|Institutional Source||Beutler Lab|
|Gene Name||carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15|
|Synonyms||MAd5, GalNAcS-6ST, MAd5, 4631426J05Rik|
|Is this an essential gene?||Probably non essential (E-score: 0.065)|
|Stock #||R9093 (G1)|
|Chromosomal Location||132235780-132317228 bp(-) (GRCm38)|
|Type of Mutation||critical splice donor site (2 bp from exon)|
|DNA Base Change (assembly)||A to T at 132268917 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000076682 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000077472] [ENSMUST00000080215] [ENSMUST00000124096]|
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Chondroitin sulfate (CS) is a glycosaminoglycan which is an important structural component of the extracellular matrix and which links to proteins to form proteoglycans. Chondroitin sulfate E (CS-E) is an isomer of chondroitin sulfate in which the C-4 and C-6 hydroxyl groups are sulfated. This gene encodes a type II transmembrane glycoprotein that acts as a sulfotransferase to transfer sulfate to the C-6 hydroxal group of chondroitin sulfate. This gene has also been identified as being co-expressed with RAG1 in B-cells and as potentially acting as a B-cell surface signaling receptor. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased litter size and abnormal bone marrow-derived mast cell morphology. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Chst15||
(F):5'- ACCTTTAGCCTCTAGAATCATGAAC -3'
(R):5'- CTCTGCGCAAGGTTTTCTGG -3'
(F):5'- ACACTGGTGTTTTGTCGTTATATTAC -3'
(R):5'- AAGGTTTTCTGGGGCCACC -3'