Mutagenetix > Incidental Mutation

Incidental Mutation 'R9095:Nav2'

691287

Institutional Source

Beutler Lab

Gene Symbol

Nav2

Ensembl Gene

ENSMUSG00000052512

Gene Name

neuron navigator 2

Synonyms

Rainb1, Unc53H2, 5330421F07Rik, POMFIL2, HELAD1, RAINB2

MMRRC Submission

068910-MU

Accession Numbers

Essential gene?

Possibly essential (E-score: 0.550) question?

Stock #

R9095 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

48608796-49259838 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 49254293 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Methionine at position 2364 (V2364M)

Ref Sequence

ENSEMBL: ENSMUSP00000067448 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000064395] [ENSMUST00000183659] [ENSMUST00000184945]

AlphaFold

E9Q842

Predicted Effect

probably damaging
Transcript: ENSMUST00000064395
AA Change: V2364M

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000067448
Gene: ENSMUSG00000052512
AA Change: V2364M

Domain	Start	End	E-Value	Type
CH	84	187	1.58e-13	SMART
low complexity region	202	210	N/A	INTRINSIC
low complexity region	297	310	N/A	INTRINSIC
low complexity region	337	348	N/A	INTRINSIC
low complexity region	412	424	N/A	INTRINSIC
coiled coil region	486	516	N/A	INTRINSIC
low complexity region	580	591	N/A	INTRINSIC
low complexity region	613	625	N/A	INTRINSIC
low complexity region	640	662	N/A	INTRINSIC
low complexity region	846	857	N/A	INTRINSIC
low complexity region	920	944	N/A	INTRINSIC
low complexity region	947	967	N/A	INTRINSIC
low complexity region	990	1004	N/A	INTRINSIC
low complexity region	1062	1074	N/A	INTRINSIC
low complexity region	1343	1360	N/A	INTRINSIC
low complexity region	1368	1385	N/A	INTRINSIC
low complexity region	1417	1432	N/A	INTRINSIC
low complexity region	1454	1466	N/A	INTRINSIC
low complexity region	1526	1540	N/A	INTRINSIC
low complexity region	1614	1628	N/A	INTRINSIC
coiled coil region	1630	1717	N/A	INTRINSIC
low complexity region	1789	1800	N/A	INTRINSIC
coiled coil region	1841	1909	N/A	INTRINSIC
AAA	2093	2247	1.69e-5	SMART
low complexity region	2404	2430	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000183659
AA Change: V2303M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000139309
Gene: ENSMUSG00000052512
AA Change: V2303M

Domain	Start	End	E-Value	Type
low complexity region	2	11	N/A	INTRINSIC
CH	23	126	6.19e-16	SMART
low complexity region	141	149	N/A	INTRINSIC
low complexity region	236	249	N/A	INTRINSIC
low complexity region	276	287	N/A	INTRINSIC
low complexity region	351	363	N/A	INTRINSIC
coiled coil region	425	455	N/A	INTRINSIC
low complexity region	519	530	N/A	INTRINSIC
low complexity region	552	564	N/A	INTRINSIC
low complexity region	579	601	N/A	INTRINSIC
low complexity region	785	796	N/A	INTRINSIC
low complexity region	859	883	N/A	INTRINSIC
low complexity region	886	906	N/A	INTRINSIC
low complexity region	929	943	N/A	INTRINSIC
low complexity region	1001	1013	N/A	INTRINSIC
low complexity region	1282	1299	N/A	INTRINSIC
low complexity region	1307	1324	N/A	INTRINSIC
low complexity region	1356	1371	N/A	INTRINSIC
low complexity region	1393	1405	N/A	INTRINSIC
low complexity region	1465	1479	N/A	INTRINSIC
low complexity region	1553	1567	N/A	INTRINSIC
coiled coil region	1569	1656	N/A	INTRINSIC
low complexity region	1728	1739	N/A	INTRINSIC
coiled coil region	1780	1848	N/A	INTRINSIC
AAA	2032	2186	1.69e-5	SMART
low complexity region	2343	2369	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000184945
AA Change: V2364M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000139045
Gene: ENSMUSG00000052512
AA Change: V2364M

