Mutagenetix > Incidental Mutation

Incidental Mutation 'R9086:Lrrk2'

690631

Institutional Source

Beutler Lab

Gene Symbol

Lrrk2

Ensembl Gene

ENSMUSG00000036273

Gene Name

leucine-rich repeat kinase 2

Synonyms

9330188B09Rik, 4921513O20Rik, LOC381026, cI-46, D630001M17Rik

MMRRC Submission

068905-MU

Accession Numbers

Genbank: NM_025730; MGI: 1913975

Essential gene?

Possibly essential (E-score: 0.520) question?

Stock #

R9086 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

91673175-91816120 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 91755848 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Arginine at position 1532 (K1532R)

Ref Sequence

ENSEMBL: ENSMUSP00000052584 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000060642]

AlphaFold

Q5S006

Predicted Effect

probably benign
Transcript: ENSMUST00000060642
AA Change: K1532R

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)

SMART Domains

Protein: ENSMUSP00000052584
Gene: ENSMUSG00000036273
AA Change: K1532R

Domain	Start	End	E-Value	Type
low complexity region	138	156	N/A	INTRINSIC
low complexity region	332	347	N/A	INTRINSIC
ANK	708	737	3.95e1	SMART
ANK	770	800	4.58e2	SMART
low complexity region	890	901	N/A	INTRINSIC
low complexity region	953	966	N/A	INTRINSIC
low complexity region	971	979	N/A	INTRINSIC
LRR	1010	1033	9.96e-1	SMART
LRR	1034	1057	8.01e0	SMART
LRR	1082	1105	2.45e0	SMART
LRR	1128	1151	9.3e-1	SMART
LRR	1195	1219	3.24e0	SMART
LRR	1244	1266	3.87e1	SMART
LRR	1267	1291	4.98e1	SMART
Pfam:Roc	1336	1456	4.9e-32	PFAM
Pfam:Ras	1336	1489	3.3e-17	PFAM
Pfam:COR	1524	1740	4e-28	PFAM
Pfam:Pkinase	1881	2132	4.7e-40	PFAM
Pfam:Pkinase_Tyr	1882	2132	6.8e-39	PFAM
WD40	2231	2276	3.09e-1	SMART
WD40	2401	2438	1.37e2	SMART

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.7%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-in allele exhibit impaired response to dopamine, amphetamine, and quinpirole. Mice homozygous for one knock-out allele exhibit increased neurite growth. Mice homozygous for different knock-out alleles exhibit alopecia due to excessive grooming or kdiney atrophy. [provided by MGI curators]

Allele List at MGI

All alleles(7) : Targeted, knock-out(6) Targeted, other(1)

