Incidental Mutation 'R9091:Map4k4'
| ID |
690963 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Map4k4
|
| Ensembl Gene |
ENSMUSG00000026074 |
| Gene Name |
mitogen-activated protein kinase kinase kinase kinase 4 |
| Synonyms |
9430080K19Rik, Nik |
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R9091 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
1 |
| Chromosomal Location |
39940073-40065470 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 40042923 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tryptophan to Arginine
at position 593
(W593R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000141400
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000163854]
[ENSMUST00000168431]
[ENSMUST00000191964]
[ENSMUST00000192509]
[ENSMUST00000193682]
[ENSMUST00000195860]
[ENSMUST00000195259]
[ENSMUST00000195636]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000163854
AA Change: W593R
PolyPhen 2
Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)
|
| SMART Domains |
Protein: ENSMUSP00000126961
Gene: ENSMUSG00000026074
AA Change: W593R
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
6.87e-95 |
SMART |
|
low complexity region
|
318 |
342 |
N/A |
INTRINSIC |
|
coiled coil region
|
357 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
503 |
512 |
N/A |
INTRINSIC |
|
low complexity region
|
687 |
698 |
N/A |
INTRINSIC |
|
low complexity region
|
721 |
747 |
N/A |
INTRINSIC |
|
low complexity region
|
754 |
763 |
N/A |
INTRINSIC |
|
low complexity region
|
811 |
837 |
N/A |
INTRINSIC |
|
low complexity region
|
891 |
904 |
N/A |
INTRINSIC |
|
low complexity region
|
919 |
929 |
N/A |
INTRINSIC |
|
CNH
|
970 |
1268 |
2.76e-127 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000168431
|
| SMART Domains |
Protein: ENSMUSP00000129796
Gene: ENSMUSG00000026074
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
6.87e-95 |
SMART |
|
low complexity region
|
318 |
342 |
N/A |
INTRINSIC |
|
coiled coil region
|
357 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
503 |
512 |
N/A |
INTRINSIC |
|
low complexity region
|
633 |
644 |
N/A |
INTRINSIC |
|
low complexity region
|
667 |
693 |
N/A |
INTRINSIC |
|
low complexity region
|
700 |
709 |
N/A |
INTRINSIC |
|
low complexity region
|
757 |
783 |
N/A |
INTRINSIC |
|
low complexity region
|
837 |
850 |
N/A |
INTRINSIC |
|
low complexity region
|
865 |
875 |
N/A |
INTRINSIC |
|
CNH
|
916 |
1214 |
2.76e-127 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000191865
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000191964
AA Change: W101R
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000141235
Gene: ENSMUSG00000026074
AA Change: W101R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
4 |
28 |
N/A |
INTRINSIC |
|
SCOP:d1i7qa_
|
35 |
139 |
7e-3 |
SMART |
|
low complexity region
|
195 |
206 |
N/A |
INTRINSIC |
|
| Predicted Effect |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000192509
AA Change: W539R
|
| SMART Domains |
Protein: ENSMUSP00000141665
Gene: ENSMUSG00000026074
AA Change: W539R
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
6.87e-95 |
SMART |
|
low complexity region
|
318 |
342 |
N/A |
INTRINSIC |
|
coiled coil region
|
357 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
503 |
512 |
N/A |
INTRINSIC |
|
low complexity region
|
633 |
644 |
N/A |
