Incidental Mutation 'R9084:Or6d15'
ID 690458
Institutional Source Beutler Lab
Gene Symbol Or6d15
Ensembl Gene ENSMUSG00000050654
Gene Name olfactory receptor family 6 subfamily D member 15
Synonyms GA_x54KRFPKN04-58217732-58216800, MOR119-2, Olfr215
MMRRC Submission 068903-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # R9084 (G1)
Quality Score 225.009
Status Validated
Chromosome 6
Chromosomal Location 116558973-116559905 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 116559232 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Histidine at position 225 (R225H)
Ref Sequence ENSEMBL: ENSMUSP00000052425 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061723]
AlphaFold Q8VF82
Predicted Effect probably benign
Transcript: ENSMUST00000061723
AA Change: R225H

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000052425
Gene: ENSMUSG00000050654
AA Change: R225H

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 5e-47 PFAM
Pfam:7TM_GPCR_Srsx 33 258 1.8e-5 PFAM
Pfam:7tm_1 39 288 2.9e-15 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency 100% (62/62)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930590J08Rik A G 6: 91,892,016 (GRCm39) K93E probably damaging Het
Adam21 T C 12: 81,606,160 (GRCm39) Y534C probably damaging Het
Add1 A G 5: 34,763,186 (GRCm39) T125A probably damaging Het
Ank3 T C 10: 69,786,879 (GRCm39) V981A probably benign Het
Ankrd34b T A 13: 92,575,720 (GRCm39) D317E probably benign Het
Arhgap9 T C 10: 127,158,114 (GRCm39) S44P possibly damaging Het
Atg7 T C 6: 114,678,896 (GRCm39) S370P probably damaging Het
Atp1b2 T C 11: 69,492,388 (GRCm39) D224G probably damaging Het
C1qtnf6 T C 15: 78,409,283 (GRCm39) Y188C probably damaging Het
Col22a1 T C 15: 71,691,929 (GRCm39) D1297G unknown Het
Cpne7 C T 8: 123,856,951 (GRCm39) P402L probably damaging Het
Csmd1 T C 8: 16,138,325 (GRCm39) I1576V probably benign Het
Cyp2a12 T C 7: 26,735,944 (GRCm39) F451S probably damaging Het
Dusp6 T C 10: 99,099,692 (GRCm39) S47P probably benign Het
Fam163a T A 1: 155,955,730 (GRCm39) I21F probably damaging Het
Fer1l5 A G 1: 36,429,619 (GRCm39) D457G probably benign Het
Fyn C T 10: 39,402,845 (GRCm39) R206C probably damaging Het
Git2 G T 5: 114,902,515 (GRCm39) H172Q probably damaging Het
Gm21698 T A 5: 26,190,244 (GRCm39) H151L probably damaging Het
Gm4924 T A 10: 82,213,953 (GRCm39) C584S unknown Het
Hspb8 A G 5: 116,560,492 (GRCm39) L16P probably benign Het
Ipo9 T C 1: 135,334,563 (GRCm39) H282R probably benign Het
Kcnn1 GTCCTCCTCCTCCTCCTCCTC GTCCTCCTCCTCCTCCTC 8: 71,307,810 (GRCm39) probably benign Het
Kmt2a T C 9: 44,740,130 (GRCm39) D1871G unknown Het
Lrrk2 A T 15: 91,634,469 (GRCm39) Q1411L Het
Med13 A G 11: 86,191,621 (GRCm39) S914P probably damaging Het
Med15 T C 16: 17,471,072 (GRCm39) H706R probably damaging Het
Mfsd2a T C 4: 122,843,994 (GRCm39) Y325C probably damaging Het
Mrpl9 T A 3: 94,354,558 (GRCm39) probably benign Het
Ncoa2 A C 1: 13,244,653 (GRCm39) S682A probably damaging Het
Nfe2l1 A T 11: 96,710,957 (GRCm39) M424K probably damaging Het
Nid1 T C 13: 13,652,925 (GRCm39) probably null Het
Or1f19 T G 16: 3,410,617 (GRCm39) M119R probably damaging Het
Or4f7 A G 2: 111,644,996 (GRCm39) L25P probably damaging Het
Or4k15b T C 14: 50,271,916 (GRCm39) I315V probably benign Het