Other mutations in this stock

Total: 69 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4932415D10Rik	C	T	10: 82,288,743 (GRCm38)	S2811N	probably benign	Het
Abca9	T	C	11: 110,102,053 (GRCm38)	E1595G	probably damaging	Het
Ank1	T	C	8: 23,099,620 (GRCm38)	V608A	probably damaging	Het
Arl14epl	T	C	18: 46,932,594 (GRCm38)	V142A	possibly damaging	Het
Atp8a1	T	C	5: 67,774,816 (GRCm38)	D210G		Het
Baz1b	T	C	5: 135,231,684 (GRCm38)	F1112L	probably damaging	Het
Cage1	T	A	13: 38,022,922 (GRCm38)	I316F	probably damaging	Het
Car2	A	C	3: 14,887,908 (GRCm38)	T37P	probably benign	Het
Catsper2	TAGGATGGCTTTTCTCAGGATAGCTTTTCTCAGGATGGCTTTTCTCAGGATAGCTTTTCTCAGGATGGCTTTTCTCAGGATAGCTTTTCT	TAGGATGGCTTTTCTCAGGATAGCTTTTCTCAGGATGGCTTTTCTCAGGATAGCTTTTCT	2: 121,397,572 (GRCm38)		probably benign	Het
Cntnap3	T	A	13: 64,781,759 (GRCm38)	D542V	probably damaging	Het
Coro1b	T	C	19: 4,152,526 (GRCm38)	Y338H	probably damaging	Het
Ctdspl2	G	A	2: 122,007,817 (GRCm38)		probably null	Het
Cyp2a12	T	C	7: 27,036,519 (GRCm38)	F451S	probably damaging	Het
Dpm2	T	C	2: 32,572,379 (GRCm38)	L59P	probably damaging	Het
Duoxa2	A	G	2: 122,301,340 (GRCm38)	Y170C	probably damaging	Het
Dus2	T	A	8: 106,015,941 (GRCm38)	Y34*	probably null	Het
Dzip3	A	G	16: 48,961,130 (GRCm38)	I266T	possibly damaging	Het
Ebf3	T	C	7: 137,199,265 (GRCm38)	T455A	possibly damaging	Het
Echdc2	C	T	4: 108,169,879 (GRCm38)	Q74*	probably null	Het
Efhc1	T	C	1: 20,955,368 (GRCm38)	Y33H	probably damaging	Het
Fam20a	A	T	11: 109,675,928 (GRCm38)	C378*	probably null	Het
Fbxo25	C	A	8: 13,939,621 (GRCm38)	P356Q	probably damaging	Het
Fig4	G	T	10: 41,285,403 (GRCm38)	T59K	possibly damaging	Het
Gbp10	T	A	5: 105,218,503 (GRCm38)	M512L	probably benign	Het
Gdf10	T	A	14: 33,932,264 (GRCm38)	Y243N	probably damaging	Het
Golga5	T	A	12: 102,492,217 (GRCm38)	S640T	probably benign	Het
Hils1	A	T	11: 94,968,257 (GRCm38)	K126M	possibly damaging	Het
Ints1	A	T	5: 139,758,192 (GRCm38)	H1540Q	probably benign	Het
Lipo3	A	T	19: 33,557,129 (GRCm38)	L310Q	probably benign	Het
Ltc4s	T	C	11: 50,237,247 (GRCm38)	Y59C	probably damaging	Het
Macf1	T	A	4: 123,484,151 (GRCm38)	H1427L	probably damaging	Het
Mroh2b	A	G	15: 4,953,272 (GRCm38)		probably null	Het
