Incidental Mutation 'R9089:Kynu'
ID 690794
Institutional Source Beutler Lab
Gene Symbol Kynu
Ensembl Gene ENSMUSG00000026866
Gene Name kynureninase
Synonyms L-kynurenine hydrolase, 4432411A05Rik
MMRRC Submission 068907-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9089 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 43445341-43572734 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 43489620 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 135 (M135K)
Ref Sequence ENSEMBL: ENSMUSP00000028223 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028223] [ENSMUST00000050511] [ENSMUST00000112826]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000028223
AA Change: M135K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000028223
Gene: ENSMUSG00000026866
AA Change: M135K

DomainStartEndE-ValueType
Pfam:Aminotran_5 70 400 3.8e-15 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000050511
AA Change: M135K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000061775
Gene: ENSMUSG00000026866
AA Change: M135K

DomainStartEndE-ValueType
Pfam:Aminotran_5 70 307 7.8e-12 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000112826
AA Change: M135K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000108445
Gene: ENSMUSG00000026866
AA Change: M135K

DomainStartEndE-ValueType
Pfam:Aminotran_5 70 405 8.4e-17 PFAM
Meta Mutation Damage Score 0.9151 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 100% (67/67)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700122O11Rik T A 17: 48,347,951 (GRCm39) R118* probably null Het
Acadsb T C 7: 131,027,504 (GRCm39) V68A probably damaging Het
Adgb T C 10: 10,318,432 (GRCm39) R137G probably benign Het
Adgrl3 C A 5: 81,808,291 (GRCm39) N622K possibly damaging Het
Ager C A 17: 34,819,579 (GRCm39) P366T probably benign Het
Barx2 C A 9: 31,765,443 (GRCm39) W184L probably damaging Het
Bckdha A C 7: 25,341,144 (GRCm39) N72K probably benign Het
Blm A T 7: 80,162,867 (GRCm39) D161E probably damaging Het
Ccdc121rt2 A T 5: 112,598,757 (GRCm39) R435W probably damaging Het
Cd96 G T 16: 45,870,068 (GRCm39) T467N probably benign Het
Cdk13 A T 13: 17,978,444 (GRCm39) S265T unknown Het
Col6a5 A C 9: 105,766,142 (GRCm39) I1926S probably damaging Het
Csgalnact2 A T 6: 118,097,983 (GRCm39) V361D probably damaging Het
Cstf1 T A 2: 172,217,807 (GRCm39) M140K Het
Ddx41 A T 13: 55,683,424 (GRCm39) S128T probably benign Het
Deaf1 A T 7: 140,877,465 (GRCm39) V554D probably damaging Het
Dido1 C T 2: 180,303,293 (GRCm39) S1537N probably benign Het
Dmwd T C 7: 18,811,980 (GRCm39) S145P probably damaging Het
Eftud2 A G 11: 102,759,971 (GRCm39) S125P probably benign Het
Gga1 A G 15: 78,773,952 (GRCm39) D325G probably damaging Het
Gm43518 T C 5: 124,072,329 (GRCm39) probably null Het
Got1l1 A T 8: 27,690,889 (GRCm39) V53E probably damaging Het
Helz2 A T 2: 180,881,433 (GRCm39) C350S probably damaging Het
Ipo7 T A 7: 109,643,666 (GRCm39) F398I possibly damaging Het
Itga11 A G 9: 62,678,662 (GRCm39) N943S probably damaging Het
Itpa T A 2: 130,509,857 (GRCm39) probably null Het
Itpr3 G A 17: 27,337,651 (GRCm39) probably benign Het
Kbtbd4 A T 2: 90,737,909 (GRCm39) N220Y possibly damaging Het
Kdm5b T A 1: 134,535,506 (GRCm39) F594L probably damaging Het
Klhdc4 C T 8: 122,524,684 (GRCm39) V446I probably benign Het
Klk1b1 A G 7: 43,620,668 (GRCm39) I253V possibly damaging Het
Lgi1 T C 19: 38,294,095 (GRCm39) I289T possibly damaging Het
Lhx2 A G 2: 38,250,045 (GRCm39) N288S probably damaging Het
Lrp6 G C 6: 134,488,169 (GRCm39) A309G probably damaging Het
Map2 T A 1: 66,452,098 (GRCm39) N329K probably benign Het
Med15 G A 16: 17,473,421 (GRCm39) P476L unknown Het
Muc16 A T 9: 18,555,846 (GRCm39) N3482K unknown Het
Nemf A C 12: 69,400,628 (GRCm39) V149G probably damaging Het