INTRINSIC |
|
low complexity region
|
667 |
693 |
N/A |
INTRINSIC |
|
low complexity region
|
700 |
709 |
N/A |
INTRINSIC |
|
low complexity region
|
757 |
783 |
N/A |
INTRINSIC |
|
low complexity region
|
837 |
850 |
N/A |
INTRINSIC |
|
low complexity region
|
865 |
875 |
N/A |
INTRINSIC |
|
CNH
|
916 |
1214 |
2.76e-127 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000193682
|
| SMART Domains |
Protein: ENSMUSP00000141862
Gene: ENSMUSG00000026074
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
6.87e-95 |
SMART |
|
low complexity region
|
318 |
342 |
N/A |
INTRINSIC |
|
coiled coil region
|
357 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
503 |
512 |
N/A |
INTRINSIC |
|
low complexity region
|
556 |
567 |
N/A |
INTRINSIC |
|
low complexity region
|
590 |
616 |
N/A |
INTRINSIC |
|
low complexity region
|
623 |
632 |
N/A |
INTRINSIC |
|
low complexity region
|
680 |
706 |
N/A |
INTRINSIC |
|
low complexity region
|
785 |
814 |
N/A |
INTRINSIC |
|
low complexity region
|
824 |
837 |
N/A |
INTRINSIC |
|
low complexity region
|
852 |
862 |
N/A |
INTRINSIC |
|
CNH
|
903 |
1201 |
2.76e-127 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000195860
AA Change: W593R
PolyPhen 2
Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
|
| SMART Domains |
Protein: ENSMUSP00000141400
Gene: ENSMUSG00000026074
AA Change: W593R
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
6.87e-95 |
SMART |
|
low complexity region
|
318 |
342 |
N/A |
INTRINSIC |
|
coiled coil region
|
357 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
503 |
512 |
N/A |
INTRINSIC |
|
low complexity region
|
687 |
698 |
N/A |
INTRINSIC |
|
low complexity region
|
721 |
747 |
N/A |
INTRINSIC |
|
low complexity region
|
754 |
763 |
N/A |
INTRINSIC |
|
low complexity region
|
811 |
837 |
N/A |
INTRINSIC |
|
low complexity region
|
891 |
904 |
N/A |
INTRINSIC |
|
low complexity region
|
919 |
929 |
N/A |
INTRINSIC |
|
CNH
|
970 |
1268 |
2.76e-127 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000195259
|
| SMART Domains |
Protein: ENSMUSP00000142056
Gene: ENSMUSG00000026074
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
6.87e-95 |
SMART |
|
low complexity region
|
318 |
342 |
N/A |
INTRINSIC |
|
coiled coil region
|
357 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
503 |
512 |
N/A |
INTRINSIC |
|
low complexity region
|
610 |
621 |
N/A |
INTRINSIC |
|
low complexity region
|
644 |
670 |
N/A |
INTRINSIC |
|
low complexity region
|
677 |
686 |
N/A |
INTRINSIC |
|
low complexity region
|
731 |
757 |
N/A |
INTRINSIC |
|
low complexity region
|
811 |
824 |
N/A |
INTRINSIC |
|
low complexity region
|
839 |
849 |
N/A |
INTRINSIC |
|
CNH
|
890 |
1188 |
2.76e-127 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000195636
|
| SMART Domains |
Protein: ENSMUSP00000141613
Gene: ENSMUSG00000026074
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
3.4e-97 |
SMART |
|
low complexity region
|
318 |
342 |
N/A |
INTRINSIC |
|
coiled coil region
|
357 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
503 |
512 |
N/A |
INTRINSIC |
|
low complexity region
|
610 |
621 |
N/A |
INTRINSIC |
|
low complexity region
|
644 |
670 |
N/A |
INTRINSIC |
|
low complexity region
|
677 |
686 |
N/A |
INTRINSIC |
|
low complexity region
|
731 |
757 |
N/A |
INTRINSIC |
|
low complexity region
|
836 |
865 |
