Incidental Mutation 'R9092:Vmn2r101'
| ID |
691095 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r101
|
| Ensembl Gene |
ENSMUSG00000094892 |
| Gene Name |
vomeronasal 2, receptor 101 |
| Synonyms |
EG627576 |
| MMRRC Submission |
068908-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.102)
|
| Stock # |
R9092 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
19797493-19832579 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 19809807 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Serine
at position 198
(T198S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000131583
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000171914]
|
| AlphaFold |
E9PZS9 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000171914
AA Change: T198S
PolyPhen 2
Score 0.066 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000131583
Gene: ENSMUSG00000094892
AA Change: T198S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
466 |
1.6e-36 |
PFAM |
|
Pfam:NCD3G
|
509 |
562 |
6.4e-22 |
PFAM |
|
Pfam:7tm_3
|
595 |
830 |
1.4e-51 |
PFAM |
|
| Meta Mutation Damage Score |
0.0846 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.8%
- 20x: 99.4%
|
| Validation Efficiency |
93% (56/60) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 60 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Chl1 |
T |
C |
6: 103,645,815 (GRCm39) |
|
probably benign |
Het |
| Crtc3 |
T |
C |
7: 80,239,628 (GRCm39) |
M575V |
probably benign |
Het |
| Cux1 |
T |
A |
5: 136,514,671 (GRCm39) |
N22I |
probably damaging |
Het |
| Dcun1d2 |
G |
A |
8: 13,307,935 (GRCm39) |
R248W |
probably damaging |
Het |
| Dlc1 |
G |
T |
8: 37,199,860 (GRCm39) |
H7Q |
probably benign |
Het |
| Drd2 |
A |
G |
9: 49,307,004 (GRCm39) |
D30G |
probably benign |
Het |
| Duxf3 |
GCCC |
GCC |
10: 58,066,944 (GRCm39) |
|
probably null |
Het |
| E2f7 |
T |
C |
10: 110,616,874 (GRCm39) |
S705P |
probably benign |
Het |
| Ephb3 |
G |
A |
16: 21,041,214 (GRCm39) |
S977N |
probably benign |
Het |
| F13a1 |
T |
G |
13: 37,089,993 (GRCm39) |
D448A |
probably benign |
Het |
| Fam216b |
T |
C |
14: 78,322,537 (GRCm39) |
T56A |
possibly damaging |
Het |
| Fcho2 |
T |
C |
13: 98,886,391 (GRCm39) |
T408A |
probably benign |
Het |
| Flvcr1 |
A |
T |
1: 190,740,364 (GRCm39) |
V552E |
|
Het |
| Gab3 |
CTT |
CTTGTT |
X: 74,043,612 (GRCm39) |
|
probably benign |
Het |
| Gab3 |
TCT |
TCTGCT |
X: 74,043,602 (GRCm39) |
|
probably benign |
Het |
| Galnt15 |
A |
G |
14: 31,780,196 (GRCm39) |
K622E |
probably benign |
Het |
| Gjb3 |
GCCAGATGCGCCCA |
GCCAGATGCGCCCAGATGCGCCCA |
4: 127,220,458 (GRCm39) |
|
probably null |
Het |
| Gjb3 |
A |
AGATGCGCCCG |
4: 127,220,471 (GRCm39) |
|
probably null |
Het |
| Gm5414 |
T |
G |
15: 101,536,345 (GRCm39) |
R93S |
probably benign |
Het |
| Gtf2i |
A |
G |
5: 134,318,241 (GRCm39) |
*87Q |
probably null |
Het |
| Il7r |
T |
A |
15: 9,510,270 (GRCm39) |
H261L |
probably benign |
Het |
| Itsn1 |
T |
A |
16: 91,609,002 (GRCm39) |
M250K |
possibly damaging |
Het |
| Krt9 |
TCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCC |
TCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCC |
11: 100,079,903 (GRCm39) |
|
probably benign |
Het |
| Liat1 |
A |
G |
11: 75,893,887 (GRCm39) |
D88G |
possibly damaging |
Het |
| Lrrc47 |
C |
A |
4: 154,096,421 (GRCm39) |
T72K |
possibly damaging |
Het |
| Map2k4 |
C |
A |
11: 65,581,599 (GRCm39) |
R371L |
probably benign |
Het |
| Mmrn2 |
T |
C |
14: 34,118,587 (GRCm39) |
F158L |
probably benign |
Het |
| Mtus1 |
A |
T |
8: 41,455,475 (GRCm39) |
L242Q |
probably damaging |
Het |
| Myo5a |
T |
C |
9: 75,054,414 (GRCm39) |
|
probably null |
Het |
| Noc3l |
T |
A |
19: 38,798,487 (GRCm39) |
K305I |
probably damaging |
Het |
| Or4p8 |
T |
C |
2: 88,727,321 (GRCm39) |
T207A |
probably damaging |
Het |
| Pag1 |
T |
C |
3: 9,764,848 (GRCm39) |
T102A |
probably benign |
Het |
| Pam |
A |
G |
1: 97,791,976 (GRCm39) |
S482P |
probably benign |
Het |
| Pax1 |
T |
G |
2: 147,204,287 (GRCm39) |
W23G |
unknown |
Het |
| Pcdhgb1 |
T |
A |
18: 37,813,989 (GRCm39) |
V160D |
possibly damaging |
Het |
| Pdzph1 |
T |
C |
17: 59,280,125 (GRCm39) |
D719G |
probably damaging |
Het |
| Phlda1 |
T |
C |
10: 111,342,474 (GRCm39) |
