Incidental Mutation 'R8773:Slc22a14'
ID 690318
Institutional Source Beutler Lab
Gene Symbol Slc22a14
Ensembl Gene ENSMUSG00000070280
Gene Name solute carrier family 22 (organic cation transporter), member 14
Synonyms LOC382113
MMRRC Submission 068627-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.056) question?
Stock # R8773 (G1)
Quality Score 160.009
Status Validated
Chromosome 9
Chromosomal Location 118998521-119019496 bp(-) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) A to T at 119059290 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000134667 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000170400] [ENSMUST00000173185]
AlphaFold Q497L9
Predicted Effect probably benign
Transcript: ENSMUST00000170400
SMART Domains Protein: ENSMUSP00000131982
Gene: ENSMUSG00000070280

DomainStartEndE-ValueType
transmembrane domain 68 90 N/A INTRINSIC
Pfam:Sugar_tr 150 555 1.2e-28 PFAM
Pfam:MFS_1 178 514 7.6e-28 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000173185
SMART Domains Protein: ENSMUSP00000134667
Gene: ENSMUSG00000092212

DomainStartEndE-ValueType
transmembrane domain 22 44 N/A INTRINSIC
Pfam:MFS_1 141 349 3.4e-12 PFAM
Pfam:Sugar_tr 162 333 7e-9 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 98% (63/64)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the organic-cation transporter family. It is located in a gene cluster with another member of the family, organic cation transporter like 3. The encoded protein is a transmembrane protein which is thought to transport small molecules and since this protein is conserved among several species, it is suggested to have a fundamental role in mammalian systems. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921509C19Rik A T 2: 151,314,062 (GRCm39) S539T possibly damaging Het
Abcc6 C T 7: 45,634,569 (GRCm39) R1136Q probably benign Het
Abhd12b A C 12: 70,213,708 (GRCm39) probably null Het
Agk T G 6: 40,334,050 (GRCm39) V98G possibly damaging Het
Apbb2 A G 5: 66,609,252 (GRCm39) S132P probably damaging Het
Apc2 T C 10: 80,142,046 (GRCm39) S322P probably damaging Het
Armc3 T C 2: 19,293,667 (GRCm39) V486A probably benign Het
Asxl2 A G 12: 3,507,200 (GRCm39) K131E probably damaging Het
Atp13a4 A G 16: 29,260,398 (GRCm39) V560A Het
Bnc1 C T 7: 81,623,719 (GRCm39) G503S probably damaging Het
Bsn C A 9: 107,987,704 (GRCm39) V2683F unknown Het
Btbd7 A T 12: 102,804,241 (GRCm39) N266K probably benign Het
Ccdc121rt2 T C 5: 112,597,681 (GRCm39) V76A probably benign Het
Cdca7l G A 12: 117,839,346 (GRCm39) D350N possibly damaging Het
Cfap251 A G 5: 123,411,913 (GRCm39) D515G probably benign Het
Ciao2a A T 9: 66,045,667 (GRCm39) N145I probably damaging Het
Col6a3 T A 1: 90,696,171 (GRCm39) D3239V unknown Het
Col9a1 T A 1: 24,224,208 (GRCm39) I130N unknown Het
Cr2 A G 1: 194,840,913 (GRCm39) W460R probably damaging Het
Cyb561d2 A G 9: 107,417,583 (GRCm39) F56S probably damaging Het
Dnaaf1 A G 8: 120,302,194 (GRCm39) I32V probably benign Het
Dnah11 T A 12: 117,958,950 (GRCm39) T2978S possibly damaging Het
Dsg2 T A 18: 20,716,056 (GRCm39) D302E probably damaging Het
Faf1 T A 4: 109,699,507 (GRCm39) F351I possibly damaging Het
Gimap8 C A 6: 48,633,545 (GRCm39) Q455K probably benign Het
Hps6 C G 19: 45,994,141 (GRCm39) R693G possibly damaging Het
Irx1 C T 13: 72,107,635 (GRCm39) G349D probably damaging Het
Itga8 C G 2: 12,187,495 (GRCm39) G728A probably damaging Het
Lcat T C 8: 106,666,710 (GRCm39) T271A possibly damaging Het
Mapkapk2 T C 1: 130,983,679 (GRCm39) H308R probably damaging Het
Mast1 A T 8: 85,642,953 (GRCm39) N947K probably damaging Het
Mpeg1 A T 19: 12,440,419 (GRCm39) I626F probably damaging Het
Mrtfa T C 15: 80,902,274 (GRCm39) S349G possibly damaging Het
Myh15 T C 16: 49,015,900 (GRCm39) S1859P possibly damaging Het
Nlrx1 A T 9: 44,167,712 (GRCm39) D728E probably benign Het
Or1j8 A G 2: 36,192,387 (GRCm39) T279A probably benign Het
Or8c19-ps1 G T 9: 38,220,516 (GRCm39) V142F probably benign Het
Pcdhb18 A T 18: 37,624,562 (GRCm39) S631C probably damaging Het
Pcdhga11 C A 18: 37,890,364 (GRCm39) Y457* probably null Het
Pcdhga5 T C 18: 37,829,823 (GRCm39) I757T probably benign Het