N/A |
INTRINSIC |
|
low complexity region
|
875 |
888 |
N/A |
INTRINSIC |
|
low complexity region
|
903 |
913 |
N/A |
INTRINSIC |
|
CNH
|
954 |
1252 |
1.4e-129 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.4%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for disruptions in this gene die as embryos around day E9.5-10.5. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 81 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Actrt3 |
T |
A |
3: 30,652,781 (GRCm39) |
E104D |
probably damaging |
Het |
| Arih2 |
A |
T |
9: 108,493,890 (GRCm39) |
D174E |
probably damaging |
Het |
| Asprv1 |
T |
C |
6: 86,606,077 (GRCm39) |
F308L |
probably damaging |
Het |
| Baiap2l2 |
A |
G |
15: 79,168,205 (GRCm39) |
|
probably null |
Het |
| Btla |
T |
C |
16: 45,064,656 (GRCm39) |
F203L |
possibly damaging |
Het |
| C1rb |
A |
T |
6: 124,551,947 (GRCm39) |
D283V |
probably damaging |
Het |
| C87436 |
C |
G |
6: 86,442,813 (GRCm39) |
Q462E |
probably benign |
Het |
| Ccdc149 |
T |
C |
5: 52,563,352 (GRCm39) |
D147G |
possibly damaging |
Het |
| Chd6 |
A |
T |
2: 160,871,793 (GRCm39) |
L214* |
probably null |
Het |
| Chrna4 |
C |
A |
2: 180,670,643 (GRCm39) |
R371L |
possibly damaging |
Het |
| Cit |
C |
A |
5: 115,984,161 (GRCm39) |
|
probably benign |
Het |
| Cpne5 |
A |
G |
17: 29,444,163 (GRCm39) |
|
probably null |
Het |
| Cr1l |
T |
C |
1: 194,789,204 (GRCm39) |
E400G |
possibly damaging |
Het |
| Creb3l2 |
T |
C |
6: 37,332,583 (GRCm39) |
N304D |
probably damaging |
Het |
| Cyp17a1 |
T |
C |
19: 46,656,030 (GRCm39) |
T420A |
probably benign |
Het |
| Cyp24a1 |
A |
G |
2: 170,327,853 (GRCm39) |
I463T |
probably damaging |
Het |
| Cyp3a41b |
A |
T |
5: 145,514,973 (GRCm39) |
I84N |
probably damaging |
Het |
| Dnajc6 |
G |
A |
4: 101,496,559 (GRCm39) |
V909M |
possibly damaging |
Het |
| Dtl |
A |
G |
1: 191,288,923 (GRCm39) |
Y264H |
probably damaging |
Het |
| Dysf |
C |
T |
6: 84,077,216 (GRCm39) |
R660* |
probably null |
Het |
| Egf |
A |
G |
3: 129,529,449 (GRCm39) |
|
probably null |
Het |
| Eva1c |
T |
C |
16: 90,701,231 (GRCm39) |
S402P |
probably benign |
Het |
| Fcho2 |
A |
T |
13: 98,925,869 (GRCm39) |
|
probably null |
Het |
| Fhdc1 |
G |
A |
3: 84,352,290 (GRCm39) |
R197C |
unknown |
Het |
| Foxa2 |
T |
A |
2: 147,886,426 (GRCm39) |
M136L |
probably benign |
Het |
| Gm10226 |
T |
C |
17: 21,910,866 (GRCm39) |
C34R |
possibly damaging |
Het |
| Gm29735 |
ACAGCAGCAGGGCTTGCAGCAGCTGGACTGGCAGCAGCAGGGCTTGCAGCAGCTGGACTGGCAGCAGCAGGGCTTGCAGCAGCTGGACTGGCAGCAGCAGGGCTTGCAGCAGCTGGACTGGCAGCAGCAGGGCTTGCAACAGCAGGATTCGCAGCAGCAGGGCTTGCAGCAGCTGGACTGGCAGCAGCAAGGCTTGCAGCAGCTGGACTGGCAGCAGCAGGGCTTGCA |
ACAGCAGCAGGGCTTGCAGCAGCTGGACTGGCAGCAGCAGGGCTTGCAGCAGCTGGACTGGCAGCAGCAGGGCTTGCAGCAGCTGGACTGGCAGCAGCAGGGCTTGCAACAGCAGGATTCGCAGCAGCAGGGCTTGCAGCAGCTGGACTGGCAGCAGCAAGGCTTGCAGCAGCTGGACTGGCAGCAGCAGGGCTTGCA |
7: 141,710,266 (GRCm39) |
|
probably benign |
Het |
| Gm8947 |
T |
C |
1: 151,068,853 (GRCm39) |
S229P |
probably benign |
Het |
| Ighv9-2 |
A |
T |
12: 114,072,896 (GRCm39) |
S26T |
probably damaging |
Het |
| Itpr3 |
G |
A |
17: 27,337,651 (GRCm39) |
|
probably benign |
Het |
| Kat6a |
T |
G |
8: 23,420,190 (GRCm39) |
I745M |
probably damaging |
Het |
| Klhdc1 |
T |
C |
12: 69,309,968 (GRCm39) |
L290P |
probably damaging |
Het |
| Lcp2 |
C |
T |
11: 34,039,688 (GRCm39) |
T496I |
|
Het |
| Mefv |
