Mutagenetix > Incidental Mutation

Incidental Mutation 'R9091:Pkd1l2'

691000

Institutional Source

Beutler Lab

Gene Symbol

Pkd1l2

Ensembl Gene

ENSMUSG00000034416

Gene Name

polycystic kidney disease 1 like 2

Synonyms

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R9091 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

116995679-117082449 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 117032694 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Glutamic Acid at position 1516 (K1516E)

Ref Sequence

ENSEMBL: ENSMUSP00000104721 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000098375] [ENSMUST00000109093]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000098375
AA Change: K1515E

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000095977
Gene: ENSMUSG00000034416
AA Change: K1515E

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
CLECT	26	152	1.56e-21	SMART
Pfam:Gal_Lectin	168	250	1.8e-18	PFAM
PKD	260	341	3.84e-1	SMART
low complexity region	496	507	N/A	INTRINSIC
Pfam:REJ	510	886	1.8e-13	PFAM
low complexity region	1050	1060	N/A	INTRINSIC
GPS	1278	1327	1.61e-11	SMART
transmembrane domain	1346	1365	N/A	INTRINSIC
LH2	1390	1509	6.05e-13	SMART
transmembrane domain	1552	1574	N/A	INTRINSIC
transmembrane domain	1589	1611	N/A	INTRINSIC
transmembrane domain	1815	1837	N/A	INTRINSIC
transmembrane domain	1852	1874	N/A	INTRINSIC
transmembrane domain	1940	1962	N/A	INTRINSIC
Pfam:PKD_channel	1980	2403	6.4e-107	PFAM
Pfam:Ion_trans	2187	2396	2.5e-12	PFAM
low complexity region	2441	2458	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000109093
AA Change: K1516E

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000104721
Gene: ENSMUSG00000034416
AA Change: K1516E

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
CLECT	26	152	1.56e-21	SMART
Pfam:Gal_Lectin	168	250	6.9e-19	PFAM
PKD	260	341	3.84e-1	SMART
low complexity region	496	507	N/A	INTRINSIC
Pfam:REJ	519	883	7e-11	PFAM
low complexity region	1051	1061	N/A	INTRINSIC
GPS	1279	1328	1.61e-11	SMART
transmembrane domain	1347	1366	N/A	INTRINSIC
LH2	1391	1510	6.05e-13	SMART
transmembrane domain	1553	1575	N/A	INTRINSIC
transmembrane domain	1590	1612	N/A	INTRINSIC
transmembrane domain	1816	1838	N/A	INTRINSIC
transmembrane domain	1853	1875	N/A	INTRINSIC
transmembrane domain	1941	1963	N/A	INTRINSIC
Pfam:PKD_channel	1981	2403	5.9e-106	PFAM
Pfam:Ion_trans	2138	2409	3.4e-12	PFAM
low complexity region	2442	2459	N/A	INTRINSIC

Meta Mutation Damage Score

0.6329

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.4%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the polycystin protein family. The encoded protein contains 11 transmembrane domains, a latrophilin/CL-1-like GPCR proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. This protein may function as a component of cation channel pores. This gene appears to be a polymorphic pseudogene in humans, where some individuals contain a non-functional allele. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Allele List at MGI

