Incidental Mutation 'R9084:Fyn'
ID 690469
Institutional Source Beutler Lab
Gene Symbol Fyn
Ensembl Gene ENSMUSG00000019843
Gene Name Fyn proto-oncogene
Synonyms Src Kinase p59
MMRRC Submission 068903-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R9084 (G1)
Quality Score 225.009
Status Validated
Chromosome 10
Chromosomal Location 39245735-39441377 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 39402845 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Cysteine at position 206 (R206C)
Ref Sequence ENSEMBL: ENSMUSP00000097547 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000063091] [ENSMUST00000099967] [ENSMUST00000126486] [ENSMUST00000135242] [ENSMUST00000136659] [ENSMUST00000146287]
AlphaFold P39688
Predicted Effect
SMART Domains Protein: ENSMUSP00000057707
Gene: ENSMUSG00000019843
AA Change: R206C

DomainStartEndE-ValueType
SH3 85 142 4.21e-24 SMART
SH2 147 237 3.86e-34 SMART
TyrKc 268 517 8.07e-133 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000099967
AA Change: R206C

PolyPhen 2 Score 0.969 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000097547
Gene: ENSMUSG00000019843
AA Change: R206C

DomainStartEndE-ValueType
SH3 85 142 4.21e-24 SMART
SH2 147 237 1.65e-33 SMART
TyrKc 271 520 1.08e-133 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000126486
AA Change: R206C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000115233
Gene: ENSMUSG00000019843
AA Change: R206C

DomainStartEndE-ValueType
SH3 85 142 4.21e-24 SMART
SH2 147 237 3.86e-34 SMART
TyrKc 268 517 8.07e-133 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000135242
AA Change: R206C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000117111
Gene: ENSMUSG00000019843
AA Change: R206C

DomainStartEndE-ValueType
SH3 85 142 4.21e-24 SMART
SH2 147 237 3.86e-34 SMART
TyrKc 268 517 8.07e-133 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000136659
AA Change: R206C

PolyPhen 2 Score 0.952 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000118131
Gene: ENSMUSG00000019843
AA Change: R206C

DomainStartEndE-ValueType
SH3 85 142 4.21e-24 SMART
SH2 147 237 4.37e-33 SMART
TyrKc 222 465 7.5e-119 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000146287
AA Change: R206C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000114188
Gene: ENSMUSG00000019843
AA Change: R206C