Or6c69c A T 10: 129,910,941 (GRCm39) M221L probably benign Het
Or6c69c G C 10: 129,910,969 (GRCm39) S230T probably benign Het
Or8g33 A T 9: 39,337,521 (GRCm39) V282E probably damaging Het
Pcnt T C 10: 76,235,826 (GRCm39) D1385G probably benign Het
Pcx A G 19: 4,669,868 (GRCm39) Y846C probably damaging Het
Prune2 A G 19: 17,097,741 (GRCm39) M1082V probably damaging Het
Ptprm A C 17: 67,263,948 (GRCm39) V433G possibly damaging Het
Pvr G T 7: 19,650,937 (GRCm39) Q196K possibly damaging Het
Reck A G 4: 43,922,809 (GRCm39) probably benign Het
Ripk2 T C 4: 16,123,795 (GRCm39) D460G probably damaging Het
Ryr2 T C 13: 11,616,724 (GRCm39) D3898G probably damaging Het
Skint8 A G 4: 111,794,210 (GRCm39) H200R probably benign Het
Slamf1 A T 1: 171,602,522 (GRCm39) D83V probably damaging Het
Snx25 T C 8: 46,521,203 (GRCm39) *143W probably null Het
Spata31d1c A G 13: 65,182,959 (GRCm39) D167G probably benign Het
Sting1 A T 18: 35,869,155 (GRCm39) I178N probably damaging Het
Syne1 T A 10: 5,289,240 (GRCm39) D1420V probably benign Het
Tlcd5 C T 9: 43,022,664 (GRCm39) R230Q probably benign Het
Tmem116 A G 5: 121,627,387 (GRCm39) S211G Het
Tmprss6 C T 15: 78,338,417 (GRCm39) V310M probably damaging Het
Ttn A G 2: 76,612,722 (GRCm39) I17119T probably damaging Het
Tubb1 T A 2: 174,299,197 (GRCm39) M293K possibly damaging Het
Unc13d AATGCCTCCCATGCC AATGCCTCCCATGCCTCCCATGCC 11: 115,958,998 (GRCm39) probably benign Het
Uncx T C 5: 139,529,753 (GRCm39) M2T possibly damaging Het
Washc4 T C 10: 83,422,499 (GRCm39) F943L possibly damaging Het
Xkr9 G A 1: 13,742,733 (GRCm39) C6Y probably benign Het
Zfp458 A T 13: 67,407,633 (GRCm39) V74E probably benign Het
Other mutations in Or6d15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01666:Or6d15 APN 6 116,559,296 (GRCm39) missense possibly damaging 0.93
IGL02959:Or6d15 APN 6 116,559,505 (GRCm39) missense probably damaging 1.00
IGL03053:Or6d15 APN 6 116,559,206 (GRCm39) missense possibly damaging 0.50
R0078:Or6d15 UTSW 6 116,559,701 (GRCm39) missense probably damaging 0.96
R0277:Or6d15 UTSW 6 116,559,562 (GRCm39) missense probably damaging 0.99
R0323:Or6d15 UTSW 6 116,559,562 (GRCm39) missense probably damaging 0.99
R0399:Or6d15 UTSW 6 116,559,742 (GRCm39) missense probably benign 0.00
R0545:Or6d15 UTSW 6 116,559,617 (GRCm39) missense probably benign 0.01
R1213:Or6d15 UTSW 6 116,559,827 (GRCm39) missense probably benign 0.00
R1775:Or6d15 UTSW 6 116,559,925 (GRCm39) start gained probably benign
R1789:Or6d15 UTSW 6 116,559,658 (GRCm39) missense probably damaging 1.00
R4724:Or6d15 UTSW 6 116,559,898 (GRCm39) missense probably damaging 1.00
R5391:Or6d15 UTSW 6 116,559,808 (GRCm39) missense probably damaging 1.00
R5392:Or6d15 UTSW 6 116,559,379 (GRCm39) missense probably damaging 1.00
R5686:Or6d15 UTSW 6 116,559,890 (GRCm39) missense probably benign 0.00
R6124:Or6d15 UTSW 6 116,559,446 (GRCm39) missense probably benign 0.05
R7080:Or6d15 UTSW 6 116,559,314 (GRCm39) missense probably damaging 1.00
R7355:Or6d15 UTSW 6 116,559,916 (GRCm39) start gained probably benign
Z1177:Or6d15 UTSW 6 116,559,514 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- TGTTACGCAGGGTGTAGATGAC -3'
(R):5'- ACGGTATCACGGTTATCCTTC -3'

Sequencing Primer
(F):5'- TGTAGATGACGGGGTTCAGAAGC -3'
(R):5'- ATCACGGTTATCCTTCTGTGG -3'
Posted On 2021-12-30