Other mutations in this stock

Total: 81 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4921501E09Rik	A	C	17: 33,067,727 (GRCm38)	C34G	probably damaging	Het
Actrt3	T	A	3: 30,598,632 (GRCm38)	E104D	probably damaging	Het
Arih2	A	T	9: 108,616,691 (GRCm38)	D174E	probably damaging	Het
Armc4	T	A	18: 7,217,846 (GRCm38)	K623*	probably null	Het
Asprv1	T	C	6: 86,629,095 (GRCm38)	F308L	probably damaging	Het
Baiap2l2	A	G	15: 79,284,005 (GRCm38)		probably null	Het
Btla	T	C	16: 45,244,293 (GRCm38)	F203L	possibly damaging	Het
C1rb	A	T	6: 124,574,988 (GRCm38)	D283V	probably damaging	Het
C87436	C	G	6: 86,465,831 (GRCm38)	Q462E	probably benign	Het
Ccdc149	T	C	5: 52,406,010 (GRCm38)	D147G	possibly damaging	Het
Chd6	A	T	2: 161,029,873 (GRCm38)	L214*	probably null	Het
Chrna4	C	A	2: 181,028,850 (GRCm38)	R371L	possibly damaging	Het
Cit	C	A	5: 115,846,102 (GRCm38)		probably benign	Het
Cpne5	A	G	17: 29,225,189 (GRCm38)		probably null	Het
Cr1l	T	C	1: 195,106,896 (GRCm38)	E400G	possibly damaging	Het
Creb3l2	T	C	6: 37,355,648 (GRCm38)	N304D	probably damaging	Het
Cyp17a1	T	C	19: 46,667,591 (GRCm38)	T420A	probably benign	Het
Cyp24a1	A	G	2: 170,485,933 (GRCm38)	I463T	probably damaging	Het
Cyp3a41b	A	T	5: 145,578,163 (GRCm38)	I84N	probably damaging	Het
Dnajc6	G	A	4: 101,639,362 (GRCm38)	V909M	possibly damaging	Het
Dtl	A	G	1: 191,556,811 (GRCm38)	Y264H	probably damaging	Het
Dysf	C	T	6: 84,100,234 (GRCm38)	R660*	probably null	Het
Egf	A	G	3: 129,735,800 (GRCm38)		probably null	Het
Eva1c	T	C	16: 90,904,343 (GRCm38)	S402P	probably benign	Het
Fcho2	A	T	13: 98,789,361 (GRCm38)		probably null	Het
Fhdc1	G	A	3: 84,444,983 (GRCm38)	R197C	unknown	Het
Foxa2	T	A	2: 148,044,506 (GRCm38)	M136L	probably benign	Het
Gm10226	T	C	17: 21,691,959 (GRCm38)	C34R	possibly damaging	Het
Gm29735	ACAGCAGCAGGGCTTGCAGCAGCTGGACTGGCAGCAGCAGGGCTTGCAGCAGCTGGACTGGCAGCAGCAGGGCTTGCAGCAGCTGGACTGGCAGCAGCAGGGCTTGCAGCAGCTGGACTGGCAGCAGCAGGGCTTGCAACAGCAGGATTCGCAGCAGCAGGGCTTGCAGCAGCTGGACTGGCAGCAGCAAGGCTTGCAGCAGCTGGACTGGCAGCAGCAGGGCTTGCA	ACAGCAGCAGGGCTTGCAGCAGCTGGACTGGCAGCAGCAGGGCTTGCAGCAGCTGGACTGGCAGCAGCAGGGCTTGCAGCAGCTGGACTGGCAGCAGCAGGGCTTGCAACAGCAGGATTCGCAGCAGCAGGGCTTGCAGCAGCTGGACTGGCAGCAGCAAGGCTTGCAGCAGCTGGACTGGCAGCAGCAGGGCTTGCA	7: 142,156,529 (GRCm38)		probably benign	Het
Gm8947	T	C	1: 151,193,102 (GRCm38)	S229P	probably benign	Het
Ighv9-2	A	T	12: 114,109,276 (GRCm38)	S26T	probably damaging	Het
Itpr3	G	A	17: 27,118,677 (GRCm38)		probably benign	Het
Kat6a	T	G	8: 22,930,174 (GRCm38)	I745M	probably damaging	Het
Klhdc1	T	C	12: 69,263,194 (GRCm38)	L290P	probably damaging	Het
Lcp2	C	T	11: 34,089,688 (GRCm38)	T496I		Het
Map4k4	T	C	1: 40,003,763 (GRCm38)	W593R	probably benign	Het
Mefv	T	G	16: 3,717,977 (GRCm38)	Q29P	probably damaging	Het