T |
G |
16: 3,535,841 (GRCm39) |
Q29P |
probably damaging |
Het |
| Mgat5b |
T |
C |
11: 116,859,269 (GRCm39) |
Y34H |
|
Het |
| Mlip |
C |
T |
9: 77,137,080 (GRCm39) |
R609Q |
probably benign |
Het |
| Muc2 |
A |
G |
7: 141,290,816 (GRCm39) |
D34G |
|
Het |
| Nbeal1 |
C |
T |
1: 60,307,548 (GRCm39) |
P1687S |
possibly damaging |
Het |
| Notch1 |
T |
A |
2: 26,369,895 (GRCm39) |
I477L |
probably damaging |
Het |
| Odad2 |
T |
A |
18: 7,217,846 (GRCm39) |
K623* |
probably null |
Het |
| Or1l4b |
G |
A |
2: 37,037,047 (GRCm39) |
M274I |
probably benign |
Het |
| Or1s2 |
T |
C |
19: 13,758,333 (GRCm39) |
V117A |
probably benign |
Het |
| Or4a2 |
A |
T |
2: 89,248,712 (GRCm39) |
L15Q |
probably damaging |
Het |
| Or51v8 |
T |
A |
7: 103,320,124 (GRCm39) |
N38I |
probably damaging |
Het |
| Or6c214 |
A |
G |
10: 129,591,148 (GRCm39) |
M57T |
probably damaging |
Het |
| Pak5 |
A |
T |
2: 135,958,688 (GRCm39) |
S133R |
probably damaging |
Het |
| Pcyt1a |
C |
A |
16: 32,285,332 (GRCm39) |
D187E |
probably benign |
Het |
| Pdlim7 |
G |
T |
13: 55,655,354 (GRCm39) |
T161K |
probably damaging |
Het |
| Phf8-ps |
A |
C |
17: 33,286,701 (GRCm39) |
C34G |
probably damaging |
Het |
| Pik3r4 |
A |
G |
9: 105,547,108 (GRCm39) |
K962R |
probably benign |
Het |
| Pkd1l2 |
T |
C |
8: 117,759,433 (GRCm39) |
K1516E |
probably damaging |
Het |
| Plk5 |
C |
G |
10: 80,193,830 (GRCm39) |
R40G |
probably damaging |
Het |
| Ptchd3 |
A |
T |
11: 121,733,180 (GRCm39) |
Y690F |
probably benign |
Het |
| Ptpn13 |
A |
T |
5: 103,649,735 (GRCm39) |
R379S |
possibly damaging |
Het |
| Rbm27 |
C |
T |
18: 42,438,829 (GRCm39) |
A410V |
probably benign |
Het |
| Rnase4 |
A |
G |
14: 51,342,662 (GRCm39) |
T129A |
probably benign |
Het |
| Serpinb11 |
C |
T |
1: 107,304,533 (GRCm39) |
T166I |
probably benign |
Het |
| Shank2 |
A |
G |
7: 143,963,705 (GRCm39) |
T438A |
possibly damaging |
Het |
| Slc13a2 |
T |
C |
11: 78,295,258 (GRCm39) |
N172D |
probably damaging |
Het |
| Slc2a8 |
A |
G |
2: 32,864,864 (GRCm39) |
F428L |
probably damaging |
Het |
| Slc38a6 |
T |
C |
12: 73,398,544 (GRCm39) |
M358T |
probably benign |
Het |
| Snx29 |
A |
G |
16: 11,213,155 (GRCm39) |
H107R |
probably benign |
Het |
| Sorbs2 |
T |
G |
8: 46,248,774 (GRCm39) |
V675G |
probably benign |
Het |
| Spint3 |
G |
A |
2: 164,415,154 (GRCm39) |
A21V |
probably benign |
Het |
| Susd1 |
A |
T |
4: 59,412,226 (GRCm39) |
V162E |
probably benign |
Het |
| Syne2 |
T |
G |
12: 75,977,834 (GRCm39) |
N1426K |
probably damaging |
Het |
| Synj2 |
T |
C |
17: 6,067,875 (GRCm39) |
V638A |
possibly damaging |
Het |
| Thada |
A |
T |
17: 84,538,589 (GRCm39) |
L1473Q |
probably damaging |
Het |
| Trim36 |
G |
A |
18: 46,300,580 (GRCm39) |
S697L |
possibly damaging |
Het |
| Ttbk1 |
A |
T |
17: 46,781,517 (GRCm39) |
I412N |
possibly damaging |
Het |
| Tubb2a |
T |
C |
13: 34,258,578 (GRCm39) |
D404G |
probably damaging |
Het |
| Tyk2 |
T |
A |
9: 21,035,841 (GRCm39) |
N114Y |
probably damaging |
Het |
| Umodl1 |
A |
G |
17: 31,185,678 (GRCm39) |
D139G |
probably damaging |
Het |
| Vmn2r101 |
T |
A |
17: 19,810,244 (GRCm39) |
N343K |
probably benign |
Het |
| Vnn1 |
A |
G |
10: 23,780,464 (GRCm39) |
D484G |
probably damaging |
Het |
| Vps13b |
A |
G |
15: 35,770,919 (GRCm39) |
T2121A |
probably benign |
Het |
| Wdr81 |
T |
C |
11: 75,345,216 (GRCm39) |
E17G |