L70S |
possibly damaging |
Het |
| Pikfyve |
G |
A |
1: 65,283,559 (GRCm39) |
R732K |
probably damaging |
Het |
| Pkd1 |
G |
T |
17: 24,788,347 (GRCm39) |
V702F |
possibly damaging |
Het |
| Pkhd1 |
A |
G |
1: 20,632,586 (GRCm39) |
Y610H |
probably benign |
Het |
| Pofut1 |
T |
G |
2: 153,101,508 (GRCm39) |
H87Q |
probably benign |
Het |
| Runx2 |
C |
A |
17: 45,046,443 (GRCm39) |
D109Y |
probably damaging |
Het |
| Serpina1b |
T |
A |
12: 103,696,540 (GRCm39) |
I290F |
probably benign |
Het |
| Sez6 |
G |
A |
11: 77,865,121 (GRCm39) |
E623K |
possibly damaging |
Het |
| Sh3tc1 |
T |
C |
5: 35,874,321 (GRCm39) |
N198S |
probably benign |
Het |
| Slc27a6 |
C |
A |
18: 58,742,330 (GRCm39) |
R515S |
probably benign |
Het |
| Sorbs3 |
C |
T |
14: 70,445,004 (GRCm39) |
V25I |
probably benign |
Het |
| Speg |
A |
G |
1: 75,399,378 (GRCm39) |
E2275G |
probably benign |
Het |
| Tmem161b |
C |
T |
13: 84,440,503 (GRCm39) |
T307I |
possibly damaging |
Het |
| Tmem30a |
T |
C |
9: 79,678,581 (GRCm39) |
D361G |
probably damaging |
Het |
| Tmprss11c |
T |
C |
5: 86,385,495 (GRCm39) |
T326A |
probably benign |
Het |
| Tpbg |
T |
C |
9: 85,726,916 (GRCm39) |
V295A |
possibly damaging |
Het |
| Ulk4 |
A |
T |
9: 120,903,003 (GRCm39) |
I1158N |
|
Het |
| Utp20 |
C |
A |
10: 88,604,679 (GRCm39) |
A1739S |
probably benign |
Het |
| Utp20 |
T |
C |
10: 88,611,180 (GRCm39) |
N1379S |
probably damaging |
Het |
| Vmn1r66 |
T |
A |
7: 10,008,110 (GRCm39) |
I308F |
possibly damaging |
Het |
| Vps16 |
T |
C |
2: 130,281,593 (GRCm39) |
I318T |
probably damaging |
Het |
| Wdr11 |
T |
A |
7: 129,226,451 (GRCm39) |
W750R |
probably damaging |
Het |
| Zfp608 |
A |
G |
18: 55,031,648 (GRCm39) |
I764T |
probably benign |
Het |
| Zfp708 |
C |
A |
13: 67,218,564 (GRCm39) |
D420Y |
probably damaging |
Het |
|
| Other mutations in Vmn2r101 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01121:Vmn2r101
|
APN |
17 |
19,809,936 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02125:Vmn2r101
|
APN |
17 |
19,809,963 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02300:Vmn2r101
|
APN |
17 |
19,832,199 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02682:Vmn2r101
|
APN |
17 |
19,832,507 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL02825:Vmn2r101
|
APN |
17 |
19,810,132 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02862:Vmn2r101
|
APN |
17 |
19,831,867 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02943:Vmn2r101
|
APN |
17 |
19,831,666 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0371:Vmn2r101
|
UTSW |
17 |
19,810,394 (GRCm39) |
missense |
probably benign |
0.07 |
|
R0462:Vmn2r101
|
UTSW |
17 |
19,810,431 (GRCm39) |
missense |
probably benign |
0.04 |
|
R0492:Vmn2r101
|
UTSW |
17 |
19,809,245 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0654:Vmn2r101
|
UTSW |
17 |
19,810,373 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1120:Vmn2r101
|
UTSW |
17 |
19,797,723 (GRCm39) |
splice site |
probably benign |
|
|
R1323:Vmn2r101
|
UTSW |
17 |
19,832,313 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1323:Vmn2r101
|
UTSW |
17 |
19,832,313 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1676:Vmn2r101
|
UTSW |
17 |
19,832,184 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2023:Vmn2r101
|
UTSW |
17 |
19,810,368 (GRCm39) |
nonsense |
probably null |
|
|
R2149:Vmn2r101
|
UTSW |
17 |
19,809,225 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2350:Vmn2r101
|
UTSW |
17 |
19,810,045 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2760:Vmn2r101
|
UTSW |
17 |
19,809,901 (GRCm39) |
missense |
probably benign |
0.14 |
|
R3085:Vmn2r101
|
UTSW |
17 |
19,809,077 (GRCm39) |
splice site |
probably null |
|
|
R3086:Vmn2r101
|
UTSW |
17 |
19,809,077 (GRCm39) |
splice site |
probably null |
|
|
R3719:Vmn2r101
|
UTSW |
17 |
19,809,811 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R3771:Vmn2r101
|
UTSW |
17 |
19,809,919 (GRCm39) |
missense |
probably benign |
|
|
R3773:Vmn2r101
|
UTSW |
17 |
19,809,919 (GRCm39) |
missense |
probably benign |
|
|
R4225:Vmn2r101
|
UTSW |
17 |
19,831,951 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4248:Vmn2r101
|
UTSW |
17 |