Mgat5b	T	C	11: 116,968,443 (GRCm38)	Y34H		Het
Mlip	C	T	9: 77,229,798 (GRCm38)	R609Q	probably benign	Het
Muc2	A	G	7: 141,704,267 (GRCm38)	D34G		Het
Nbeal1	C	T	1: 60,268,389 (GRCm38)	P1687S	possibly damaging	Het
Notch1	T	A	2: 26,479,883 (GRCm38)	I477L	probably damaging	Het
Olfr1239	A	T	2: 89,418,368 (GRCm38)	L15Q	probably damaging	Het
Olfr1496	T	C	19: 13,780,969 (GRCm38)	V117A	probably benign	Het
Olfr364-ps1	G	A	2: 37,147,035 (GRCm38)	M274I	probably benign	Het
Olfr624	T	A	7: 103,670,917 (GRCm38)	N38I	probably damaging	Het
Olfr807	A	G	10: 129,755,279 (GRCm38)	M57T	probably damaging	Het
Pak7	A	T	2: 136,116,768 (GRCm38)	S133R	probably damaging	Het
Pcyt1a	C	A	16: 32,466,514 (GRCm38)	D187E	probably benign	Het
Pdlim7	G	T	13: 55,507,541 (GRCm38)	T161K	probably damaging	Het
Pik3r4	A	G	9: 105,669,909 (GRCm38)	K962R	probably benign	Het
Plk5	C	G	10: 80,357,996 (GRCm38)	R40G	probably damaging	Het
Ptchd3	A	T	11: 121,842,354 (GRCm38)	Y690F	probably benign	Het
Ptpn13	A	T	5: 103,501,869 (GRCm38)	R379S	possibly damaging	Het
Rbm27	C	T	18: 42,305,764 (GRCm38)	A410V	probably benign	Het
Rnase4	A	G	14: 51,105,205 (GRCm38)	T129A	probably benign	Het
Serpinb11	C	T	1: 107,376,803 (GRCm38)	T166I	probably benign	Het
Shank2	A	G	7: 144,409,968 (GRCm38)	T438A	possibly damaging	Het
Slc13a2	T	C	11: 78,404,432 (GRCm38)	N172D	probably damaging	Het
Slc2a8	A	G	2: 32,974,852 (GRCm38)	F428L	probably damaging	Het
Slc38a6	T	C	12: 73,351,770 (GRCm38)	M358T	probably benign	Het
Snx29	A	G	16: 11,395,291 (GRCm38)	H107R	probably benign	Het
Sorbs2	T	G	8: 45,795,737 (GRCm38)	V675G	probably benign	Het
Spint3	G	A	2: 164,573,234 (GRCm38)	A21V	probably benign	Het
Susd1	A	T	4: 59,412,226 (GRCm38)	V162E	probably benign	Het
Syne2	T	G	12: 75,931,060 (GRCm38)	N1426K	probably damaging	Het
Synj2	T	C	17: 6,017,600 (GRCm38)	V638A	possibly damaging	Het
Thada	A	T	17: 84,231,161 (GRCm38)	L1473Q	probably damaging	Het
Trim36	G	A	18: 46,167,513 (GRCm38)	S697L	possibly damaging	Het
Ttbk1	A	T	17: 46,470,591 (GRCm38)	I412N	possibly damaging	Het
Tubb2a	T	C	13: 34,074,595 (GRCm38)	D404G	probably damaging	Het
Tyk2	T	A	9: 21,124,545 (GRCm38)	N114Y	probably damaging	Het
Umodl1	A	G	17: 30,966,704 (GRCm38)	D139G	probably damaging	Het
Vmn2r101	T	A	17: 19,589,982 (GRCm38)	N343K	probably benign	Het
Vnn1	A	G	10: 23,904,566 (GRCm38)	D484G	probably damaging	Het
Vps13b	A	G	15: 35,770,773 (GRCm38)	T2121A	probably benign	Het
Wdr81	T	C	11: 75,454,390 (GRCm38)	E17G	probably benign	Het
Wnk2	T	G	13: 49,071,029 (GRCm38)	K1117Q	probably benign	Het
Zbtb46	C	T	2: 181,424,345 (GRCm38)	R4Q	probably benign	Het
Zfp608	T	A	18: 54,899,118 (GRCm38)	K583N	probably damaging	Het
Zfp729b	A	T	13: 67,592,361 (GRCm38)	L595H	probably damaging	Het