Mthfd1l	A	T	10: 3,973,412 (GRCm38)	D53V	probably benign	Het
Muc4	C	A	16: 32,757,468 (GRCm38)	P303Q		Het
Nrxn1	A	G	17: 90,162,364 (GRCm38)	F1293S	probably damaging	Het
Nrxn2	G	A	19: 6,490,078 (GRCm38)	E803K	probably damaging	Het
Nup155	A	G	15: 8,148,346 (GRCm38)	D1071G	possibly damaging	Het
Olfr319	T	A	11: 58,702,129 (GRCm38)	S143T	possibly damaging	Het
Olfr364-ps1	T	A	2: 37,146,414 (GRCm38)	D67E	probably damaging	Het
Olfr700	A	T	7: 106,805,919 (GRCm38)	I181N	probably benign	Het
Papln	A	G	12: 83,774,859 (GRCm38)	E287G	probably damaging	Het
Pex13	C	A	11: 23,665,760 (GRCm38)	G29C	probably damaging	Het
Phrf1	C	A	7: 141,259,499 (GRCm38)	T869K	unknown	Het
Pitrm1	A	G	13: 6,577,481 (GRCm38)	T912A	probably benign	Het
Pla2g4c	A	G	7: 13,337,767 (GRCm38)	K171E	probably benign	Het
Pnpla7	A	T	2: 25,039,697 (GRCm38)	T833S	probably damaging	Het
Por	G	T	5: 135,716,064 (GRCm38)		probably null	Het
Rab3ip	G	A	10: 116,939,405 (GRCm38)	S16L	probably damaging	Het
Rabgef1	A	T	5: 130,211,951 (GRCm38)	I304F	probably benign	Het
Rbbp8	T	C	18: 11,742,679 (GRCm38)	V883A	possibly damaging	Het
Rnase4	A	G	14: 51,104,972 (GRCm38)	D51G	possibly damaging	Het
Rnf13	A	C	3: 57,833,576 (GRCm38)	D291A	probably benign	Het
Rps6kb2	A	T	19: 4,159,271 (GRCm38)	I191N	probably damaging	Het
Scn1a	A	G	2: 66,351,014 (GRCm38)	L55S	probably benign	Het
Son	T	A	16: 91,670,530 (GRCm38)	F2260I	unknown	Het
Ssr1	A	G	13: 37,983,473 (GRCm38)	I238T	probably benign	Het
Stk11ip	A	G	1: 75,530,174 (GRCm38)	E633G	possibly damaging	Het
Svs3a	A	G	2: 164,290,142 (GRCm38)	Y211C	probably benign	Het
Sytl1	T	A	4: 133,260,864 (GRCm38)	E60D	possibly damaging	Het
Tlr1	T	C	5: 64,925,855 (GRCm38)	I460V	probably damaging	Het
Tmem136	C	T	9: 43,111,369 (GRCm38)	R230Q	probably benign	Het
Tmem64	T	C	4: 15,266,718 (GRCm38)	I256T	probably damaging	Het
Ttll5	G	A	12: 85,917,742 (GRCm38)	A553T	possibly damaging	Het
Ttll5	A	T	12: 86,024,333 (GRCm38)	T1327S	probably benign	Het
Upp2	T	A	2: 58,790,165 (GRCm38)	C334*	probably null	Het
Wdr74	C	A	19: 8,735,994 (GRCm38)	N24K	possibly damaging	Het
Zbtb42	G	A	12: 112,679,414 (GRCm38)	V8I	probably benign	Het
Zfp541	T	A	7: 16,090,404 (GRCm38)	L1078Q	probably damaging	Het
Zfr2	T	C	10: 81,240,195 (GRCm38)	V212A	probably damaging	Het

