Incidental Mutation 'R9084:Or6c69c'
ID 690477
Institutional Source Beutler Lab
Gene Symbol Or6c69c
Ensembl Gene ENSMUSG00000058251
Gene Name olfactory receptor family 6 subfamily C member 69C
Synonyms MOR113-2, Olfr822, GA_x6K02T2PULF-11745102-11746040
MMRRC Submission 068903-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # R9084 (G1)
Quality Score 225.009
Status Validated
Chromosome 10
Chromosomal Location 129910281-129911219 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to C at 129910969 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Threonine at position 230 (S230T)
Ref Sequence ENSEMBL: ENSMUSP00000150652 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080460] [ENSMUST00000216879]
AlphaFold Q8VFU1
Predicted Effect probably benign
Transcript: ENSMUST00000080460
AA Change: S230T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000079316
Gene: ENSMUSG00000058251
AA Change: S230T

DomainStartEndE-ValueType
Pfam:7tm_4 29 307 1.1e-49 PFAM
Pfam:7tm_1 39 288 9.3e-26 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216879
AA Change: S230T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency 100% (62/62)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930590J08Rik A G 6: 91,892,016 (GRCm39) K93E probably damaging Het
Adam21 T C 12: 81,606,160 (GRCm39) Y534C probably damaging Het
Add1 A G 5: 34,763,186 (GRCm39) T125A probably damaging Het
Ank3 T C 10: 69,786,879 (GRCm39) V981A probably benign Het
Ankrd34b T A 13: 92,575,720 (GRCm39) D317E probably benign Het
Arhgap9 T C 10: 127,158,114 (GRCm39) S44P possibly damaging Het
Atg7 T C 6: 114,678,896 (GRCm39) S370P probably damaging Het
Atp1b2 T C 11: 69,492,388 (GRCm39) D224G probably damaging Het
C1qtnf6 T C 15: 78,409,283 (GRCm39) Y188C probably damaging Het
Col22a1 T C 15: 71,691,929 (GRCm39) D1297G unknown Het
Cpne7 C T 8: 123,856,951 (GRCm39) P402L probably damaging Het
Csmd1 T C 8: 16,138,325 (GRCm39) I1576V probably benign Het
Cyp2a12 T C 7: 26,735,944 (GRCm39) F451S probably damaging Het
Dusp6 T C 10: 99,099,692 (GRCm39) S47P probably benign Het
Fam163a T A 1: 155,955,730 (GRCm39) I21F probably damaging Het
Fer1l5 A G 1: 36,429,619 (GRCm39) D457G probably benign Het
Fyn C T 10: 39,402,845 (GRCm39) R206C probably damaging Het
Git2 G T 5: 114,902,515 (GRCm39) H172Q probably damaging Het
Gm21698 T A 5: 26,190,244 (GRCm39) H151L probably damaging Het
Gm4924 T A 10: 82,213,953 (GRCm39) C584S unknown Het
Hspb8 A G 5: 116,560,492 (GRCm39) L16P probably benign Het
Ipo9 T C 1: 135,334,563 (GRCm39) H282R probably benign Het
Kcnn1 GTCCTCCTCCTCCTCCTCCTC GTCCTCCTCCTCCTCCTC 8: 71,307,810 (GRCm39) probably benign Het
Kmt2a T C 9: 44,740,130 (GRCm39) D1871G unknown Het
Lrrk2 A T 15: 91,634,469 (GRCm39) Q1411L Het
Med13 A G 11: 86,191,621 (GRCm39) S914P probably damaging Het
Med15 T C 16: 17,471,072 (GRCm39) H706R probably damaging Het
Mfsd2a T C 4: 122,843,994 (GRCm39) Y325C probably damaging Het
Mrpl9 T A 3: 94,354,558 (GRCm39) probably benign Het
Ncoa2 A C 1: 13,244,653 (GRCm39) S682A probably damaging Het
Nfe2l1 A T 11: 96,710,957 (GRCm39) M424K probably damaging Het
Nid1 T C 13: 13,652,925 (GRCm39) probably null Het
Or1f19 T G 16: 3,410,617 (GRCm39) M119R probably damaging Het
Or4f7 A G 2: 111,644,996 (GRCm39) L25P probably damaging Het
Or4k15b T C 14: 50,271,916 (GRCm39) I315V probably benign Het
Or6d15 C T 6: 116,559,232 (GRCm39) R225H probably benign Het
Or8g33 A T 9: 39,337,521 (GRCm39) V282E probably damaging Het
Pcnt T C 10: 76,235,826 (GRCm39) D1385G probably benign Het
Pcx A G 19: 4,669,868 (GRCm39) Y846C probably damaging Het
Prune2 A G 19: 17,097,741 (GRCm39) M1082V probably damaging Het