Domain	Start	End	E-Value	Type
CH	84	187	1.58e-13	SMART
low complexity region	202	210	N/A	INTRINSIC
low complexity region	297	310	N/A	INTRINSIC
low complexity region	337	348	N/A	INTRINSIC
low complexity region	412	424	N/A	INTRINSIC
coiled coil region	486	516	N/A	INTRINSIC
low complexity region	580	591	N/A	INTRINSIC
low complexity region	613	625	N/A	INTRINSIC
low complexity region	640	662	N/A	INTRINSIC
low complexity region	846	857	N/A	INTRINSIC
low complexity region	920	944	N/A	INTRINSIC
low complexity region	947	967	N/A	INTRINSIC
low complexity region	990	1004	N/A	INTRINSIC
low complexity region	1062	1074	N/A	INTRINSIC
low complexity region	1343	1360	N/A	INTRINSIC
low complexity region	1368	1385	N/A	INTRINSIC
low complexity region	1417	1432	N/A	INTRINSIC
low complexity region	1454	1466	N/A	INTRINSIC
low complexity region	1526	1540	N/A	INTRINSIC
low complexity region	1614	1628	N/A	INTRINSIC
coiled coil region	1630	1717	N/A	INTRINSIC
low complexity region	1789	1800	N/A	INTRINSIC
coiled coil region	1841	1909	N/A	INTRINSIC
AAA	2093	2247	1.69e-5	SMART
low complexity region	2404	2430	N/A	INTRINSIC