Other mutations in Lrrk2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00159:Lrrk2	APN	15	91,747,799 (GRCm38)	missense	possibly damaging	0.90
IGL00542:Lrrk2	APN	15	91,699,943 (GRCm38)	missense	probably benign
IGL00770:Lrrk2	APN	15	91,801,833 (GRCm38)	splice site	probably benign
IGL00774:Lrrk2	APN	15	91,801,833 (GRCm38)	splice site	probably benign
IGL00791:Lrrk2	APN	15	91,779,841 (GRCm38)	missense	probably damaging	1.00
IGL00827:Lrrk2	APN	15	91,755,790 (GRCm38)	missense	probably damaging	1.00
IGL00843:Lrrk2	APN	15	91,757,058 (GRCm38)	missense	possibly damaging	0.58
IGL01109:Lrrk2	APN	15	91,738,832 (GRCm38)	missense	probably damaging	1.00
IGL01293:Lrrk2	APN	15	91,726,137 (GRCm38)	missense	probably benign	0.21
IGL01296:Lrrk2	APN	15	91,683,142 (GRCm38)	missense	probably benign
IGL01301:Lrrk2	APN	15	91,767,339 (GRCm38)	missense	probably damaging	1.00
IGL01360:Lrrk2	APN	15	91,700,569 (GRCm38)	splice site	probably null
IGL01465:Lrrk2	APN	15	91,728,925 (GRCm38)	missense	probably benign	0.21
IGL01529:Lrrk2	APN	15	91,812,313 (GRCm38)	missense	possibly damaging	0.92
IGL01557:Lrrk2	APN	15	91,699,989 (GRCm38)	missense	probably damaging	1.00
IGL01560:Lrrk2	APN	15	91,774,988 (GRCm38)	missense	probably benign	0.33
IGL01991:Lrrk2	APN	15	91,779,946 (GRCm38)	missense	probably damaging	0.99
IGL02003:Lrrk2	APN	15	91,731,491 (GRCm38)	missense	probably damaging	0.99
IGL02325:Lrrk2	APN	15	91,726,308 (GRCm38)	critical splice donor site	probably null
IGL02711:Lrrk2	APN	15	91,685,822 (GRCm38)	missense	possibly damaging	0.71
IGL02869:Lrrk2	APN	15	91,750,277 (GRCm38)	missense	probably damaging	1.00
IGL03104:Lrrk2	APN	15	91,747,755 (GRCm38)	missense	possibly damaging	0.68
IGL03179:Lrrk2	APN	15	91,700,578 (GRCm38)	missense	probably damaging	1.00
IGL03395:Lrrk2	APN	15	91,797,414 (GRCm38)	splice site	probably null
horned	UTSW	15	91,772,858 (GRCm38)	missense	probably damaging	1.00
R1312_Lrrk2_980	UTSW	15	91,699,895 (GRCm38)	missense	probably damaging	1.00
R4710_lrrk2_232	UTSW	15	91,699,927 (GRCm38)	missense	possibly damaging	0.88
R5245_Lrrk2_127	UTSW	15	91,796,089 (GRCm38)	missense	probably damaging	1.00
spree	UTSW	15	91,702,247 (GRCm38)	missense	probably benign	0.00
Spur	UTSW	15	91,774,995 (GRCm38)	nonsense	probably null
3-1:Lrrk2	UTSW	15	91,801,934 (GRCm38)	missense	probably benign	0.01
ANU18:Lrrk2	UTSW	15	91,767,339 (GRCm38)	missense	probably damaging	1.00
H8562:Lrrk2	UTSW	15	91,673,358 (GRCm38)	missense	probably benign
H8786:Lrrk2	UTSW	15	91,673,358 (GRCm38)	missense	probably benign
IGL02835:Lrrk2	UTSW	15	91,814,660 (GRCm38)	critical splice acceptor site	probably null
R0014:Lrrk2	UTSW	15	91,802,045 (GRCm38)	splice site	probably benign
R0014:Lrrk2	UTSW	15	91,802,045 (GRCm38)	splice site	probably benign
R0078:Lrrk2	UTSW	15	91,734,009 (GRCm38)	missense	probably benign	0.01
R0100:Lrrk2	UTSW	15	91,745,796 (GRCm38)	missense	probably damaging	1.00
R0282:Lrrk2	UTSW	15	91,778,414 (GRCm38)	splice site	probably benign
R0448:Lrrk2	UTSW	15	91,709,305 (GRCm38)	missense	probably damaging	0.99
R0449:Lrrk2	UTSW	15	91,750,275 (GRCm38)	missense	probably damaging	1.00