Ptprm A C 17: 67,263,948 (GRCm39) V433G possibly damaging Het
Pvr G T 7: 19,650,937 (GRCm39) Q196K possibly damaging Het
Reck A G 4: 43,922,809 (GRCm39) probably benign Het
Ripk2 T C 4: 16,123,795 (GRCm39) D460G probably damaging Het
Ryr2 T C 13: 11,616,724 (GRCm39) D3898G probably damaging Het
Skint8 A G 4: 111,794,210 (GRCm39) H200R probably benign Het
Slamf1 A T 1: 171,602,522 (GRCm39) D83V probably damaging Het
Snx25 T C 8: 46,521,203 (GRCm39) *143W probably null Het
Spata31d1c A G 13: 65,182,959 (GRCm39) D167G probably benign Het
Sting1 A T 18: 35,869,155 (GRCm39) I178N probably damaging Het
Syne1 T A 10: 5,289,240 (GRCm39) D1420V probably benign Het
Tlcd5 C T 9: 43,022,664 (GRCm39) R230Q probably benign Het
Tmem116 A G 5: 121,627,387 (GRCm39) S211G Het
Tmprss6 C T 15: 78,338,417 (GRCm39) V310M probably damaging Het
Ttn A G 2: 76,612,722 (GRCm39) I17119T probably damaging Het
Tubb1 T A 2: 174,299,197 (GRCm39) M293K possibly damaging Het
Unc13d AATGCCTCCCATGCC AATGCCTCCCATGCCTCCCATGCC 11: 115,958,998 (GRCm39) probably benign Het
Uncx T C 5: 139,529,753 (GRCm39) M2T possibly damaging Het
Washc4 T C 10: 83,422,499 (GRCm39) F943L possibly damaging Het
Xkr9 G A 1: 13,742,733 (GRCm39) C6Y probably benign Het
Zfp458 A T 13: 67,407,633 (GRCm39) V74E probably benign Het
Other mutations in Or6c69c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01624:Or6c69c APN 10 129,910,519 (GRCm39) missense probably damaging 1.00
IGL01975:Or6c69c APN 10 129,911,139 (GRCm39) missense probably damaging 1.00
IGL02354:Or6c69c APN 10 129,911,143 (GRCm39) missense probably damaging 1.00
IGL02361:Or6c69c APN 10 129,911,143 (GRCm39) missense probably damaging 1.00
IGL03184:Or6c69c APN 10 129,910,627 (GRCm39) missense possibly damaging 0.82
IGL03197:Or6c69c APN 10 129,910,548 (GRCm39) missense probably damaging 0.99
IGL03343:Or6c69c APN 10 129,911,125 (GRCm39) missense probably damaging 1.00
R0310:Or6c69c UTSW 10 129,910,692 (GRCm39) missense probably benign 0.00
R1288:Or6c69c UTSW 10 129,911,154 (GRCm39) missense probably damaging 1.00
R1502:Or6c69c UTSW 10 129,910,741 (GRCm39) missense probably damaging 0.97
R1527:Or6c69c UTSW 10 129,911,061 (GRCm39) missense probably damaging 1.00
R3771:Or6c69c UTSW 10 129,911,143 (GRCm39) missense probably damaging 1.00
R5022:Or6c69c UTSW 10 129,910,462 (GRCm39) missense probably damaging 1.00
R5472:Or6c69c UTSW 10 129,910,898 (GRCm39) missense probably damaging 0.97
R5552:Or6c69c UTSW 10 129,911,014 (GRCm39) missense probably damaging 0.99
R6451:Or6c69c UTSW 10 129,911,007 (GRCm39) missense probably benign 0.01
R6986:Or6c69c UTSW 10 129,911,199 (GRCm39) missense possibly damaging 0.63
R8101:Or6c69c UTSW 10 129,910,875 (GRCm39) missense probably benign
R8468:Or6c69c UTSW 10 129,910,303 (GRCm39) missense probably benign 0.03
R8785:Or6c69c UTSW 10 129,910,485 (GRCm39) missense probably benign 0.01
R8988:Or6c69c UTSW 10 129,910,522 (GRCm39) missense possibly damaging 0.95
R9083:Or6c69c UTSW 10 129,910,969 (GRCm39) missense probably benign
R9083:Or6c69c UTSW 10 129,910,941 (GRCm39) missense probably benign
R9084:Or6c69c UTSW 10 129,910,941 (GRCm39) missense probably benign
R9366:Or6c69c UTSW 10 129,911,067 (GRCm39) nonsense probably null
R9773:Or6c69c UTSW 10 129,910,360 (GRCm39) missense possibly damaging 0.65
X0024:Or6c69c UTSW 10 129,910,594 (GRCm39) missense probably damaging 0.99
Z1176:Or6c69c UTSW 10 129,910,973 (GRCm39) missense probably benign 0.06
Predicted Primers PCR Primer
(F):5'- AGGCTTGAATCTCGACTTCTGTG -3'
(R):5'- TGCTGATTCCTCAAGGTGTAG -3'

Sequencing Primer
(F):5'- TGTGCTTCCAACATCATTGATC -3'
(R):5'- CCTCAAGGTGTAGATAAAAGGATTC -3'
Posted On 2021-12-30