicted Primers PCR Primer
(F):5'- CAGCAAATCGATCATAAGCCATTG -3'
(R):5'- AGACCAACAAAGGGCTCTGC -3'

Sequencing Primer
(F):5'- TAAGCCATTGCCCCCAGGAG -3'
(R):5'- CCAACAAAGGGCTCTGCTATTGTG -3'
Posted On 2021-11-19