R0610:Lrrk2	UTSW	15	91,815,416 (GRCm38)	missense	probably benign
R0617:Lrrk2	UTSW	15	91,752,278 (GRCm38)	missense	probably benign	0.00
R0632:Lrrk2	UTSW	15	91,796,028 (GRCm38)	missense	probably damaging	0.98
R0639:Lrrk2	UTSW	15	91,772,996 (GRCm38)	missense	probably benign	0.03
R0661:Lrrk2	UTSW	15	91,787,016 (GRCm38)	missense	probably damaging	1.00
R0666:Lrrk2	UTSW	15	91,757,070 (GRCm38)	critical splice donor site	probably null
R0764:Lrrk2	UTSW	15	91,775,046 (GRCm38)	splice site	probably null
R0766:Lrrk2	UTSW	15	91,699,895 (GRCm38)	missense	probably damaging	1.00
R0845:Lrrk2	UTSW	15	91,755,962 (GRCm38)	missense	probably benign	0.22
R0940:Lrrk2	UTSW	15	91,729,081 (GRCm38)	missense	possibly damaging	0.83
R0970:Lrrk2	UTSW	15	91,729,169 (GRCm38)	missense	probably benign	0.22
R1080:Lrrk2	UTSW	15	91,673,689 (GRCm38)	missense	probably benign	0.01
R1114:Lrrk2	UTSW	15	91,700,468 (GRCm38)	nonsense	probably null
R1223:Lrrk2	UTSW	15	91,673,635 (GRCm38)	missense	probably benign	0.00
R1289:Lrrk2	UTSW	15	91,812,360 (GRCm38)	missense	probably benign	0.00
R1296:Lrrk2	UTSW	15	91,728,920 (GRCm38)	missense	probably damaging	1.00
R1312:Lrrk2	UTSW	15	91,699,895 (GRCm38)	missense	probably damaging	1.00
R1637:Lrrk2	UTSW	15	91,734,058 (GRCm38)	missense	probably benign
R1773:Lrrk2	UTSW	15	91,779,981 (GRCm38)	missense	possibly damaging	0.96
R1809:Lrrk2	UTSW	15	91,699,892 (GRCm38)	missense	possibly damaging	0.86
R1839:Lrrk2	UTSW	15	91,683,134 (GRCm38)	missense	probably benign	0.00
R1946:Lrrk2	UTSW	15	91,736,661 (GRCm38)	splice site	probably null
R2160:Lrrk2	UTSW	15	91,796,060 (GRCm38)	missense	probably damaging	1.00
R2232:Lrrk2	UTSW	15	91,764,716 (GRCm38)	missense	probably benign	0.05
R2419:Lrrk2	UTSW	15	91,797,526 (GRCm38)	splice site	probably benign
R2516:Lrrk2	UTSW	15	91,755,927 (GRCm38)	missense	probably benign
R3110:Lrrk2	UTSW	15	91,814,695 (GRCm38)	missense	probably benign	0.02
R3112:Lrrk2	UTSW	15	91,814,695 (GRCm38)	missense	probably benign	0.02
R3801:Lrrk2	UTSW	15	91,737,111 (GRCm38)	missense	probably benign
R3842:Lrrk2	UTSW	15	91,755,916 (GRCm38)	missense	probably benign	0.01
R3903:Lrrk2	UTSW	15	91,747,701 (GRCm38)	missense	probably damaging	1.00
R3903:Lrrk2	UTSW	15	91,747,700 (GRCm38)	missense	probably damaging	1.00
R3930:Lrrk2	UTSW	15	91,767,461 (GRCm38)	critical splice donor site	probably null
R3937:Lrrk2	UTSW	15	91,778,504 (GRCm38)	missense	probably damaging	0.98
R3938:Lrrk2	UTSW	15	91,778,504 (GRCm38)	missense	probably damaging	0.98
R3938:Lrrk2	UTSW	15	91,712,780 (GRCm38)	missense	possibly damaging	0.69
R3982:Lrrk2	UTSW	15	91,709,284 (GRCm38)	missense	probably benign	0.22
R4125:Lrrk2	UTSW	15	91,815,483 (GRCm38)	missense	probably benign	0.01
R4130:Lrrk2	UTSW	15	91,755,794 (GRCm38)	missense	probably benign	0.19
R4296:Lrrk2	UTSW	15	91,699,895 (GRCm38)	missense	probably damaging	1.00
R4465:Lrrk2	UTSW	15	91,747,820 (GRCm38)	missense	probably damaging	0.96
R4478:Lrrk2	UTSW	15	91,723,188 (GRCm38)	missense	probably damaging	1.00
R4517:Lrrk2	UTSW	15	91,705,120 (GRCm38)	missense	probably benign
R4539:Lrrk2	UTSW	15	91,729,142 (GRCm38)	missense	possibly damaging	0.86
R4654:Lrrk2	UTSW	15	91,765,681 (GRCm38)	missense	probably damaging	0.96