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 98.9%

Validation Efficiency

100% (75/75)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the neuron navigator gene family, which may play a role in cellular growth and migration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
PHENOTYPE: Homozygous null mice display impaired olfaction and hearing, increased latency in a hot plate test, degeneration of the optic nerve, decreased exploration in new environments, and weight loss. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 76 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca17	C	T	17: 24,500,370 (GRCm39)	V1274M	probably damaging	Het
Abca4	A	G	3: 121,967,556 (GRCm39)	H2202R	possibly damaging	Het
Ablim3	A	G	18: 61,953,463 (GRCm39)	L350P	probably benign	Het
Adamts17	C	T	7: 66,654,117 (GRCm39)	T449I	probably damaging	Het
Ankrd39	T	A	1: 36,586,241 (GRCm39)	D9V	probably benign	Het
Arhgef7	T	C	8: 11,835,819 (GRCm39)	V192A	probably damaging	Het
Art4	C	T	6: 136,834,269 (GRCm39)		probably benign	Het
Atg4a-ps	A	T	3: 103,553,254 (GRCm39)	V29E	possibly damaging	Het
Ccdc180	A	T	4: 45,949,466 (GRCm39)	K1574*	probably null	Het
Cfap54	T	G	10: 92,846,882 (GRCm39)	T1028P	probably damaging	Het
Clip2	C	T	5: 134,532,254 (GRCm39)	R517H	possibly damaging	Het
Col5a1	A	G	2: 27,914,665 (GRCm39)	T94A	probably benign	Het
Cpne1	T	A	2: 155,918,210 (GRCm39)		probably null	Het
Csnk2a1-ps3	A	T	1: 156,352,213 (GRCm39)	Y138F	probably benign	Het
Cyp2f2	T	A	7: 26,830,667 (GRCm39)	M346K	possibly damaging	Het
D130040H23Rik	AAGAATATATTCTACAGAATATA	AAGAATATA	8: 69,755,748 (GRCm39)		probably null	Het
Ddi2	T	A	4: 141,419,590 (GRCm39)	I387F	probably benign	Het
Dsg1b	A	G	18: 20,523,282 (GRCm39)	N103S	probably damaging	Het
Duxf3	GCCC	GCC	10: 58,066,944 (GRCm39)		probably null	Het
Dysf	A	G	6: 84,156,666 (GRCm39)	I1464V	probably benign	Het
Epha2	A	G	4: 141,044,012 (GRCm39)	Y314C	possibly damaging	Het
Etl4	A	G	2: 20,782,964 (GRCm39)	E675G	probably damaging	Het
Fam114a1	A	C	5: 65,188,733 (GRCm39)	I488L	probably benign	Het
Fbxo31	G	A	8: 122,281,136 (GRCm39)	R337C	probably damaging	Het
Fn1	A	C	1: 71,647,149 (GRCm39)	I1547S	probably null	Het
Garre1	A	T	7: 33,956,770 (GRCm39)		probably null	Het
Get1	T	A	16: 95,954,244 (GRCm39)		probably benign	Het
Gm14305	T	A	2: 176,413,045 (GRCm39)	Y312*	probably null	Het
Golm2	T	A	2: 121,756,096 (GRCm39)	L375Q	probably damaging	Het
Gpihbp1	A	G	15: 75,469,641 (GRCm39)	T119A	possibly damaging	Het
Harbi1	T	G	2: 91,542,980 (GRCm39)	V147G	probably damaging	Het
Ifit1bl1	T	C	19: 34,571,899 (GRCm39)	Y186C	probably damaging	Het
Ighv13-2	C	A	12: 114,321,494 (GRCm39)	A82S	probably benign	Het
Itpr1	T	A	6: 108,364,352 (GRCm39)	D827E	probably benign	Het
Krtap4-2	C	T	11: 99,525,801 (GRCm39)	G17D	unknown	Het
Ly6a	A	T	15: 74,867,333 (GRCm39)		probably benign	Het
Mad1l1	C	T	5: 140,288,741 (GRCm39)	E203K	probably damaging	Het
Mapk14	C	A	17: 28,934,413 (GRCm39)	D101E	probably benign	Het
Meis3	G	T	7: 15,917,764 (GRCm39)	G306W	probably damaging	Het
Mixl1	T	C	1: 180,524,402 (GRCm39)	D59G	probably benign	Het
Nell1	T	C	7: 50,506,150 (GRCm39)	S786P	possibly damaging	Het
Or13a25	T	G	7: 140,247,813 (GRCm39)	N197K	probably damaging	Het
Or51e2	C	A	7: 102,391,473 (GRCm39)	V246L	possibly damaging	Het
Or51g1	A	G	7: 102,633,687 (GRCm39)	L228P	probably damaging	Het
Or5b107	T	G	19: 13,143,310 (GRCm39)	S311A	probably benign	Het
Pcdhgb8	A	T	18: 37,896,052 (GRCm39)	D374V	probably damaging	Het
Phactr2	A	G	10: 13,129,386 (GRCm39)	I294T	probably benign	Het
Plekha4	C	T	7: 45,190,492 (GRCm39)	A400V	probably damaging	Het
Pramel21	T	C	4: 143,341,760 (GRCm39)	F63S	probably damaging	Het
Pramel4	C	A	4: 143,794,928 (GRCm39)	D441E	probably benign	Het
Prr12	G	A	7: 44,695,267 (GRCm39)	P1400S	unknown	Het
Prss3b	T	A	6: 41,010,038 (GRCm39)	N99Y	possibly damaging	Het
Rbm6	G	A	9: 107,669,089 (GRCm39)	Q608*	probably null	Het
Scamp1	T	A	13: 94,369,598 (GRCm39)	I76F	probably benign	Het
Sez6	G	A	11: 77,865,121 (GRCm39)	E623K	possibly damaging	Het
Sirt1	A	T	10: 63,158,077 (GRCm39)	S446T	probably damaging	Het
Slc25a54	A	G	3: 109,019,404 (GRCm39)	K336R	probably benign	Het
Spag17	G	T	3: 99,912,092 (GRCm39)	V321F	possibly damaging	Het
Sstr1	A	G	12: 58,259,620 (GRCm39)	Y81C	probably damaging	Het
St8sia4	T	C	1: 95,519,525 (GRCm39)	K321R	probably damaging	Het
Stac3	T	C	10: 127,343,584 (GRCm39)	F242S	probably damaging	Het
Tanc2	T	G	11: 105,758,104 (GRCm39)	S622A	probably benign	Het
Tcf4	G	A	18: 69,598,464 (GRCm39)	D106N	possibly damaging	Het
Tfrc	T	A	16: 32,433,571 (GRCm39)	I75N	possibly damaging	Het
Tigd2	G	A	6: 59,187,509 (GRCm39)	W125*	probably null	Het
Tjp1	T	C	7: 64,952,745 (GRCm39)	T1530A	possibly damaging	Het
Tmem132a	T	A	19: 10,844,412 (GRCm39)	H62L	probably benign	Het
Tmem89	T	C	9: 108,743,729 (GRCm39)	S10P	unknown	Het
Trrap	C	T	5: 144,733,961 (GRCm39)	P938L	probably damaging	Het
Unc80	C	A	1: 66,545,912 (GRCm39)	P488T	probably damaging	Het
Uri1	C	A	7: 37,662,873 (GRCm39)	G374C	probably damaging	Het
Utp20	T	C	10: 88,611,180 (GRCm39)	N1379S	probably damaging	Het
Vcan	G	T	13: 89,852,644 (GRCm39)	T772K	probably benign	Het
Zbtb37	A	T	1: 160,847,941 (GRCm39)	Y355*	probably null	Het
Zfp3	A	G	11: 70,662,405 (GRCm39)	I121M	probably benign	Het
Zfp629	A	T	7: 127,209,547 (GRCm39)	L754Q	probably damaging	Het