Other mutations in Pkd1l2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01338:Pkd1l2	APN	8	117,059,520 (GRCm38)	nonsense	probably null
IGL01353:Pkd1l2	APN	8	117,057,443 (GRCm38)	missense	probably benign	0.24
IGL01362:Pkd1l2	APN	8	117,021,856 (GRCm38)	missense	probably damaging	1.00
IGL01486:Pkd1l2	APN	8	117,059,592 (GRCm38)	missense	probably benign
IGL01672:Pkd1l2	APN	8	117,080,732 (GRCm38)	missense	possibly damaging	0.94
IGL01696:Pkd1l2	APN	8	117,056,387 (GRCm38)	missense	probably benign	0.12
IGL01819:Pkd1l2	APN	8	116,998,174 (GRCm38)	missense	probably damaging	1.00
IGL01833:Pkd1l2	APN	8	117,060,525 (GRCm38)	missense	probably benign	0.00
IGL01981:Pkd1l2	APN	8	117,016,916 (GRCm38)	missense	probably benign	0.04
IGL02066:Pkd1l2	APN	8	117,009,564 (GRCm38)	splice site	probably benign
IGL02381:Pkd1l2	APN	8	117,035,800 (GRCm38)	splice site	probably benign
IGL02416:Pkd1l2	APN	8	117,040,835 (GRCm38)	missense	possibly damaging	0.82
IGL02736:Pkd1l2	APN	8	117,040,666 (GRCm38)	missense	probably benign	0.00
IGL02828:Pkd1l2	APN	8	117,029,559 (GRCm38)	missense	probably benign
IGL02861:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL02862:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL02883:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL02884:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL02894:Pkd1l2	APN	8	117,013,891 (GRCm38)	missense	probably damaging	0.97
IGL02900:Pkd1l2	APN	8	117,024,091 (GRCm38)	missense	probably benign	0.03
IGL02901:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL02929:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL02941:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL02957:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL02969:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL03028:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL03059:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL03065:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL03066:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL03083:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL03084:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL03124:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL03162:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL03165:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL03335:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL03357:Pkd1l2	APN	8	116,995,809 (GRCm38)	missense	probably damaging	1.00
IGL02835:Pkd1l2	UTSW	8	117,065,745 (GRCm38)	missense	probably benign	0.07
PIT4453001:Pkd1l2	UTSW	8	117,022,022 (GRCm38)	missense	probably benign	0.00