Pcgf5 G A 19: 36,389,348 (GRCm39) probably benign Het
Pdf A G 8: 107,775,100 (GRCm39) V44A possibly damaging Het
Pip4p1 T C 14: 51,166,503 (GRCm39) T194A possibly damaging Het
Prtg A T 9: 72,819,583 (GRCm39) *1192L probably null Het
Ptk7 A G 17: 46,877,193 (GRCm39) F955S possibly damaging Het
Rbp3 C A 14: 33,684,492 (GRCm39) Q1174K possibly damaging Het
Rufy1 T C 11: 50,321,796 (GRCm39) D46G possibly damaging Het
Sbf2 A G 7: 109,948,202 (GRCm39) V1216A probably benign Het
Serpina11 A G 12: 103,952,722 (GRCm39) V18A unknown Het
Serpinb6a T A 13: 34,115,543 (GRCm39) N47I probably damaging Het
Shc2 T C 10: 79,456,924 (GRCm39) H564R probably damaging Het
Sirt7 T A 11: 120,514,888 (GRCm39) R115* probably null Het
Stra8 T A 6: 34,912,581 (GRCm39) S331T probably damaging Het
Tm9sf2 A G 14: 122,380,883 (GRCm39) T324A probably benign Het
Tmem268 T C 4: 63,498,530 (GRCm39) S224P probably benign Het
Tns1 T C 1: 73,976,407 (GRCm39) D1147G probably damaging Het
Tomm22 C T 15: 79,555,311 (GRCm39) probably benign Het
Top1 A G 2: 160,556,158 (GRCm39) Y539C probably damaging Het
Tpp2 T A 1: 44,009,552 (GRCm39) probably benign Het
Trav3-1 T C 14: 52,818,428 (GRCm39) V34A probably damaging Het
Tspyl5 T C 15: 33,687,238 (GRCm39) N236D possibly damaging Het
Ttc41 A G 10: 86,565,679 (GRCm39) D411G probably benign Het
Vmn1r128 A T 7: 21,083,922 (GRCm39) M209L probably benign Het
Xirp2 T A 2: 67,355,527 (GRCm39) D3429E probably benign Het
Zfp418 A T 7: 7,185,797 (GRCm39) T587S probably benign Het
Other mutations in Slc22a14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00338:Slc22a14 APN 9 119,007,579 (GRCm39) missense possibly damaging 0.58
R0086:Slc22a14 UTSW 9 119,051,804 (GRCm39) critical splice donor site probably benign
R0505:Slc22a14 UTSW 9 119,001,100 (GRCm39) splice site probably benign
R0593:Slc22a14 UTSW 9 118,998,919 (GRCm39) missense probably benign 0.15
R0597:Slc22a14 UTSW 9 119,001,190 (GRCm39) missense probably damaging 0.99
R0674:Slc22a14 UTSW 9 119,007,608 (GRCm39) missense probably damaging 1.00
R1290:Slc22a14 UTSW 9 119,007,518 (GRCm39) missense probably damaging 1.00
R1459:Slc22a14 UTSW 9 119,052,827 (GRCm39) missense possibly damaging 0.70
R1706:Slc22a14 UTSW 9 119,010,050 (GRCm39) missense probably benign 0.06
R3980:Slc22a14 UTSW 9 119,007,552 (GRCm39) missense probably benign 0.02
R4166:Slc22a14 UTSW 9 119,008,934 (GRCm39) missense possibly damaging 0.53
R4166:Slc22a14 UTSW 9 119,007,498 (GRCm39) missense probably benign 0.00
R4574:Slc22a14 UTSW 9 119,008,561 (GRCm39) missense probably damaging 0.99
R4959:Slc22a14 UTSW 9 119,003,101 (GRCm39) small deletion probably benign
R4973:Slc22a14 UTSW 9 119,003,101 (GRCm39) small deletion probably benign
R5273:Slc22a14 UTSW 9 118,999,704 (GRCm39) missense probably benign 0.08
R5330:Slc22a14 UTSW 9 119,059,662 (GRCm39) missense probably damaging 1.00
R5331:Slc22a14 UTSW 9 119,059,662 (GRCm39) missense probably damaging 1.00
R5543:Slc22a14 UTSW 9 119,002,674 (GRCm39) missense probably benign 0.01
R5801:Slc22a14 UTSW 9 119,001,149 (GRCm39) missense probably benign 0.01
R6521:Slc22a14 UTSW 9 119,049,835 (GRCm39) splice site probably null
R6622:Slc22a14 UTSW 9 118,999,643 (GRCm39) missense possibly damaging 0.81
R6948:Slc22a14 UTSW 9 119,060,482 (GRCm39) missense probably damaging 1.00
R7027:Slc22a14 UTSW 9 119,060,281 (GRCm39) splice site probably null
R7731:Slc22a14 UTSW 9 118,999,677 (GRCm39) missense possibly damaging 0.95
R7985:Slc22a14 UTSW 9 118,999,704 (GRCm39) missense probably benign 0.01
R8412:Slc22a14 UTSW 9 119,009,922 (GRCm39) missense probably benign 0.00
R8508:Slc22a14 UTSW 9 119,009,651 (GRCm39) missense probably damaging 1.00
R8674:Slc22a14 UTSW 9 119,007,467 (GRCm39) missense probably null 1.00
R8950:Slc22a14 UTSW 9 118,998,778 (GRCm39) missense possibly damaging 0.71
R9484:Slc22a14 UTSW 9 119,009,615 (GRCm39) missense probably damaging 1.00
R9633:Slc22a14 UTSW 9 119,008,528 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TCATTCACAGCATAGAAAGCTCTG -3'
(R):5'- TTGCCTACCTACCAGGGAAAAC -3'

Sequencing Primer
(F):5'- GCATAGAAAGCTCTGCTATGAC -3'
(R):5'- CCAGAATAGGCTTGCCGG -3'
Posted On 2021-11-25