Other mutations in Nav2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01097:Nav2	APN	7	49,220,942 (GRCm39)	missense	probably damaging	1.00
IGL01150:Nav2	APN	7	49,102,269 (GRCm39)	missense	probably benign	0.17
IGL01649:Nav2	APN	7	49,225,477 (GRCm39)	missense	probably damaging	1.00
IGL01662:Nav2	APN	7	49,220,957 (GRCm39)	missense	probably damaging	1.00
IGL02297:Nav2	APN	7	49,243,977 (GRCm39)	missense	probably damaging	0.98
IGL02313:Nav2	APN	7	49,208,521 (GRCm39)	missense	probably damaging	0.99
IGL02441:Nav2	APN	7	49,102,260 (GRCm39)	missense	probably damaging	1.00
IGL02472:Nav2	APN	7	49,195,789 (GRCm39)	missense	probably damaging	1.00
IGL02477:Nav2	APN	7	49,232,623 (GRCm39)	missense	probably damaging	0.99
IGL02725:Nav2	APN	7	49,214,843 (GRCm39)	missense	probably damaging	1.00
IGL02944:Nav2	APN	7	49,070,004 (GRCm39)	missense	probably damaging	0.99
IGL02953:Nav2	APN	7	49,198,171 (GRCm39)	missense	probably damaging	1.00
IGL03105:Nav2	APN	7	49,114,627 (GRCm39)	missense	probably damaging	1.00
IGL03234:Nav2	APN	7	49,111,756 (GRCm39)	missense	possibly damaging	0.94
IGL03274:Nav2	APN	7	49,011,847 (GRCm39)	missense	probably damaging	1.00
IGL03294:Nav2	APN	7	49,141,205 (GRCm39)	nonsense	probably null
R0006:Nav2	UTSW	7	49,102,978 (GRCm39)	missense	possibly damaging	0.50
R0070:Nav2	UTSW	7	49,220,462 (GRCm39)	missense	probably damaging	1.00
R0113:Nav2	UTSW	7	49,185,701 (GRCm39)	missense	probably damaging	1.00
R0306:Nav2	UTSW	7	49,195,651 (GRCm39)	missense	probably benign	0.01
R0346:Nav2	UTSW	7	49,254,333 (GRCm39)	missense	probably benign	0.11
R0539:Nav2	UTSW	7	49,111,686 (GRCm39)	missense	probably damaging	1.00
R0669:Nav2	UTSW	7	49,058,431 (GRCm39)	missense	probably damaging	1.00
R0785:Nav2	UTSW	7	49,070,081 (GRCm39)	missense	probably benign	0.06
R0970:Nav2	UTSW	7	49,233,901 (GRCm39)	missense	probably damaging	1.00
R1162:Nav2	UTSW	7	49,185,788 (GRCm39)	splice site	probably benign
R1274:Nav2	UTSW	7	49,254,178 (GRCm39)	nonsense	probably null
R1463:Nav2	UTSW	7	49,185,710 (GRCm39)	missense	probably damaging	1.00
R1464:Nav2	UTSW	7	49,011,952 (GRCm39)	missense	probably damaging	1.00
R1464:Nav2	UTSW	7	49,011,952 (GRCm39)	missense	probably damaging	1.00
R1536:Nav2	UTSW	7	49,195,682 (GRCm39)	missense	probably damaging	1.00
R1612:Nav2	UTSW	7	49,220,959 (GRCm39)	missense	probably damaging	1.00
R1638:Nav2	UTSW	7	49,102,213 (GRCm39)	missense	probably benign
R1731:Nav2	UTSW	7	49,197,922 (GRCm39)	missense	probably damaging	1.00
R1734:Nav2	UTSW	7	49,225,468 (GRCm39)	missense	probably damaging	1.00
R1865:Nav2	UTSW	7	49,197,943 (GRCm39)	missense	possibly damaging	0.95
R1945:Nav2	UTSW	7	49,114,620 (GRCm39)	missense	probably damaging	1.00
R1997:Nav2	UTSW	7	49,198,219 (GRCm39)	missense	probably benign	0.16
R2061:Nav2	UTSW	7	49,248,645 (GRCm39)	splice site	probably benign