R0127:Pkd1l2	UTSW	8	117,050,048 (GRCm38)	splice site	probably benign
R0309:Pkd1l2	UTSW	8	116,997,576 (GRCm38)	missense	probably damaging	0.99
R0365:Pkd1l2	UTSW	8	117,021,850 (GRCm38)	missense	probably benign	0.02
R0526:Pkd1l2	UTSW	8	117,082,260 (GRCm38)	missense	probably damaging	1.00
R0571:Pkd1l2	UTSW	8	117,082,218 (GRCm38)	missense	probably benign	0.01
R0716:Pkd1l2	UTSW	8	117,051,100 (GRCm38)	missense	probably damaging	1.00
R0787:Pkd1l2	UTSW	8	117,076,177 (GRCm38)	missense	possibly damaging	0.90
R0893:Pkd1l2	UTSW	8	117,044,492 (GRCm38)	missense	probably damaging	0.99
R1256:Pkd1l2	UTSW	8	117,019,543 (GRCm38)	critical splice acceptor site	probably null
R1391:Pkd1l2	UTSW	8	117,054,934 (GRCm38)	missense	possibly damaging	0.87
R1474:Pkd1l2	UTSW	8	117,065,497 (GRCm38)	splice site	probably benign
R1491:Pkd1l2	UTSW	8	117,028,408 (GRCm38)	missense	probably damaging	1.00
R1520:Pkd1l2	UTSW	8	117,046,159 (GRCm38)	missense	probably benign	0.00
R1521:Pkd1l2	UTSW	8	117,065,500 (GRCm38)	splice site	probably null
R1544:Pkd1l2	UTSW	8	117,038,235 (GRCm38)	frame shift	probably null
R1558:Pkd1l2	UTSW	8	117,082,252 (GRCm38)	missense	possibly damaging	0.94
R1673:Pkd1l2	UTSW	8	117,040,775 (GRCm38)	missense	probably benign	0.00
R1691:Pkd1l2	UTSW	8	117,056,419 (GRCm38)	missense	possibly damaging	0.60
R1754:Pkd1l2	UTSW	8	117,030,719 (GRCm38)	missense	possibly damaging	0.81
R1857:Pkd1l2	UTSW	8	117,040,669 (GRCm38)	missense	possibly damaging	0.70
R1939:Pkd1l2	UTSW	8	117,046,182 (GRCm38)	nonsense	probably null
R1955:Pkd1l2	UTSW	8	117,043,361 (GRCm38)	missense	probably benign
R1957:Pkd1l2	UTSW	8	117,030,682 (GRCm38)	missense	probably damaging	1.00
R1959:Pkd1l2	UTSW	8	117,043,231 (GRCm38)	critical splice donor site	probably null
R2024:Pkd1l2	UTSW	8	117,019,533 (GRCm38)	missense	probably benign
R2046:Pkd1l2	UTSW	8	116,999,955 (GRCm38)	missense	probably damaging	1.00
R2102:Pkd1l2	UTSW	8	117,081,469 (GRCm38)	missense	probably damaging	0.98
R2116:Pkd1l2	UTSW	8	117,030,722 (GRCm38)	missense	possibly damaging	0.93
R2148:Pkd1l2	UTSW	8	117,056,325 (GRCm38)	missense	probably damaging	0.98
R2251:Pkd1l2	UTSW	8	117,057,438 (GRCm38)	missense	probably damaging	1.00
R2252:Pkd1l2	UTSW	8	117,057,438 (GRCm38)	missense	probably damaging	1.00
R2366:Pkd1l2	UTSW	8	117,043,317 (GRCm38)	missense	probably benign	0.01
R2566:Pkd1l2	UTSW	8	117,019,494 (GRCm38)	missense	probably damaging	1.00
R2872:Pkd1l2	UTSW	8	117,038,164 (GRCm38)	missense	probably benign	0.10
R2872:Pkd1l2	UTSW	8	117,038,164 (GRCm38)	missense	probably benign	0.10
R2985:Pkd1l2	UTSW	8	117,065,551 (GRCm38)	missense	probably benign	0.00