Notch3 T C 17: 32,370,521 (GRCm39) S706G probably benign Het
Nphp4 T C 4: 152,645,673 (GRCm39) V1227A possibly damaging Het
Or1e31 A G 11: 73,690,052 (GRCm39) F177S probably damaging Het
Or2a52 A T 6: 43,144,917 (GRCm39) R308S probably benign Het
Or6c70 A G 10: 129,710,488 (GRCm39) L46P probably damaging Het
Parp2 A G 14: 51,052,327 (GRCm39) T102A probably damaging Het
Pcdhgc3 T C 18: 37,941,264 (GRCm39) V555A possibly damaging Het
Plk5 C G 10: 80,193,830 (GRCm39) R40G probably damaging Het
Ralgapa1 A C 12: 55,723,351 (GRCm39) L1725R probably damaging Het
Reln G T 5: 22,130,198 (GRCm39) D2704E probably benign Het
Sart3 C A 5: 113,891,756 (GRCm39) E405D possibly damaging Het
Scin A T 12: 40,131,703 (GRCm39) L277* probably null Het
Sec62 T A 3: 30,868,383 (GRCm39) V204E probably benign Het
Serpina3a T C 12: 104,085,956 (GRCm39) I137T possibly damaging Het
Sh3rf1 T C 8: 61,825,613 (GRCm39) M536T probably benign Het
Slc45a4 T C 15: 73,457,953 (GRCm39) H532R probably damaging Het
Svs5 A G 2: 164,079,341 (GRCm39) F189L probably benign Het
Synm T C 7: 67,408,766 (GRCm39) D204G probably damaging Het
Tmtc1 A T 6: 148,147,215 (GRCm39) H827Q possibly damaging Het
Tnfrsf25 T A 4: 152,201,929 (GRCm39) C135* probably null Het
Unc13b T G 4: 43,095,847 (GRCm39) I85S probably damaging Het
Ush2a T A 1: 188,487,374 (GRCm39) Y3047* probably null Het
Vmn1r75 T C 7: 11,614,453 (GRCm39) S62P probably damaging Het
Vps50 T C 6: 3,536,884 (GRCm39) V285A probably benign Het
Vwa5b1 T A 4: 138,296,742 (GRCm39) D1095V probably benign Het
Zdhhc21 T A 4: 82,725,292 (GRCm39) D208V probably damaging Het
Zfp422 A C 6: 116,604,086 (GRCm39) probably benign Het
Other mutations in Kynu
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01524:Kynu APN 2 43,561,394 (GRCm39) missense possibly damaging 0.91
IGL01974:Kynu APN 2 43,571,352 (GRCm39) unclassified probably benign
R0099:Kynu UTSW 2 43,519,065 (GRCm39) critical splice donor site probably null
R0304:Kynu UTSW 2 43,569,893 (GRCm39) missense probably damaging 0.99
R1681:Kynu UTSW 2 43,569,837 (GRCm39) missense probably damaging 1.00
R1799:Kynu UTSW 2 43,494,169 (GRCm39) missense possibly damaging 0.65
R2016:Kynu UTSW 2 43,494,289 (GRCm39) nonsense probably null
R2345:Kynu UTSW 2 43,471,397 (GRCm39) missense probably damaging 1.00
R3085:Kynu UTSW 2 43,492,312 (GRCm39) missense probably benign 0.00
R3825:Kynu UTSW 2 43,571,451 (GRCm39) missense probably benign
R4091:Kynu UTSW 2 43,569,884 (GRCm39) missense possibly damaging 0.94
R4241:Kynu UTSW 2 43,571,422 (GRCm39) missense probably benign 0.00
R4594:Kynu UTSW 2 43,569,902 (GRCm39) missense probably benign 0.00
R4673:Kynu UTSW 2 43,569,815 (GRCm39) missense probably damaging 1.00
R4871:Kynu UTSW 2 43,569,830 (GRCm39) missense possibly damaging 0.58
R5371:Kynu UTSW 2 43,479,406 (GRCm39) missense probably benign 0.00
R6272:Kynu UTSW 2 43,525,001 (GRCm39) missense probably benign 0.01
R6342:Kynu UTSW 2 43,571,463 (GRCm39) missense probably benign 0.09
R6866:Kynu UTSW 2 43,453,122 (GRCm39) nonsense probably null
R7203:Kynu UTSW 2 43,571,365 (GRCm39) missense probably damaging 1.00
R8163:Kynu UTSW 2 43,518,966 (GRCm39) missense probably damaging 1.00
R9024:Kynu UTSW 2 43,490,807 (GRCm39) missense possibly damaging 0.62
R9303:Kynu UTSW 2 43,569,768 (GRCm39) missense probably damaging 0.99
R9305:Kynu UTSW 2 43,569,768 (GRCm39) missense probably damaging 0.99
R9506:Kynu UTSW 2 43,571,414 (GRCm39) missense probably damaging 1.00
R9702:Kynu UTSW 2 43,479,469 (GRCm39) missense probably damaging 1.00
R9759:Kynu UTSW 2 43,569,881 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- GTAAATTGGTCGGTAGGGACAC -3'
(R):5'- ATGTTTAAGCAGGAACCAGGAAATC -3'

Sequencing Primer
(F):5'- GGTAGGGACACCTCCATTATTC -3'
(R):5'- CCAGGAAATCATGGTCTAGCATTTC -3'
Posted On 2021-12-30