R2117:Nav2	UTSW	7	49,114,328 (GRCm39)	missense	probably benign	0.00
R2174:Nav2	UTSW	7	49,102,411 (GRCm39)	missense	probably damaging	0.99
R2182:Nav2	UTSW	7	49,247,002 (GRCm39)	missense	probably benign	0.38
R2251:Nav2	UTSW	7	49,103,025 (GRCm39)	missense	probably damaging	1.00
R2283:Nav2	UTSW	7	49,141,152 (GRCm39)	missense	probably damaging	1.00
R2343:Nav2	UTSW	7	49,248,565 (GRCm39)	missense	possibly damaging	0.82
R2472:Nav2	UTSW	7	49,058,632 (GRCm39)	missense	probably benign
R2568:Nav2	UTSW	7	49,247,312 (GRCm39)	missense	probably damaging	1.00
R2656:Nav2	UTSW	7	49,195,690 (GRCm39)	missense	probably damaging	1.00
R2964:Nav2	UTSW	7	49,206,780 (GRCm39)	missense	probably damaging	1.00
R2966:Nav2	UTSW	7	49,206,780 (GRCm39)	missense	probably damaging	1.00
R3817:Nav2	UTSW	7	49,114,310 (GRCm39)	missense	probably benign	0.00
R3834:Nav2	UTSW	7	49,195,606 (GRCm39)	missense	possibly damaging	0.91
R4207:Nav2	UTSW	7	49,246,979 (GRCm39)	missense	probably damaging	1.00
R4207:Nav2	UTSW	7	49,222,046 (GRCm39)	splice site	probably null
R4411:Nav2	UTSW	7	49,047,857 (GRCm39)	missense	probably benign	0.37
R4413:Nav2	UTSW	7	49,047,857 (GRCm39)	missense	probably benign	0.37
R4440:Nav2	UTSW	7	49,225,011 (GRCm39)	splice site	probably benign
R4440:Nav2	UTSW	7	49,201,785 (GRCm39)	missense	possibly damaging	0.86
R4454:Nav2	UTSW	7	49,198,292 (GRCm39)	splice site	probably null
R4729:Nav2	UTSW	7	49,102,567 (GRCm39)	missense	probably benign	0.17
R4801:Nav2	UTSW	7	49,195,600 (GRCm39)	missense	possibly damaging	0.94
R4802:Nav2	UTSW	7	49,195,600 (GRCm39)	missense	possibly damaging	0.94
R4824:Nav2	UTSW	7	49,058,749 (GRCm39)	intron	probably benign
R4887:Nav2	UTSW	7	49,198,182 (GRCm39)	nonsense	probably null
R4908:Nav2	UTSW	7	49,254,258 (GRCm39)	missense	probably damaging	1.00
R4952:Nav2	UTSW	7	48,954,288 (GRCm39)	intron	probably benign
R4965:Nav2	UTSW	7	49,202,625 (GRCm39)	nonsense	probably null
R5169:Nav2	UTSW	7	49,198,231 (GRCm39)	nonsense	probably null
R5224:Nav2	UTSW	7	49,201,473 (GRCm39)	missense	probably benign	0.00
R5249:Nav2	UTSW	7	49,185,661 (GRCm39)	missense	probably damaging	1.00
R5285:Nav2	UTSW	7	49,197,982 (GRCm39)	missense	probably damaging	1.00
R5314:Nav2	UTSW	7	49,058,440 (GRCm39)	small deletion	probably benign
R5320:Nav2	UTSW	7	49,141,121 (GRCm39)	missense	probably benign	0.00
R5377:Nav2	UTSW	7	49,238,908 (GRCm39)	missense	probably benign	0.02
R5471:Nav2	UTSW	7	49,197,917 (GRCm39)	missense	probably damaging	1.00
R5754:Nav2	UTSW	7	49,206,794 (GRCm39)	missense	probably damaging	1.00
R5832:Nav2	UTSW	7	49,197,817 (GRCm39)	splice site	probably null
R5884:Nav2	UTSW	7	49,246,917 (GRCm39)	nonsense	probably null
R5921:Nav2	UTSW	7	48,954,324 (GRCm39)	intron	probably benign
R6180:Nav2	UTSW	7	49,107,915 (GRCm39)	missense	probably benign	0.39
R6208:Nav2	UTSW	7	49,213,851 (GRCm39)	missense	probably damaging	0.99