19,809,376 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4290:Vmn2r101
|
UTSW |
17 |
19,832,303 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4291:Vmn2r101
|
UTSW |
17 |
19,832,303 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4293:Vmn2r101
|
UTSW |
17 |
19,832,303 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4307:Vmn2r101
|
UTSW |
17 |
19,810,423 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4721:Vmn2r101
|
UTSW |
17 |
19,832,287 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4829:Vmn2r101
|
UTSW |
17 |
19,832,229 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5022:Vmn2r101
|
UTSW |
17 |
19,831,649 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5110:Vmn2r101
|
UTSW |
17 |
19,831,897 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5244:Vmn2r101
|
UTSW |
17 |
19,831,788 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5397:Vmn2r101
|
UTSW |
17 |
19,809,104 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5875:Vmn2r101
|
UTSW |
17 |
19,809,092 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5944:Vmn2r101
|
UTSW |
17 |
19,809,769 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6216:Vmn2r101
|
UTSW |
17 |
19,811,267 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6334:Vmn2r101
|
UTSW |
17 |
19,810,112 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6512:Vmn2r101
|
UTSW |
17 |
19,809,146 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6607:Vmn2r101
|
UTSW |
17 |
19,832,296 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6965:Vmn2r101
|
UTSW |
17 |
19,811,284 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7101:Vmn2r101
|
UTSW |
17 |
19,809,350 (GRCm39) |
missense |
probably null |
0.14 |
|
R7183:Vmn2r101
|
UTSW |
17 |
19,832,440 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7344:Vmn2r101
|
UTSW |
17 |
19,832,059 (GRCm39) |
missense |
probably benign |
0.38 |
|
R7375:Vmn2r101
|
UTSW |
17 |
19,831,652 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7574:Vmn2r101
|
UTSW |
17 |
19,831,899 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R7575:Vmn2r101
|
UTSW |
17 |
19,831,654 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7592:Vmn2r101
|
UTSW |
17 |
19,811,443 (GRCm39) |
splice site |
probably null |
|
|
R7626:Vmn2r101
|
UTSW |
17 |
19,832,192 (GRCm39) |
nonsense |
probably null |
|
|
R7715:Vmn2r101
|
UTSW |
17 |
19,832,177 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7730:Vmn2r101
|
UTSW |
17 |
19,831,950 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R8078:Vmn2r101
|
UTSW |
17 |
19,810,507 (GRCm39) |
missense |
probably benign |
0.07 |
|
R8228:Vmn2r101
|
UTSW |
17 |
19,811,284 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8283:Vmn2r101
|
UTSW |
17 |
19,832,253 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8712:Vmn2r101
|
UTSW |
17 |
19,811,397 (GRCm39) |
missense |
probably benign |
0.24 |
|
R8765:Vmn2r101
|
UTSW |
17 |
19,809,245 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9091:Vmn2r101
|
UTSW |
17 |
19,810,244 (GRCm39) |
missense |
probably benign |
|
|
R9113:Vmn2r101
|
UTSW |
17 |
19,811,288 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R9158:Vmn2r101
|
UTSW |
17 |
19,809,161 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9168:Vmn2r101
|
UTSW |
17 |
19,809,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9235:Vmn2r101
|
UTSW |
17 |
19,810,238 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9270:Vmn2r101
|
UTSW |
17 |
19,810,244 (GRCm39) |
missense |
probably benign |
|
|
R9290:Vmn2r101
|
UTSW |
17 |
19,811,395 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9296:Vmn2r101
|
UTSW |
17 |
19,810,047 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9602:Vmn2r101
|
UTSW |
17 |
19,831,780 (GRCm39) |
nonsense |
probably null |
|
|
R9706:Vmn2r101
|
UTSW |
17 |
19,809,925 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Vmn2r101
|
UTSW |
17 |
19,809,237 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
| Predicted Primers |
PCR Primer
(F):5'- AATCCAGTAAACCCTTGAGAGAG -3'
(R):5'- ATGTGAAGTCCATGTGCCTGG -3'
Sequencing Primer
(F):5'- TAAACCCTTGAGAGAGACTTACAG -3'
(R):5'- GTGCCTGGGATCATTTTTACAAAAGC -3'
|
| Posted On |
2021-12-30 |
Incidental Mutation