R3055:Pkd1l2	UTSW	8	117,068,315 (GRCm38)	critical splice acceptor site	probably null
R3436:Pkd1l2	UTSW	8	117,040,739 (GRCm38)	missense	probably benign	0.01
R4732:Pkd1l2	UTSW	8	116,995,842 (GRCm38)	critical splice acceptor site	probably null
R4733:Pkd1l2	UTSW	8	116,995,842 (GRCm38)	critical splice acceptor site	probably null
R4763:Pkd1l2	UTSW	8	117,019,429 (GRCm38)	missense	probably damaging	0.96
R4789:Pkd1l2	UTSW	8	117,011,575 (GRCm38)	missense	probably damaging	0.99
R4921:Pkd1l2	UTSW	8	117,054,885 (GRCm38)	missense	probably benign	0.03
R4921:Pkd1l2	UTSW	8	117,072,549 (GRCm38)	missense	probably damaging	0.97
R4999:Pkd1l2	UTSW	8	117,047,374 (GRCm38)	splice site	probably null
R5057:Pkd1l2	UTSW	8	117,055,008 (GRCm38)	missense	probably benign	0.21
R5209:Pkd1l2	UTSW	8	117,056,442 (GRCm38)	missense	probably benign	0.23
R5241:Pkd1l2	UTSW	8	117,035,118 (GRCm38)	missense	probably damaging	1.00
R5480:Pkd1l2	UTSW	8	117,030,649 (GRCm38)	missense	probably damaging	0.99
R5501:Pkd1l2	UTSW	8	117,065,830 (GRCm38)	missense	probably damaging	0.98
R5533:Pkd1l2	UTSW	8	117,068,116 (GRCm38)	missense	probably benign	0.03
R5582:Pkd1l2	UTSW	8	117,040,783 (GRCm38)	nonsense	probably null
R5610:Pkd1l2	UTSW	8	117,042,320 (GRCm38)	missense	probably benign	0.04
R5770:Pkd1l2	UTSW	8	117,055,018 (GRCm38)	missense	probably damaging	1.00
R5854:Pkd1l2	UTSW	8	117,065,746 (GRCm38)	missense	possibly damaging	0.48
R5867:Pkd1l2	UTSW	8	117,055,011 (GRCm38)	missense	probably damaging	0.96
R5881:Pkd1l2	UTSW	8	116,997,582 (GRCm38)	missense	probably damaging	0.99
R5906:Pkd1l2	UTSW	8	117,029,648 (GRCm38)	missense	probably damaging	1.00
R5909:Pkd1l2	UTSW	8	117,024,056 (GRCm38)	missense	probably benign	0.00
R6030:Pkd1l2	UTSW	8	117,043,237 (GRCm38)	missense	probably damaging	1.00
R6030:Pkd1l2	UTSW	8	117,043,237 (GRCm38)	missense	probably damaging	1.00
R6084:Pkd1l2	UTSW	8	117,013,987 (GRCm38)	missense	probably damaging	1.00
R6122:Pkd1l2	UTSW	8	117,082,368 (GRCm38)	missense	probably benign	0.02
R6216:Pkd1l2	UTSW	8	117,081,470 (GRCm38)	missense	probably damaging	1.00
R6406:Pkd1l2	UTSW	8	117,035,847 (GRCm38)	missense	probably damaging	0.99
R6417:Pkd1l2	UTSW	8	117,013,899 (GRCm38)	missense	probably damaging	1.00
R6420:Pkd1l2	UTSW	8	117,013,899 (GRCm38)	missense	probably damaging	1.00
R6601:Pkd1l2	UTSW	8	117,040,666 (GRCm38)	missense	probably benign	0.00
R6743:Pkd1l2	UTSW	8	117,030,631 (GRCm38)	missense	probably damaging	1.00
R7053:Pkd1l2	UTSW	8	117,013,942 (GRCm38)	missense	probably damaging	1.00
R7144:Pkd1l2	UTSW	8	117,076,131 (GRCm38)	nonsense	probably null
R7148:Pkd1l2	UTSW	8	117,080,786 (GRCm38)	missense	probably benign	0.00