probably benign |
Het |
| Wnk2 |
T |
G |
13: 49,224,505 (GRCm39) |
K1117Q |
probably benign |
Het |
| Zbtb46 |
C |
T |
2: 181,066,138 (GRCm39) |
R4Q |
probably benign |
Het |
| Zfp608 |
T |
A |
18: 55,032,190 (GRCm39) |
K583N |
probably damaging |
Het |
| Zfp729b |
A |
T |
13: 67,740,480 (GRCm39) |
L595H |
probably damaging |
Het |
|
| Other mutations in Map4k4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00328:Map4k4
|
APN |
1 |
40,043,976 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00417:Map4k4
|
APN |
1 |
40,053,692 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL00516:Map4k4
|
APN |
1 |
40,053,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01545:Map4k4
|
APN |
1 |
40,053,389 (GRCm39) |
splice site |
probably benign |
|
|
IGL02092:Map4k4
|
APN |
1 |
40,063,508 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02092:Map4k4
|
APN |
1 |
40,025,943 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL02570:Map4k4
|
APN |
1 |
40,019,739 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL02626:Map4k4
|
APN |
1 |
40,053,257 (GRCm39) |
splice site |
probably benign |
|
|
IGL02993:Map4k4
|
APN |
1 |
40,053,348 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL03178:Map4k4
|
APN |
1 |
40,025,853 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
tank
|
UTSW |
1 |
40,044,024 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL02835:Map4k4
|
UTSW |
1 |
40,049,760 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0496:Map4k4
|
UTSW |
1 |
40,045,982 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0498:Map4k4
|
UTSW |
1 |
40,029,338 (GRCm39) |
missense |
probably benign |
0.22 |
|
R0588:Map4k4
|
UTSW |
1 |
40,044,024 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R0674:Map4k4
|
UTSW |
1 |
40,042,975 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1205:Map4k4
|
UTSW |
1 |
40,043,004 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1349:Map4k4
|
UTSW |
1 |
40,060,319 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1615:Map4k4
|
UTSW |
1 |
40,045,990 (GRCm39) |
splice site |
probably benign |
|
|
R1763:Map4k4
|
UTSW |
1 |
40,039,917 (GRCm39) |
splice site |
probably benign |
|
|
R1800:Map4k4
|
UTSW |
1 |
40,062,620 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1893:Map4k4
|
UTSW |
1 |
40,040,717 (GRCm39) |
missense |
probably benign |
0.08 |
|
R2411:Map4k4
|
UTSW |
1 |
40,046,656 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2851:Map4k4
|
UTSW |
1 |
40,039,915 (GRCm39) |
splice site |
probably benign |
|
|
R2852:Map4k4
|
UTSW |
1 |
40,039,915 (GRCm39) |
splice site |
probably benign |
|
|
R2987:Map4k4
|
UTSW |
1 |
40,025,925 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3087:Map4k4
|
UTSW |
1 |
40,060,242 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R3688:Map4k4
|
UTSW |
1 |
40,024,331 (GRCm39) |
splice site |
probably null |
|
|
R4075:Map4k4
|
UTSW |
1 |
40,062,622 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4304:Map4k4
|
UTSW |
1 |
40,013,132 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R4564:Map4k4
|
UTSW |
1 |
40,028,135 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4569:Map4k4
|
UTSW |
1 |
40,039,698 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4613:Map4k4
|
UTSW |
1 |
40,056,351 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4715:Map4k4
|
UTSW |
1 |