R4710:Lrrk2	UTSW	15	91,699,927 (GRCm38)	missense	possibly damaging	0.88
R4722:Lrrk2	UTSW	15	91,688,901 (GRCm38)	missense	probably damaging	1.00
R4723:Lrrk2	UTSW	15	91,764,759 (GRCm38)	missense	probably damaging	1.00
R4732:Lrrk2	UTSW	15	91,765,747 (GRCm38)	missense	probably damaging	1.00
R4732:Lrrk2	UTSW	15	91,688,849 (GRCm38)	missense	probably damaging	1.00
R4733:Lrrk2	UTSW	15	91,765,747 (GRCm38)	missense	probably damaging	1.00
R4733:Lrrk2	UTSW	15	91,688,849 (GRCm38)	missense	probably damaging	1.00
R4787:Lrrk2	UTSW	15	91,712,828 (GRCm38)	missense	probably benign
R4945:Lrrk2	UTSW	15	91,804,920 (GRCm38)	missense	probably benign	0.02
R4948:Lrrk2	UTSW	15	91,803,389 (GRCm38)	missense	probably benign	0.20
R5000:Lrrk2	UTSW	15	91,749,878 (GRCm38)	missense	probably damaging	1.00
R5031:Lrrk2	UTSW	15	91,700,619 (GRCm38)	missense	possibly damaging	0.50
R5067:Lrrk2	UTSW	15	91,765,790 (GRCm38)	missense	probably benign	0.01
R5245:Lrrk2	UTSW	15	91,796,089 (GRCm38)	missense	probably damaging	1.00
R5341:Lrrk2	UTSW	15	91,772,858 (GRCm38)	missense	probably damaging	1.00
R5460:Lrrk2	UTSW	15	91,814,644 (GRCm38)	splice site	probably null
R5551:Lrrk2	UTSW	15	91,812,350 (GRCm38)	missense	probably benign
R5574:Lrrk2	UTSW	15	91,787,016 (GRCm38)	missense	probably damaging	1.00
R5577:Lrrk2	UTSW	15	91,765,745 (GRCm38)	missense	probably damaging	1.00
R5685:Lrrk2	UTSW	15	91,803,301 (GRCm38)	nonsense	probably null
R5712:Lrrk2	UTSW	15	91,702,222 (GRCm38)	nonsense	probably null
R5728:Lrrk2	UTSW	15	91,774,974 (GRCm38)	missense	probably benign	0.36
R5782:Lrrk2	UTSW	15	91,702,183 (GRCm38)	missense	probably damaging	1.00
R5788:Lrrk2	UTSW	15	91,764,648 (GRCm38)	missense	possibly damaging	0.55
R5821:Lrrk2	UTSW	15	91,709,390 (GRCm38)	critical splice donor site	probably null
R5852:Lrrk2	UTSW	15	91,755,949 (GRCm38)	missense	probably damaging	1.00
R5934:Lrrk2	UTSW	15	91,734,046 (GRCm38)	missense	probably benign	0.00
R5935:Lrrk2	UTSW	15	91,745,831 (GRCm38)	missense	probably benign	0.14
R5979:Lrrk2	UTSW	15	91,772,945 (GRCm38)	missense	possibly damaging	0.47
R6101:Lrrk2	UTSW	15	91,723,135 (GRCm38)	missense	probably benign	0.10
R6114:Lrrk2	UTSW	15	91,747,826 (GRCm38)	missense	probably benign	0.33
R6259:Lrrk2	UTSW	15	91,702,247 (GRCm38)	missense	probably benign	0.00
R6376:Lrrk2	UTSW	15	91,742,266 (GRCm38)	missense	possibly damaging	0.89
R6417:Lrrk2	UTSW	15	91,812,346 (GRCm38)	missense	probably benign	0.03
R6420:Lrrk2	UTSW	15	91,812,346 (GRCm38)	missense	probably benign	0.03
R6737:Lrrk2	UTSW	15	91,723,218 (GRCm38)	missense	possibly damaging	0.50
R7056:Lrrk2	UTSW	15	91,774,995 (GRCm38)	nonsense	probably null
R7072:Lrrk2	UTSW	15	91,801,920 (GRCm38)	missense	probably benign	0.03
R7109:Lrrk2	UTSW	15	91,764,782 (GRCm38)	missense	probably damaging	1.00
R7128:Lrrk2	UTSW	15	91,801,885 (GRCm38)	missense	probably benign
R7144:Lrrk2	UTSW	15	91,734,055 (GRCm38)	missense	possibly damaging	0.54
R7187:Lrrk2	UTSW	15	91,757,001 (GRCm38)	missense	possibly damaging	0.92
R7270:Lrrk2	UTSW	15	91,700,441 (GRCm38)	missense	probably benign	0.01
R7356:Lrrk2	UTSW	15	91,738,744 (GRCm38)	missense	probably benign	0.07