R7169:Pkd1l2	UTSW	8	117,040,835 (GRCm38)	missense	possibly damaging	0.82
R7217:Pkd1l2	UTSW	8	116,995,797 (GRCm38)	missense	probably benign	0.24
R7310:Pkd1l2	UTSW	8	117,024,034 (GRCm38)	missense	probably benign
R7382:Pkd1l2	UTSW	8	117,054,871 (GRCm38)	missense	possibly damaging	0.95
R7397:Pkd1l2	UTSW	8	117,035,902 (GRCm38)	missense	possibly damaging	0.94
R7408:Pkd1l2	UTSW	8	117,028,479 (GRCm38)	missense	possibly damaging	0.77
R7437:Pkd1l2	UTSW	8	117,030,682 (GRCm38)	missense	probably damaging	0.96
R7492:Pkd1l2	UTSW	8	117,068,110 (GRCm38)	missense	probably damaging	1.00
R7496:Pkd1l2	UTSW	8	117,060,594 (GRCm38)	missense	possibly damaging	0.89
R7519:Pkd1l2	UTSW	8	117,065,529 (GRCm38)	missense	probably benign
R7590:Pkd1l2	UTSW	8	117,080,786 (GRCm38)	missense	probably benign	0.00
R7623:Pkd1l2	UTSW	8	117,029,645 (GRCm38)	missense	probably damaging	1.00
R7768:Pkd1l2	UTSW	8	117,054,860 (GRCm38)	critical splice donor site	probably null
R7897:Pkd1l2	UTSW	8	116,998,088 (GRCm38)	missense	possibly damaging	0.69
R7982:Pkd1l2	UTSW	8	117,051,187 (GRCm38)	missense	possibly damaging	0.70
R8024:Pkd1l2	UTSW	8	117,076,182 (GRCm38)	missense	possibly damaging	0.85
R8140:Pkd1l2	UTSW	8	117,047,497 (GRCm38)	missense	probably benign
R8145:Pkd1l2	UTSW	8	117,055,003 (GRCm38)	missense	probably benign
R8228:Pkd1l2	UTSW	8	117,065,775 (GRCm38)	missense	probably damaging	0.97
R8252:Pkd1l2	UTSW	8	117,040,733 (GRCm38)	missense	probably benign	0.29
R8500:Pkd1l2	UTSW	8	117,047,563 (GRCm38)	critical splice acceptor site	probably null
R8732:Pkd1l2	UTSW	8	117,065,572 (GRCm38)	missense	probably benign	0.28
R8809:Pkd1l2	UTSW	8	116,999,921 (GRCm38)	missense	probably damaging	1.00
R8896:Pkd1l2	UTSW	8	117,013,876 (GRCm38)	missense	possibly damaging	0.91
R8961:Pkd1l2	UTSW	8	116,999,978 (GRCm38)	missense	possibly damaging	0.52
R8985:Pkd1l2	UTSW	8	117,038,110 (GRCm38)	missense	probably benign	0.01
R9008:Pkd1l2	UTSW	8	117,042,298 (GRCm38)	missense	probably benign	0.32
R9138:Pkd1l2	UTSW	8	117,055,009 (GRCm38)	missense	probably benign	0.43
R9160:Pkd1l2	UTSW	8	117,040,669 (GRCm38)	missense	possibly damaging	0.70
R9249:Pkd1l2	UTSW	8	117,019,420 (GRCm38)	missense	probably damaging	0.99
R9270:Pkd1l2	UTSW	8	117,032,694 (GRCm38)	missense	probably damaging	1.00
R9735:Pkd1l2	UTSW	8	117,046,081 (GRCm38)	missense	possibly damaging	0.94
Z1176:Pkd1l2	UTSW	8	117,054,914 (GRCm38)	missense	probably damaging	1.00
Z1177:Pkd1l2	UTSW	8	117,030,691 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- ACAGAACATTTGGACCAGCAG -3'
(R):5'- GGGGTTCCTTTTCTGAAGATCC -3'

Sequencing Primer
(F):5'- ATTTGGACCAGCAGTGTCAC -3'
(R):5'- GAAGATCCTACCTCTGTGATGTC -3'

Posted On

2021-12-30