40,058,724 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4788:Map4k4
|
UTSW |
1 |
40,043,076 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4926:Map4k4
|
UTSW |
1 |
40,056,385 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4943:Map4k4
|
UTSW |
1 |
40,058,754 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5033:Map4k4
|
UTSW |
1 |
40,046,662 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5177:Map4k4
|
UTSW |
1 |
40,025,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5297:Map4k4
|
UTSW |
1 |
40,001,377 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5844:Map4k4
|
UTSW |
1 |
40,039,036 (GRCm39) |
splice site |
probably benign |
|
|
R5952:Map4k4
|
UTSW |
1 |
40,039,082 (GRCm39) |
unclassified |
probably benign |
|
|
R6111:Map4k4
|
UTSW |
1 |
40,050,822 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6125:Map4k4
|
UTSW |
1 |
40,043,125 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R6838:Map4k4
|
UTSW |
1 |
40,015,882 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6927:Map4k4
|
UTSW |
1 |
40,050,842 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7008:Map4k4
|
UTSW |
1 |
40,028,131 (GRCm39) |
missense |
probably benign |
0.44 |
|
R7164:Map4k4
|
UTSW |
1 |
40,013,132 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R7195:Map4k4
|
UTSW |
1 |
40,058,829 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7352:Map4k4
|
UTSW |
1 |
40,001,387 (GRCm39) |
missense |
unknown |
|
|
R7589:Map4k4
|
UTSW |
1 |
40,060,251 (GRCm39) |
nonsense |
probably null |
|
|
R7816:Map4k4
|
UTSW |
1 |
40,053,368 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7869:Map4k4
|
UTSW |
1 |
40,013,204 (GRCm39) |
missense |
unknown |
|
|
R8013:Map4k4
|
UTSW |
1 |
40,001,372 (GRCm39) |
missense |
unknown |
|
|
R8145:Map4k4
|
UTSW |
1 |
40,039,694 (GRCm39) |
missense |
|
|
|
R8154:Map4k4
|
UTSW |
1 |
40,060,302 (GRCm39) |
nonsense |
probably null |
|
|
R8254:Map4k4
|
UTSW |
1 |
40,045,835 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8266:Map4k4
|
UTSW |
1 |
40,050,813 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8375:Map4k4
|
UTSW |
1 |
40,063,801 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8487:Map4k4
|
UTSW |
1 |
40,028,136 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8699:Map4k4
|
UTSW |
1 |
40,015,910 (GRCm39) |
missense |
unknown |
|
|
R8726:Map4k4
|
UTSW |
1 |
40,043,142 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8907:Map4k4
|
UTSW |
1 |
40,058,770 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8956:Map4k4
|
UTSW |
1 |
40,039,840 (GRCm39) |
missense |
probably benign |
0.11 |
|
R8963:Map4k4
|
UTSW |
1 |
40,039,740 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9234:Map4k4
|
UTSW |
1 |
40,029,261 (GRCm39) |
missense |
unknown |
|
|
R9270:Map4k4
|
UTSW |
1 |
40,042,923 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9438:Map4k4
|
UTSW |
1 |
40,045,952 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9689:Map4k4
|
UTSW |
1 |
40,058,722 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9771:Map4k4
|
UTSW |
1 |
40,025,877 (GRCm39) |
missense |
unknown |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GGCACTTTCCCTTATGCGTG -3'
(R):5'- TCTGATCTAGACCAAGCCTTTTG -3'
Sequencing Primer
(F):5'- ATGCGTGTGCCTTTGCTC -3'
(R):5'- GCCTTTTGGGTGGGCTC -3'
|
| Posted On |
2021-12-30 |
Incidental Mutation