R6373:Nav2	UTSW	7	49,102,923 (GRCm39)	missense	probably damaging	1.00
R6450:Nav2	UTSW	7	49,244,114 (GRCm39)	missense	probably damaging	1.00
R6522:Nav2	UTSW	7	49,247,281 (GRCm39)	missense	probably damaging	1.00
R6626:Nav2	UTSW	7	49,244,100 (GRCm39)	missense	probably damaging	1.00
R6695:Nav2	UTSW	7	49,114,652 (GRCm39)	missense	probably benign	0.04
R6705:Nav2	UTSW	7	49,201,664 (GRCm39)	missense	probably damaging	1.00
R6842:Nav2	UTSW	7	49,107,917 (GRCm39)	missense	possibly damaging	0.91
R6847:Nav2	UTSW	7	49,141,204 (GRCm39)	missense	probably benign	0.14
R7287:Nav2	UTSW	7	49,070,076 (GRCm39)	missense	probably benign	0.01
R7312:Nav2	UTSW	7	49,111,672 (GRCm39)	missense	possibly damaging	0.55
R7315:Nav2	UTSW	7	49,198,037 (GRCm39)	missense	possibly damaging	0.61
R7337:Nav2	UTSW	7	49,201,521 (GRCm39)	missense	possibly damaging	0.56
R7366:Nav2	UTSW	7	49,203,951 (GRCm39)	splice site	probably null
R7451:Nav2	UTSW	7	49,202,577 (GRCm39)	splice site	probably null
R7545:Nav2	UTSW	7	49,232,605 (GRCm39)	missense	probably damaging	1.00
R7706:Nav2	UTSW	7	49,244,067 (GRCm39)	missense	probably benign	0.35
R7730:Nav2	UTSW	7	49,222,145 (GRCm39)	missense	probably damaging	1.00
R7812:Nav2	UTSW	7	49,246,921 (GRCm39)	missense	probably benign	0.13
R8097:Nav2	UTSW	7	49,237,525 (GRCm39)	missense	probably damaging	1.00
R8110:Nav2	UTSW	7	49,201,698 (GRCm39)	nonsense	probably null
R8119:Nav2	UTSW	7	49,103,232 (GRCm39)	missense	probably damaging	0.99
R8298:Nav2	UTSW	7	49,204,009 (GRCm39)	critical splice donor site	probably null
R8306:Nav2	UTSW	7	49,195,765 (GRCm39)	missense	probably benign	0.33
R8331:Nav2	UTSW	7	49,102,371 (GRCm39)	missense	probably benign
R8402:Nav2	UTSW	7	49,103,185 (GRCm39)	missense	probably benign	0.43
R8421:Nav2	UTSW	7	49,102,269 (GRCm39)	missense	probably benign
R8478:Nav2	UTSW	7	49,111,733 (GRCm39)	missense	probably damaging	0.99
R8724:Nav2	UTSW	7	49,141,184 (GRCm39)	missense	possibly damaging	0.82
R8753:Nav2	UTSW	7	49,102,320 (GRCm39)	missense	probably benign
R8835:Nav2	UTSW	7	49,248,551 (GRCm39)	missense	possibly damaging	0.83
R8933:Nav2	UTSW	7	49,111,705 (GRCm39)	missense	probably damaging	1.00
R8957:Nav2	UTSW	7	49,220,964 (GRCm39)	missense	probably damaging	1.00
R9069:Nav2	UTSW	7	49,208,561 (GRCm39)	missense	probably damaging	0.99
R9223:Nav2	UTSW	7	49,202,599 (GRCm39)	missense	probably damaging	1.00
R9261:Nav2	UTSW	7	49,246,904 (GRCm39)	missense	probably damaging	1.00
X0023:Nav2	UTSW	7	49,197,647 (GRCm39)	missense	possibly damaging	0.47
Z1177:Nav2	UTSW	7	49,243,971 (GRCm39)	missense	probably benign	0.01
Z1177:Nav2	UTSW	7	49,102,509 (GRCm39)	missense	possibly damaging	0.47

Predicted Primers

PCR Primer
(F):5'- TCCATTAAGCTACAGAACTGGGG -3'
(R):5'- CTATCAATGGGGTGAGTCCAGC -3'

Sequencing Primer
(F):5'- CTGGGGCAACAAGAGAGAGTCTC -3'
(R):5'- AGCCTTCCACAACAAGCTTTTG -3'

Posted On

2021-12-30