DomainStartEndE-ValueType
SH3 85 142 4.21e-24 SMART
SH2 147 237 3.86e-34 SMART
TyrKc 268 517 8.07e-133 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency 100% (62/62)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. [provided by RefSeq, Jul 2008]
PHENOTYPE: Different targeted allele homozygotes show different defects, including seizure susceptibility, anxiety, impaired suckling, myelination, LTP and spatial learning, and defects in immune system, circadian rhythm, testes weight and olfactory bulb formation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930590J08Rik A G 6: 91,892,016 (GRCm39) K93E probably damaging Het
Adam21 T C 12: 81,606,160 (GRCm39) Y534C probably damaging Het
Add1 A G 5: 34,763,186 (GRCm39) T125A probably damaging Het
Ank3 T C 10: 69,786,879 (GRCm39) V981A probably benign Het
Ankrd34b T A 13: 92,575,720 (GRCm39) D317E probably benign Het
Arhgap9 T C 10: 127,158,114 (GRCm39) S44P possibly damaging Het
Atg7 T C 6: 114,678,896 (GRCm39) S370P probably damaging Het
Atp1b2 T C 11: 69,492,388 (GRCm39) D224G probably damaging Het
C1qtnf6 T C 15: 78,409,283 (GRCm39) Y188C probably damaging Het
Col22a1 T C 15: 71,691,929 (GRCm39) D1297G unknown Het
Cpne7 C T 8: 123,856,951 (GRCm39) P402L probably damaging Het
Csmd1 T C 8: 16,138,325 (GRCm39) I1576V probably benign Het
Cyp2a12 T C 7: 26,735,944 (GRCm39) F451S probably damaging Het
Dusp6 T C 10: 99,099,692 (GRCm39) S47P probably benign Het
Fam163a T A 1: 155,955,730 (GRCm39) I21F probably damaging Het
Fer1l5 A G 1: 36,429,619 (GRCm39) D457G probably benign Het
Git2 G T 5: 114,902,515 (GRCm39) H172Q probably damaging Het
Gm21698 T A 5: 26,190,244 (GRCm39) H151L probably damaging Het
Gm4924 T A 10: 82,213,953 (GRCm39) C584S unknown Het
Hspb8 A G 5: 116,560,492 (GRCm39) L16P probably benign Het
Ipo9 T C 1: 135,334,563 (GRCm39) H282R probably benign Het
Kcnn1 GTCCTCCTCCTCCTCCTCCTC GTCCTCCTCCTCCTCCTC 8: 71,307,810 (GRCm39) probably benign Het
Kmt2a T C 9: 44,740,130 (GRCm39) D1871G unknown Het
Lrrk2 A T 15: 91,634,469 (GRCm39) Q1411L Het
Med13 A G 11: 86,191,621 (GRCm39) S914P probably damaging Het
Med15 T C 16: 17,471,072 (GRCm39) H706R probably damaging Het
Mfsd2a T C 4: 122,843,994 (GRCm39) Y325C probably damaging Het
Mrpl9 T A 3: 94,354,558 (GRCm39) probably benign Het
Ncoa2 A C 1: 13,244,653 (GRCm39) S682A probably damaging Het
Nfe2l1 A T 11: 96,710,957 (GRCm39) M424K probably damaging Het
Nid1 T C 13: 13,652,925 (GRCm39) probably null Het
Or1f19 T G 16: 3,410,617 (GRCm39) M119R probably damaging Het
Or4f7 A G 2: 111,644,996 (GRCm39) L25P probably damaging Het
Or4k15b T C 14: 50,271,916 (GRCm39) I315V probably benign Het
Or6c69c A T 10: 129,910,941 (GRCm39) M221L probably benign Het
Or6c69c G C 10: 129,910,969 (GRCm39) S230T probably benign Het
Or6d15 C T 6: 116,559,232 (GRCm39) R225H probably benign Het
Or8g33 A T 9: 39,337,521 (GRCm39) V282E probably damaging Het
Pcnt T C 10: 76,235,826 (GRCm39) D1385G probably benign Het
Pcx A G 19: 4,669,868 (GRCm39) Y846C probably damaging Het
Prune2 A G 19: 17,097,741 (GRCm39) M1082V probably damaging Het
Ptprm A C 17: 67,263,948 (GRCm39) V433G possibly damaging Het
Pvr G T 7: 19,650,937 (GRCm39) Q196K possibly damaging Het
Reck A G 4: 43,922,809 (GRCm39) probably benign Het
Ripk2 T C 4: 16,123,795 (GRCm39) D460G probably damaging Het
Ryr2 T C 13: 11,616,724 (GRCm39) D3898G probably damaging Het
Skint8 A G 4: 111,794,210 (GRCm39) H200R probably benign Het
Slamf1 A T 1: 171,602,522 (GRCm39) D83V probably damaging Het
Snx25 T C 8: 46,521,203 (GRCm39) *143W probably null Het
Spata31d1c A G 13: 65,182,959 (GRCm39) D167G probably benign Het
Sting1 A T 18: 35,869,155 (GRCm39) I178N probably damaging Het
Syne1 T A 10: 5,289,240 (GRCm39) D1420V probably benign Het
Tlcd5 C T 9: 43,022,664 (GRCm39) R230Q probably benign Het
Tmem116 A G 5: 121,627,387 (GRCm39) S211G Het
Tmprss6 C T 15: 78,338,417 (GRCm39) V310M probably damaging Het
Ttn A G 2: 76,612,722 (GRCm39) I17119T probably damaging Het
Tubb1 T A 2: 174,299,197 (GRCm39) M293K possibly damaging Het
Unc13d AATGCCTCCCATGCC AATGCCTCCCATGCCTCCCATGCC 11: 115,958,998 (GRCm39) probably benign Het
Uncx T C 5: 139,529,753 (GRCm39) M2T possibly damaging Het
Washc4 T C 10: 83,422,499 (GRCm39) F943L possibly damaging Het
Xkr9 G A 1: 13,742,733 (GRCm39) C6Y probably benign Het
Zfp458 A T 13: 67,407,633 (GRCm39) V74E probably benign Het
Other mutations in Fyn
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01988:Fyn APN 10 39,409,917 (GRCm39) nonsense probably null
IGL02626:Fyn APN 10 39,402,798 (GRCm39) missense probably damaging 1.00
H8562:Fyn UTSW 10 39,387,950 (GRCm39) missense probably benign 0.00
R0128:Fyn UTSW 10 39,387,978 (GRCm39) missense probably benign 0.00
R0130:Fyn UTSW 10 39,387,978 (GRCm39) missense probably benign 0.00
R0336:Fyn UTSW 10 39,402,897 (GRCm39) missense possibly damaging 0.52
R1446:Fyn UTSW 10 39,398,775 (GRCm39) missense probably benign 0.43
R1498:Fyn UTSW 10 39,408,120 (GRCm39) missense possibly damaging 0.90
R1539:Fyn UTSW 10 39,408,066 (GRCm39) missense possibly damaging 0.94
R1912:Fyn UTSW 10 39,402,828 (GRCm39) missense possibly damaging 0.94
R2198:Fyn UTSW 10 39,405,541 (GRCm39) missense probably benign 0.13
R2339:Fyn UTSW 10 39,398,781 (GRCm39) missense probably benign 0.00
R3107:Fyn UTSW 10 39,427,451 (GRCm39) missense probably damaging 1.00
R3109:Fyn UTSW 10 39,427,451 (GRCm39) missense probably damaging 1.00
R5068:Fyn UTSW 10 39,402,839 (GRCm39) missense probably damaging 1.00
R5233:Fyn UTSW 10 39,405,936 (GRCm39) missense probably benign
R5929:Fyn UTSW 10 39,427,457 (GRCm39) missense probably damaging 1.00
R6360:Fyn UTSW 10 39,402,879 (GRCm39) missense possibly damaging 0.83
R6379:Fyn UTSW 10 39,331,070 (GRCm39) start gained probably benign
R6490:Fyn UTSW 10 39,427,398 (GRCm39) missense probably damaging 1.00
R7179:Fyn UTSW 10 39,408,120 (GRCm39) missense possibly damaging 0.90
R8087:Fyn UTSW 10 39,405,553 (GRCm39) nonsense probably null
R8246:Fyn UTSW 10 39,405,525 (GRCm39) missense probably damaging 1.00
R9167:Fyn UTSW 10 39,402,811 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TGGCAGGATAGCAAAAGTTGTC -3'
(R):5'- GGACAGCTCTACCTAGTGACTC -3'

Sequencing Primer
(F):5'- CAGGATAGCAAAAGTTGTCTTTGTCC -3'
(R):5'- ACCTAGTGACTCTGTCCCG -3'
Posted On 2021-12-30