R7360:Lrrk2	UTSW	15	91,731,655 (GRCm38)	critical splice donor site	probably null
R7373:Lrrk2	UTSW	15	91,700,004 (GRCm38)	critical splice donor site	probably null
R7465:Lrrk2	UTSW	15	91,767,340 (GRCm38)	missense	probably damaging	1.00
R7477:Lrrk2	UTSW	15	91,812,325 (GRCm38)	missense	probably damaging	0.98
R7614:Lrrk2	UTSW	15	91,772,858 (GRCm38)	missense	probably damaging	1.00
R7622:Lrrk2	UTSW	15	91,812,323 (GRCm38)	missense	probably damaging	1.00
R7658:Lrrk2	UTSW	15	91,700,358 (GRCm38)	missense	possibly damaging	0.91
R7679:Lrrk2	UTSW	15	91,726,186 (GRCm38)	missense	possibly damaging	0.58
R7737:Lrrk2	UTSW	15	91,815,446 (GRCm38)	missense	probably damaging	0.98
R7739:Lrrk2	UTSW	15	91,700,613 (GRCm38)	missense	probably damaging	1.00
R7740:Lrrk2	UTSW	15	91,767,324 (GRCm38)	missense	probably damaging	1.00
R7908:Lrrk2	UTSW	15	91,726,152 (GRCm38)	missense	probably damaging	1.00
R8299:Lrrk2	UTSW	15	91,673,240 (GRCm38)	start gained	probably benign
R8389:Lrrk2	UTSW	15	91,699,991 (GRCm38)	missense	probably damaging	1.00
R8462:Lrrk2	UTSW	15	91,731,477 (GRCm38)	missense	probably benign
R8698:Lrrk2	UTSW	15	91,752,197 (GRCm38)	missense	probably benign	0.38
R8947:Lrrk2	UTSW	15	91,702,270 (GRCm38)	nonsense	probably null
R9084:Lrrk2	UTSW	15	91,750,266 (GRCm38)	missense
R9096:Lrrk2	UTSW	15	91,673,256 (GRCm38)	start gained	probably benign
R9097:Lrrk2	UTSW	15	91,673,256 (GRCm38)	start gained	probably benign
R9267:Lrrk2	UTSW	15	91,700,426 (GRCm38)	missense	probably damaging	0.99
R9285:Lrrk2	UTSW	15	91,778,483 (GRCm38)	missense	probably damaging	1.00
R9341:Lrrk2	UTSW	15	91,700,415 (GRCm38)	missense	probably benign	0.18
R9343:Lrrk2	UTSW	15	91,700,415 (GRCm38)	missense	probably benign	0.18
R9371:Lrrk2	UTSW	15	91,723,204 (GRCm38)	missense	probably damaging	1.00
R9424:Lrrk2	UTSW	15	91,752,185 (GRCm38)	nonsense	probably null
R9489:Lrrk2	UTSW	15	91,737,217 (GRCm38)	missense	probably benign	0.37
R9502:Lrrk2	UTSW	15	91,723,162 (GRCm38)	missense	probably damaging	0.98
R9563:Lrrk2	UTSW	15	91,749,840 (GRCm38)	missense	possibly damaging	0.90
R9576:Lrrk2	UTSW	15	91,752,185 (GRCm38)	nonsense	probably null
R9605:Lrrk2	UTSW	15	91,737,217 (GRCm38)	missense	probably benign	0.37
R9635:Lrrk2	UTSW	15	91,812,324 (GRCm38)	missense	probably benign	0.21
R9641:Lrrk2	UTSW	15	91,787,048 (GRCm38)	missense	possibly damaging	0.94
R9660:Lrrk2	UTSW	15	91,734,025 (GRCm38)	missense	probably benign	0.00
R9673:Lrrk2	UTSW	15	91,765,681 (GRCm38)	missense	probably damaging	1.00
R9708:Lrrk2	UTSW	15	91,750,279 (GRCm38)	nonsense	probably null
R9728:Lrrk2	UTSW	15	91,734,025 (GRCm38)	missense	probably benign	0.00
R9757:Lrrk2	UTSW	15	91,811,026 (GRCm38)	missense	probably benign	0.03
RF001:Lrrk2	UTSW	15	91,736,633 (GRCm38)	missense	probably benign	0.11
X0028:Lrrk2	UTSW	15	91,738,851 (GRCm38)	missense	probably benign	0.00
Z1088:Lrrk2	UTSW	15	91,726,240 (GRCm38)	missense	probably benign	0.12

Predicted Primers

PCR Primer
(F):5'- CACAGATTTTCCCCTCCAAATTGAC -3'
(R):5'- AAACTGTCATGGCGGGACAC -3'

Sequencing Primer
(F):5'- CTTCTGTTCACTACCATTTAGATAGG -3'
(R):5'- TCATGGCGGGACACTGGAG -3'

Posted On

2021-12-30